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Journal Articles

Novel therapeutics for SF3B1 mutant cancers which exploit the missplicing of DCAF16

Free
Michal Sekrecki, Agata Sekrecka, Rohan Lattupally, Kenny Le, Xunhong Cao, Vicky Chen, Zhe Zhuang, Brendan Dwyer, Crystal Zhou, Charu Tiwari, Austin Gabel, Won Jun Kim, Robert Stanley, Salima Benbarche, Jose Pineda, Nathanael Gray, Tian Zhang, Peter Greenberg, Jason Gotlib, Gabriel Mannis, William Shomali, Giselle Salmasi, Tait Shanafelt, Capucine van Rechem, Xiaoyu Zhang, Bita Fakhri, Sydney Lu
Journal: Blood
Blood (2025) 146 (Supplement 1): 1474.
https://doi.org/10.1182/blood-2025-1474
Published: 2025
Journal Articles

Profiling drug sensitivity in CLL B cells after BTK inhibitor progression using a novel drug panel

Free
Weiguo Han, Emmanuel Contreras Guzman, Aisharya Bhattacharya, Sutapa Sinha, Zhiquan Wang, Kari Rabe, Stephen Anthony, Nathanael Gray, Gerald Crabtree, Esteban Braggio, Saad Kenderian, Sameer Parikh, Neil Kay
Journal: Blood
Blood (2025) 146 (Supplement 1): 7407.
https://doi.org/10.1182/blood-2025-7407
Published: 2025
Journal Articles

MALT1 Degradation with a Proteolysis-Targeting Chimera for the Treatment of Activated B-Cell Type Diffuse Large B-Cell Lymphoma

Free
Madhav R Seshadri, Lorena Fontan, Prasanna Sreevatsan, David Scott, John Hatcher, Guangyan Du, Min Xia, Ilkay Us, Nathanael Gray, Ari Melnick
Journal: Blood
Blood (2021) 138 (Supplement 1): 269.
https://doi.org/10.1182/blood-2021-153855
Published: 2021
Journal Articles

Chemically Induced Degradation of MALT1 to Treat B-Cell Lymphomas

Free
Lorena Fontan, PhD, John Hatcher, PhD, David Scott, Qi Qiao, Ilkay Us, Guangyan Du, Matthew Durant, Jimmy Wilson, Hao Wu, PhD, Nathanael Gray, Ari Melnick, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2073.
https://doi.org/10.1182/blood-2019-130666
Published: 2019
Journal Articles

Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma

Free
Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Sondra L. Downey-Kopyscinski, PhD, Geoffrey Matthews, PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Joshua Dempster, PhD, Robin M. Meyers, PhD, Jordan Bryan, James M. McFarland, Johanna Brueggenthies, Huihui Tang, PhD, Megan Bariteau, BSc, Minasri Borah, Quinlan L Sievers, PhD, Benjamin Ebert, MD, Brian Glassner, PhD, Christopher J. Ott, PhD, Nicholas P Kwiatkowski, PhD, John G Doench, PhD, Daniel Auclair, Joan Levy, PhD, Lawrence H. Boise, PhD, Jonathan J Keats, PhD, Jonathan D. Licht, MD, Richard Groen, Nathanael Gray, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4407.
https://doi.org/10.1182/blood-2019-130901
Published: 2019
Journal Articles

Targeting Salt-Inducible Kinase 3 As a Therapeutic Approach for Acute Myeloid Leukemia

Free
Shan Lin, Yusuke Tarumoto, Jinhua Wang, PhD, Joseph Milazzo, Yali Xu, Nathanael Gray, Christopher Vakoc, Kimberly Stegmaier, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3941.
https://doi.org/10.1182/blood-2019-125278
Published: 2019
Journal Articles

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Free
Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey M Matthews, PhD, Dennis Buckley, Joseline Raja, Quinlan L Sievers, PhD, Olga Dashevsky, PhD, Haley Poarch, Huihui Tang, PhD, Megan Bariteau, BSc, Michal Sheffer, PhD, Sondra L. Downey-Kopyscinski, PhD, Paul Hengeveld, Brian Glassner, PhD, Eugen Dhimolea, PhD, Christopher J. Ott, PhD, Tinghu Zhang, PhD, Nicholas P Kwiatkowski, PhD, Jacob P. Laubach, MD, Robert L. Schlossman, MD, Paul G. Richardson, MD, Aedin Culhane, PhD, Richard W.J. Groen, PhD, Eric Fischer, Benjamin L. Ebert, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, PhD, Daniel Auclair, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, James Bradner, MD, Nathanael Gray, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 318.
https://doi.org/10.1182/blood-2019-130549
Published: 2019
Journal Articles

A Novel HCK and BTK Dual Inhibitor Kin-8194 Shows Superior Activity over Ibrutinib and Overcomes BTK C481S Mediated Ibrutinib Resistance in Vitro and In Vivo in MYD88 Mutated B-Cell Lymphomas

Free
Guang Yang, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Amanda Kofides, Lian Xu, MS, Nicholas Tsakmaklis, Maria Demos, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Cristina Jimenez, PhD, Zachary R Hunter, PhD, Christopher Patterson, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael Gray, Steven P Treon, MD PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 394.
https://doi.org/10.1182/blood-2019-130636
Published: 2019
Journal Articles

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Free
Ken Morita, MD PhD, Shuning He, PhD, Radosław P. Nowak, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Eric S. Fischer, PhD, A. Thomas Look, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 406.
https://doi.org/10.1182/blood-2019-123573
Published: 2019
Journal Articles

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

Free
Christopher J. Ott, PhD, Raphael Szalat, MD, Matthew Lawlor, Mehmet Kemal Samur, PhD, Yan Xu, MD, Charles B Epstein, Charles Y Lin, PhD, Rao Prabhala, PhD, Nina Farrell, Lauren D Walter, Logan Schwartz, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Kenneth Anderson, MD, Richard A. Young, PhD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1313.
https://doi.org/10.1182/blood-2018-99-119941
Published: 2018
Journal Articles

A Unique N-Phenylbenzamide Inhibitor Targeting Non-Receptor Tyrosine Kinases Potently Suppresses AML Cell Growth In Vitro and In Vivo

Free
Mark C Weir, PhD, Sherry Shu, PhD, Sabine Hellwig, PhD, Ravi Patel, Li Chen, PhD, Li Tan, PhD, Nathanael Gray, PhD, Thomas Smithgall, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3813.
https://doi.org/10.1182/blood.V130.Suppl_1.3813.3813
Published: 2017
Journal Articles

Integration of Functional Dependencies and Molecular Alterations of Myeloma Cells

Free
Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Ryosuke Shirasaki, MD PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Paul Hengeveld, Johanna Bruggenthies, Eugen Dhimolea, PhD, Huihui Tang, PhD, Megan Bariteau, Andrew Aguirre, MD PhD, Quinlan Sievers, BA, Benjamin L. Ebert, MD PhD, Brian Glassner, PhD, Christopher J. Ott, PhD, Dennis Buckley, Nicholas P Kwiatkowski, PhD, Jonathan D. Licht, MD, Nathanael Gray, PhD, Joshua Dempster, PhD, Richard WJ Groen, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Aedin Culhane, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1212.
https://doi.org/10.1182/blood.V130.Suppl_1.1212.1212
Published: 2017
Journal Articles

Systematic Characterization of the "Resistome" of Tumor Cells Against Panels of Small Molecule Inhibitors — Application in the Context of Inhibitors of Transcriptional Cyclin-Dependent Kinases (tCDKs) and Implications for Future "Individualized" Clinical Applications

Free
Ryosuke Shirasaki, MD, Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Sara Gandolfi, MD, Eugen Dhimolea, PhD, Olga Dashevsky, PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Tinghu Zhang, PhD, Megan Bariteau, Jeffrey Sorrell, BA, Nicholas P Kwiatkowski, PhD, Nathanael Gray, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3343.
https://doi.org/10.1182/blood.V130.Suppl_1.3343.3343
Published: 2017
Journal Articles

A Novel, Highly Selective IRAK1 Inhibitor Jh-X-119-01 Shows Synergistic Tumor Cell Killing with Ibrutinib in MYD88 Mutated B-Cell Lymphoma Cells

Free
Guang Yang, PhD, John Hatcher, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji Chen, BS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Gloria Chan, MS, Zachary Hunter, PhD, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Nathanael Gray, PhD, Steven P Treon, MDPhDFRCP, Sara Buhrlage, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 719.
https://doi.org/10.1182/blood.V130.Suppl_1.719.719
Published: 2017
Journal Articles

Inhibition of USP10 Induces Degradation of Oncogenic FLT3: A Novel Approach to Therapy of Leukemia

Free
Sara Buhrlage, PhD, Ellen Weisberg, MD, Nathan Schauer, Jing Yang, PhD, Ilaria Lamberto, PhD, Laura Doherty, Atsushi Nonami, MDPhD, Amanda L. Christie, BS, David M. Weinstock, MD, Richard M. Stone, MD, Nathanael Gray, PhD, James D Griffin, MD
Journal: Blood
Blood (2016) 128 (22): 524.
https://doi.org/10.1182/blood.V128.22.524.524
Published: 2016
Journal Articles

Aberrant Phosphorylation of MEF2C Is Dispensable for Hematopoiesis, and Induces Chemotherapy Resistance and Susceptibility to MARK Kinase Inhibition Therapy in Acute Myeloid Leukemia

Free
Fiona C Brown, PhD, Eric Still, Paolo Cifani, PhD, Casie Reed, Scott Ficarro, PhD, Jie He, PhD, Richard Koche, PhD, Patrick Bhola, PhD, Peter Romanienko, PhD, Willie Mark, PhD, Andrei V. Krivtsov, PhD, Anthony Letai, MD PhD, Nathanael Gray, PhD, Jarrod Marto, PhD, Scott A. Armstrong, MD PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2016) 128 (22): 436.
https://doi.org/10.1182/blood.V128.22.436.436
Published: 2016
Journal Articles

HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib

Free
Guang Yang, Sara J. Buhrlage, Li Tan, Xia Liu, Jie Chen, Lian Xu, Nicholas Tsakmaklis, Jiaji G. Chen, Christopher J. Patterson, Jennifer R. Brown, Jorge J. Castillo, Wei Zhang, Xiaofeng Zhang, Shuai Liu, Philip Cohen, Zachary R. Hunter, Nathanael Gray, Steven P. Treon
Journal: Blood
Blood (2016) 127 (25): 3237–3252.
https://doi.org/10.1182/blood-2016-01-695098
Published: 2016
Journal Articles

HCK Is a Highly Relevant Target of Ibrutinib in MYD88 Mutated Waldenstrom's Macroglobulinemia and Diffuse Large B-Cell Lymphoma

Free
Guang Yang, PhD, Sara Buhrlage, PhD, Li Tan, PhD, Xia Liu, MD, Jie Chen, PhD, Zachary Hunter, PhD, Lian Xu, Nicholas Tsakmaklis, Jiaji Chen, Christopher J Patterson, MFA, Jorge J Castillo, MD, Wei Zhang, PhD, Nathanael Gray, PhD, Steven P Treon, MD PhD
Journal: Blood
Blood (2015) 126 (23): 705.
https://doi.org/10.1182/blood.V126.23.705.705
Published: 2015
Journal Articles

Genomic and Proteomic Analysis of Primary Chemoresistance and Induction Failure in Acute Myeloid Leukemia

Free
Fiona Brown, PhD, Eric Still, Paolo Cifani, PhD, Scott Ficarro, PhD, Gayle Pouliot, MD PhD, Esther Drill, PhD, Mithat Gonen, PhD, Jie He, PhD, Sohail Balasubramanian, M.S., Shan Zhong, PhD, Dean Pavlick, Bahar Yilmazel, Andrei V. Krivtsov, PhD, Todd A. Alonzo, PhD, Soheil Meshinchi, MD PhD, Steven M. Kornblau, MD, Richard M. Stone, MD, Guido Marcucci, MD, John C. Byrd, MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD, Nathanael Gray, PhD, Jarrod Marto, PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2015) 126 (23): 88.
https://doi.org/10.1182/blood.V126.23.88.88
Published: 2015
Journal Articles

Targeting IRAK1/IRAK4 Signaling in Waldenstrom's Macroglobulinemia

Free
Guang Yang, PhD, Xia Liu, MD, Jie Chen, PhD, Lian Xu, Nicholas Tsakmaklis, Jiaji Chen, Christopher J Patterson, MFA, Jorge J Castillo, MD, Philip Cohen, Li Tan, PhD, Sara Buhrlage, PhD, Nathanael Gray, PhD, Steven P Treon, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4004.
https://doi.org/10.1182/blood.V126.23.4004.4004
Published: 2015