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Journal Articles

Non-Canonical Gli1 Activation Mediates Profibrotic Hematopoiesis-Stroma Crosstalk in MPN

Jessica E. Pritchard, Juliette Pearce, Inge Snoeren, Stijn Fuchs, Katrin Götz, Silke Wagner, Kathrin Olschok, Nicolas Chatain, Steffen Koschmieder, Marie-Luise Berres, Ivan Costa, Helene Gleitz, Rafael Kramann, Rebekka K. Schneider

Blood (2022) 140 (Supplement 1): 6728–6729.

https://doi.org/10.1182/blood-2022-160142

Published: 2022

Journal Articles

Metaphyseal Stromal Progenitor Cells Are Skewed Via Wnt-Activation Towards Osteogenesis in Progressed Myelofibrosis

Bella Banjanin, James Nagai, Yevin Mun, Inge Snoeren, Stijn Fuchs, Marek Weiler, Fabian Kiessling, Twan Lammers, Kishor Sivaraj, Ralf Adams, Cesar Nombela-Arrieta, Ivan Costa, Rebekka K. Schneider

Blood (2022) 140 (Supplement 1): 3856–3857.

https://doi.org/10.1182/blood-2022-166219

Published: 2022

Journal Articles

Type 1 Calreticulin Mutations Differentially Activate the IRE1α-XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms

Blood (2021) 138 (Supplement 1): 628.

https://doi.org/10.1182/blood-2021-147859

Published: 2021

Journal Articles

SRSF2-P95Hdelays Myelofibrosis Development through Altered JAK/STAT Signaling in JAK2-V617F Megakaryocytes

Blood (2021) 138 (Supplement 1): 2544.

https://doi.org/10.1182/blood-2021-149757

Published: 2021

Journal Articles

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

Blood (2020) 136 (18): 2051–2064.

https://doi.org/10.1182/blood.2019004095

Published: 2020

Includes: Supplemental data

Journal Articles

Transcriptional Landscape of the Microenvironment in Bone Marrow Fibrosis at Single Cell Level

Nils B. Leimkühler, Ronghui Li, MSc, Helene Gleitz, PhD, Inge Snoeren, MSc, Stijn Fuchs, Martina Crysandt, MD, Steffen Koschmieder, Christoph Kuppe, MD, Guntram Buesche, MD, Hans H Kreipe, MD PhD, Ivan Costa, PhD, Rafael Kramann, MD PhD, Rebekka K. Schneider, MD PhD

Blood (2019) 134 (Supplement_1): 1675.

https://doi.org/10.1182/blood-2019-126897

Published: 2019

Journal Articles

Deconstructing the Clonal Advantage and Clonal Stability of 5q- Candidate Genes in Del(5q) MDS on a Single Cell Level

Ursula S.A. Stalmann, MD, Fabio Ticconi, MSc, Ronghui Li, MSc, Aaron B. Wong, PhD, Glenn Cowley, PhD, David E. Root, PhD, Dirk Heckl, PhD, Inge Snoeren, MSc, Sergio Martinez, PhDMSc, Tim H Brümmendorf, MD, Andreas Schuppert, PhD, Ivan Costa, PhD, Benjamin L. Ebert, MD PhD, Rebekka K. Schneider, MD PhD

Blood (2019) 134 (Supplement_1): 559.

https://doi.org/10.1182/blood-2019-122588

Published: 2019

Journal Articles

Puzzling pieces of chromosome 7 loss or deletion

Rebekka K. Schneider, Ruud Delwel

Blood (2018) 131 (26): 2871–2872.

https://doi.org/10.1182/blood-2018-04-844746

Published: 2018

Journal Articles

The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis

Rafael Kramann, Rebekka K. Schneider

Blood (2018) 131 (19): 2111–2119.

https://doi.org/10.1182/blood-2018-02-834820

Published: 2018

Journal Articles

Thrombosis in Myeloproliferative Neoplasms Is Linked to Increased Neutrophil Extracellular Trap (NET) Formation

Ofir Wolach, MD, Rob S Sellar, MD, Kimberly Martinod, PhD, Marie E. McConkey, PhD, Alexander J. Silver, B.S., Ryan Chappell, Richard M. Stone, MD, Martha Wadleigh, MD, David P Steensma, MD, Daniel J. DeAngelo, MD PhD, Ilene Galinsky, MSN, ANPc, Rebekka K. Schneider, MD, Robert F. Padera, MD PhD, Ann Mullally, MD, Denisa D. Wagner, PhD, Benjamin L. Ebert, MD PhD

Blood (2016) 128 (22): 633.

https://doi.org/10.1182/blood.V128.22.633.633

Published: 2016

Journal Articles

Physical Interaction Between Mutant Calreticulin and the Thrombopoietin Receptor Is Required for Hematopoietic Transformation

Shannon Elf, PhD, Nouran Abdelfattah, MPhil, Edwin Chen, PhD, Javier Perales-Patón, Emily Rosen, BS, Amy Ko, Fabian Peisker, Natalie Florescu, Silvia Giannini, PhD, Ofir Wolach, MD, Elizabeth A. Morgan, MD, Julie-Aurore Losman, MD, PhD, Rebekka K. Schneider, MD, Fatima Al-Shahrour, PhD, Ann Mullally, MD

Blood (2015) 126 (23): LBA-4.

https://doi.org/10.1182/blood.V126.23.LBA-4.LBA-4

Published: 2015

Journal Articles

A Novel Conditional Knockout of the Diamond Blackfan Anemia Gene Rpl11 Shows Failure of Erythropoiesis, a Marked Increase in BFU-E Progenitors By Phenotype That Proliferate Poorly in Culture, and Activation of p53 Target Genes

Cailin E Joyce, PhD, Meaghan McGuinness, BS, Rebekka K Schneider, MD, Mark D. Fleming, MD DPhil, Dean R Campagna, BS, Paul J Schmidt, PhD, Benjamin L Ebert, MD PhD, Carl D. Novina, MDPhD, Colin A. Sieff, MB.BCh

Blood (2015) 126 (23): 1205.

https://doi.org/10.1182/blood.V126.23.1205.1205

Published: 2015

Journal Articles

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms

Edwin Chen, Rebekka K. Schneider, Lawrence J. Breyfogle, Emily A. Rosen, Luke Poveromo, Shannon Elf, Amy Ko, Kristina Brumme, Ross Levine, Benjamin L. Ebert, Ann Mullally

Blood (2015) 125 (2): 327–335.

https://doi.org/10.1182/blood-2014-04-567024

Published: 2015

Includes: Supplemental data

Journal Articles

Reduced Protein Synthesis and p53 Activation in Late-Stage Erythroblasts Mediate the Erythroid Differentiation Defect in Mice with Ribosomal Protein S14 Haploinsufficiency

Rebekka K. Schneider, MD, Marie E. McConkey, PhD, Lisa P. Chu, Benjamin L. Ebert, MDPhD

Blood (2014) 124 (21): 1892.

https://doi.org/10.1182/blood.V124.21.1892.1892

Published: 2014

Journal Articles

Loss of TET2 Function in Myelodysplastic Syndrome Results in Intragenic Hypermethylation and Alterations in mRNA Splicing

Allegra M Lord, Kendell Clement, Rebekka K. Schneider, MD, McConkey Marie, PhD, Michelle C. Chen, Ross L. Levine, MD, Ann Mullally, MD, Naomi Galili, PhD, Abdullah Mahmood Ali, PhD, Azra Raza, MD, Rafael Bejar, MD PhD, Alexander Meissner, PhD, Benjamin L. Ebert, MDPhD

Blood (2014) 124 (21): 775.

https://doi.org/10.1182/blood.V124.21.775.775

Published: 2014

Journal Articles

Mutant Splicing Factor 3b Subunit 1 (SF3B1) Causes Dysregulated Erythropoiesis and a Stem Cell Disadvantage

Esther A. Obeng, MDPhD, Marie E. McConkey, PhD, Dean Campagna, Rebekka K. Schneider, MD, Michelle C. Chen, Paul J Schmidt, PhD, Ann Mullally, MD, Mark D. Fleming, MD DPhil, Benjamin L. Ebert, MD DPhil

Blood (2014) 124 (21): 828.

https://doi.org/10.1182/blood.V124.21.828.828

Published: 2014

Journal Articles

Lenalidomide Induces Ubiquitination and Degradation of CSNK1A1 in MDS with Del(5q)

Emma C. Fink, Jan Krönke, MD, Slater N. Hurst, Namrata D. Udeshi, PhD, Tanya Svinkina, Rebekka K. Schneider, MD, Marie E. McConkey, PhD, Marcus Järås, PhD, Lars Bullinger, MD PhD, Steven A. Carr, PhD, Benjamin L. Ebert, MD DPhil

Blood (2014) 124 (21): 4.

https://doi.org/10.1182/blood.V124.21.4.4

Published: 2014

Journal Articles

Tet2 Loss Accelerates The Myeloproliferative Neoplasm (MPN) Phenotype Of Jak2V617F Knockin Mice But Is Insufficient To Cause Leukemic Transformation

Edwin Chen, Lawrence J Breyfogle, Rebekka K. Schneider, MD, Luke Poveromo, BS, Ross L. Levine, MD, Benjamin L. Ebert, MD, PhD, Ann Mullally, MD

Blood (2013) 122 (21): 4095.

https://doi.org/10.1182/blood.V122.21.4095.4095

Published: 2013

Journal Articles

Sustained Alterations In Bone Marrow Stromal Cells From Patients With Myeloproliferative Neoplasms (MPN) Contribute To Remodelling Of The Bone Marrow Microenvironment Prior To The Manifestation Of Myelofibrosis

Rebekka K. Schneider, MD, Isabelle Leisten, Susanne Ziegler, PhD, Anne Schumacher, Björn Rath, MD, Dirk Fahrenkamp, Gerhard Mueller-Newen, PhD, Martina Crysandt, MD, Stefan Wilop, MD, Edgar Jost, MD, Ruth Knuechel, MD, Tim H. Bruemmendorf, MD, Patrick Ziegler, PhD

Blood (2013) 122 (21): 4102.

https://doi.org/10.1182/blood.V122.21.4102.4102

Published: 2013

Journal Articles

Critical Role Of Casein Kinase (Ck)1α Heterozygote Gene Inactivation In The Clonal Advantage Of Hematopoietic Stem Cells In Del(5q) MDS

Rebekka K. Schneider, MD, Dirk Heckl, PhD, Marcus Järås, PhD, Lisa Chu, McConkey Marie, PhD, Ann Mullally, MD, Benjamin L Ebert, MD, PhD

Blood (2013) 122 (21): 98.

https://doi.org/10.1182/blood.V122.21.98.98

Published: 2013

NARROW

Non-Canonical Gli1 Activation Mediates Profibrotic Hematopoiesis-Stroma Crosstalk in MPN

Metaphyseal Stromal Progenitor Cells Are Skewed Via Wnt-Activation Towards Osteogenesis in Progressed Myelofibrosis

Type 1 Calreticulin Mutations Differentially Activate the IRE1α-XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms

SRSF2-P95Hdelays Myelofibrosis Development through Altered JAK/STAT Signaling in JAK2-V617F Megakaryocytes

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

Transcriptional Landscape of the Microenvironment in Bone Marrow Fibrosis at Single Cell Level

Deconstructing the Clonal Advantage and Clonal Stability of 5q- Candidate Genes in Del(5q) MDS on a Single Cell Level

Puzzling pieces of chromosome 7 loss or deletion

The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis

Thrombosis in Myeloproliferative Neoplasms Is Linked to Increased Neutrophil Extracellular Trap (NET) Formation

Physical Interaction Between Mutant Calreticulin and the Thrombopoietin Receptor Is Required for Hematopoietic Transformation

A Novel Conditional Knockout of the Diamond Blackfan Anemia Gene Rpl11 Shows Failure of Erythropoiesis, a Marked Increase in BFU-E Progenitors By Phenotype That Proliferate Poorly in Culture, and Activation of p53 Target Genes

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms

Reduced Protein Synthesis and p53 Activation in Late-Stage Erythroblasts Mediate the Erythroid Differentiation Defect in Mice with Ribosomal Protein S14 Haploinsufficiency

Loss of TET2 Function in Myelodysplastic Syndrome Results in Intragenic Hypermethylation and Alterations in mRNA Splicing

Mutant Splicing Factor 3b Subunit 1 (SF3B1) Causes Dysregulated Erythropoiesis and a Stem Cell Disadvantage

Lenalidomide Induces Ubiquitination and Degradation of CSNK1A1 in MDS with Del(5q)

Tet2 Loss Accelerates The Myeloproliferative Neoplasm (MPN) Phenotype Of Jak2V617F Knockin Mice But Is Insufficient To Cause Leukemic Transformation

Sustained Alterations In Bone Marrow Stromal Cells From Patients With Myeloproliferative Neoplasms (MPN) Contribute To Remodelling Of The Bone Marrow Microenvironment Prior To The Manifestation Of Myelofibrosis

Critical Role Of Casein Kinase (Ck)1α Heterozygote Gene Inactivation In The Clonal Advantage Of Hematopoietic Stem Cells In Del(5q) MDS

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American Society of Hematology

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American Society of Hematology

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