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Dipti Gupta
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Journal Articles

Heme-Regulated eIF2α Kinase (HRI) Inhibition Decreases PKR Activation in HUDEP2 Cells

Yannis Hara, Dipti Gupta, Courtney Mercadante, Kim Alving, Yukio Nakamura, Sriram Krishnamoorthy, Alexandra Hicks, Melanie Demers
Journal: Blood
Blood (2021) 138 (Supplement 1): 2035.
https://doi.org/10.1182/blood-2021-144679
Published: 2021
Journal Articles

Genetic Silencing of KEAP1 Induces NRF2 Mediated Oxidative Stress Pathway in Human Erythroid Cells

Dipti Gupta, Samuel Lessard, PhD, Shujia Dai, Yukio Nakamura, MD PhD, Alexandra Hicks, PhD, Thomas K Harris, PhD, Sriram Krishnamoorthy, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-139730
Published: 2020
Journal Articles

Catalytic Activity of Heme-Regulated eIF2 Alpha Kinase (HRI) Regulates Fetal Hemoglobin

Dipti Gupta, Yannis Hara, PhD, Samuel Lessard, PhD, Sarah Sturtevant, BSc, Yukio Nakamura, MD PhD, Sriram Krishnamoorthy, PhD, Melanie Demers, PhD, Alexandra Hicks, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7.
https://doi.org/10.1182/blood-2020-139991
Published: 2020
Journal Articles

Characterization of a Genetically Engineered HUDEP2 Cell Line Harboring a Sickle Cell Disease Mutation As a Potential Research Tool for Preclinical Sickle Cell Disease Drug Discovery

Dipti Gupta, Sarah Sturtevant, BSc, Benjamin Vieira, BS, Yukio Nakamura, MD PhD, Sriram Krishnamoorthy, PhD, Melanie Demers, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3559.
https://doi.org/10.1182/blood-2019-127330
Published: 2019
Journal Articles

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Melanie Demers, PhD, Sarah Sturtevant, BSc, Kevin Guertin, PhD, Dipti Gupta, Kunal Desai, MS, Benjamin Vieira, BS, Alexandra Hicks, PhD, Ayman Ismail, PhD, Yukio Nakamura, MD PhD, Bronner Goncalves, MD PhD, Giuseppe Di Caprio, PhD, Ethan Schonbrun, PhD, Scott Hansen, BS, Martin K. Safo, PhD, David K. Wood, PhD, John M. Higgins, MD PhD, David R. Light, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2260.
https://doi.org/10.1182/blood-2019-128727
Published: 2019
Journal Articles

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Dipti Gupta, Samuel Lessard, PhD, Nancy Moore, Jicheng Duan, PhD, Yukio Nakamura, MD PhD, Feng-Chun Yang, MD PhD, Alexandra Hicks, PhD, David R. Light, PhD, Sriram Krishnamoorthy, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 210.
https://doi.org/10.1182/blood-2019-129479
Published: 2019
Journal Articles

Nrf2 Activation and Fetal Hemoglobin Induction in Sickle Cell Disease

Sriram Krishnamoorthy, Dipti Gupta, William E. Hobbs, MD PhD, Christine Loh, PhD, David R. Light, Robert Peters, PhD, Sarah Sturtevant, Betty Pace, MD, Yukio Nakamura, Brian Lucas, Benjamin F. Vieira
Journal: Blood
Blood (2016) 128 (22): 4840.
https://doi.org/10.1182/blood.V128.22.4840.4840
Published: 2016
Journal Articles

Rivaroxaban for Stroke Prevention in Patients with Non-Valvular Atrial Fibrillation and Active Cancer

Eva Simona Laube, MD, Anthony Yu, MD, Dipti Gupta, MD MPH, Yimei Miao, BS, Patrick Samedy, MS, Jonathan Wills, BA, Stephen J. Harnicar, PharmD, BCOP, BCPS, Gerald A. Soff, MD, Simon Mantha, MD MPH
Journal: Blood
Blood (2016) 128 (22): 2621.
https://doi.org/10.1182/blood.V128.22.2621.2621
Published: 2016
Journal Articles

Dimethyl Fumarate Induces Fetal Hemoglobin in Sickle Cell Disease

Sriram Krishnamoorthy, PhD, Dipti Gupta, MS, Sarah Sturtevant, Biaoru Li, PhD, Levi C Makala, DVM, MBA, PhD, William E. Hobbs, MDPhD, David R. Light, PhD, Betty Pace, MD
Journal: Blood
Blood (2015) 126 (23): 410.
https://doi.org/10.1182/blood.V126.23.410.410
Published: 2015
Journal Articles

Natalizumab Blocks VLA-4 Mediated Red Blood Cell Adhesion and Is a Potential Therapy for Sickle Cell Disease

Patrick C. Hines, MD PhD, Sriram Krishnamoorthy, PhD, Jennell White, PhD, Dipti Gupta, MS, Arjan van der Flier, PhD, Moira M. Lancelot, MD, Robert T. Peters, PhD BS, Haiyan Jiang, PhD, William E Hobbs, MD PhD, David R. Light, PhD
Journal: Blood
Blood (2014) 124 (21): 221.
https://doi.org/10.1182/blood.V124.21.221.221
Published: 2014