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Laura Bruins
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Journal Articles

Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes

Clinical Trials & Observations
K. Martin Kortüm, Elias K. Mai, Nur H. Hanafiah, Chang-Xi Shi, Yuan-Xiao Zhu, Laura Bruins, Santiago Barrio, Patrick Jedlowski, Maximilian Merz, Jing Xu, Robert A. Stewart, Mindaugas Andrulis, Anna Jauch, Jens Hillengass, Hartmut Goldschmidt, P. Leif Bergsagel, Esteban Braggio, A. Keith Stewart, Marc S. Raab
Journal: Blood
Blood (2016) 128 (9): 1226–1233.
https://doi.org/10.1182/blood-2016-02-698092
Published: 2016
Includes: Supplemental data
Journal Articles

M3P Sequencing Panel Identifies TP53 Mutational Status As a Prognostic Factor in Chemotherapy-Naive Multiple Myeloma

Davine Hofste op Bruinink, MD MSc, K. Martin Kortüm, MD, Mark van Duin, PhD, Mathijs A. Sanders, PhD, Remco Hoogenboezem, MSc, Michael Vermeulen, BSc, Laura Bruins, Jonathan Ahmann, Annemiek Broijl, MD PhD, Sonja Zweegman, MD PhD, Esteban Braggio, PhD, Bronno van der Holt, PhD, A. Keith Stewart, MD PhD, Pieter Sonneveld, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2984.
https://doi.org/10.1182/blood.V126.23.2984.2984
Published: 2015
Journal Articles

Ikaros Degradation Efficiency Correlates with Response of Multiple Myeloma (MM) Cells to IMiD Therapy and Is Blocked By Proteasome Inhibitors

Chang-Xin Shi, PhD, Yuan Xiao Zhu, PhD, Patrick Jedlowski, Laura Bruins, Martin Kortuem, MD, A. Keith Stewart, MD
Journal: Blood
Blood (2014) 124 (21): 2247.
https://doi.org/10.1182/blood.V124.21.2247.2247
Published: 2014
Journal Articles

Development Of a 47 Gene Sequencing Panel For Common Mutations Present In Multiple Myeloma : Preliminary Results In 77 p53 Deleted Patients

K. Martin Kortuem, MD, Christian Langer, MD, Esteban Braggio, Ph.D., Scott Van Wier, Jan Egan, PhD, Laura Bruins, Jessica Schmidt, Lars Bullinger, MD, PhD, Miriam Kull, MD, Stefan Knop, MD, Hermann Einsele, MD, A. Keith Stewart, MBA, MB, CHB
Journal: Blood
Blood (2013) 122 (21): 4449.
https://doi.org/10.1182/blood.V122.21.4449.4449
Published: 2013
Journal Articles

A Synthetic Lethality Druggable Genome RNAi Screen Identifies Genes Mediating Sensitivity To Lenalidomide In Multiple Myeloma Including RSK2

Yuan Xiao Zhu, Ph.D., Laura Bruins, Chang-Xin Shi, Ph.D., Jessica Schmidt, Chris Sereduk, Mia Champion, Ph.D., Esteban Braggio, Ph.D., Holly Yin, Ph.D., A. Keith Stewart, MBChB
Journal: Blood
Blood (2013) 122 (21): 3084.
https://doi.org/10.1182/blood.V122.21.3084.3084
Published: 2013
Journal Articles

Cereblon Expression Predicts Response, Progression Free and Overall Survival After Pomalidomide and Dexamethasone Therapy in Multiple Myeloma

Steven R. Schuster, MD, Klaus Martin Kortuem, MD, Yuan Xiao Zhu, PhD, Esteban Braggio, Ph.D., Chang-Xin Shi, PhD, Laura Bruins, Jessica Schmidt, Gregory Ahmann, BS, Shaji K. Kumar, MD, S. Vincent Rajkumar, Joseph R. Mikhael, MD, Vivek Roy, M.D., Betsy R. LaPlant, Kristina Laumann, Bart Barlogie, MD, John D Shaughnessy, Jr., PhD, Rafael Fonseca, MD, Leif Bergsagel, MD, Martha Q Lacy, MD, Keith Stewart, MD
Journal: Blood
Blood (2012) 120 (21): 194.
https://doi.org/10.1182/blood.V120.21.194.194
Published: 2012
Journal Articles

Cereblon Binding IMiD Small Molecules Mediate Myeloma Cell Death Via IRF4

Yuan Xiao Zhu, Ph.D., Chang-Xin Shi, Ph.D., Laura Bruins, Klaus Martin Kortuem, MD, Jessica Schmidt, Xiu-Bao Chang, Ph.D., Esteban Braggio, Ph.D., Leif Bergsagel, M.D., Keith Stewart, MBA, MB, CHB
Journal: Blood
Blood (2012) 120 (21): 1807.
https://doi.org/10.1182/blood.V120.21.1807.1807
Published: 2012
Journal Articles

Cereblon Expression Is Required for the Anti-Myeloma Activity of Lenalidomide and Pomalidomide

Yuan Xiao Zhu, PhD, Esteban Braggio, PhD, Chang-Xin Shi, PhD, Jessica Schmidt, Laura Bruins, Steven R. Schuster, MD, Rafael Fonseca, MD, P. Leif Bergsagel, MD, Chad C. Bjorklund, Ph.D., Robert Z. Orlowski, MD, PhD, A. Keith Stewart, MD
Journal: Blood
Blood (2011) 118 (21): 127.
https://doi.org/10.1182/blood.V118.21.127.127
Published: 2011
Journal Articles

RNAi Screen of the Druggable Genome Identifies Modulators of Proteasome Inhibitor Sensitivity in Myeloma Including CDK5.

Yuan Xiao Zhu, PhD, Rodger E. Tiedemann, MBChB, PhD, FRACP, FRCPA, Chang-Xin Shi, PhD, Jessica Schmidt, BS, Laura Bruins, Jonathan J Keats, PhD, Holly Yin, PhD, Chris Sereduk, Spyro Mousses, PhD, A. Keith Stewart, MBChB
Journal: Blood
Blood (2009) 114 (22): 602.
https://doi.org/10.1182/blood.V114.22.602.602
Published: 2009