1-10 of 10
John Hatcher
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Diverse signaling and vulnerabilities accompany distinct BTK mutations associated with clinical resistance to COVALENT, non-COVALENT and protacs targeting BTK in MYD88 mutated lymphomas.

Free
Shirong Liu, Xia Liu, Amanda Kofides, John Hatcher, Nickolas Tsakmaklis, Abigail Peachey, Dominic Pizzarella, Alberto Guijosa, Jinhua Wang, Maria Luisa Guerrera, Christopher Patterson, Zachary Hunter, Shayna Sarosiek, Jorge Castillo, Sara Buhrlage, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 2171.
https://doi.org/10.1182/blood-2025-2171
Published: 2025
Journal Articles

Novel mechanistic insights for IRAK1 and IRAK4 signaling provide a framework for the development of dual IRAK1 and IRAK4 protacs for MYD88 mutated lymphomas.

Free
Xia Liu, Shirong Liu, Amanda Kofides, Dominic Pizzarella, Jinhua Wang, Sara Buhrlage, Nickolas Tsakmaklis, Abigail Peachey, Alberto Guijosa, Hao Sun, Maria Luisa Guerrera, Christopher Patterson, Shayna Sarosiek, Jorge Castillo, Zachary Hunter, John Hatcher, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 5324.
https://doi.org/10.1182/blood-2025-5324
Published: 2025
Journal Articles

Discovery of an undocumented pattern of intron retention that is abundant in healthy B-cells and circumvented in Waldenstrom's macroglobulinemia impacting genes driving cellular growth and survival

Free
Zachary Hunter, Amanda Kofides, Abigail Peachey, Nickolas Tsakmaklis, Maria Luisa Guerrera, Xia Liu, Shirong Liu, Hao Sun, Alberto Guijosa, John Hatcher, Dominic Pizzarella, Christopher Patterson, Andrew Branagan, Shayna Sarosiek, Jorge Castillo, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 3544.
https://doi.org/10.1182/blood-2025-3544
Published: 2025
Journal Articles

Regulatory network analysis identifies changes in ahr, TFAP4, and AP-1 transcription factors as top drivers of symptomatic disease progression in Waldenstrom's macroglobulinemia.

Free
Zachary Hunter, Derrick DeConti, Brian Lawney, Nickolas Tsakmaklis, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Hao Sun, Dominic Pizzarella, Abigail Peachey, Alberto Guijosa, John Hatcher, Kirsten Meid, Christopher Patterson, Torsten Steinbrunn, Constantine Mitsiades, John Quackenbush, Andrew Branagan, Shayna Sarosiek, Jorge Castillo, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 3543.
https://doi.org/10.1182/blood-2025-3543
Published: 2025
Journal Articles

LOX1 expression identifies a population of polymorphonuclear myeloid-derived suppressor cells that are highly enriched in bone marrow samples of treatment-Naïve and BTKi-Relapsed/Refractory WM patients and show constitutive activation of BTK

Free
Maria Luisa Guerrera, Abigail Peachey, Xia Liu, Dominic Pizzarella, Amanda Kofides, Nickolas Tsakmaklis, Hao Sun, Shirong Liu, Alberto Guijosa, John Hatcher, Christopher Patterson, Nina Budano, Julia Nguyen, Kirsten Meid, Andrew Branagan, Jorge Castillo, Shayna Sarosiek, Samir Parekh, Zachary Hunter, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 5731.
https://doi.org/10.1182/blood-2025-5731
Published: 2025
Journal Articles

Zanubrutinib and pirtobrutinib (ZAP) but not ibrutinib and pirtobrutinib (IAP) show synergistic tumor cell killing and suppression of BTK and downstream signaling in MYD88 mutated lymphoma cells.

Free
Dominic Pizzarella, Amanda Kofides, Xia Liu, John Hatcher, Alberto Guijosa, Nickolas Tsakmaklis, Abigail Peachey, Jinhua Wang, Maria Luisa Guerrera, Christopher Patterson, Zachary Hunter, Hao Sun, Shayna Sarosiek, Jorge Castillo, Sara Buhrlage, Sirano Dhe-Paganon, Steven Treon, Shirong Liu
Journal: Blood
Blood (2025) 146 (Supplement 1): 7453.
https://doi.org/10.1182/blood-2025-7453
Published: 2025
Journal Articles

CD20 (MS4A1) mutations are strongly associated with prior chemoimmunotherapy exposure in Waldenström macroglobulinemia and have predicted functional consequences for the development of CD20-directed cellular therapies.

Free
Alberto Guijosa, Nickolas Tsakmaklis, Sirano Dhe-Paganon, John Hatcher, Andres Ramirez, Dominic Pizzarella, Amanda Kofides, Abigail Peachey, Shirong Liu, Hao Sun, Xia Liu, Maria Luisa Guerrera, Andrew Branagan, Gottfried von Keudell, Shayna Sarosiek, Jorge Castillo, Zachary Hunter, Steven Treon
Journal: Blood
Blood (2025) 146 (Supplement 1): 3611.
https://doi.org/10.1182/blood-2025-3611
Published: 2025
Journal Articles

MALT1 Degradation with a Proteolysis-Targeting Chimera for the Treatment of Activated B-Cell Type Diffuse Large B-Cell Lymphoma

Free
Madhav R Seshadri, Lorena Fontan, Prasanna Sreevatsan, David Scott, John Hatcher, Guangyan Du, Min Xia, Ilkay Us, Nathanael Gray, Ari Melnick
Journal: Blood
Blood (2021) 138 (Supplement 1): 269.
https://doi.org/10.1182/blood-2021-153855
Published: 2021
Journal Articles

Chemically Induced Degradation of MALT1 to Treat B-Cell Lymphomas

Free
Lorena Fontan, PhD, John Hatcher, PhD, David Scott, Qi Qiao, Ilkay Us, Guangyan Du, Matthew Durant, Jimmy Wilson, Hao Wu, PhD, Nathanael Gray, Ari Melnick, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2073.
https://doi.org/10.1182/blood-2019-130666
Published: 2019
Journal Articles

A Novel, Highly Selective IRAK1 Inhibitor Jh-X-119-01 Shows Synergistic Tumor Cell Killing with Ibrutinib in MYD88 Mutated B-Cell Lymphoma Cells

Free
Guang Yang, PhD, John Hatcher, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji Chen, BS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Gloria Chan, MS, Zachary Hunter, PhD, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Nathanael Gray, PhD, Steven P Treon, MDPhDFRCP, Sara Buhrlage, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 719.
https://doi.org/10.1182/blood.V130.Suppl_1.719.719
Published: 2017