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Journal Articles

The UBE2J2/UBE2K-MARCH5 Ubiquitination Machinery Regulates Apoptosis in Response to Venetoclax in Acute Myeloid Leukemia

Constanze Schneider, Shan Lin, Angela H Su, Gabriela Alexe, Kimberly Stegmaier
Journal: Blood
Blood (2023) 142 (Supplement 1): 2785.
https://doi.org/10.1182/blood-2023-182312
Published: 2023
Journal Articles

Identifying Targeted Therapies for CBFA2T3 - GLIS2 Acute Myeloid Leukemia

Fanny Gonzales, Shan Lin, Delan Khalid, Jana M Ellegast, Gabriela Alexe, Kimberly Stegmaier
Journal: Blood
Blood (2023) 142 (Supplement 1): 4174.
https://doi.org/10.1182/blood-2023-187187
Published: 2023
Journal Articles

Mechanisms of the CBFA2T3-GLIS2 Fusion in AML Maintenance

Fanny C Gonzales, Shan Lin, Delan Khalid, Jana M Ellegast, Gabriela Alexe, Kimberly Stegmaier
Journal: Blood
Blood (2022) 140 (Supplement 1): 5864–5865.
https://doi.org/10.1182/blood-2022-166664
Published: 2022
Journal Articles

Epigenetic regulator genes direct lineage switching in  MLL/AF4 leukemia

Ricky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, Vasily V. Grinev, Anetta Ptasinska, Paulynn S. Chin, Claus Meyer, Sirintra Nakjang, Jayne Y. Hehir-Kwa, Daniel Williamson, Pierre Cauchy, Peter Keane, Salam A. Assi, Minoo Ashtiani, Sophie G. Kellaway, Maria R. Imperato, Fotini Vogiatzi, Elizabeth K. Schweighart, Shan Lin, Mark Wunderlich, Janine Stutterheim, Alexander Komkov, Elena Zerkalenkova, Paul Evans, Hesta McNeill, Alex Elder, Natalia Martinez-Soria, Sarah E. Fordham, Yuzhe Shi, Lisa J. Russell, Deepali Pal, Alex Smith, Zoya Kingsbury, Jennifer Becq, Cornelia Eckert, Oskar A. Haas, Peter Carey, Simon Bailey, Roderick Skinner, Natalia Miakova, Matthew Collin, Venetia Bigley, Muzlifah Haniffa, Rolf Marschalek, Christine J. Harrison, Catherine A. Cargo, Denis Schewe, Yulia Olshanskaya, Michael J. Thirman, Peter N. Cockerill, James C. Mulloy, Helen J. Blair, Josef Vormoor, James M. Allan, Constanze Bonifer, Olaf Heidenreich, Simon Bomken
Journal: Blood
Blood (2022) 140 (17): 1875–1890.
https://doi.org/10.1182/blood.2021015036
Published: 2022
Includes: Supplemental data
Journal Articles

An In Vivo CRISPR Screening Platform to Identify New Therapeutic Targets in AML

Shan Lin, Clement Larrue, Nastassja K. Scheidegger, Bo Kyung A. Seong, Neekesh V Dharia, Caroline Wechsler, Guillaume Kugener, Amanda L Robinchaud, Amy Conway, Biniam Adane, Scott Younger, Federica Piccioni, Lynn Lee, Mark Wunderlich, Jerome Tamburini, Kimberly Stegmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 266.
https://doi.org/10.1182/blood-2021-153039
Published: 2021
Journal Articles

Unleashing Cell-Intrinsic Inflammation As a Strategy to Kill AML Blasts

Jana M Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Maxim Pimkin, Linda Ross, Neekesh V Dharia, Amanda L Robinchaud, Amy Conway, Delan Khalid, Mark Wunderlich, Lina Benajiba, Behnam Nabet, Nathanael S Gray, Stuart H. Orkin, Kimberly Stegmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 3305.
https://doi.org/10.1182/blood-2021-151511
Published: 2021
Journal Articles

SLC5A3 Transports Myo-Inositol to Support the Growth of Acute Myeloid Leukemia

Shan Lin, Nastassja K. Scheidegger, Gabriela Alexe, Bo Kyung A. Seong, Neekesh V Dharia, Caroline Wechsler, Guillaume Kugener, Amanda L Robinchaud, Amy Conway, Biniam Adane, Scott Younger, Federica Piccioni, Lynn Lee, Mark Wunderlich, Kimberly Stegmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 3319.
https://doi.org/10.1182/blood-2021-152023
Published: 2021
Journal Articles

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo

Yusuke Tarumoto, Shan Lin, Jinhua Wang, Joseph P. Milazzo, Yali Xu, Bin Lu, Zhaolin Yang, Yiliang Wei, Sofya Polyanskaya, Mark Wunderlich, Nathanael S. Gray, Kimberly Stegmaier, Christopher R. Vakoc
Journal: Blood
Blood (2020) 135 (1): 56–70.
https://doi.org/10.1182/blood.2019001576
Published: 2020
Includes: Supplemental data
Journal Articles

Targeting Salt-Inducible Kinase 3 As a Therapeutic Approach for Acute Myeloid Leukemia

Shan Lin, Yusuke Tarumoto, Jinhua Wang, PhD, Joseph Milazzo, Yali Xu, Nathanael Gray, Christopher Vakoc, Kimberly Stegmaier, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3941.
https://doi.org/10.1182/blood-2019-125278
Published: 2019
Journal Articles

mTOR Restricts Chromatin Access and Genomic Activity to Maintain Hematopoietic Stem Cell Quiescence and Engraftment

Cuiqing Fan, PhD, Chuntao Zhao, PhD, Feng Zhang, Xiongwei Cai, PhD, Lingli Xu, Shan Lin, PhD, Xiaoyi Chen, PhD, Fukun Guo, PhD, Richard Q Lu, PhD, Weidong Tian, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2416.
https://doi.org/10.1182/blood.V130.Suppl_1.2416.2416
Published: 2017
Journal Articles

A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program

Shan Lin, Anetta Ptasinska, Xiaoting Chen, Mahesh Shrestha, Salam A. Assi, Paulynn S. Chin, Maria R. Imperato, B. J. Aronow, Jingsong Zhang, Matthew T. Weirauch, Constanze Bonifer, James C. Mulloy
Journal: Blood
Blood (2017) 130 (10): 1213–1222.
https://doi.org/10.1182/blood-2016-11-750976
Published: 2017
Includes: Supplemental data
Journal Articles

The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitment

Brief Report
Shan Lin, Roger T. Luo, Mahesh Shrestha, Michael J. Thirman, James C. Mulloy
Journal: Blood
Blood (2017) 130 (7): 903–907.
https://doi.org/10.1182/blood-2017-04-777185
Published: 2017
Includes: Supplemental data
Journal Articles

The Transcriptome Heterogeneity of MLL-Fusion ALL Is Driven By Fusion Partners Via Distinct Chromatin Binding

Shan Lin, Anetta Ptasinska, PhD, Salam Adli Assi, Jon Kerry, Ruhikanta A. Meetei, PhD, Roger T. Luo, PhD, Michael J. Thirman, MD, Thomas Milne, PhD, Constanze Bonifer, PhD, James C. Mulloy, PhD
Journal: Blood
Blood (2016) 128 (22): 576.
https://doi.org/10.1182/blood.V128.22.576.576
Published: 2016
Journal Articles

Lymphoid Lineage Preference of MLL-AF4 Is Revealed in a Species-Specific Model

Shan Lin, Roger T. Luo, PhD, Mark Wunderlich, MS, Joseph J. Kaberlein, Ahmad Rayes, MDMSc, John Anastasi, MD, Maureen M O'Brien, MD, James C. Mulloy, PhD, Michael J. Thirman, MD
Journal: Blood
Blood (2015) 126 (23): 2454.
https://doi.org/10.1182/blood.V126.23.2454.2454
Published: 2015
Journal Articles

Tumor Suppressor FOXO1 Serves As a Critical Oncogenic Mediator in AML1-ETO Leukemia

Shan Lin, Jinsong Zhang, PhD, James C. Mulloy, PhD
Journal: Blood
Blood (2014) 124 (21): 264.
https://doi.org/10.1182/blood.V124.21.264.264
Published: 2014
Journal Articles

The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO

Fu-Sheng Chou, Andrea Griesinger, Mark Wunderlich, Shan Lin, Kevin A. Link, Mahesh Shrestha, Susumu Goyama, Benjamin Mizukawa, Shuhong Shen, Guido Marcucci, James C. Mulloy
Journal: Blood
Blood (2012) 120 (4): 709–719.
https://doi.org/10.1182/blood-2012-01-403212
Published: 2012
Includes: Supplemental data
Journal Articles

Oncogene Dosage Is a Major Determinant of Leukemogenic Transformation by AE9a

Kevin A. Link, PhD, Shan Lin, Kakajan Komurov, PhD, Mark Wunderlich, MS, James C. Mulloy, PhD
Journal: Blood
Blood (2011) 118 (21): 1358.
https://doi.org/10.1182/blood.V118.21.1358.1358
Published: 2011