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Journal Articles

Antibody-drug conjugate adverse effects can be understood and addressed based on immune complex clearance mechanisms

Ronald P. Taylor, Margaret A. Lindorfer

Blood (2024) 144 (2): 137–144.

https://doi.org/10.1182/blood.2024024442

Published: 2024

Journal Articles

T cells reinforce NK cell–mediated ADCC

Ronald P. Taylor

Blood (2024) 143 (18): 1786–1787.

https://doi.org/10.1182/blood.2024024444

Published: 2024

Journal Articles

Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

Zalaya K. Ivy, John D. Belcher, Iryna A. Khasabova, Chunsheng Chen, Joseph P. Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, Julia Nguyen, Victoria M. Rogness, Joan D. Beckman, Sergey G. Khasabov, Kalpna Gupta, Ronald P. Taylor, Donald A. Simone, Gregory M. Vercellotti

Blood (2023) 142 (22): 1918–1927.

https://doi.org/10.1182/blood.2022019282

Published: 2023

Includes: Supplemental data

Journal Articles

Low Dose Rituximab Efficiently Clears Circulating CLL Cells and Maintains Sensitivity to Antibody Dependent Cellular Phagocytosis (ADCP)

Clare B Heffernan, Charles C Chu, Jennifer E Bruno, Christine A Herne, Andrea M Baran, Ronald P Taylor, Paul M. Barr, Michael R. Elliott, Clive S Zent

Blood (2023) 142 (Supplement 1): 6548.

https://doi.org/10.1182/blood-2023-175019

Published: 2023

Journal Articles

Rituximab Induces an Inflammatory Cytokine Response with Increased IP-10 (CXCR10) in Patients with Infusion Reactions

Clive S. Zent, Jeremiah E. Moore, Paige C. Bloom, Charles C. Chu, Jennifer E. Bruno, Christine A. Herne, Andrea M Baran, Sally A. Quataert, Tim R. Mosmann, Ronald P. Taylor, Danielle S. Wallace, Michael R. Elliott, Paul M. Barr

Blood (2022) 140 (Supplement 1): 4171–4172.

https://doi.org/10.1182/blood-2022-162858

Published: 2022

Journal Articles

Risk-Adapted, Ofatumumab-Based Chemoimmunotherapy and Maintenance in Treatment-Naïve CLL: A Phase II Study

Blood (2019) 134 (Supplement_1): 5474.

https://doi.org/10.1182/blood-2019-126698

Published: 2019

Journal Articles

Null donors favor prepared immunologists

Ronald P. Taylor

Blood (2019) 133 (13): 1389–1390.

https://doi.org/10.1182/blood-2019-01-898775

Published: 2019

Journal Articles

Duohexabody-CD37, a Novel Bispecific Antibody with a Hexamerization-Enhancing Mutation Targeting CD37, Demonstrates Superior Complement-Dependent Cytotoxicity in Preclinical B-Cell Malignancy Models

Simone C. Oostindie, MSc, Hilma J. Van Der Horst, MSc, Marije B. Overdijk, PhD, Kristin Strumane, PhD, Sandra Verploegen, PhD, Margaret A. Lindorfer, PhD, Erica M. Cook, B.A., Martine E.D. Chamuleau, MD, Tuna Mutis, PhD, Janine Schuurman, PhD, A. Kate Sasser, PhD, Ronald P. Taylor, PhD, Paul W. H. I. Parren, PhD, Frank J. Beurskens, PhD, Esther C. W. Breij, PhD

Blood (2018) 132 (Supplement 1): 4170.

https://doi.org/10.1182/blood-2018-99-114723

Published: 2018

Journal Articles

Neutrophils: positive or negative?

Ronald P. Taylor

Blood (2017) 129 (19): 2596–2597.

https://doi.org/10.1182/blood-2017-03-774695

Published: 2017

Journal Articles

Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation

Terry Robert Schaid, Jr., BA, Julia Nguyen, BS, Chunsheng Chen, PhD, Fuad Abdulla, DVM, Trevor Killeen, Hao Nguyen, Joseph Edmund, MBBS, Margaret A Lindorfer, PhD, Ronald P Taylor, PhD, Agustin P Dalmasso, MD, John D Belcher, PhD, Gregory M Vercellotti, MD

Blood (2016) 128 (22): 158.

https://doi.org/10.1182/blood.V128.22.158.158

Published: 2016

Journal Articles

Fcγ-receptor–mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments

Ronald P. Taylor, Margaret A. Lindorfer

Blood (2015) 125 (5): 762–766.

https://doi.org/10.1182/blood-2014-10-569244

Published: 2015

Journal Articles

Enhanced IgG Hexamerization Mediates Efficient C1q Docking and Complement-Dependent Cytotoxicity; Preclinical Proof Of Concept On Primary CLL and Burkitt Lymphoma

Frank J Beurskens, PhD, Rob N de Jong, PhD, Sandra Verploegen, PhD, Marleen Voorhorst, Kristin Strumane, PhD, Margaret A. Lindorfer, PhD, Ronald P. Taylor, PhD, Erica Ollmann Saphire, PhD, Dennis Burton, PhD, Janine Schuurman, PhD, Paul W.H.I. Parren, PhD

Blood (2013) 122 (21): 375.

https://doi.org/10.1182/blood.V122.21.375.375

Published: 2013

Journal Articles

Gnawing at Metchnikoff’s paradigm

Ronald P. Taylor

Blood (2013) 122 (17): 2922–2924.

https://doi.org/10.1182/blood-2013-07-514083

Published: 2013

Journal Articles

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment opsonization

Antonio M. Risitano, Rosario Notaro, Caterina Pascariello, Michela Sica, Luigi del Vecchio, Christopher J. Horvath, Masha Fridkis-Hareli, Carmine Selleri, Margaret A. Lindorfer, Ronald P. Taylor, Lucio Luzzatto, V. Michael Holers

Blood (2012) 119 (26): 6307–6316.

https://doi.org/10.1182/blood-2011-12-398792

Published: 2012

Includes: Supplemental data

Journal Articles

Resistance to Complement Dependent Cytotoxicity in CLL Cells From Patients Treated with Ofatumumab

Nisar A. Baig, Ronald P. Taylor, PhD, Margaret A. Lindorfer, PhD, Amy K Church, Betsy R. LaPlant, Emily S. Pavey, Tait D. Shanafelt, MD, Timothy G. Call, MD, Neil Kay, MD, Grzegorz S. Nowakowski, MD, Clive S. Zent, MD

Blood (2011) 118 (21): 2836.

https://doi.org/10.1182/blood.V118.21.2836.2836

Published: 2011

Journal Articles

C3-Mediated Extravascular Hemolysis In Paroxysmal Nocturnal Hemoglobinuria: An In Vitro Model to Dissect Complement C3 Activation Comparing the Effects of Complement Inhibitors Eculizumab, 3E7 and TT30 on C3 Fragment Processing and Hemolysis of PNH Erythrocytes

Antonio M. Risitano, MD, PhD, Caterina Pascariello, Luigi Del Vecchio, MD, Christopher J Horvath, DVM, MS, DACVP, Masha Fridkis-Hareli, PhD, V. Michael Holers, MD, Margaret A Lindorfer, PhD, Ronald P Taylor, PhD

Blood (2010) 116 (21): 637.

https://doi.org/10.1182/blood.V116.21.637.637

Published: 2010

Journal Articles

Complement Activation and Cytotoxicity In CLL Cells Treated with Alemtuzumab and Ofatumumab: Evidence for Multiple Mechanisms of Resistance to Complement Dependent Cytotoxicity

Nisar A Baig, Amy K Church, Grzegorz S. Nowakowski, MD, Ronald P Taylor, PhD, Margaret A Lindorfer, PhD, Clive S. Zent, MD

Blood (2010) 116 (21): 3575.

https://doi.org/10.1182/blood.V116.21.3575.3575

Published: 2010

Journal Articles

CLL Cells From Subjects Treated with Rituximab and Alemtuzumab Can Lose Target Antigen and Develop Resistance to Mab-Mediated Complement Dependent Cytotoxicity

Ronald P Taylor, PhD, Clive S. Zent, MD, Paul V Beum, PhD, Margaret A Lindorfer, PhD, George Weiner, MD

Blood (2010) 116 (21): 3585.

https://doi.org/10.1182/blood.V116.21.3585.3585

Published: 2010

Journal Articles

Rapid Clearance of Rituximab Contributes to the Continued High Incidence of Autoimmune Complications of Chemoimmunotherapy for Chronic Lymphocytic Leukemia

Clifton C. Mo, MD, Mohammed Z.H. Farooqui, DO, Paul V. Beum, PhD, Ndegwa Njuguna, MD, Gerald E Marti, MD, PhD, Wyndham H. Wilson, MD, PhD, Ronald P. Taylor, PhD, Adrian U. Wiestner, MD, PhD

Blood (2010) 116 (21): 4628.

https://doi.org/10.1182/blood.V116.21.4628.4628

Published: 2010

Journal Articles

Examination of the Relative Rates of Rituximab-Mediated Loss of CD20 From B Cells Via Trogocytosis Versus Internalization. Implications for Rituximab Therapy of CLL

Ronald P Taylor, PhD, Paul V Beum, PhD, Margaret A Lindorfer, PhD, Elizabeth M Peek

Blood (2010) 116 (21): 2404.

https://doi.org/10.1182/blood.V116.21.2404.2404

Published: 2010

NARROW

Antibody-drug conjugate adverse effects can be understood and addressed based on immune complex clearance mechanisms

T cells reinforce NK cell–mediated ADCC

Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

Low Dose Rituximab Efficiently Clears Circulating CLL Cells and Maintains Sensitivity to Antibody Dependent Cellular Phagocytosis (ADCP)

Rituximab Induces an Inflammatory Cytokine Response with Increased IP-10 (CXCR10) in Patients with Infusion Reactions

Risk-Adapted, Ofatumumab-Based Chemoimmunotherapy and Maintenance in Treatment-Naïve CLL: A Phase II Study

Null donors favor prepared immunologists

Duohexabody-CD37, a Novel Bispecific Antibody with a Hexamerization-Enhancing Mutation Targeting CD37, Demonstrates Superior Complement-Dependent Cytotoxicity in Preclinical B-Cell Malignancy Models

Neutrophils: positive or negative?

Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation

Fcγ-receptor–mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments

Enhanced IgG Hexamerization Mediates Efficient C1q Docking and Complement-Dependent Cytotoxicity; Preclinical Proof Of Concept On Primary CLL and Burkitt Lymphoma

Gnawing at Metchnikoff’s paradigm

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment opsonization

Resistance to Complement Dependent Cytotoxicity in CLL Cells From Patients Treated with Ofatumumab

C3-Mediated Extravascular Hemolysis In Paroxysmal Nocturnal Hemoglobinuria: An In Vitro Model to Dissect Complement C3 Activation Comparing the Effects of Complement Inhibitors Eculizumab, 3E7 and TT30 on C3 Fragment Processing and Hemolysis of PNH Erythrocytes

Complement Activation and Cytotoxicity In CLL Cells Treated with Alemtuzumab and Ofatumumab: Evidence for Multiple Mechanisms of Resistance to Complement Dependent Cytotoxicity

CLL Cells From Subjects Treated with Rituximab and Alemtuzumab Can Lose Target Antigen and Develop Resistance to Mab-Mediated Complement Dependent Cytotoxicity

Rapid Clearance of Rituximab Contributes to the Continued High Incidence of Autoimmune Complications of Chemoimmunotherapy for Chronic Lymphocytic Leukemia

Examination of the Relative Rates of Rituximab-Mediated Loss of CD20 From B Cells Via Trogocytosis Versus Internalization. Implications for Rituximab Therapy of CLL

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American Society of Hematology

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American Society of Hematology

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