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David R. Light
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Journal Articles

SGK1 Inhibition Induces Fetal Hemoglobin in Erythroid Cells

Yannis Hara, Mark Stottlemyer, Kim Alving, Nis Halland, Alexandra Hicks, David R. Light
Journal: Blood
Blood (2021) 138 (Supplement 1): 963.
https://doi.org/10.1182/blood-2021-146071
Published: 2021
Journal Articles

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Melanie Demers, PhD, Sarah Sturtevant, BSc, Kevin Guertin, PhD, Dipti Gupta, Kunal Desai, MS, Benjamin Vieira, BS, Alexandra Hicks, PhD, Ayman Ismail, PhD, Yukio Nakamura, MD PhD, Bronner Goncalves, MD PhD, Giuseppe Di Caprio, PhD, Ethan Schonbrun, PhD, Scott Hansen, BS, Martin K. Safo, PhD, David K. Wood, PhD, John M. Higgins, MD PhD, David R. Light, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2260.
https://doi.org/10.1182/blood-2019-128727
Published: 2019
Journal Articles

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Dipti Gupta, Samuel Lessard, PhD, Nancy Moore, Jicheng Duan, PhD, Yukio Nakamura, MD PhD, Feng-Chun Yang, MD PhD, Alexandra Hicks, PhD, David R. Light, PhD, Sriram Krishnamoorthy, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 210.
https://doi.org/10.1182/blood-2019-129479
Published: 2019
Journal Articles

LC-MS Analysis of Anti-Sickling Compounds in Cord Blood Derived RBCs Demonstrates Modification of Fetal Hemoglobin and Globin Chain Binding Preferences

Benjamin Vieira, Vu P. Hong, Kunal Desai, Martin K. Safo, David R. Light
Journal: Blood
Blood (2018) 132 (Supplement 1): 1074.
https://doi.org/10.1182/blood-2018-99-116319
Published: 2018
Journal Articles

Nrf2 Activation and Fetal Hemoglobin Induction in Sickle Cell Disease

Sriram Krishnamoorthy, Dipti Gupta, William E. Hobbs, MD PhD, Christine Loh, PhD, David R. Light, Robert Peters, PhD, Sarah Sturtevant, Betty Pace, MD, Yukio Nakamura, Brian Lucas, Benjamin F. Vieira
Journal: Blood
Blood (2016) 128 (22): 4840.
https://doi.org/10.1182/blood.V128.22.4840.4840
Published: 2016
Journal Articles

Prolonged Half-Life and Improved Recovery of Recombinant Factor IX-XTEN Fusion Proteins in Hemophilia B Mouse Model

Arjan van der Flier, PhD, Zhiqian Lucy Liu, PhD, Zhan Liu, MSc, Oblaise Mercury, BS, Ayman Ismail, PhD, Ekta Seth-Chhabra, PhD, John Kulman, PhD, Volker Schellenberger, PhD, David R. Light, PhD, Robert Peters, PhD
Journal: Blood
Blood (2015) 126 (23): 2271.
https://doi.org/10.1182/blood.V126.23.2271.2271
Published: 2015
Journal Articles

Dimethyl Fumarate Induces Fetal Hemoglobin in Sickle Cell Disease

Sriram Krishnamoorthy, PhD, Dipti Gupta, MS, Sarah Sturtevant, Biaoru Li, PhD, Levi C Makala, DVM, MBA, PhD, William E. Hobbs, MDPhD, David R. Light, PhD, Betty Pace, MD
Journal: Blood
Blood (2015) 126 (23): 410.
https://doi.org/10.1182/blood.V126.23.410.410
Published: 2015
Journal Articles

Enhancing the Acute Hemostatic Efficacy in Cynomolgus Monkeys By Targeting Activated Coagulation Factor VII to Platelets

Siyuan Tan, PhD, Joe Salas, PhD, Kai Chen, Tamera Ashworth, Sarah Smith, Elena Kistanova, Nancy Moore, Marisol Acosta, Anxhela Kole, David R. Light, PhD, Robert Peters, PhD, Haiyan Jiang, PhD
Journal: Blood
Blood (2014) 124 (21): 1488.
https://doi.org/10.1182/blood.V124.21.1488.1488
Published: 2014
Journal Articles

Natalizumab Blocks VLA-4 Mediated Red Blood Cell Adhesion and Is a Potential Therapy for Sickle Cell Disease

Patrick C. Hines, MD PhD, Sriram Krishnamoorthy, PhD, Jennell White, PhD, Dipti Gupta, MS, Arjan van der Flier, PhD, Moira M. Lancelot, MD, Robert T. Peters, PhD BS, Haiyan Jiang, PhD, William E Hobbs, MD PhD, David R. Light, PhD
Journal: Blood
Blood (2014) 124 (21): 221.
https://doi.org/10.1182/blood.V124.21.221.221
Published: 2014
Journal Articles

An Immunodeficient Mouse Model With Circulating Human Platelets To Evaluate The Platelet Clearance and Pharmacokinetics Of Platelet-Targeted Coagulation Factor VIIa

Siyuan Tan, PhD, Kai Chen, MS, Joe Salas, Ph.D., Robert Peters, Ph.D., David R. Light, PhD, Haiyan Jiang, PhD
Journal: Blood
Blood (2013) 122 (21): 2345.
https://doi.org/10.1182/blood.V122.21.2345.2345
Published: 2013
Journal Articles

Immunohistochemical Staining of rFVIIIFc and rFVIII in Liver Cells Differentiates Between a VWF-Dependent and Independent Clearance Pathway in Mice

Arjan van der Flier, PhD, Zhan Liu, David R. Light, PhD, Haiyan Jiang, PhD
Journal: Blood
Blood (2013) 122 (21): 2331.
https://doi.org/10.1182/blood.V122.21.2331.2331
Published: 2013
Journal Articles

Different Contribution of Hematopoietic and Somatic Cell Types Expressing FcRn to the Prolonged Half-Life of Recombinant Factor VIII Fc and Recombinant FIX Fc

Arjan van der Flier, PhD, Zhan Liu, Douglas Drager, Sebastien Vallee, PhD, Kai Chen, Siyuan Tan, PhD, Keith Wharton, MD, PhD, David R. Light, PhD, Haiyan Jiang, PhD
Journal: Blood
Blood (2012) 120 (21): 1103.
https://doi.org/10.1182/blood.V120.21.1103.1103
Published: 2012
Journal Articles

Cellular Uptake of rFVIIIFc in Liver Is Primarily Contributed by Sinusoidal Endothelial Cells.

Siyuan Tan, PhD, Kai Chen, Arjan van der Flier, PhD, Zhan Liu, David R. Light, PhD, Haiyan Jiang, PhD
Journal: Blood
Blood (2012) 120 (21): 2219.
https://doi.org/10.1182/blood.V120.21.2219.2219
Published: 2012
Journal Articles

Structural Comparability Between Recombinant FVIII-Fc and Its Isolated FVIII and Fc Constituents

John Kulman, Ph.D., Susan Tsutakawa, PhD, George Bou-Assaf, PhD, Steven Berkowitz, PhD, David R. Light, PhD, Adam Mezo, PhD, Deping Wang, PhD, Marc Whitlow, PhD, Liz Culyba, PhD, John Tainer, PhD, Robert Peters, PhD
Journal: Blood
Blood (2012) 120 (21): 1135.
https://doi.org/10.1182/blood.V120.21.1135.1135
Published: 2012