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Journal Articles

4D intravital imaging studies identify platelets as the predominant cellular procoagulant surface in a mouse hemostasis model

Abigail Ballard-Kordeliski, Robert H. Lee, Ellen C. O’Shaughnessy, Paul Y. Kim, Summer R. Jones, Rafal Pawlinski, Matthew J. Flick, David S. Paul, Nigel Mackman, David A. Adalsteinsson, Wolfgang Bergmeier

Blood (2024) 144 (10): 1116–1126.

https://doi.org/10.1182/blood.2023022608

Published: 2024

Includes: Multimedia, Supplemental data

Journal Articles

Validation of Townes As Mice As a Model of Chronic Kidney Disease and Venous Thrombosis Associated with Sickle Cell Trait

Malgorzata Kasztan, Steven P Grover, Fatima Trebak, Mohammad O Sako, Nigel S. Key, Rafal Pawlinski

Blood (2023) 142 (Supplement 1): 564.

https://doi.org/10.1182/blood-2023-186635

Published: 2023

Journal Articles

Pharmacologic Reduction of Platelet Count Attenuates Whole Blood Hypofibrinolysis in a Mouse Model of Sickle Cell Disease

Anton Ilich, Karnsasin Seanoon, Fatima Trebak, Andras Gruber, Nigel S. Key, Rafal Pawlinski

Blood (2023) 142 (Supplement 1): 562.

https://doi.org/10.1182/blood-2023-187098

Published: 2023

Journal Articles

Hypertonicity and/or Acidosis Induce Marked Rheological Changes Under Hypoxic Conditions in Sickle Trait Red Blood Cells

Patrick Ellsworth, Izabela Pawlinski, Rachel Sielaty, Anton Ilich, Chatphatai Moonla, Yuriy Prokopenko, Dougald M. Monroe, Rafal Pawlinski, Nigel S. Key

Blood (2023) 142 (Supplement 1): 1113.

https://doi.org/10.1182/blood-2023-187112

Published: 2023

Journal Articles

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Blood (2023) 141 (15): 1871–1883.

https://doi.org/10.1182/blood.2022017074

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

Protease Activated Receptor-1 (PAR-1) Inhibition By Parmodulin 2, but Not Vorapaxar, Protects Sickle Cell Mice from Heme-Induced Acute Chest Syndrome

Nirupama Ramadas, Kailyn Lowder, Rafal Pawlinski, Erica Sparkenbaugh

Blood (2022) 140 (Supplement 1): 2512.

https://doi.org/10.1182/blood-2022-162629

Published: 2022

Journal Articles

Parmodulin, an Allosteric Inhibitor of Protease Activated Receptor 1 (PAR1) Protects Sickle Cell Mice from Thromboinflammation and Endothelial Dysfunction

Nirupama Ramadas, Kailyn Lowder, Laurent O. Mosnier, Rafal Pawlinski, Erica Sparkenbaugh

Blood (2022) 140 (Supplement 1): 5389–5390.

https://doi.org/10.1182/blood-2022-166708

Published: 2022

Journal Articles

P-Selectin Deficiency Reduces Acute Vascular Complications but Not Chronic Organ Damage in Sickle Cell Mice

Erica Sparkenbaugh, Malgorzata Kasztan, Megan D Miller, Elizabeth A Binning, Christina M Abrams, Brandi Reeves, Prithu Sundd, Rafal Pawlinski

Blood (2021) 138 (Supplement 1): 187.

https://doi.org/10.1182/blood-2021-153671

Published: 2021

Journal Articles

Inhibition of Factor XII Attenuates Prothrombotic Complications in Sickle Cell Mice

Erica Sparkenbaugh, Christina M Abrams, Megan D Miller, Brian C Cooley, Anton Ilich, Shreya Yadav, Michael Wallisch, Nigel S Key, Andras Gruber, Felicity N. E. Gavins, Rafal Pawlinski

Blood (2021) 138 (Supplement 1): 189.

https://doi.org/10.1182/blood-2021-152753

Published: 2021

Journal Articles

Synthetic Heparan Sulfate Compounds Attenuate Vascular Complications Associated with Sickle Cell Disease

Christina M Abrams, Erica Sparkenbaugh, Yongmei Xu, Chunsheng Chen, Kasemsiri Chandarajoti, Lantarima Bhoopat, John D Belcher, Gregory M. Vercellotti, Jian Liu, Rafal Pawlinski

Blood (2021) 138 (Supplement 1): 857.

https://doi.org/10.1182/blood-2021-148486

Published: 2021

Journal Articles

Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure

Michael W. Henderson, Erica M. Sparkenbaugh, Shaobin Wang, Anton Ilich, Denis F. Noubouossie, Reiner Mailer, Thomas Renné, Matthew J. Flick, James P. Luyendyk, Zu-Lin Chen, Sidney Strickland, R. Todd Stravitz, Keith R. McCrae, Nigel S. Key, Rafal Pawlinski

Blood (2021) 138 (3): 259–272.

https://doi.org/10.1182/blood.2020006198

Published: 2021

Includes: Supplemental data

Journal Articles

Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease

Junaid Ansari, Elena Y. Senchenkova, Shantel A. Vital, Zaki Al-Yafeai, Gaganpreet Kaur, Erica M. Sparkenbaugh, A. Wayne Orr, Rafal Pawlinski, Robert P. Hebbel, D. Neil Granger, Paul Kubes, Felicity N. E. Gavins

Blood (2021) 137 (11): 1538–1549.

https://doi.org/10.1182/blood.2020009166

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

Biased PAR-1 Signaling Regulates Thrombo-Inflammation in a Mouse Model of Sickle Cell Disease

Erica Sparkenbaugh, PhD, John H. Griffin, PhD, Laurent O Mosnier, Rafal Pawlinski, PhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-139862

Published: 2020

Journal Articles

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Erica M. Sparkenbaugh, Chunsheng Chen, Tomasz Brzoska, Julia Nguyen, Shaobin Wang, Gregory M. Vercellotti, Nigel S. Key, Prithu Sundd, John D. Belcher, Rafal Pawlinski

Blood (2020) 135 (20): 1783–1787.

https://doi.org/10.1182/blood.2019003543

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways

Denis F. Noubouossie, Michael W. Henderson, Micah Mooberry, Anton Ilich, Patrick Ellsworth, Mark Piegore, Sarah C. Skinner, Rafal Pawlinski, Ian Welsby, Thomas Renné, Maureane Hoffman, Dougald M. Monroe, Nigel S. Key

Blood (2020) 135 (10): 755–765.

https://doi.org/10.1182/blood.2019001643

Published: 2020

Includes: Supplemental data

Journal Articles

High Molecular Weight Kininogen but Not Factor XII Deficiency Attenuates Acetaminophen-Induced Liver Injury in Mice

Michael Wayne Henderson, MSc, Erica Sparkenbaugh, PhD BS, Denis Noubouossie, MD PhD, Reiner Mailer, Thomas Renne, MD PhD, Keith R McCrae, MD, Nigel S. Key, MBChB, FRCP, Rafal Pawlinski, PhD

Blood (2019) 134 (Supplement_1): 3621.

https://doi.org/10.1182/blood-2019-127206

Published: 2019

Journal Articles

Red blood cells modulate structure and dynamics of venous clot formation in sickle cell disease

Camille Faes, Anton Ilich, Amandine Sotiaux, Erica M. Sparkenbaugh, Michael W. Henderson, Laura Buczek, Joan D. Beckman, Patrick Ellsworth, Denis F. Noubouossie, Lantarima Bhoopat, Mark Piegore, Céline Renoux, Wolfgang Bergmeier, Yara Park, Kenneth I. Ataga, Brian Cooley, Alisa S. Wolberg, Nigel S. Key, Rafal Pawlinski

Blood (2019) 133 (23): 2529–2541.

https://doi.org/10.1182/blood.2019000424

Published: 2019

Includes: Multimedia, Supplemental data

Journal Articles

Thrombin-Mediated Activation of PAR-1 Contributes to Microvascular Stasis in Mouse Models of Sickle Cell Disease Via Increased Endothelial Expression of P-Selectin and VWF

Erica Sparkenbaugh, PhD BS, Chunsheng Chen, MD, Julia Nguyen, BS, Shaobin Wang, PhD, Gregory M. Vercellotti, MD, John D Belcher, PhD, Rafal Pawlinski, PhD

Blood (2018) 132 (Supplement 1): 266.

https://doi.org/10.1182/blood-2018-99-116238

Published: 2018

Journal Articles

High Molecular Weight Kininogen Contributes to End-Organ Damage and Mortality in a Mouse Model of Sickle Cell Disease

Erica Sparkenbaugh, PhD BS, Kathryn Wilson, BS, Malgorzata Kasztan, PhD, David M. Pollock, PhD, Keith R. McCrae, MD, Rafal Pawlinski, PhD

Blood (2018) 132 (Supplement 1): 268.

https://doi.org/10.1182/blood-2018-99-116526

Published: 2018

Journal Articles

Upregulation of Tissue Factor May Contribute to Thrombosis in Polycythemia Vera and Essential Thrombocythemia

Brandi Reeves, MD, Soo Jin Kim, MS, Jihyun Song, PhD, Radhika Gangaraju, MD, Rafal Pawlinski, PhD, Perumal Thiagarajan, MD, Victor R. Gordeuk, MD, Nigel S. Key, MBChB, FRCP, Josef T. Prchal, MD

Blood (2018) 132 (Supplement 1): 2513.

https://doi.org/10.1182/blood-2018-99-117812

Published: 2018

NARROW

4D intravital imaging studies identify platelets as the predominant cellular procoagulant surface in a mouse hemostasis model

Validation of Townes As Mice As a Model of Chronic Kidney Disease and Venous Thrombosis Associated with Sickle Cell Trait

Pharmacologic Reduction of Platelet Count Attenuates Whole Blood Hypofibrinolysis in a Mouse Model of Sickle Cell Disease

Hypertonicity and/or Acidosis Induce Marked Rheological Changes Under Hypoxic Conditions in Sickle Trait Red Blood Cells

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Protease Activated Receptor-1 (PAR-1) Inhibition By Parmodulin 2, but Not Vorapaxar, Protects Sickle Cell Mice from Heme-Induced Acute Chest Syndrome

Parmodulin, an Allosteric Inhibitor of Protease Activated Receptor 1 (PAR1) Protects Sickle Cell Mice from Thromboinflammation and Endothelial Dysfunction

P-Selectin Deficiency Reduces Acute Vascular Complications but Not Chronic Organ Damage in Sickle Cell Mice

Inhibition of Factor XII Attenuates Prothrombotic Complications in Sickle Cell Mice

Synthetic Heparan Sulfate Compounds Attenuate Vascular Complications Associated with Sickle Cell Disease

Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure

Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease

Biased PAR-1 Signaling Regulates Thrombo-Inflammation in a Mouse Model of Sickle Cell Disease

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways

High Molecular Weight Kininogen but Not Factor XII Deficiency Attenuates Acetaminophen-Induced Liver Injury in Mice

Red blood cells modulate structure and dynamics of venous clot formation in sickle cell disease

Thrombin-Mediated Activation of PAR-1 Contributes to Microvascular Stasis in Mouse Models of Sickle Cell Disease Via Increased Endothelial Expression of P-Selectin and VWF

High Molecular Weight Kininogen Contributes to End-Organ Damage and Mortality in a Mouse Model of Sickle Cell Disease

Upregulation of Tissue Factor May Contribute to Thrombosis in Polycythemia Vera and Essential Thrombocythemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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