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Journal Articles

Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

Zalaya K. Ivy, John D. Belcher, Iryna A. Khasabova, Chunsheng Chen, Joseph P. Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, Julia Nguyen, Victoria M. Rogness, Joan D. Beckman, Sergey G. Khasabov, Kalpna Gupta, Ronald P. Taylor, Donald A. Simone, Gregory M. Vercellotti

Blood (2023) 142 (22): 1918–1927.

https://doi.org/10.1182/blood.2022019282

Published: 2023

Includes: Supplemental data

Journal Articles

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Blood (2023) 141 (15): 1871–1883.

https://doi.org/10.1182/blood.2022017074

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

Histone Deacetylase 6 Inhibition Prevents Vaso-Occlusion and Pain in Sickle Cell Mice

Aithanh Nguyen, Joseph P Juliette, Alison Wong, Elena Aronovich, Maya Abdullah, Julia Nguyen, Fuad Abdulla, Chunsheng Chen, Iryna A Khasabova, John D Belcher, Gregory M. Vercellotti, Donald Simone, Joan D Beckman

Blood (2022) 140 (Supplement 1): 2500–2501.

https://doi.org/10.1182/blood-2022-163508

Published: 2022

Journal Articles

Cold Exposure Induces Vaso-Occlusion and Hyperalgesia in Mice with Sickle Cell Disease That Is Dependent on Complement Activation

Zalaya K Ivy, John D Belcher, Iryna A Khasabova, Chunsheng Chen, Joseph P Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, Julia Nguyen, Victoria M Rogness, Sergey Khasabov, Kalpna Gupta, Donald Simone, Gregory M. Vercellotti

Blood (2022) 140 (Supplement 1): 443–444.

https://doi.org/10.1182/blood-2022-157597

Published: 2022

Journal Articles

Extracellular Vesicles from Sickle Red Blood Cells Activate Endothelial Cells and Trigger Von Willebrand Factor-Mediated Sickle Red Cell Adhesion

Ran An, Yuncheng Man, Kevin Cheng, Tianyi Zhang, Chunsheng Chen, Erdem Kucukal, William Wulftange, Utku Goreke, Allison Bode, Lalitha Nayak, Gregory M. Vercellotti, John D Belcher, Jane Alison Little, Umut A. Gurkan

Blood (2022) 140 (Supplement 1): 8223–8225.

https://doi.org/10.1182/blood-2022-170438

Published: 2022

Journal Articles

ML-0207/ASP8731: A Novel BACH1 Inhibitor That Induces Fetal Hemoglobin in Treatment of Sickle Cell Disease

Selva Nataraja, Maneet Singh, Shilpa Demes, Lyndsay Olson, Jeff Stanwix, Margaret Biddle, Emer Clarke, Yongzhao Huang, Julia Nguyen, Chunsheng Chen, Ping Zhang, Fuad Abdulla, Gregory M. Vercellotti, John D Belcher

Blood (2021) 138 (Supplement 1): 854.

https://doi.org/10.1182/blood-2021-151606

Published: 2021

Journal Articles

Synthetic Heparan Sulfate Compounds Attenuate Vascular Complications Associated with Sickle Cell Disease

Christina M Abrams, Erica Sparkenbaugh, Yongmei Xu, Chunsheng Chen, Kasemsiri Chandarajoti, Lantarima Bhoopat, John D Belcher, Gregory M. Vercellotti, Jian Liu, Rafal Pawlinski

Blood (2021) 138 (Supplement 1): 857.

https://doi.org/10.1182/blood-2021-148486

Published: 2021

Journal Articles

Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease

Thomas Gentinetta, PhD, Gregory M. Vercellotti, MD, Chunsheng Chen, Julia Nguyen, Fuad Abdulla, Ping Zhang, PhD, Gregory J Kato, MD, Nathan Brinkman, PhD, Adrian Zuercher, PhD, John D Belcher, PhD

Blood (2020) 136 (Supplement 1): 9.

https://doi.org/10.1182/blood-2020-140236

Published: 2020

Journal Articles

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Erica M. Sparkenbaugh, Chunsheng Chen, Tomasz Brzoska, Julia Nguyen, Shaobin Wang, Gregory M. Vercellotti, Nigel S. Key, Prithu Sundd, John D. Belcher, Rafal Pawlinski

Blood (2020) 135 (20): 1783–1787.

https://doi.org/10.1182/blood.2019003543

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Deletion of TLR4 in Townes SS Mice Prevents Microvascular Stasis in Response to Hemin, LPS and Hypoxia/Reoxygenation: Role of Inflammation

John D Belcher, PhD, Fuad Abdulla, Chunsheng Chen, Ping Zhang, PhD, Dormarie Rivera-Rodriguez, Rachel Kirchner, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Kristine Nachbor, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 3555.

https://doi.org/10.1182/blood-2019-127114

Published: 2019

Journal Articles

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

John D Belcher, PhD, Margaret Biddle, PhD, Domi Stickens, PhD, Lyndsay Olson, Eric Bell, Chunsheng Chen, Fuad Abdulla, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 983.

https://doi.org/10.1182/blood-2019-127300

Published: 2019

Journal Articles

Thrombin-Mediated Activation of PAR-1 Contributes to Microvascular Stasis in Mouse Models of Sickle Cell Disease Via Increased Endothelial Expression of P-Selectin and VWF

Erica Sparkenbaugh, PhD BS, Chunsheng Chen, MD, Julia Nguyen, BS, Shaobin Wang, PhD, Gregory M. Vercellotti, MD, John D Belcher, PhD, Rafal Pawlinski, PhD

Blood (2018) 132 (Supplement 1): 266.

https://doi.org/10.1182/blood-2018-99-116238

Published: 2018

Journal Articles

Oral Carbon Monoxide Therapy in Murine Models of Sickle Cell Disease: Beneficial Effects on Vaso-Occlusion, Inflammation and Anemia

John D Belcher, PhD, Edward Gomperts, MD, Julia Nguyen, BS, Chunsheng Chen, MD, Fuad Abdulla, Hao Nguyen, Tran Vo, Karina Bursch, Zachary M Kiser, PhD, Howard Levy, MDPhD, Leo E Otterbein, PhD, Gregory M Vercellotti, MD FACP

Blood (2017) 130 (Supplement 1): 2232.

https://doi.org/10.1182/blood.V130.Suppl_1.2232.2232

Published: 2017

Journal Articles

A Novel, Highly Potent and Selective PDE9 Inhibitor for the Treatment of Sickle Cell Disease

James G McArthur, PhD, Thiago Maciel, PhD, Chunsheng Chen, PhD, Aurelie Fricot, Dione Kobayashi, PhD, Julia Nguyen, BS, Phong Nguyen, Anna Parachova, PhD, Fuad Abdulla, Gregory M. Vercellotti, MD, Niels Svenstrup, PhD, John D Belcher, PhD

Blood (2016) 128 (22): 268.

https://doi.org/10.1182/blood.V128.22.268.268

Published: 2016

Journal Articles

Haptoglobin and Hemopexin Infusion Efficiently Activates the Nrf2/HO-1 Axis and Inhibits Inflammation and Vaso-Occlusion in Murine Sickle Cell Disease

John D Belcher, PhD, Chunsheng Chen, PhD, Julia Nguyen, BS, Fuad Abdulla, DVM, Phong Nguyen, BS, Hao Nguyen, Ping Zhang, PhD, Nathan Brinkman, Gregory M Vercellotti, MD

Blood (2016) 128 (22): 2477.

https://doi.org/10.1182/blood.V128.22.2477.2477

Published: 2016

Journal Articles

Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation

Terry Robert Schaid, Jr., BA, Julia Nguyen, BS, Chunsheng Chen, PhD, Fuad Abdulla, DVM, Trevor Killeen, Hao Nguyen, Joseph Edmund, MBBS, Margaret A Lindorfer, PhD, Ronald P Taylor, PhD, Agustin P Dalmasso, MD, John D Belcher, PhD, Gregory M Vercellotti, MD

Blood (2016) 128 (22): 158.

https://doi.org/10.1182/blood.V128.22.158.158

Published: 2016

Journal Articles

Hemopexin Gene Therapy Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Cell Mice

Gregory M Vercellotti, Ping Zhang, PhD, Chunsheng Chen, PhD, Julia Nguyen, BS, Fuad Abdulla, DVM, Phong Nguyen, BS, Carlos Nowotny, Aman Irfanullah, Ann Smith, PhD, Clifford J. Steer, MD, John D. Belcher, PhD

Blood (2015) 126 (23): 412.

https://doi.org/10.1182/blood.V126.23.412.412

Published: 2015

Journal Articles

Phenotypic Characterization the Townes Sickle Mice

Julia Nguyen, BS, Fuad Abdulla, Chunsheng Chen, Phong Nguyen, Minh Nguyen, Benjamin Tittle, Gerard O'Sullivan, MVB, MSc, PhD MACVSc, John D. Belcher, PhD, Gregory M. Vercellotti, MD

Blood (2014) 124 (21): 4916.

https://doi.org/10.1182/blood.V124.21.4916.4916

Published: 2014

Journal Articles

Dimethyl Fumarate Induces Cytoprotection and Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Mice

John D. Belcher, PhD, Julia Nguyen, Chunsheng Chen, Fuad Abdulla, Phong Nguyen, Minh Nguyen, Ping Zhang, PhD, Pauline Xu, Nicholas J. Slipek, Gregory M. Vercellotti, MD

Blood (2014) 124 (21): 219.

https://doi.org/10.1182/blood.V124.21.219.219

Published: 2014

Journal Articles

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

John D. Belcher, Chunsheng Chen, Julia Nguyen, Liming Milbauer, Fuad Abdulla, Abdu I. Alayash, Ann Smith, Karl A. Nath, Robert P. Hebbel, Gregory M. Vercellotti

Blood (2014) 123 (3): 377–390.

https://doi.org/10.1182/blood-2013-04-495887

Published: 2014

Includes: Supplemental data

NARROW

Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Histone Deacetylase 6 Inhibition Prevents Vaso-Occlusion and Pain in Sickle Cell Mice

Cold Exposure Induces Vaso-Occlusion and Hyperalgesia in Mice with Sickle Cell Disease That Is Dependent on Complement Activation

Extracellular Vesicles from Sickle Red Blood Cells Activate Endothelial Cells and Trigger Von Willebrand Factor-Mediated Sickle Red Cell Adhesion

ML-0207/ASP8731: A Novel BACH1 Inhibitor That Induces Fetal Hemoglobin in Treatment of Sickle Cell Disease

Synthetic Heparan Sulfate Compounds Attenuate Vascular Complications Associated with Sickle Cell Disease

Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Deletion of TLR4 in Townes SS Mice Prevents Microvascular Stasis in Response to Hemin, LPS and Hypoxia/Reoxygenation: Role of Inflammation

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

Thrombin-Mediated Activation of PAR-1 Contributes to Microvascular Stasis in Mouse Models of Sickle Cell Disease Via Increased Endothelial Expression of P-Selectin and VWF

Oral Carbon Monoxide Therapy in Murine Models of Sickle Cell Disease: Beneficial Effects on Vaso-Occlusion, Inflammation and Anemia

A Novel, Highly Potent and Selective PDE9 Inhibitor for the Treatment of Sickle Cell Disease

Haptoglobin and Hemopexin Infusion Efficiently Activates the Nrf2/HO-1 Axis and Inhibits Inflammation and Vaso-Occlusion in Murine Sickle Cell Disease

Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation

Hemopexin Gene Therapy Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Cell Mice

Phenotypic Characterization the Townes Sickle Mice

Dimethyl Fumarate Induces Cytoprotection and Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Mice

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

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American Society of Hematology

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American Society of Hematology

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