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David E. Root
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Journal Articles

Progression signature underlies clonal evolution and dissemination of multiple myeloma

Yu Jia Shen, Yuji Mishima, Jiantao Shi, Romanos Sklavenitis-Pistofidis, Robert A. Redd, Michele Moschetta, Salomon Manier, Aldo M. Roccaro, Antonio Sacco, Yu-Tzu Tai, Francois Mercier, Yawara Kawano, Nang Kham Su, Brianna Berrios, John G. Doench, David E. Root, Franziska Michor, David T. Scadden, Irene M. Ghobrial
Journal: Blood
Blood (2021) 137 (17): 2360–2372.
https://doi.org/10.1182/blood.2020005885
Published: 2021
Includes: Supplemental data
Journal Articles

Deconstructing the Clonal Advantage and Clonal Stability of 5q- Candidate Genes in Del(5q) MDS on a Single Cell Level

Ursula S.A. Stalmann, MD, Fabio Ticconi, MSc, Ronghui Li, MSc, Aaron B. Wong, PhD, Glenn Cowley, PhD, David E. Root, PhD, Dirk Heckl, PhD, Inge Snoeren, MSc, Sergio Martinez, PhDMSc, Tim H Brümmendorf, MD, Andreas Schuppert, PhD, Ivan Costa, PhD, Benjamin L. Ebert, MD PhD, Rebekka K. Schneider, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 559.
https://doi.org/10.1182/blood-2019-122588
Published: 2019
Journal Articles

The DNA Methylation Maintenance Protein UHRF1 Regulates Fetal Globin Expression Independent of HBG Promoter DNA Methylation

Ruopeng Feng, PhD, Phillip A Doerfler, PhD, Yu Yao, MD, Xing Tang, PhD, Yong-Dong Wang, PhD, Chunliang Li, PhD, David E. Root, PhD, Yong Cheng, PhD, Mitchell J. Weiss, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 410.
https://doi.org/10.1182/blood-2018-99-115589
Published: 2018
Journal Articles

Deciphering Clonal Evolution and Dissemination of Multiple Myeloma Cells In Vivo

Yujia Shen, PhD, Yuji Mishima, Jiantao Shi, PhD, Michele Moschetta, MD, Salomon Manier, MD PhD, Aldo M. Roccaro, MDPhD, Francois Mercier, MD FRCPC, Satoshi Takagi, PhD, Yawara Kawano, MD PhD, Shokichi Tsukamoto, MD PhD, Ilyas Sahin, Antonio Sacco, Daisy Huynh, MS, Brianna Berrios, BS, Romanos Pistofidis, MD, Jihye Park, PhD, Oksana Zavidij, PhD, Sabrin Tahri, MD, John G Doench, PhD, David E. Root, PhD, Franziska Michor, PhD, David T. Scadden, MD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 55.
https://doi.org/10.1182/blood-2018-99-113916
Published: 2018
Journal Articles

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

Theresa Placke, Katrin Faber, Atsushi Nonami, Sarah L. Putwain, Helmut R. Salih, Florian H. Heidel, Alwin Krämer, David E. Root, David A. Barbie, Andrei V. Krivtsov, Scott A. Armstrong, William C. Hahn, Brian J. Huntly, Stephen M. Sykes, Michael D. Milsom, Claudia Scholl, Stefan Fröhling
Journal: Blood
Blood (2014) 124 (1): 13–23.
https://doi.org/10.1182/blood-2014-02-558114
Published: 2014
Includes: Supplemental data
Journal Articles

Requirement For CDK6 In MLL-Rearranged Acute Myeloid Leukemia

Theresa Placke, PhD, Katrin Faber, PhD, Atsushi Nonami, MD, Helmut R. Salih, MD, Stephen M. Sykes, PhD, David E. Root, PhD, David A. Barbie, MD, William C. Hahn, MD, PhD, Michael D. Milsom, PhD, Claudia Scholl, MD, Stefan Fröhling, MD
Journal: Blood
Blood (2013) 122 (21): 3782.
https://doi.org/10.1182/blood.V122.21.3782.3782
Published: 2013
Journal Articles

Targeted ShRNA Screening Identified Critical Role of Pleckstrin-2 in Erythropoiesis

Ganesan Keerthivasan, MBBS, MD, Jing Yang, MS, Piu Wong, PhD, John Doench, PhD, David E. Root, PhD, Peng Ji, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3199.
https://doi.org/10.1182/blood.V120.21.3199.3199
Published: 2012
Journal Articles

In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

Peter Miller Graduate Student Brigham and Womens Miller, Fatima Al-Shahrour, PhD, Kimberly A. Hartwell, PhD, Lisa P Chu, Jaras Marcus, Rishi V Puram, Alexandre Puissant, Kevin Callahan, PhD, John M Ashton, Marie Ellen McConkey, BSc, PhD, Luke Poveromo, Glenn Cowley, PhD, Michael G Kharas, PhD, Myriam Labelle, PhD, Sebastian Shterental, Muhammad Al-Hajj, Christopher Shelton, Scott A. Armstrong, MD, PhD, David E. Root, PhD, Richard Hynes, PhD, Siddhartha Mukherjee, MD, PhD, Kimberly Stegmaier, MD, Craig T. Jordan, PhD, Benjamin L. Ebert, MD, D.Phil
Journal: Blood
Blood (2011) 118 (21): 758.
https://doi.org/10.1182/blood.V118.21.758.758
Published: 2011
Journal Articles

Oncogene Cooperativity Analysis Reveals a Novel Set of Genes That Regulate the In Vivo Growth and Survival of Leukemia Stem Cells

John M Ashton, Marlene Balys, Sarah Neering, Glenn Cowley, PhD, David E. Root, PhD, Peter G. Miller, PhD, Benjamin Ebert, MD, Helene McMurray, PhD, Duane C Hassane, PhD, Hartmut Land, PhD, Craig T. Jordan, PhD
Journal: Blood
Blood (2011) 118 (21): 553.
https://doi.org/10.1182/blood.V118.21.553.553
Published: 2011
Journal Articles

High-Throughput RNA Interference Screening Identifies Synthetic Lethality Between Oncogenic KRAS Dependency and Suppression of STK33

Claudia Scholl, Stefan Frohling, Ian F. Dunn, David A. Barbie, Anna C. Schinzel, So Young Kim, Serena J. Silver, Lars Bullinger, Peter Sandy, Jesse S. Boehm, David E. Root, Tyler Jacks, William C. Hahn, D. Gary Gilliland
Journal: Blood
Blood (2008) 112 (11): 3806.
https://doi.org/10.1182/blood.V112.11.3806.3806
Published: 2008