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Journal Articles

Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

Zalaya K. Ivy, John D. Belcher, Iryna A. Khasabova, Chunsheng Chen, Joseph P. Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, Julia Nguyen, Victoria M. Rogness, Joan D. Beckman, Sergey G. Khasabov, Kalpna Gupta, Ronald P. Taylor, Donald A. Simone, Gregory M. Vercellotti

Blood (2023) 142 (22): 1918–1927.

https://doi.org/10.1182/blood.2022019282

Published: 2023

Includes: Supplemental data

Journal Articles

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Blood (2023) 141 (15): 1871–1883.

https://doi.org/10.1182/blood.2022017074

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

Histone Deacetylase 6 Inhibition Prevents Vaso-Occlusion and Pain in Sickle Cell Mice

Aithanh Nguyen, Joseph P Juliette, Alison Wong, Elena Aronovich, Maya Abdullah, Julia Nguyen, Fuad Abdulla, Chunsheng Chen, Iryna A Khasabova, John D Belcher, Gregory M. Vercellotti, Donald Simone, Joan D Beckman

Blood (2022) 140 (Supplement 1): 2500–2501.

https://doi.org/10.1182/blood-2022-163508

Published: 2022

Journal Articles

Cold Exposure Induces Vaso-Occlusion and Hyperalgesia in Mice with Sickle Cell Disease That Is Dependent on Complement Activation

Zalaya K Ivy, John D Belcher, Iryna A Khasabova, Chunsheng Chen, Joseph P Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, Julia Nguyen, Victoria M Rogness, Sergey Khasabov, Kalpna Gupta, Donald Simone, Gregory M. Vercellotti

Blood (2022) 140 (Supplement 1): 443–444.

https://doi.org/10.1182/blood-2022-157597

Published: 2022

Journal Articles

Extracellular Vesicles from Sickle Red Blood Cells Activate Endothelial Cells and Trigger Von Willebrand Factor-Mediated Sickle Red Cell Adhesion

Ran An, Yuncheng Man, Kevin Cheng, Tianyi Zhang, Chunsheng Chen, Erdem Kucukal, William Wulftange, Utku Goreke, Allison Bode, Lalitha Nayak, Gregory M. Vercellotti, John D Belcher, Jane Alison Little, Umut A. Gurkan

Blood (2022) 140 (Supplement 1): 8223–8225.

https://doi.org/10.1182/blood-2022-170438

Published: 2022

Journal Articles

A model of painful vaso-occlusive crisis in mice with sickle cell disease

Iryna I. Khasabova, Joseph Juliette, Victoria M. Rogness, Sergey G. Khasabov, Mikhail Y. Golovko, Svetlana A. Golovko, Stacy Kiven, Kalpna Gupta, John D. Belcher, Gregory M. Vercellotti, Virginia S. Seybold, Donald A. Simone

Blood (2022) 140 (16): 1826–1830.

https://doi.org/10.1182/blood.2022017309

Published: 2022

Journal Articles

ML-0207/ASP8731: A Novel BACH1 Inhibitor That Induces Fetal Hemoglobin in Treatment of Sickle Cell Disease

Selva Nataraja, Maneet Singh, Shilpa Demes, Lyndsay Olson, Jeff Stanwix, Margaret Biddle, Emer Clarke, Yongzhao Huang, Julia Nguyen, Chunsheng Chen, Ping Zhang, Fuad Abdulla, Gregory M. Vercellotti, John D Belcher

Blood (2021) 138 (Supplement 1): 854.

https://doi.org/10.1182/blood-2021-151606

Published: 2021

Journal Articles

Synthetic Heparan Sulfate Compounds Attenuate Vascular Complications Associated with Sickle Cell Disease

Christina M Abrams, Erica Sparkenbaugh, Yongmei Xu, Chunsheng Chen, Kasemsiri Chandarajoti, Lantarima Bhoopat, John D Belcher, Gregory M. Vercellotti, Jian Liu, Rafal Pawlinski

Blood (2021) 138 (Supplement 1): 857.

https://doi.org/10.1182/blood-2021-148486

Published: 2021

Journal Articles

Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease

Thomas Gentinetta, PhD, Gregory M. Vercellotti, MD, Chunsheng Chen, Julia Nguyen, Fuad Abdulla, Ping Zhang, PhD, Gregory J Kato, MD, Nathan Brinkman, PhD, Adrian Zuercher, PhD, John D Belcher, PhD

Blood (2020) 136 (Supplement 1): 9.

https://doi.org/10.1182/blood-2020-140236

Published: 2020

Journal Articles

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Erica M. Sparkenbaugh, Chunsheng Chen, Tomasz Brzoska, Julia Nguyen, Shaobin Wang, Gregory M. Vercellotti, Nigel S. Key, Prithu Sundd, John D. Belcher, Rafal Pawlinski

Blood (2020) 135 (20): 1783–1787.

https://doi.org/10.1182/blood.2019003543

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Increased Release of Soluble MD-2 in Sickle Cell Disease and Its Role in Pro-Inflammatory Signaling in Endothelial Cells

Ping Zhang, PhD, John D Belcher, PhD, Julia Nguyen, Fuad Abdulla, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 208.

https://doi.org/10.1182/blood-2019-122912

Published: 2019

Journal Articles

Identification of a Heme Activation Site on the MD-2/TLR4 Complex

John D Belcher, PhD, Ping Zhang, PhD, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, John O Trent, PhD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 209.

https://doi.org/10.1182/blood-2019-123788

Published: 2019

Journal Articles

Deletion of TLR4 in Townes SS Mice Prevents Microvascular Stasis in Response to Hemin, LPS and Hypoxia/Reoxygenation: Role of Inflammation

John D Belcher, PhD, Fuad Abdulla, Chunsheng Chen, Ping Zhang, PhD, Dormarie Rivera-Rodriguez, Rachel Kirchner, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Kristine Nachbor, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 3555.

https://doi.org/10.1182/blood-2019-127114

Published: 2019

Journal Articles

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

John D Belcher, PhD, Margaret Biddle, PhD, Domi Stickens, PhD, Lyndsay Olson, Eric Bell, Chunsheng Chen, Fuad Abdulla, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 983.

https://doi.org/10.1182/blood-2019-127300

Published: 2019

Journal Articles

Thrombin-Mediated Activation of PAR-1 Contributes to Microvascular Stasis in Mouse Models of Sickle Cell Disease Via Increased Endothelial Expression of P-Selectin and VWF

Erica Sparkenbaugh, PhD BS, Chunsheng Chen, MD, Julia Nguyen, BS, Shaobin Wang, PhD, Gregory M. Vercellotti, MD, John D Belcher, PhD, Rafal Pawlinski, PhD

Blood (2018) 132 (Supplement 1): 266.

https://doi.org/10.1182/blood-2018-99-116238

Published: 2018

Journal Articles

Decreased Erythrocyte Binding Capability for Neutrophil Siglec-9 Is a Source of Oxidative Stress in Sickle Cell Disease

Zachary Monroe Kiser, BS, PhD, Greta L Becker, Julia Nguyen, BS, Anel Lizcano, PhD, John D Belcher, PhD, Ajit P. Varki, MBBS, Gregory M. Vercellotti, MD

Blood (2018) 132 (Supplement 1): 3650.

https://doi.org/10.1182/blood-2018-99-113579

Published: 2018

Journal Articles

Oral Carbon Monoxide Therapy in Murine Models of Sickle Cell Disease: Beneficial Effects on Vaso-Occlusion, Inflammation and Anemia

John D Belcher, PhD, Edward Gomperts, MD, Julia Nguyen, BS, Chunsheng Chen, MD, Fuad Abdulla, Hao Nguyen, Tran Vo, Karina Bursch, Zachary M Kiser, PhD, Howard Levy, MDPhD, Leo E Otterbein, PhD, Gregory M Vercellotti, MD FACP

Blood (2017) 130 (Supplement 1): 2232.

https://doi.org/10.1182/blood.V130.Suppl_1.2232.2232

Published: 2017

Journal Articles

A Novel, Highly Potent and Selective PDE9 Inhibitor for the Treatment of Sickle Cell Disease

James G McArthur, PhD, Thiago Maciel, PhD, Chunsheng Chen, PhD, Aurelie Fricot, Dione Kobayashi, PhD, Julia Nguyen, BS, Phong Nguyen, Anna Parachova, PhD, Fuad Abdulla, Gregory M. Vercellotti, MD, Niels Svenstrup, PhD, John D Belcher, PhD

Blood (2016) 128 (22): 268.

https://doi.org/10.1182/blood.V128.22.268.268

Published: 2016

Journal Articles

Serum Haptoglobin and Hemopexin Levels in Pediatric SS and SC Disease Patients: Biomarker of Hemolysis and Inflammation

Rayra Pereira Santiago, MSc, Caroline Conceição Guarda, MSc, Camylla Vilas Boas Figueiredo, Graduated, Luciana Magalhaes Fiuza, Graduation student, Corynne Stephanie Ahouefa Adanho, MSc, Milena Magalhães Aleluia, MSc, Dalila Luciola Zanette, PhD, Magda Oliveira Seixas Carvalho, PhD, Isa Menezes Lyra, MD PhD, Valma Maria Lopes, MD, Julia Nguyen, BS, Trevor Killeen, Hao Nguyen, Gregory M. Vercellotti, MD, John D. Belcher, PhD, Marilda Souza Goncalves, PhD

Blood (2016) 128 (22): 3649.

https://doi.org/10.1182/blood.V128.22.3649.3649

Published: 2016

Journal Articles

Systemic Heme and Iron Overload Results in Depletion of Serum Hemopexin, Haptoglobin and Transferrin and Correlates with Markers of Endothelial Activation and Lipid Oxidation in Beta Thalassemia Major and Intermedia

Francesca Vinchi, PhD, Gregory M Vercellotti, MD, John D. Belcher, PhD, Eitan Fibach, PhD, Hala Zreid, MD, Rushdy Rasras, Hussam Ghoti, MD, Martina U. Muckenthaler, PhD, Eliezer A. Rachmilewitz, MD

Blood (2016) 128 (22): 2469.

https://doi.org/10.1182/blood.V128.22.2469.2469

Published: 2016

NARROW

Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Histone Deacetylase 6 Inhibition Prevents Vaso-Occlusion and Pain in Sickle Cell Mice

Cold Exposure Induces Vaso-Occlusion and Hyperalgesia in Mice with Sickle Cell Disease That Is Dependent on Complement Activation

Extracellular Vesicles from Sickle Red Blood Cells Activate Endothelial Cells and Trigger Von Willebrand Factor-Mediated Sickle Red Cell Adhesion

A model of painful vaso-occlusive crisis in mice with sickle cell disease

ML-0207/ASP8731: A Novel BACH1 Inhibitor That Induces Fetal Hemoglobin in Treatment of Sickle Cell Disease

Synthetic Heparan Sulfate Compounds Attenuate Vascular Complications Associated with Sickle Cell Disease

Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Increased Release of Soluble MD-2 in Sickle Cell Disease and Its Role in Pro-Inflammatory Signaling in Endothelial Cells

Identification of a Heme Activation Site on the MD-2/TLR4 Complex

Deletion of TLR4 in Townes SS Mice Prevents Microvascular Stasis in Response to Hemin, LPS and Hypoxia/Reoxygenation: Role of Inflammation

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

Thrombin-Mediated Activation of PAR-1 Contributes to Microvascular Stasis in Mouse Models of Sickle Cell Disease Via Increased Endothelial Expression of P-Selectin and VWF

Decreased Erythrocyte Binding Capability for Neutrophil Siglec-9 Is a Source of Oxidative Stress in Sickle Cell Disease

Oral Carbon Monoxide Therapy in Murine Models of Sickle Cell Disease: Beneficial Effects on Vaso-Occlusion, Inflammation and Anemia

A Novel, Highly Potent and Selective PDE9 Inhibitor for the Treatment of Sickle Cell Disease

Serum Haptoglobin and Hemopexin Levels in Pediatric SS and SC Disease Patients: Biomarker of Hemolysis and Inflammation

Systemic Heme and Iron Overload Results in Depletion of Serum Hemopexin, Haptoglobin and Transferrin and Correlates with Markers of Endothelial Activation and Lipid Oxidation in Beta Thalassemia Major and Intermedia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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