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Journal Articles

Oncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable EVI1-CtBP1/2 Interaction and By Repressing Myeloid Regulator CEBPA

Dorien Pastoors, Marije Havermans, Remco Hoogenboezem, Roger Mulet-Lazaro, Duncan Brian, Leonie Smeenk, Claudia Erpelinck-Verschueren, Stanley van Herk, Bas Wouters, Jeroen A.A. Demmers, Johannes Zuber, Tariq Enver, Richard WJ Groen, Eric Bindels, Ruud Delwel

Blood (2022) 140 (Supplement 1): 83–84.

https://doi.org/10.1182/blood-2022-156994

Published: 2022

Journal Articles

Allele-Specific Expression of GATA2 in AML with CEBPA Biallelic Mutations

Roger Mulet-Lazaro, MSc, Stanley van Herk, B.Sc., Claudia Erpelinck-Verschueren, B.Sc., Mathijs A. Sanders, PhD MSc, Eric Bindels, PhD, Peter Valk, PhD, Michael Rehli, PhD, Claudia Gebhard, PhD, Ruud Delwel, PhD, B.J. Wouters

Blood (2019) 134 (Supplement_1): 1235.

https://doi.org/10.1182/blood-2019-129766

Published: 2019

Journal Articles

Integrated Analysis of Global DNA Methylation and Transcription Reveals a Leukemia Subtype with Extreme Hypermethylation Associated with Silencing of Regulators of Differentiation

Claudia Gebhard, PhD, Roger Mulet-Lazaro, B.Sc., Lucia Schwarzfischer, Dagmar Glatz, Margit Nuetzel, Daniel Heudobler, MD, Sandra Pohl, Wolfgang Herr, MD, Gerhard Ehninger, MD, Claudia Erpelinck-Verschueren, B.Sc., Stanley van Herk, B.Sc., B.J. Wouters, Christian Thiede, MD, Ruud Delwel, PhD, Michael Rehli, PhD

Blood (2018) 132 (Supplement 1): 2608.

https://doi.org/10.1182/blood-2018-99-118521

Published: 2018

Journal Articles

Complex 3q26/EVI1 Rearrangements Genocopy Inv(3)/t(3;3) Acute Myeloid Leukemias By Enhancer Hijacking, EVI1 Overexpression, Absent MDS1-EVI1 and Low GATA2 Expression

Sophie Ottema, MSc, Roger Mulet-Lazaro, B.Sc., Berna Beverloo, PhD, Marije Havermans, Ir, Claudia Erpelinck-Verschueren, B.Sc., Tim Grob, MD, Peter Valk, PhD, Eric Bindels, PhD, Torsten Haferlach, MD, Claudia Haferlach, MD, Leonie Smeenk, PhD, Ruud Delwel, PhD

Blood (2018) 132 (Supplement 1): 2766.

https://doi.org/10.1182/blood-2018-99-113339

Published: 2018

Journal Articles

Archived Bone Marrow Smears Are an Excellent Source for NGS-Based Mutation Detection in Acute Myeloid Leukemia

Adil S.A. Al Hinai, MSc, Francois G. Kavelaars, Melissa Rijken, Tim Grob, MD, Kirsten Gussinklo, Annelieke Zeilemaker, Claudia Erpelinck-Verschueren, B.Sc., Mathijs A. Sanders, PhD, Kirsten van Lom, Peter J.M. Valk, PhD

Blood (2018) 132 (Supplement 1): 2783.

https://doi.org/10.1182/blood-2018-99-118066

Published: 2018

Journal Articles

A Leukemic Progression Model of Severe Congenital Neutropenia Uncovers a Novel Mechanism of AML Development Involving Elevated Inflammatory Responses, Mutation of CXXC4 and Decreased TET2 Levels

Patricia Olofsen, MSc, Szabolcs Fatrai, PhD, Paulette van Strien, BSc, Julia Obenauer, MSc, Remco Hoogenboezem, MSc, Claudia Erpelinck-Verschueren, B.Sc., Onno Roovers, BSc, Torsten Haferlach, MD, Peter Valk, PhD, Rebekka Schneider, MDPhD, Emma De Pater, PhD, Ivo Touw, PhD

Blood (2018) 132 (Supplement 1): 540.

https://doi.org/10.1182/blood-2018-99-115914

Published: 2018

Journal Articles

Multiple Myeloma with a Deletion of Chromosome 17p: TP53 Mutations Are Highly Prevalent and Negatively Affect Prognosis

Blood (2016) 128 (22): 3271.

https://doi.org/10.1182/blood.V128.22.3271.3271

Published: 2016

Journal Articles

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

Ana Flávia Tibúrcio Ribeiro, Marta Pratcorona, Claudia Erpelinck-Verschueren, Veronika Rockova, Mathijs Sanders, Saman Abbas, Maria E. Figueroa, Annelieke Zeilemaker, Ari Melnick, Bob Löwenberg, Peter J. M. Valk, Ruud Delwel

Blood (2012) 119 (24): 5824–5831.

https://doi.org/10.1182/blood-2011-07-367961

Published: 2012

Includes: Supplemental data

Journal Articles

Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1

Sanne Lugthart, Maria E. Figueroa, Eric Bindels, Lucy Skrabanek, Peter J. M. Valk, Yushan Li, Stefan Meyer, Claudia Erpelinck-Verschueren, John Greally, Bob Löwenberg, Ari Melnick, Ruud Delwel

Blood (2011) 117 (1): 234–241.

https://doi.org/10.1182/blood-2010-04-281337

Published: 2011

Includes: Supplemental data

Journal Articles

DNA Methylation Profiling Predicts Clinical Outcomes and Reveals Unique Insights Into the Molecular Complexity of Acute Myeloid Leukemia.

Maria E Figueroa, MD, Sanne Lugthart, MD, Yushan Li, Claudia Erpelinck-Verschueren, Xutao Deng, Paul J. Christos, PhD, Elizabeth Schifano, Jim Booth, Lucy Skrabanek, Fabien Campagne, Madhu Mazumdar, PhD, John Greally, MB, PhD, Peter Valk, Bob Lowenberg, MD, PhD, Ruud Delwel, PhD, Ari Melnick

Blood (2009) 114 (22): 707.

https://doi.org/10.1182/blood.V114.22.707.707

Published: 2009

Journal Articles

Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status

Fernando P. G. Silva, Sigrid M. A. Swagemakers, Claudia Erpelinck-Verschueren, Bas J. Wouters, Ruud Delwel, Harry Vrieling, Peter van der Spek, Peter J. M. Valk, Micheline Giphart-Gassler

Blood (2009) 114 (14): 3001–3007.

https://doi.org/10.1182/blood-2009-03-211334

Published: 2009

Includes: Supplemental data

Journal Articles

Epigenetic Signatures Identify New Clinically Relevant Subtypes and Define Gene Regulatory Patterns in Patients with Acute Myeloid Leukemia (AML)

Maria E Figueroa, MD, Sanne Lugthart, MD, Yushan Li, Claudia Erpelinck-Verschueren, Paul J Christos, MS, MPH, Madhu Mazumdar, PhD, Bob Löwenberg, MD, PhD, John Greally, MB, PhD, Peter JM Valk, PhD, Ruud Delwel, PhD, Ari Melnick, MD

Blood (2008) 112 (11): 756.

https://doi.org/10.1182/blood.V112.11.756.756

Published: 2008

Journal Articles

Two Different EVI1 Expressing Poor-Risk AML Subgroups with Distinct Epigenetic Signatures Uncovered by Genome Wide DNA Methylation Profiling

Sanne Lugthart, MD, Maria E Figueroa, MD, Peter JM Valk, PhD, Yushan Li, Claudia Erpelinck-Verschueren, John Greally, MB, PhD, Bob Löwenberg, MD, PhD, Ari Melnick, MD, Ruud Delwel, PhD

Blood (2008) 112 (11): 757.

https://doi.org/10.1182/blood.V112.11.757.757

Published: 2008

NARROW

Oncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable EVI1-CtBP1/2 Interaction and By Repressing Myeloid Regulator CEBPA

Allele-Specific Expression of GATA2 in AML with CEBPA Biallelic Mutations

Integrated Analysis of Global DNA Methylation and Transcription Reveals a Leukemia Subtype with Extreme Hypermethylation Associated with Silencing of Regulators of Differentiation

Complex 3q26/EVI1 Rearrangements Genocopy Inv(3)/t(3;3) Acute Myeloid Leukemias By Enhancer Hijacking, EVI1 Overexpression, Absent MDS1-EVI1 and Low GATA2 Expression

Archived Bone Marrow Smears Are an Excellent Source for NGS-Based Mutation Detection in Acute Myeloid Leukemia

A Leukemic Progression Model of Severe Congenital Neutropenia Uncovers a Novel Mechanism of AML Development Involving Elevated Inflammatory Responses, Mutation of CXXC4 and Decreased TET2 Levels

Multiple Myeloma with a Deletion of Chromosome 17p: TP53 Mutations Are Highly Prevalent and Negatively Affect Prognosis

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1

DNA Methylation Profiling Predicts Clinical Outcomes and Reveals Unique Insights Into the Molecular Complexity of Acute Myeloid Leukemia.

Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status

Epigenetic Signatures Identify New Clinically Relevant Subtypes and Define Gene Regulatory Patterns in Patients with Acute Myeloid Leukemia (AML)

Two Different EVI1 Expressing Poor-Risk AML Subgroups with Distinct Epigenetic Signatures Uncovered by Genome Wide DNA Methylation Profiling

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American Society of Hematology

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American Society of Hematology

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