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Journal Articles

Venetoclax or pirtobrutinib in relapsed/refractory Waldenström macroglobulinemia: Clinical and molecular predictors and sequencing implications

Alberto Guijosa, Nickolas Tsakmaklis, Margaret Kobs, Nina Budano, Julia Nguyen, Alexandra Eurell, Maria Luisa Guerrera, Gottfried von Keudell, Andrew Branagan, Zachary Hunter, Steven Treon, Shayna Sarosiek, Jorge Castillo

Blood (2025) 146 (Supplement 1): 3577.

https://doi.org/10.1182/blood-2025-3577

Published: 2025

Journal Articles

High VGPR/CR rates with pirtobrutinib plus venetoclax in previously treated Waldenström macroglobulinemia: Results from a multicenter phase II study

Blood (2025) 146 (Supplement 1): 225.

https://doi.org/10.1182/blood-2025-225

Published: 2025

Journal Articles

Deep responses following treatment with loncastuximab tesirine (WM-NET1 trial) in patients with Relapsed/Refractory including those withhigh-risk, TP53-altered Waldenström macroglobulinemia.

Shayna Sarosiek, Mary Kwok, Prashant Kapoor, Hannah Chory, Nina Budano, Julia Nguyen, Alexandra Eurell, Kirsten Meid, Alberto Guijosa, Nickolas Tsakmaklis, Zachary Hunter, Andrew Branagan, Steven Treon, Jorge Castillo

Blood (2025) 146 (Supplement 1): 581.

https://doi.org/10.1182/blood-2025-581

Published: 2025

Journal Articles

C1-INH and atiii inhibit vaso-occlusion and vascular inflammation in sickle cell disease mice

John Belcher, Julia Nguyen, Fuad Abdulla, Chunsheng Chen, Conglin Ruan, Larisa Belyanskaya, Sigurd Knaub, Olaf Walter, Gregory Vercellotti

Blood (2025) 146 (Supplement 1): 835.

https://doi.org/10.1182/blood-2025-835

Published: 2025

Journal Articles

Application of dorsal skin fold chamber microvascular thrombosis model in JAK2V617F mice

Paul Krenik, Julia Nguyen, Chunsheng Chen, Fuad Abdulla, Pattarapol Muepae, Conglin Ruan, Maya Abdulla, Kaelyn Chen, Nithita Nanthatanti, Gregory Vercellotti, John Belcher, Joan Beckman

Blood (2025) 146 (Supplement 1): 421.

https://doi.org/10.1182/blood-2025-421

Published: 2025

Journal Articles

Mass spectrometry demonstrates very frequent multi-clonality in familial Waldenström macroglobulinemia and shows distinct IgM profiles across IgM-related disorders.

Alberto Guijosa, Nickolas Tsakmaklis, Abigail Peachey, Nicholas Paciaroni, Nina Budano, Julia Nguyen, Kirsten Meid, Maria Luisa Guerrera, Christopher Patterson, Andrew Branagan, Shayna Sarosiek, Zachary Hunter, Jorge Castillo, Steven Treon

Blood (2025) 146 (Supplement 1): 5392.

https://doi.org/10.1182/blood-2025-5392

Published: 2025

Journal Articles

Final report of a phase II study of ibrutinib and venetoclax in previously untreated Waldenström macroglobulinemia

Jorge Castillo, Andrew Branagan, Gottfried von Keudell, Alberto Guijosa, Nina Budano, Julia Nguyen, Alexandra Eurell, Kirsten Meid, Maria Luisa Guerrera, Amanda Kofides, Shirong Liu, Xia Liu, Nickolas Tsakmaklis, Zachary Hunter, Steven Treon, Shayna Sarosiek

Blood (2025) 146 (Supplement 1): 1794.

https://doi.org/10.1182/blood-2025-1794

Published: 2025

Journal Articles

LOX1 expression identifies a population of polymorphonuclear myeloid-derived suppressor cells that are highly enriched in bone marrow samples of treatment-Naïve and BTKi-Relapsed/Refractory WM patients and show constitutive activation of BTK

Blood (2025) 146 (Supplement 1): 5731.

https://doi.org/10.1182/blood-2025-5731

Published: 2025

Journal Articles

G-CSF receptor is a signaling node linking thrombo-inflammation to vaso-occlusion in sickle cell disease: Target for a new phase 2 trial

Gregory Kato, Tomasz Kaminski, Paolo Rossato, Fnu Manikanta, Nicholas Swendrowski, Nicole Westerfeld, Arne Wehling, Carlos Roca, Steffi Knoll Machado, Timo Kraushaar, Branislav Krljanac, Fuad Abdulla, Julia Nguyen, Chunsheng Chen, Conglin Ruan, Markus Brechmann, Gregory Vercellotti, Prithu Sundd, John Belcher

Blood (2025) 146 (Supplement 1): 838.

https://doi.org/10.1182/blood-2025-838

Published: 2025

Journal Articles

Bruton Tyrosine Kinase Inhibitor Rilzabrutinib Reduces Vaso-Occlusion and Markers of Inflammation and Adhesion in Transgenic Mice with Sickle Cell Disease

Ahmed Daak, David R. Light, Fuad Abdulla, Chunsheng Chen, Julia Nguyen, Conglin Ruan, Michael Storek, Dimitry Ofengeim, Alexandra Hicks, Michelle Lee, Vincent Mikol, Gregory M. Vercellotti, John D. Belcher

Blood (2024) 144 (Supplement 1): 2482.

https://doi.org/10.1182/blood-2024-200182

Published: 2024

Journal Articles

Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

Zalaya K. Ivy, John D. Belcher, Iryna A. Khasabova, Chunsheng Chen, Joseph P. Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, Julia Nguyen, Victoria M. Rogness, Joan D. Beckman, Sergey G. Khasabov, Kalpna Gupta, Ronald P. Taylor, Donald A. Simone, Gregory M. Vercellotti

Blood (2023) 142 (22): 1918–1927.

https://doi.org/10.1182/blood.2022019282

Published: 2023

Includes: Supplemental data

Journal Articles

Effect of Integrin α 4 β 1 -VCAM-1 Interactions in JAK2 V617F Myeloproliferative Neoplasm Pro-Thrombotic Interactions

Angelica DaSilva, Joan D Beckman, Maya Abdullah, Elena Aronovich, Aithanh Viet Nguyen, Julia Nguyen, David Wood

Blood (2023) 142 (Supplement 1): 1194.

https://doi.org/10.1182/blood-2023-182170

Published: 2023

Journal Articles

Cold Exposure Induces Vaso-Occlusion and Hyperalgesia in Mice with Sickle Cell Disease That Is Dependent on Complement Activation

Zalaya K Ivy, John D Belcher, Iryna A Khasabova, Chunsheng Chen, Joseph P Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, Julia Nguyen, Victoria M Rogness, Sergey Khasabov, Kalpna Gupta, Donald Simone, Gregory M. Vercellotti

Blood (2022) 140 (Supplement 1): 443–444.

https://doi.org/10.1182/blood-2022-157597

Published: 2022

Journal Articles

Histone Deacetylase 6 Inhibition Prevents Vaso-Occlusion and Pain in Sickle Cell Mice

Aithanh Nguyen, Joseph P Juliette, Alison Wong, Elena Aronovich, Maya Abdullah, Julia Nguyen, Fuad Abdulla, Chunsheng Chen, Iryna A Khasabova, John D Belcher, Gregory M. Vercellotti, Donald Simone, Joan D Beckman

Blood (2022) 140 (Supplement 1): 2500–2501.

https://doi.org/10.1182/blood-2022-163508

Published: 2022

Journal Articles

ML-0207/ASP8731: A Novel BACH1 Inhibitor That Induces Fetal Hemoglobin in Treatment of Sickle Cell Disease

Selva Nataraja, Maneet Singh, Shilpa Demes, Lyndsay Olson, Jeff Stanwix, Margaret Biddle, Emer Clarke, Yongzhao Huang, Julia Nguyen, Chunsheng Chen, Ping Zhang, Fuad Abdulla, Gregory M. Vercellotti, John D Belcher

Blood (2021) 138 (Supplement 1): 854.

https://doi.org/10.1182/blood-2021-151606

Published: 2021

Journal Articles

Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease

Thomas Gentinetta, PhD, Gregory M. Vercellotti, MD, Chunsheng Chen, Julia Nguyen, Fuad Abdulla, Ping Zhang, PhD, Gregory J Kato, MD, Nathan Brinkman, PhD, Adrian Zuercher, PhD, John D Belcher, PhD

Blood (2020) 136 (Supplement 1): 9.

https://doi.org/10.1182/blood-2020-140236

Published: 2020

Journal Articles

Ruxolitinib Reduces Endothelial Pro-Adhesive Interactions: Implications for JAK2 V617+ MPN Thrombosis

Angelica DaSilva, BS, Elena Aronovich, PhD, Aithanh Nguyen, Julia Nguyen, David Reynolds, Geneva D. Doak, B.S., PhD, Gregory M. Vercellotti, MD, David K. Wood, PhD, Joan D. Beckman, MDPhD

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-140116

Published: 2020

Journal Articles

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Erica M. Sparkenbaugh, Chunsheng Chen, Tomasz Brzoska, Julia Nguyen, Shaobin Wang, Gregory M. Vercellotti, Nigel S. Key, Prithu Sundd, John D. Belcher, Rafal Pawlinski

Blood (2020) 135 (20): 1783–1787.

https://doi.org/10.1182/blood.2019003543

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

John D Belcher, PhD, Margaret Biddle, PhD, Domi Stickens, PhD, Lyndsay Olson, Eric Bell, Chunsheng Chen, Fuad Abdulla, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 983.

https://doi.org/10.1182/blood-2019-127300

Published: 2019

Journal Articles

Deletion of TLR4 in Townes SS Mice Prevents Microvascular Stasis in Response to Hemin, LPS and Hypoxia/Reoxygenation: Role of Inflammation

John D Belcher, PhD, Fuad Abdulla, Chunsheng Chen, Ping Zhang, PhD, Dormarie Rivera-Rodriguez, Rachel Kirchner, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Kristine Nachbor, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 3555.

https://doi.org/10.1182/blood-2019-127114

Published: 2019

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Venetoclax or pirtobrutinib in relapsed/refractory Waldenström macroglobulinemia: Clinical and molecular predictors and sequencing implications

High VGPR/CR rates with pirtobrutinib plus venetoclax in previously treated Waldenström macroglobulinemia: Results from a multicenter phase II study

Deep responses following treatment with loncastuximab tesirine (WM-NET1 trial) in patients with Relapsed/Refractory including those withhigh-risk, TP53-altered Waldenström macroglobulinemia.

C1-INH and atiii inhibit vaso-occlusion and vascular inflammation in sickle cell disease mice

Application of dorsal skin fold chamber microvascular thrombosis model in JAK2V617F mice

Mass spectrometry demonstrates very frequent multi-clonality in familial Waldenström macroglobulinemia and shows distinct IgM profiles across IgM-related disorders.

Final report of a phase II study of ibrutinib and venetoclax in previously untreated Waldenström macroglobulinemia

LOX1 expression identifies a population of polymorphonuclear myeloid-derived suppressor cells that are highly enriched in bone marrow samples of treatment-Naïve and BTKi-Relapsed/Refractory WM patients and show constitutive activation of BTK

G-CSF receptor is a signaling node linking thrombo-inflammation to vaso-occlusion in sickle cell disease: Target for a new phase 2 trial

Bruton Tyrosine Kinase Inhibitor Rilzabrutinib Reduces Vaso-Occlusion and Markers of Inflammation and Adhesion in Transgenic Mice with Sickle Cell Disease

Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

Effect of Integrin α 4 β 1 -VCAM-1 Interactions in JAK2 V617F Myeloproliferative Neoplasm Pro-Thrombotic Interactions

Cold Exposure Induces Vaso-Occlusion and Hyperalgesia in Mice with Sickle Cell Disease That Is Dependent on Complement Activation

Histone Deacetylase 6 Inhibition Prevents Vaso-Occlusion and Pain in Sickle Cell Mice

ML-0207/ASP8731: A Novel BACH1 Inhibitor That Induces Fetal Hemoglobin in Treatment of Sickle Cell Disease

Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease

Ruxolitinib Reduces Endothelial Pro-Adhesive Interactions: Implications for JAK2 V617+ MPN Thrombosis

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

Deletion of TLR4 in Townes SS Mice Prevents Microvascular Stasis in Response to Hemin, LPS and Hypoxia/Reoxygenation: Role of Inflammation

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