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John G. Doench
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Journal Articles

Transcriptional control of leukemogenesis by the chromatin reader SGF29

Karina Barbosa, Anagha Deshpande, Marlenne Perales, Ping Xiang, Rabi Murad, Akula Bala Pramod, Anna Minkina, Neil Robertson, Fiorella Schischlik, Xue Lei, Younguk Sun, Adam Brown, Diana Amend, Irmela Jeremias, John G. Doench, R. Keith Humphries, Eytan Ruppin, Jay Shendure, Prashant Mali, Peter D. Adams, Aniruddha J. Deshpande
Journal: Blood
Blood (2024) 143 (8): 697–712.
https://doi.org/10.1182/blood.2023021234
Published: 2024
Includes: Supplemental data
Journal Articles

Defining a Targetable Leukemia Intrinsic Dependency on Noncanonical PI3Kgamma Signaling

Qingyu Luo, Evangeline G. Raulston, Miguel A. Prado, Xiaowei Wu, Kira Gritsman, Kezhi Yan, Christopher A. G. Booth, Ran Xu, Peter van Galen, John G. Doench, Shai Shimony, Henry W. Long, Donna S. Neuberg, Joao A. Paulo, Andrew A. Lane
Journal: Blood
Blood (2023) 142 (Supplement 1): 578.
https://doi.org/10.1182/blood-2023-178895
Published: 2023
Journal Articles

Genome-Wide Methylation Sensitive Elements Demarcate Targetable Regulatory Elements for Controllable Gene Activation

Yanjing Vera Liu, Jeremiah Suryatenggara, Hannan Wong, Jing Ping Tang, Hong Kee Tan, Junsu Kwon, Qiling Zhou, Simone Ummarino, Alexander Ebralidze, John G. Doench, Li Chai, Touati Benoukraf, Devendra Hiwase, Daniel Thomas, Annalisa Di Ruscio, Daniel G. Tenen, Mahmoud Adel Bassal
Journal: Blood
Blood (2023) 142 (Supplement 1): 3647.
https://doi.org/10.1182/blood-2023-182715
Published: 2023
Journal Articles

Whole-genome CRISPR screening identifies N- glycosylation as a genetic and therapeutic vulnerability in CALR -mutant MPNs

Jonas S. Jutzi, Anna E. Marneth, Michele Ciboddo, Angel Guerra-Moreno, María José Jiménez-Santos, Anastasia Kosmidou, James W. Dressman, Hongyan Liang, Rebecca Hamel, Patricia Lozano, Elisa Rumi, John G. Doench, Jason Gotlib, Anandi Krishnan, Shannon Elf, Fátima Al-Shahrour, Ann Mullally
Journal: Blood
Blood (2022) 140 (11): 1291–1304.
https://doi.org/10.1182/blood.2022015629
Published: 2022
Includes: Supplemental data
Journal Articles

Whole-Genome CRISPR Screening Identifies N -Glycosylation As an Essential Pathway and a Potential Novel Therapeutic Target in CALR -Mutant MPN

Anna E. Marneth, Jonas S. Jutzi, Angel Guerra-Moreno, Michele Ciboddo, María José Jiménez Santos, Anastasia Kosmidou, Rebecca Hamel, Patricia Lozano, Elisa Rumi, John G. Doench, Jason Gotlib, Anandi Krishnan, Shannon Elf, Fatima Al-Shahrour, Ann Mullally
Journal: Blood
Blood (2021) 138 (Supplement 1): 58.
https://doi.org/10.1182/blood-2021-149218
Published: 2021
Journal Articles

Progression signature underlies clonal evolution and dissemination of multiple myeloma

Yu Jia Shen, Yuji Mishima, Jiantao Shi, Romanos Sklavenitis-Pistofidis, Robert A. Redd, Michele Moschetta, Salomon Manier, Aldo M. Roccaro, Antonio Sacco, Yu-Tzu Tai, Francois Mercier, Yawara Kawano, Nang Kham Su, Brianna Berrios, John G. Doench, David E. Root, Franziska Michor, David T. Scadden, Irene M. Ghobrial
Journal: Blood
Blood (2021) 137 (17): 2360–2372.
https://doi.org/10.1182/blood.2020005885
Published: 2021
Includes: Supplemental data
Journal Articles

Functional Characterization of Genes Driving Enhanced Biological Aggressiveness of Myeloma Cells: Identification of Novel and Understudied "Drivers" of Myeloma

Huihui Tang, PhD, Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Sara Gandolfi, MD, Olga Dashevsky, PhD, Sondra L. Downey-Kopyscinski, PhD, Brian Glassner, PhD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 313.
https://doi.org/10.1182/blood-2019-128919
Published: 2019
Journal Articles

Functional Interactions between Transcription Factors Involved in Myeloma Pathogenesis - Biological and Therapeutic Implications

Sondra L. Downey-Kopyscinski, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Huihui Tang, PhD, Brian Glassner, PhD, Olga Dashevsky, PhD, Minasri Borah, Megan Bariteau, B.Sc., Richard Groen, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 315.
https://doi.org/10.1182/blood-2019-127502
Published: 2019
Journal Articles

Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma

Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Sondra L. Downey-Kopyscinski, PhD, Geoffrey Matthews, PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Joshua Dempster, PhD, Robin M. Meyers, PhD, Jordan Bryan, James M. McFarland, Johanna Brueggenthies, Huihui Tang, PhD, Megan Bariteau, BSc, Minasri Borah, Quinlan L Sievers, PhD, Benjamin Ebert, MD, Brian Glassner, PhD, Christopher J. Ott, PhD, Nicholas P Kwiatkowski, PhD, John G Doench, PhD, Daniel Auclair, Joan Levy, PhD, Lawrence H. Boise, PhD, Jonathan J Keats, PhD, Jonathan D. Licht, MD, Richard Groen, Nathanael Gray, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4407.
https://doi.org/10.1182/blood-2019-130901
Published: 2019
Journal Articles

CRISPR-Based Dual-Knockout Screens Reveals Network of Interactions between Key Dependencies for Myeloma Cells and Highlights IRF4 As a Central Regulator of Myeloma Cell Behavior

Sondra L. Downey-Kopyscinski, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Olga Dashevsky, PhD, Brian Glassner, PhD, Olivia Bare, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1915.
https://doi.org/10.1182/blood-2018-99-114986
Published: 2018
Journal Articles

Deciphering Clonal Evolution and Dissemination of Multiple Myeloma Cells In Vivo

Yujia Shen, PhD, Yuji Mishima, Jiantao Shi, PhD, Michele Moschetta, MD, Salomon Manier, MD PhD, Aldo M. Roccaro, MDPhD, Francois Mercier, MD FRCPC, Satoshi Takagi, PhD, Yawara Kawano, MD PhD, Shokichi Tsukamoto, MD PhD, Ilyas Sahin, Antonio Sacco, Daisy Huynh, MS, Brianna Berrios, BS, Romanos Pistofidis, MD, Jihye Park, PhD, Oksana Zavidij, PhD, Sabrin Tahri, MD, John G Doench, PhD, David E. Root, PhD, Franziska Michor, PhD, David T. Scadden, MD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 55.
https://doi.org/10.1182/blood-2018-99-113916
Published: 2018
Journal Articles

Genetic Determinants of Venetoclax Resistance in Lymphoid Malignancies

Romain Guieze, MD, Vivian M Liu, Daniel Rosebrock, Alexis Jourdain, PhD, María Hernández-Sánchez, PhD, Aina zurita Martinez, Sun Jing, PhD, Kaitlyn J Baranowski, Philip A. Thompson, MBBS, Heo Jin-Mi, PhD, Zacchary Cartun, Ozan Aygun, PhD, Giulia Notarangelo, Dimitri Livitz, BS, Shuqiang Li, PhD, Matthew S. Davids, MD, Jennifer R. Brown, MD PhD, William G. Wierda, MD PhD, Anthony Letai, MD PhD, Donna S Neuberg, ScD, Wade Harper, PhD, Steven A. Carr, PhD, Federica Piccioni, PhD, Christopher J. Ott, PhD, Ignaty Leshchiner, PhD, Cory Johannessen, PhD, John G Doench, PhD, Vamsi Mootha, MD PhD, Gad Getz, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 893.
https://doi.org/10.1182/blood-2018-99-118604
Published: 2018
Journal Articles

CRISPR Activation Screen for Drivers of MM Cell Proliferation

Huihui Tang, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Sondra L. Downey-Kopyscinski, PhD, Sara Gandolfi, MD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3197.
https://doi.org/10.1182/blood-2018-99-118712
Published: 2018
Journal Articles

CRISPR Activation Screen for HDAC Inhibitor Resistance

Huihui Tang, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Sondra L. Downey-Kopyscinski, PhD, Sara Gandolfi, MD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3958.
https://doi.org/10.1182/blood-2018-99-119044
Published: 2018
Journal Articles

A Genome-Wide, In Vivo, Dropout CRISPR Screen in Acute Myeloid Leukemia Identifies an Essential Role for Beta-Galactosylation in Leukemic Cell Homing

Francois Mercier, MD, Jiantao Shi, PhD, David B Sykes, MD PhD, Elizabeth Miller, Toshihiko Oki, MD PhD, Cheuk-Him Man, PhD, Xiao-Jing Yan, MD PhD, Youmna Kfoury, PhD, Dongjun Lee, PhD, John G Doench, PhD, Franziska Michor, PhD, David T. Scadden, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2493.
https://doi.org/10.1182/blood.V130.Suppl_1.2493.2493
Published: 2017
Journal Articles

In Vivo Genome-Wide Crispr Library Screen in a Xenograft Mouse Model of Tumor Growth and Metastasis of Multiple Myeloma

Yujia Shen, PhD, Salomon Manier, MD, Jihye Park, PhD, Yuji Mishima, PhD, Marzia Capelletti, PhD MMSc, Aldo M. Roccaro, MD PhD, Daisy Huynh, BS, MS, Antonio Sacco, BS, Sabrin Tahri, BS, Glenn Cowley, PhD, John G Doench, PhD, David Root, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2016) 128 (22): 1137.
https://doi.org/10.1182/blood.V128.22.1137.1137
Published: 2016
Journal Articles

Genome-Scale Screen Reveals Genes Required for Lenalidomide-Mediated Degradation of Aiolos By CRL4-CRBN

Quinlan Sievers, BA, Jessica Gasser, PhD, Glenn Cowley, PhD, John G Doench, PhD, Eric Fischer, PhD, Benjamin L Ebert, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5139.
https://doi.org/10.1182/blood.V128.22.5139.5139
Published: 2016
Journal Articles

RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program

Ly P. Vu, PhD, Camila Prieto, Elianna Amin, PhD, Gerard Minuesa, PhD, Sagar Chhangawala, Maria J Vidal, PhD, Andrei V. Krivtsov, PhD, Tim Chou, Trevor Barlowe, BA, James Taggart, BS, Patrick Tivnan, BS, Raquel P. Deering, Mithat Gonen, PhD, Maria E Figueroa, MD, Elisabeth Paietta, PhD, Martin S. Tallman, MD, Ari Melnick, MD, Ross L. Levine, MD, Fatima Al-Shahrour, PhD, Marcus Järås, Lisa Chu, Ralph Garippa, PhD, Christopher Lengner, PhD, Scott A. Armstrong, MD PhD, Glenn Cowley, PhD, David Root, PhD, John G Doench, PhD, Leandro Cerchietti, MD, Christina Leslie, PhD, Benjamin Ebert, Michael G. Kharas, PhD
Journal: Blood
Blood (2016) 128 (22): 739.
https://doi.org/10.1182/blood.V128.22.739.739
Published: 2016
Journal Articles

Balancing Proliferation, Differentiation, and Survival: Powerful Genetic and RNAi Technologies Reveal Essential microRNA Signaling for Leukemic Progenitor Cell Fitness

Sara E. Meyer, PhD, Emily Orr, Andrew M. Rogers, MS,MD, John G Doench, PhD, Bruce J. Aronow, PhD, Ashish Lal, PhD, Edwina McGlinn, PhD, H. Leighton Grimes, PhD
Journal: Blood
Blood (2015) 126 (23): 441.
https://doi.org/10.1182/blood.V126.23.441.441
Published: 2015