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Journal Articles

Functional and Morphological Characterization of RBCs Loaded with Factor IX Conjugated with an Anti-Glycophorin Ā Antibody

Alina D. Peshkova, Taylor V. Brysgel, Parth Mody, Jia Nong, Zhicheng Wang, Jacob W. Myerson, Rustem I. Litvinov, John W. Weisel, Vladimir R. Muzykantov, Patrick M. Glassman, Oscar A. Marcos-Contreras

Blood (2023) 142 (Supplement 1): 116.

https://doi.org/10.1182/blood-2023-183024

Published: 2023

Journal Articles

Simultaneous Replacement of Endothelial Thrombomodulin and Plasma Protein C: A Novel Therapeutic Strategy for Sepsis-Induced Disseminated Intravascular Coagulation

Colin F Greineder, MDPhD, Ian Johnston, BS, Carlos Hipolito Villa, MD PhD, Douglas B. Cines, MD, Mortimer Poncz, MD, Vladimir R Muzykantov, MD PhD

Blood (2016) 128 (22): 2613.

https://doi.org/10.1182/blood.V128.22.2613.2613

Published: 2016

Journal Articles

Erythrocyte Rigidity Affects Blood Clot Contraction and Formation of Polyhedrocytes

Valerie Tutwiler, Rustem I. Litvinov, PhD, Chandrasekaran Nagaswami, J. Eric Russell, MD, Don L. Siegel, MD, PhD,, Carlos Hipolito Villa, MD PhD, Daniel Pan, PhD, Vladimir R Muzykantov, MD PhD, John W. Weisel

Blood (2016) 128 (22): 3814.

https://doi.org/10.1182/blood.V128.22.3814.3814

Published: 2016

Journal Articles

Coupling Therapeutics to Human Erythrocytes Demonstrates Target-Dependent Effects on Red Cell Physiology While Preserving Efficacy

Carlos Hipolito Villa, MD PhD, Daniel Pan, PhD, Ian Johnston, BS, Colin F Greineder, MD PhD, Marion E. Reid, PhD, Douglas B. Cines, MD, Mortimer Poncz, MD, Don L. Siegel, MD, PhD,, Vladimir R Muzykantov, MD PhD

Blood (2016) 128 (22): 701.

https://doi.org/10.1182/blood.V128.22.701.701

Published: 2016

Journal Articles

A Microfluidic Model of Microvascular Inflammation: Characterization and Testing of Endothelial-Targeted Therapeutics

Colin F Greineder, MDPhD, Ian Johnston, BS, Carlos Hipolito Villa, MD PhD, Douglas B. Cines, MD, Mortimer Poncz, MD, Vladimir R Muzykantov, MDPhD

Blood (2015) 126 (23): 3454.

https://doi.org/10.1182/blood.V126.23.3454.3454

Published: 2015

Journal Articles

Thrombomodulin Fusion Proteins Coupled to Human Erythrocytes Demonstrate Anti-Thrombotic and Anti-Inflammatory Activity

Carlos Hipolito Villa, MD PhD, Colin F Greineder, MDPhD, Ian Johnston, BS, Daniel Pan, PhD, Ronald Carnemolla, PhD, Douglas B. Cines, MD, Mortimer Poncz, MD, Don L. Siegel, MD, PhD,, Vladimir R Muzykantov, MDPhD

Blood (2015) 126 (23): 3493.

https://doi.org/10.1182/blood.V126.23.3493.3493

Published: 2015

Journal Articles

A Human-Specific, Platelet-Targeted, Thrombin-Activatable Urokinase (PLT/uPA-T) Demonstrates Selective Thromboprophylactic Properties in Two in Vivo Models

Hyun Sook Ahn, Rudy Fuentes, PhD, Vincent Hayes, Douglas B. Cines, MD, Vladimir R Muzykantov, MDPhD, Sergei V. Zaytsev, PhD, Mortimer Poncz, MD

Blood (2014) 124 (21): 579.

https://doi.org/10.1182/blood.V124.21.579.579

Published: 2014

Journal Articles

Advanced drug delivery systems for antithrombotic agents

Colin F. Greineder, Melissa D. Howard, Ronald Carnemolla, Douglas B. Cines, Vladimir R. Muzykantov

Blood (2013) 122 (9): 1565–1575.

https://doi.org/10.1182/blood-2013-03-453498

Published: 2013

Includes: Supplemental data

Journal Articles

Targeting Thrombomodulin to Endothelial ICAM-1 Rather Than PECAM-1 Allows Partnering with the Endothelial Protein C Receptor and Enhances Protection of Endothelial Barrier Function

Colin F Greineder, MD, Sergei Zaytsev, PhD, Blaine Zern, PhD, Ann Marie Chacko, PhD, Vladimir R Muzykantov, MD PhD

Blood (2012) 120 (21): 3351.

https://doi.org/10.1182/blood.V120.21.3351.3351

Published: 2012

Journal Articles

Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT)

Rudy Fuentes, PhD, Hyun Sook Ahn, Vincent M. Hayes, Valerie Tutwiler, Yuhuan Wang, PhD, Daniel W. Bougie, PhD, M. Anna Kowalska, PhD, Lubica Rauova, M.D., Ph.D., Richard H. Aster, MD, Douglas B. Cines, MD, Vladimir R Muzykantov, MD PhD, Mortimer Poncz, MD, Sergei Zaitsev, PhD

Blood (2012) 120 (21): 1171.

https://doi.org/10.1182/blood.V120.21.1171.1171

Published: 2012

Journal Articles

Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis

Sergei Zaitsev, M. Anna Kowalska, Michael Neyman, Ronald Carnemolla, Samira Tliba, Bi-Sen Ding, Aaron Stonestrom, Dirk Spitzer, John P. Atkinson, Mortimer Poncz, Douglas B. Cines, Charles T. Esmon, Vladimir R. Muzykantov

Blood (2012) 119 (20): 4779–4785.

https://doi.org/10.1182/blood-2011-12-398149

Published: 2012

Includes: Multimedia, Supplemental data

Journal Articles

Platelet-Targeted Pro-Urokinase as a Novel Thromboprophylaxis Fibrinolytic Strategy

Rudy Fuentes, M. Anna Kowalska, PhD, Samira Tliba, Daniel W. Bougie, PhD, Richard H. Aster, MD, Douglas B. Cines, MD, Vladimir R. Muzykantov, Mortimer Poncz, MD, Sergei Zaitsev

Blood (2010) 116 (21): 3339.

https://doi.org/10.1182/blood.V116.21.3339.3339

Published: 2010

Journal Articles

Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation

Sergei Zaitsev, Dirk Spitzer, Juan-Carlos Murciano, Bi-Sen Ding, Samira Tliba, M. Anna Kowalska, Oscar A. Marcos-Contreras, Alice Kuo, Victoria Stepanova, John P. Atkinson, Mortimer Poncz, Douglas B. Cines, Vladimir R. Muzykantov

Blood (2010) 115 (25): 5241–5248.

https://doi.org/10.1182/blood-2010-01-261610

Published: 2010

Includes: Supplemental data

Journal Articles

Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature

Bi-Sen Ding, Nankang Hong, Juan-Carlos Murciano, Kumkum Ganguly, Claudia Gottstein, Melpo Christofidou-Solomidou, Steven M. Albelda, Aron B. Fisher, Douglas B. Cines, Vladimir R. Muzykantov

Blood (2008) 111 (4): 1999–2006.

https://doi.org/10.1182/blood-2007-07-103002

Published: 2008

Includes: Supplemental data

Journal Articles

Erythrocyte Coupled tPA Improves Outcomes of Percussion Brain Trauma in Rats.

Kumkum Ganguly, PhD, Sherman C. Stein, M.D, Robert F. Groff, B.A, Jun Zhang, M.D, Douglas H. Smith, M.D, Douglas B. Cines, M. D, Ph. D, Vladimir R. Muzykantov, M.D, Ph.D

Blood (2006) 108 (11): 897.

https://doi.org/10.1182/blood.V108.11.897.897

Published: 2006

Journal Articles

Human complement receptor type 1–directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis

Sergei Zaitsev, Kristina Danielyan, Juan-Carlos Murciano, Kumkum Ganguly, Tatiana Krasik, Ronald P. Taylor, Steven Pincus, Steven Jones, Douglas B. Cines, Vladimir R. Muzykantov

Blood (2006) 108 (6): 1895–1902.

https://doi.org/10.1182/blood-2005-11-012336

Published: 2006

Journal Articles

Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature

Bi-Sen Ding, Claudia Gottstein, Andrea Grunow, Alice Kuo, Kumkum Ganguly, Steven M. Albelda, Douglas B. Cines, Vladimir R. Muzykantov

Blood (2005) 106 (13): 4191–4198.

https://doi.org/10.1182/blood-2005-05-2002

Published: 2005

Journal Articles

Coupling Tissue Type Plasminogen Activator to Carrier Erythrocyte Protects Against Plasma Inhibitors.

Kumkum Ganguly, PhD, Douglas B. Cines, MD, PhD, Vladimir R. Muzykantov, MD, PhD

Blood (2005) 106 (11): 1881.

https://doi.org/10.1182/blood.V106.11.1881.1881

Published: 2005

Journal Articles

ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs

Silvia Muro, Christine Gajewski, Michael Koval, Vladimir R. Muzykantov

Blood (2005) 105 (2): 650–658.

https://doi.org/10.1182/blood-2004-05-1714

Published: 2005

Journal Articles

Conjugation of Plasminogen Activators to Carrier Erythrocytes Imparts New Biological Properties to Their Soluble Counterparts.

Kumkum Ganguly, PhD, Tatiana Krasik, BSN, Khalil Bdeir, PhD, Douglas B. Cines, MD, PhD, Vladimir R. Muzykantov, MD, PhD, JuanCarlos Murciano, PhD

Blood (2004) 104 (11): 534.

https://doi.org/10.1182/blood.V104.11.534.534

Published: 2004

NARROW

Functional and Morphological Characterization of RBCs Loaded with Factor IX Conjugated with an Anti-Glycophorin Ā Antibody

Simultaneous Replacement of Endothelial Thrombomodulin and Plasma Protein C: A Novel Therapeutic Strategy for Sepsis-Induced Disseminated Intravascular Coagulation

Erythrocyte Rigidity Affects Blood Clot Contraction and Formation of Polyhedrocytes

Coupling Therapeutics to Human Erythrocytes Demonstrates Target-Dependent Effects on Red Cell Physiology While Preserving Efficacy

A Microfluidic Model of Microvascular Inflammation: Characterization and Testing of Endothelial-Targeted Therapeutics

Thrombomodulin Fusion Proteins Coupled to Human Erythrocytes Demonstrate Anti-Thrombotic and Anti-Inflammatory Activity

A Human-Specific, Platelet-Targeted, Thrombin-Activatable Urokinase (PLT/uPA-T) Demonstrates Selective Thromboprophylactic Properties in Two in Vivo Models

Advanced drug delivery systems for antithrombotic agents

Targeting Thrombomodulin to Endothelial ICAM-1 Rather Than PECAM-1 Allows Partnering with the Endothelial Protein C Receptor and Enhances Protection of Endothelial Barrier Function

Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT)

Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis

Platelet-Targeted Pro-Urokinase as a Novel Thromboprophylaxis Fibrinolytic Strategy

Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation

Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculature

Erythrocyte Coupled tPA Improves Outcomes of Percussion Brain Trauma in Rats.

Human complement receptor type 1–directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysis

Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature

Coupling Tissue Type Plasminogen Activator to Carrier Erythrocyte Protects Against Plasma Inhibitors.

ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs

Conjugation of Plasminogen Activators to Carrier Erythrocytes Imparts New Biological Properties to Their Soluble Counterparts.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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