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Journal Articles

Oncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable EVI1-CtBP1/2 Interaction and By Repressing Myeloid Regulator CEBPA

Dorien Pastoors, Marije Havermans, Remco Hoogenboezem, Roger Mulet-Lazaro, Duncan Brian, Leonie Smeenk, Claudia Erpelinck-Verschueren, Stanley van Herk, Bas Wouters, Jeroen A.A. Demmers, Johannes Zuber, Tariq Enver, Richard WJ Groen, Eric Bindels, Ruud Delwel

Blood (2022) 140 (Supplement 1): 83–84.

https://doi.org/10.1182/blood-2022-156994

Published: 2022

Journal Articles

MAF Translocations Are Enriched in NDMM Patients with Elevated Levels of Circulating Tumor Cells Suggesting a Genetic Basis for Aggressive Disease Course

Cathelijne Fokkema, Madelon M.E. de Jong, Sabrin Tahri, Davine Hofste Op Bruinink, Zoltan Kellermayer, Chelsea den Hollander, Michael Vermeulen, Natalie Papazian, Mark van Duin, Remco Hoogenboezem, Michiel J.W. Wevers, Vincent H.J. van der Velden, Mathijs A. Sanders, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo

Blood (2022) 140 (Supplement 1): 9917–9918.

https://doi.org/10.1182/blood-2022-166162

Published: 2022

Journal Articles

Stromal Cell-Activated Bone Marrow Neutrophils Provide BAFF in Newly Diagnosed and Treated Multiple Myeloma

Madelon M.E. de Jong, Cathelijne Fokkema, Natalie Papazian, Teddie van Heusden, Michael Vermeulen, Sabrin Tahri, Remco Hoogenboezem, Mark van Duin, Pieter van de Woestijne, Anton Langerak, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo

Blood (2022) 140 (Supplement 1): 4181–4182.

https://doi.org/10.1182/blood-2022-166339

Published: 2022

Journal Articles

Combining Plasma Cell Leukemia-like Status with the Second Revision of the International Staging System Improves Risk Classification

Blood (2022) 140 (Supplement 1): 1566–1567.

https://doi.org/10.1182/blood-2022-170249

Published: 2022

Journal Articles

SRSF2-P95Hdelays Myelofibrosis Development through Altered JAK/STAT Signaling in JAK2-V617F Megakaryocytes

Blood (2021) 138 (Supplement 1): 2544.

https://doi.org/10.1182/blood-2021-149757

Published: 2021

Journal Articles

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

Blood (2020) 136 (18): 2051–2064.

https://doi.org/10.1182/blood.2019004095

Published: 2020

Includes: Supplemental data

Journal Articles

PML Plays a Key Role in Severe Congenital Neutropenia with Mutant ELANE Causing Neutrophil Elastase Protein Misfolding

Patricia Olofsen, MSc, Paulette van Strien, BSc, Onno Roovers, BSc, Hans De Looper, BSc, Remco Hoogenboezem, MSc, Dennis Bosch, BSc, Mehrnaz Ghazvini, PhD, Eric Bindels, PhD, Emma De Pater, PhD, Ivo Touw, PhD

Blood (2019) 134 (Supplement_1): 213.

https://doi.org/10.1182/blood-2019-122423

Published: 2019

Journal Articles

Clonal Evolution of Multiple Myeloma in Patients from Diagnosis to First Relapse, Who Were Treated in Subsequent Clinical Trials

Mark van Duin, Annemiek Broijl, Jasper Koenders, Sonja Zweegman, Monique C. Minnema, Francois G. Kavelaars, Remco Hoogenboezem, Kazem Nasserinejad, Mario Boccadoro, Peter Valk, PhD, Pieter Sonneveld

Blood (2019) 134 (Supplement_1): 1798.

https://doi.org/10.1182/blood-2019-130086

Published: 2019

Journal Articles

A Leukemic Progression Model of Severe Congenital Neutropenia Uncovers a Novel Mechanism of AML Development Involving Elevated Inflammatory Responses, Mutation of CXXC4 and Decreased TET2 Levels

Patricia Olofsen, MSc, Szabolcs Fatrai, PhD, Paulette van Strien, BSc, Julia Obenauer, MSc, Remco Hoogenboezem, MSc, Claudia Erpelinck-Verschueren, B.Sc., Onno Roovers, BSc, Torsten Haferlach, MD, Peter Valk, PhD, Rebekka Schneider, MDPhD, Emma De Pater, PhD, Ivo Touw, PhD

Blood (2018) 132 (Supplement 1): 540.

https://doi.org/10.1182/blood-2018-99-115914

Published: 2018

Journal Articles

Whole-Exome and mRNA Sequencing of Multiple Myeloma Reveal Transformation to a More High-Risk and Proliferative Tumor at Relapse

Kristine Misund, PhD, Davine Hofste Op Bruinink, MD, Eivind Coward, PhD, Remco Hoogenboezem, MSc, Even H Rustad, MD, Eivind Hovig, PhD, Anders Sundan, PhD, Ola Myklebost, PhD, Pieter Sonneveld, MD PhD, Anders Waage, MD PhD

Blood (2018) 132 (Supplement 1): 3157.

https://doi.org/10.1182/blood-2018-99-113553

Published: 2018

Journal Articles

Extensive RAG-Mediated Rearrangements and Mutations in BCR-ABL1 and BCR - ABL1 -like Adult Acute Lymphoblastic Leukemia

Mathijs A. Sanders, PhD, Anikó Szabó, MD, Carla Exalto, Remco Hoogenboezem, Annelieke Zeilemaker, Jasper E. Koenders, Peter van Geel, Anita Schelen, H. Berna Beverloo, PhD, Jan J. Cornelissen, MD PhD, Anita W. Rijneveld, MD PhD, Peter J.M. Valk, PhD

Blood (2016) 128 (22): 4067.

https://doi.org/10.1182/blood.V128.22.4067.4067

Published: 2016

Journal Articles

Inflammatory Niche Signalling Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Leukemic Evolution in Human Leukemia Predisposition Syndromes

Blood (2016) 128 (22): 428.

https://doi.org/10.1182/blood.V128.22.428.428

Published: 2016

Journal Articles

DNMT3A Mutations Enhance CpG Mutagenesis through Deregulation of the Active DNA Demethylation Pathway

Mathijs A. Sanders, PhD, Annelieke Zeilemaker, Adil al Hinai, Remco Hoogenboezem, François G. Kavelaars, BSc, Melissa Rijken, Eric M.J. Bindels, PhD, Bob Löwenberg, MD PhD, Peter J.M. Valk, PhD

Blood (2016) 128 (22): 1076.

https://doi.org/10.1182/blood.V128.22.1076.1076

Published: 2016

Journal Articles

An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation

Blood (2016) 127 (24): 2991–3003.

https://doi.org/10.1182/blood-2016-01-695759

Published: 2016

Includes: Supplemental data

Journal Articles

M3P Sequencing Panel Identifies TP53 Mutational Status As a Prognostic Factor in Chemotherapy-Naive Multiple Myeloma

Davine Hofste op Bruinink, MD MSc, K. Martin Kortüm, MD, Mark van Duin, PhD, Mathijs A. Sanders, PhD, Remco Hoogenboezem, MSc, Michael Vermeulen, BSc, Laura Bruins, Jonathan Ahmann, Annemiek Broijl, MD PhD, Sonja Zweegman, MD PhD, Esteban Braggio, PhD, Bronno van der Holt, PhD, A. Keith Stewart, MD PhD, Pieter Sonneveld, MD PhD

Blood (2015) 126 (23): 2984.

https://doi.org/10.1182/blood.V126.23.2984.2984

Published: 2015

Journal Articles

ICL-induced miR139-3p and miR199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation

Mir Farshid Alemdehy, Jurgen R. Haanstra, Hans W. J. de Looper, Paulina M. H. van Strien, Judith Verhagen-Oldenampsen, Yvette Caljouw, Mathijs A. Sanders, Remco Hoogenboezem, Arnoud H. de Ru, George M. C. Janssen, Stephanie E. Smetsers, Marc B. Bierings, Peter A. van Veelen, Marieke von Lindern, Ivo P. Touw, Stefan J. Erkeland

Blood (2015) 125 (25): 3937–3948.

https://doi.org/10.1182/blood-2014-11-612507

Published: 2015

Includes: Supplemental data

Journal Articles

Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways

Stefan Gröschel, Mathijs A. Sanders, Remco Hoogenboezem, Annelieke Zeilemaker, Marije Havermans, Claudia Erpelinck, Eric M. J. Bindels, H. Berna Beverloo, Hartmut Döhner, Bob Löwenberg, Konstanze Döhner, Ruud Delwel, Peter J. M. Valk

Blood (2015) 125 (1): 133–139.

https://doi.org/10.1182/blood-2014-07-591461

Published: 2015

Includes: Supplemental data

Journal Articles

Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling

Erdogan Taskesen, Marije Havermans, Kirsten van Lom, Mathijs A. Sanders, Yvette van Norden, Eric Bindels, Remco Hoogenboezem, Marcel J. T. Reinders, Maria E. Figueroa, Peter J. M. Valk, Bob Löwenberg, Ari Melnick, Ruud Delwel

Blood (2014) 123 (21): 3327–3335.

https://doi.org/10.1182/blood-2013-07-512855

Published: 2014

Includes: Supplemental data

Journal Articles

Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis

Blood (2014) 123 (14): 2229–2237.

https://doi.org/10.1182/blood-2013-11-538025

Published: 2014

Includes: Supplemental data

Journal Articles

The Gene Encoding Nuclear Erythroid Factor 2 (NFE2) Is Recurrently Mutated in Acute Myeloid Leukemia

Mathijs A. Sanders, Annelieke Zeilemakers, Jasper Koenders, Remco Hoogenboezem, François Kavelaars, Rob Henderson, Bob Lowenberg, MD, PhD, Peter J. M. Valk, PhD

Blood (2012) 120 (21): 1392.

https://doi.org/10.1182/blood.V120.21.1392.1392

Published: 2012

NARROW

Oncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable EVI1-CtBP1/2 Interaction and By Repressing Myeloid Regulator CEBPA

MAF Translocations Are Enriched in NDMM Patients with Elevated Levels of Circulating Tumor Cells Suggesting a Genetic Basis for Aggressive Disease Course

Stromal Cell-Activated Bone Marrow Neutrophils Provide BAFF in Newly Diagnosed and Treated Multiple Myeloma

Combining Plasma Cell Leukemia-like Status with the Second Revision of the International Staging System Improves Risk Classification

SRSF2-P95Hdelays Myelofibrosis Development through Altered JAK/STAT Signaling in JAK2-V617F Megakaryocytes

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

PML Plays a Key Role in Severe Congenital Neutropenia with Mutant ELANE Causing Neutrophil Elastase Protein Misfolding

Clonal Evolution of Multiple Myeloma in Patients from Diagnosis to First Relapse, Who Were Treated in Subsequent Clinical Trials

A Leukemic Progression Model of Severe Congenital Neutropenia Uncovers a Novel Mechanism of AML Development Involving Elevated Inflammatory Responses, Mutation of CXXC4 and Decreased TET2 Levels

Whole-Exome and mRNA Sequencing of Multiple Myeloma Reveal Transformation to a More High-Risk and Proliferative Tumor at Relapse

Extensive RAG-Mediated Rearrangements and Mutations in BCR-ABL1 and BCR - ABL1 -like Adult Acute Lymphoblastic Leukemia

Inflammatory Niche Signalling Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Leukemic Evolution in Human Leukemia Predisposition Syndromes

DNMT3A Mutations Enhance CpG Mutagenesis through Deregulation of the Active DNA Demethylation Pathway

An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation

M3P Sequencing Panel Identifies TP53 Mutational Status As a Prognostic Factor in Chemotherapy-Naive Multiple Myeloma

ICL-induced miR139-3p and miR199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation

Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways

Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling

Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis

The Gene Encoding Nuclear Erythroid Factor 2 (NFE2) Is Recurrently Mutated in Acute Myeloid Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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