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Journal Articles

Neutrophil extracellular traps drive myeloproliferation and immune dysfunction in chronic myelomonocytic leukemia

Saveg Yadav, Callie Brown, Mark Cody, Nicole Arellano, Parker Bowden, William Heaton, Maihi Skeen, Abigail Runnels, Cameron Hoppensteadt, Claudia de Araujo, Marco Marchetti, Robert Campbell, Christian Yost, Shannon Elf, Ami Patel

Blood (2025) 146 (Supplement 1): 2057.

https://doi.org/10.1182/blood-2025-2057

Published: 2025

Journal Articles

Epithelial growth factor like-7 (EGFL7) regulates hematopoiesis stem cell (HSC) activation via AP-1 suppression

Rohan Kulkarni, Yaphet Bustos, Alexander Rudich, Malith Karunasiri, Amog Urs, Ozlen Balcioglu, Wenjun Li, Sadie Chidester, Kyleigh Rodgers, Elizabeth Garfinkle, Ami Patel, Katherine Miller, Phillip Popovich, Shannon Elf, Ramiro Garzon, Chinmayee Goda, Adrienne Dorrance

Blood (2025) 146 (Supplement 1): 209.

https://doi.org/10.1182/blood-2025-209

Published: 2025

Journal Articles

A novel in-frame calreticulin mutation induces activation of JAK-STAT signaling and thrombocytosis

Abigail Runnels, Nicole Arellano, Ling Huang, Saveg Yadav, Maihi Skeen, William Heaton, Cameron Hoppensteadt, Molly Brakhane, Stephen Oh, Shannon Elf

Blood (2025) 146 (Supplement 1): 358.

https://doi.org/10.1182/blood-2025-358

Published: 2025

Journal Articles

Lactate export inhibition reveals a metabolic vulnerability in myelofibrosis

Nathan Krah, Nicole Arellano, William Heaton, Anton Rets, Srinivas Tantravahi, Juliette Pearce, Spencer Gygi, Abigail Runnels, Parker Bowden, Rebekka Schneider, Jared Rutter, Shannon Elf

Blood (2025) 146 (Supplement 1): 357.

https://doi.org/10.1182/blood-2025-357

Published: 2025

Journal Articles

Glutamine Metabolism Is Altered in Myeloproliferative Neoplasms and Represents a Potential Novel Therapeutic Target

Chad Coen, Jizhi Yan, Caner Saygin, Nicole Arellano, Mirielle Nauman, Katarzyna Zawieracz, Daniele Vanni, Silvia Catricalà, Ilaria Carola Casetti, Oscar Borsani, Elisa Rumi, Daniela Pietra, Shannon Elf, Hunter Blaylock

Blood (2023) 142 (Supplement 1): 6350.

https://doi.org/10.1182/blood-2023-189731

Published: 2023

Journal Articles

BCL-Xl Represents a Novel Therapeutic Target in Type 2 Mutant Calr-Driven Myeloproliferative Neoplasms

Mirielle Nauman, Daniele Vanni, Nicole Arellano, Thao Trang Nguyen, James LaBelle, Caner Saygin, Silvia Catricalà, Ilaria Carola Casetti, Oscar Borsani, Elisa Rumi, Daniela Pietra, Shannon Elf

Blood (2023) 142 (Supplement 1): 3148.

https://doi.org/10.1182/blood-2023-190295

Published: 2023

Journal Articles

Type 2 but Not Type 1 Calreticulin Mutants Exhibit Loss of Chaperone Function Due to C-Terminal Structural Interference, and Bind to Wild Type Calreticulin in a Dominant Negative Manner

Nicole S Arellano, Jacqueline Gomez, Harrison S Greenbaum, Michele Ciboddo, Deborah Rodriguez, Amy K Chen, Lulu Allie, Alex Rosencrance, Shannon Elf

Blood (2022) 140 (Supplement 1): 1087–1088.

https://doi.org/10.1182/blood-2022-166506

Published: 2022

Journal Articles

Whole-genome CRISPR screening identifies N- glycosylation as a genetic and therapeutic vulnerability in CALR -mutant MPNs

Jonas S. Jutzi, Anna E. Marneth, Michele Ciboddo, Angel Guerra-Moreno, María José Jiménez-Santos, Anastasia Kosmidou, James W. Dressman, Hongyan Liang, Rebecca Hamel, Patricia Lozano, Elisa Rumi, John G. Doench, Jason Gotlib, Anandi Krishnan, Shannon Elf, Fátima Al-Shahrour, Ann Mullally

Blood (2022) 140 (11): 1291–1304.

https://doi.org/10.1182/blood.2022015629

Published: 2022

Includes: Supplemental data

Journal Articles

Whole-Genome CRISPR Screening Identifies N -Glycosylation As an Essential Pathway and a Potential Novel Therapeutic Target in CALR -Mutant MPN

Anna E. Marneth, Jonas S. Jutzi, Angel Guerra-Moreno, Michele Ciboddo, María José Jiménez Santos, Anastasia Kosmidou, Rebecca Hamel, Patricia Lozano, Elisa Rumi, John G. Doench, Jason Gotlib, Anandi Krishnan, Shannon Elf, Fatima Al-Shahrour, Ann Mullally

Blood (2021) 138 (Supplement 1): 58.

https://doi.org/10.1182/blood-2021-149218

Published: 2021

Journal Articles

Myeloproliferative Neoplasm-Associated Type 2 Calreticulin Mutations Differentially Activate and Depend on the ATF6 Pathway of the UPR

Nicole S Arellano, Katarzyna Kurylowicz, Luke Maxwell, Harrison S Greenbaum, Juan Ibarra, Shannon Elf

Blood (2021) 138 (Supplement 1): 3588.

https://doi.org/10.1182/blood-2021-151632

Published: 2021

Journal Articles

Type I Calreticulin Mutations Result in Hyperactivation of Its Acetyltransferase Function and Iron Metabolism, Inducing a Susceptibility to Ferroptosis

Harrison S Greenbaum, Maria Evers, Alex Rosencrance, Luke Maxwell, Katarzyna Kurylowicz, Nicole S Arellano, Michele Ciboddo, Jinjun Gao, Juan Ibarra, Shannon Elf

Blood (2021) 138 (Supplement 1): 3593.

https://doi.org/10.1182/blood-2021-153480

Published: 2021

Journal Articles

Type 1 Calreticulin Mutations Differentially Activate the IRE1α-XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms

Blood (2021) 138 (Supplement 1): 628.

https://doi.org/10.1182/blood-2021-147859

Published: 2021

Journal Articles

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

Blood (2020) 136 (18): 2051–2064.

https://doi.org/10.1182/blood.2019004095

Published: 2020

Includes: Supplemental data

Journal Articles

Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN

Shannon Elf, Nouran S. Abdelfattah, April J. Baral, Danielle Beeson, Jeanne F. Rivera, Amy Ko, Natalie Florescu, Gabriel Birrane, Edwin Chen, Ann Mullally

Blood (2018) 131 (7): 782–786.

https://doi.org/10.1182/blood-2017-08-800896

Published: 2018

Includes: Supplemental data

Journal Articles

Functional and Molecular Basis of Thrombopoietin Receptor Activation By Mutant Calreticulin

Shannon Elf, PhD, Nouran Abdelfattah, MPhil, April Joy Baral, MSc, BSc, Danielle Beeson, Amy Ko, Natalie Florescu, Edwin Chen, PhD, Ann Mullally, MD

Blood (2017) 130 (Supplement 1): 382.

https://doi.org/10.1182/blood.V130.Suppl_1.382.382

Published: 2017

Journal Articles

Physical Interaction Between Mutant Calreticulin and the Thrombopoietin Receptor Is Required for Hematopoietic Transformation

Shannon Elf, PhD, Nouran Abdelfattah, MPhil, Edwin Chen, PhD, Javier Perales-Patón, Emily Rosen, BS, Amy Ko, Fabian Peisker, Natalie Florescu, Silvia Giannini, PhD, Ofir Wolach, MD, Elizabeth A. Morgan, MD, Julie-Aurore Losman, MD, PhD, Rebekka K. Schneider, MD, Fatima Al-Shahrour, PhD, Ann Mullally, MD

Blood (2015) 126 (23): LBA-4.

https://doi.org/10.1182/blood.V126.23.LBA-4.LBA-4

Published: 2015

Journal Articles

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms

Edwin Chen, Rebekka K. Schneider, Lawrence J. Breyfogle, Emily A. Rosen, Luke Poveromo, Shannon Elf, Amy Ko, Kristina Brumme, Ross Levine, Benjamin L. Ebert, Ann Mullally

Blood (2015) 125 (2): 327–335.

https://doi.org/10.1182/blood-2014-04-567024

Published: 2015

Includes: Supplemental data

Journal Articles

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Gang Huang, Xinghui Zhao, Lan Wang, Shannon Elf, Hao Xu, Xinyang Zhao, Goro Sashida, Yue Zhang, Yan Liu, Jennifer Lee, Silvia Menendez, Youyang Yang, Xiaomei Yan, Pu Zhang, Daniel G. Tenen, Motomi Osato, James J.-D. Hsieh, Stephen D. Nimer

Blood (2011) 118 (25): 6544–6552.

https://doi.org/10.1182/blood-2010-11-317909

Published: 2011

Includes: Supplemental data

Journal Articles

p90RSK2 is essential for FLT3-ITD– but dispensable for BCR-ABL–induced myeloid leukemia

Shannon Elf, Dean Blevins, Lingtao Jin, Tae-Wook Chung, Ifor R. Williams, Benjamin H. Lee, Jian-Xin Lin, Warren J. Leonard, Jack Taunton, Hanna J. Khoury, Sumin Kang

Blood (2011) 117 (25): 6885–6894.

https://doi.org/10.1182/blood-2010-10-315721

Published: 2011

Includes: Supplemental data

Journal Articles

p90RSK2 Is Essential for FLT3-ITD-, but Dispensable for BCR-ABL-Induced Myeloid Leukemia

Shannon Elf, Tae-Wook Chung, PhD, Dean P. Blevins, Ifor Williams, MD, PhD, H. Jean Khoury, MD, Jack Taunton, PhD, Sumin Kang, PhD

Blood (2010) 116 (21): 1716.

https://doi.org/10.1182/blood.V116.21.1716.1716

Published: 2010

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Neutrophil extracellular traps drive myeloproliferation and immune dysfunction in chronic myelomonocytic leukemia

Epithelial growth factor like-7 (EGFL7) regulates hematopoiesis stem cell (HSC) activation via AP-1 suppression

A novel in-frame calreticulin mutation induces activation of JAK-STAT signaling and thrombocytosis

Lactate export inhibition reveals a metabolic vulnerability in myelofibrosis

Glutamine Metabolism Is Altered in Myeloproliferative Neoplasms and Represents a Potential Novel Therapeutic Target

BCL-Xl Represents a Novel Therapeutic Target in Type 2 Mutant Calr-Driven Myeloproliferative Neoplasms

Type 2 but Not Type 1 Calreticulin Mutants Exhibit Loss of Chaperone Function Due to C-Terminal Structural Interference, and Bind to Wild Type Calreticulin in a Dominant Negative Manner

Whole-genome CRISPR screening identifies N- glycosylation as a genetic and therapeutic vulnerability in CALR -mutant MPNs

Whole-Genome CRISPR Screening Identifies N -Glycosylation As an Essential Pathway and a Potential Novel Therapeutic Target in CALR -Mutant MPN

Myeloproliferative Neoplasm-Associated Type 2 Calreticulin Mutations Differentially Activate and Depend on the ATF6 Pathway of the UPR

Type I Calreticulin Mutations Result in Hyperactivation of Its Acetyltransferase Function and Iron Metabolism, Inducing a Susceptibility to Ferroptosis

Type 1 Calreticulin Mutations Differentially Activate the IRE1α-XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN

Functional and Molecular Basis of Thrombopoietin Receptor Activation By Mutant Calreticulin

Physical Interaction Between Mutant Calreticulin and the Thrombopoietin Receptor Is Required for Hematopoietic Transformation

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

p90RSK2 is essential for FLT3-ITD– but dispensable for BCR-ABL–induced myeloid leukemia

p90RSK2 Is Essential for FLT3-ITD-, but Dispensable for BCR-ABL-Induced Myeloid Leukemia

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