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Journal Articles

Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

Zalaya K. Ivy, John D. Belcher, Iryna A. Khasabova, Chunsheng Chen, Joseph P. Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, Julia Nguyen, Victoria M. Rogness, Joan D. Beckman, Sergey G. Khasabov, Kalpna Gupta, Ronald P. Taylor, Donald A. Simone, Gregory M. Vercellotti

Blood (2023) 142 (22): 1918–1927.

https://doi.org/10.1182/blood.2022019282

Published: 2023

Includes: Supplemental data

Journal Articles

Histone Deacetylase 6 Inhibition Prevents Vaso-Occlusion and Pain in Sickle Cell Mice

Aithanh Nguyen, Joseph P Juliette, Alison Wong, Elena Aronovich, Maya Abdullah, Julia Nguyen, Fuad Abdulla, Chunsheng Chen, Iryna A Khasabova, John D Belcher, Gregory M. Vercellotti, Donald Simone, Joan D Beckman

Blood (2022) 140 (Supplement 1): 2500–2501.

https://doi.org/10.1182/blood-2022-163508

Published: 2022

Journal Articles

Cold Exposure Induces Vaso-Occlusion and Hyperalgesia in Mice with Sickle Cell Disease That Is Dependent on Complement Activation

Zalaya K Ivy, John D Belcher, Iryna A Khasabova, Chunsheng Chen, Joseph P Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, Julia Nguyen, Victoria M Rogness, Sergey Khasabov, Kalpna Gupta, Donald Simone, Gregory M. Vercellotti

Blood (2022) 140 (Supplement 1): 443–444.

https://doi.org/10.1182/blood-2022-157597

Published: 2022

Journal Articles

ML-0207/ASP8731: A Novel BACH1 Inhibitor That Induces Fetal Hemoglobin in Treatment of Sickle Cell Disease

Selva Nataraja, Maneet Singh, Shilpa Demes, Lyndsay Olson, Jeff Stanwix, Margaret Biddle, Emer Clarke, Yongzhao Huang, Julia Nguyen, Chunsheng Chen, Ping Zhang, Fuad Abdulla, Gregory M. Vercellotti, John D Belcher

Blood (2021) 138 (Supplement 1): 854.

https://doi.org/10.1182/blood-2021-151606

Published: 2021

Journal Articles

Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease

Thomas Gentinetta, PhD, Gregory M. Vercellotti, MD, Chunsheng Chen, Julia Nguyen, Fuad Abdulla, Ping Zhang, PhD, Gregory J Kato, MD, Nathan Brinkman, PhD, Adrian Zuercher, PhD, John D Belcher, PhD

Blood (2020) 136 (Supplement 1): 9.

https://doi.org/10.1182/blood-2020-140236

Published: 2020

Journal Articles

Deletion of TLR4 in Townes SS Mice Prevents Microvascular Stasis in Response to Hemin, LPS and Hypoxia/Reoxygenation: Role of Inflammation

John D Belcher, PhD, Fuad Abdulla, Chunsheng Chen, Ping Zhang, PhD, Dormarie Rivera-Rodriguez, Rachel Kirchner, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Kristine Nachbor, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 3555.

https://doi.org/10.1182/blood-2019-127114

Published: 2019

Journal Articles

Increased Release of Soluble MD-2 in Sickle Cell Disease and Its Role in Pro-Inflammatory Signaling in Endothelial Cells

Ping Zhang, PhD, John D Belcher, PhD, Julia Nguyen, Fuad Abdulla, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 208.

https://doi.org/10.1182/blood-2019-122912

Published: 2019

Journal Articles

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

John D Belcher, PhD, Margaret Biddle, PhD, Domi Stickens, PhD, Lyndsay Olson, Eric Bell, Chunsheng Chen, Fuad Abdulla, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 983.

https://doi.org/10.1182/blood-2019-127300

Published: 2019

Journal Articles

Oral Carbon Monoxide Therapy in Murine Models of Sickle Cell Disease: Beneficial Effects on Vaso-Occlusion, Inflammation and Anemia

John D Belcher, PhD, Edward Gomperts, MD, Julia Nguyen, BS, Chunsheng Chen, MD, Fuad Abdulla, Hao Nguyen, Tran Vo, Karina Bursch, Zachary M Kiser, PhD, Howard Levy, MDPhD, Leo E Otterbein, PhD, Gregory M Vercellotti, MD FACP

Blood (2017) 130 (Supplement 1): 2232.

https://doi.org/10.1182/blood.V130.Suppl_1.2232.2232

Published: 2017

Journal Articles

A Novel, Highly Potent and Selective PDE9 Inhibitor for the Treatment of Sickle Cell Disease

James G McArthur, PhD, Thiago Maciel, PhD, Chunsheng Chen, PhD, Aurelie Fricot, Dione Kobayashi, PhD, Julia Nguyen, BS, Phong Nguyen, Anna Parachova, PhD, Fuad Abdulla, Gregory M. Vercellotti, MD, Niels Svenstrup, PhD, John D Belcher, PhD

Blood (2016) 128 (22): 268.

https://doi.org/10.1182/blood.V128.22.268.268

Published: 2016

Journal Articles

Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation

Terry Robert Schaid, Jr., BA, Julia Nguyen, BS, Chunsheng Chen, PhD, Fuad Abdulla, DVM, Trevor Killeen, Hao Nguyen, Joseph Edmund, MBBS, Margaret A Lindorfer, PhD, Ronald P Taylor, PhD, Agustin P Dalmasso, MD, John D Belcher, PhD, Gregory M Vercellotti, MD

Blood (2016) 128 (22): 158.

https://doi.org/10.1182/blood.V128.22.158.158

Published: 2016

Journal Articles

Haptoglobin and Hemopexin Infusion Efficiently Activates the Nrf2/HO-1 Axis and Inhibits Inflammation and Vaso-Occlusion in Murine Sickle Cell Disease

John D Belcher, PhD, Chunsheng Chen, PhD, Julia Nguyen, BS, Fuad Abdulla, DVM, Phong Nguyen, BS, Hao Nguyen, Ping Zhang, PhD, Nathan Brinkman, Gregory M Vercellotti, MD

Blood (2016) 128 (22): 2477.

https://doi.org/10.1182/blood.V128.22.2477.2477

Published: 2016

Journal Articles

Hemopexin Gene Therapy Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Cell Mice

Gregory M Vercellotti, Ping Zhang, PhD, Chunsheng Chen, PhD, Julia Nguyen, BS, Fuad Abdulla, DVM, Phong Nguyen, BS, Carlos Nowotny, Aman Irfanullah, Ann Smith, PhD, Clifford J. Steer, MD, John D. Belcher, PhD

Blood (2015) 126 (23): 412.

https://doi.org/10.1182/blood.V126.23.412.412

Published: 2015

Journal Articles

Dimethyl Fumarate Induces Cytoprotection and Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Mice

John D. Belcher, PhD, Julia Nguyen, Chunsheng Chen, Fuad Abdulla, Phong Nguyen, Minh Nguyen, Ping Zhang, PhD, Pauline Xu, Nicholas J. Slipek, Gregory M. Vercellotti, MD

Blood (2014) 124 (21): 219.

https://doi.org/10.1182/blood.V124.21.219.219

Published: 2014

Journal Articles

Phenotypic Characterization the Townes Sickle Mice

Julia Nguyen, BS, Fuad Abdulla, Chunsheng Chen, Phong Nguyen, Minh Nguyen, Benjamin Tittle, Gerard O'Sullivan, MVB, MSc, PhD MACVSc, John D. Belcher, PhD, Gregory M. Vercellotti, MD

Blood (2014) 124 (21): 4916.

https://doi.org/10.1182/blood.V124.21.4916.4916

Published: 2014

Journal Articles

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

John D. Belcher, Chunsheng Chen, Julia Nguyen, Liming Milbauer, Fuad Abdulla, Abdu I. Alayash, Ann Smith, Karl A. Nath, Robert P. Hebbel, Gregory M. Vercellotti

Blood (2014) 123 (3): 377–390.

https://doi.org/10.1182/blood-2013-04-495887

Published: 2014

Includes: Supplemental data

Journal Articles

Interference With TNFα Using Long-Term Etanercept In S+S Antilles Sickle Transgenic Mice Ameliorates Abnormal Endothelial Activation, Vasoocclusion, and Pulmonary Hypertension Including Its Pulmonary Arterial Wall Remodeling

Anna Solovey, Arif Somani, Chunsheng Chen, James Kiley, Paul Marker, Fuad Abdulla, M Gerard O'Sullivan, Robert J Kelm, Jr., John D Belcher, Ph.D., Gregory M Vercellotti, Robert P Hebbel

Blood (2013) 122 (21): 728.

https://doi.org/10.1182/blood.V122.21.728.728

Published: 2013

Journal Articles

The Blood Monocyte - TNF - Endothelial Axis in Activation of Endothelial Tissue Factor in the Transgenic Sickle Mouse: Possible Relevance of Etanercept to Sickle Coagulopathy

Anna Solovey, M.D., Liming Milbauer Chang, Ph.D., Fuad Abdulla, Rahn Kollander, Paul H Marker, MS, Robert Kelm, Jr., Ph.D., Gregory M Vercellotti, MD, Robert P Hebbel, MD

Blood (2011) 118 (21): 1048.

https://doi.org/10.1182/blood.V118.21.1048.1048

Published: 2011

Journal Articles

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice

Robert P. Hebbel, Gregory M. Vercellotti, Betty S. Pace, Anna N. Solovey, Rahn Kollander, Chine F. Abanonu, Julia Nguyen, Julie V. Vineyard, John D. Belcher, Fuad Abdulla, Shadé Osifuye, John W. Eaton, Robert J. Kelm, Jr, Arne Slungaard

Blood (2010) 115 (12): 2483–2490.

https://doi.org/10.1182/blood-2009-02-204990

Published: 2010

Journal Articles

The HDAC Inhibitors Trichostatin A (TSA) and Suberoylanilide Hydroxamic Acid (SAHA) Exhibit Multiple Modalities of Benefit for the Vascular Pathology of Sickle Disease.

Robert P Hebbel, MD, Gregory M. Vercellotti, MD, Betty Pace, MD, Anna Solovey, M.D., Rahn Kollander, Chine Abanonu, Julia Nguyen, BS, Julie V. Vineyard, BS, John D Belcher, Ph.D., Fuad Abdulla, Shade Osifuye, John W. Eaton, PhD, Robert Kelm, MD, Arne Slungaard, MD

Blood (2009) 114 (22): 2586.

https://doi.org/10.1182/blood.V114.22.2586.2586

Published: 2009

NARROW

Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

Histone Deacetylase 6 Inhibition Prevents Vaso-Occlusion and Pain in Sickle Cell Mice

Cold Exposure Induces Vaso-Occlusion and Hyperalgesia in Mice with Sickle Cell Disease That Is Dependent on Complement Activation

ML-0207/ASP8731: A Novel BACH1 Inhibitor That Induces Fetal Hemoglobin in Treatment of Sickle Cell Disease

Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease

Deletion of TLR4 in Townes SS Mice Prevents Microvascular Stasis in Response to Hemin, LPS and Hypoxia/Reoxygenation: Role of Inflammation

Increased Release of Soluble MD-2 in Sickle Cell Disease and Its Role in Pro-Inflammatory Signaling in Endothelial Cells

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

Oral Carbon Monoxide Therapy in Murine Models of Sickle Cell Disease: Beneficial Effects on Vaso-Occlusion, Inflammation and Anemia

A Novel, Highly Potent and Selective PDE9 Inhibitor for the Treatment of Sickle Cell Disease

Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation

Haptoglobin and Hemopexin Infusion Efficiently Activates the Nrf2/HO-1 Axis and Inhibits Inflammation and Vaso-Occlusion in Murine Sickle Cell Disease

Hemopexin Gene Therapy Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Cell Mice

Dimethyl Fumarate Induces Cytoprotection and Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Mice

Phenotypic Characterization the Townes Sickle Mice

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Interference With TNFα Using Long-Term Etanercept In S+S Antilles Sickle Transgenic Mice Ameliorates Abnormal Endothelial Activation, Vasoocclusion, and Pulmonary Hypertension Including Its Pulmonary Arterial Wall Remodeling

The Blood Monocyte - TNF - Endothelial Axis in Activation of Endothelial Tissue Factor in the Transgenic Sickle Mouse: Possible Relevance of Etanercept to Sickle Coagulopathy

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice

The HDAC Inhibitors Trichostatin A (TSA) and Suberoylanilide Hydroxamic Acid (SAHA) Exhibit Multiple Modalities of Benefit for the Vascular Pathology of Sickle Disease.

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American Society of Hematology

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American Society of Hematology

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