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Sanne Lugthart
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Journal Articles

Predicting Vaso-Occlusive Crises in Sickle Cell Disease through Digital, Longitudinal Tracking of Wearable Metrics and Patient-Reported Outcomes

Kim Summers, Orlando Agrippa, Sanne Lugthart, Kofi Anie, Paul Telfer
Journal: Blood
Blood (2023) 142 (Supplement 1): 1059.
https://doi.org/10.1182/blood-2023-181407
Published: 2023
Journal Articles

Real-World Outcomes and Digitally Monitored Quality of Life in Voxelotor-Treated Patients with Sickle Cell Disease

Kim Summers, Orlando Agrippa, Oliver Shastri, Seraj Sharif, Kofi Anie, Paul Telfer, Sanne Lugthart
Journal: Blood
Blood (2023) 142 (Supplement 1): 2383.
https://doi.org/10.1182/blood-2023-181426
Published: 2023
Journal Articles

Improvement in Lymphoma CAR-T Outcomes over Time in the UK - CAR-T Learning Curve or Better Bridging?

Stephen Boyle, Robin Sanderson, Maeve A. O'Reilly, Tobias F. Menne, Jane Norman, Adrian Bloor, Sanne Lugthart, Sridhar Chaganti, Carlos Gonzalez-Arias, Ceri Jones, Anne-Louise Latif, Reuben Benjamin, Piers Patten, Deborah Yallop, Victoria Potter, Claire Roddie, Andrea Kuhnl
Journal: Blood
Blood (2022) 140 (Supplement 1): 4649–4651.
https://doi.org/10.1182/blood-2022-159217
Published: 2022
Journal Articles

Treatment with IMR-687, a Highly Selective PDE9 Inhibitor, Increases HbF and Reduces VOCs in Adults with Sickle Cell Disease in a Long-Term, Phase 2a, Open-Label Extension Study

Biree Andemariam, Timothy Mant, Perla Eleftheriou, Sanne Lugthart, Lanetta Bronté-Hall, Filipa Barroso, Gershwin Blyden, James Mason, Constance M Barysauskas, Joseph Yen, Karen Tang, Rahul Ballal, Kenneth Attie
Journal: Blood
Blood (2021) 138 (Supplement 1): 2046.
https://doi.org/10.1182/blood-2021-149536
Published: 2021
Journal Articles

Benefits and Safety of Long-Term Use of IMR-687 As Monotherapy or in Combination with a Stable Dose of Hydroxyurea (HU) in 2 Adult Sickle Cell Patients

Lanetta Bronte-Hall, MD MPH, MSPH, Biree Andemariam, MD, Blyden Gershwin, MD, Sanne Lugthart, MD PhD, Timothy Mant, MB, FFPM, FRCP, Jo Howard, MBBChir, MRCP, FRCPath, Henry Fok, MBBS, PhD, Perla Eleftheriou, FRCPath, MRCP, Robert Ward Hagar, MD, James Mason, DO, Rahul Ballal, PhD, Joelle Lufkin, MPH, Eleanor Lisbon, MD MPH
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-140540
Published: 2020
Journal Articles

Real-World Data of High-Grade Lymphoma Patients Treated with CD19 CAR-T in England

Andrea Kuhnl, Claire Roddie, PhD MD, Nuria Martinez-Cibrian, Tobias F Menne, MD PhD FRCPath, Kim Linton, MBChB PhD, Sanne Lugthart, Sridhar Chaganti, MDPhDMRCP,FRCPath, Robin Sanderson, MRCP,FRCPath, Maria A V Marzolini, Jane Norman, MD, Wendy Osborne, MD, John Radford, Stephen Robinson, MBBS, PhD BSc, Ram Malladi, Piers E.M. Patten, BSc, MRCP, MRCPath, PhD, Maeve A O'Reilly, MBBCHBAO, Muhammad Saif, MD, Geoff Shenton, Adrian Bloor, FRCPath, Clare J Rowntree, MBBS, PhD FRCP, FRCPath, David A. Irvine, BSc, MBBChir, MRCP, FRCPath, PhD, Orla Stewart, Arzhang Ardavan, Kate Robinson, Antonio Pagliuca, MBBS, MA, FRCP, FRCPath, Kristian M Bowles, MBBS, PhD, Graham P. Collins, MA, MBBS, MRCP, FRCPath, DPhil, Rod Johnson, Andrew K McMillan, FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 767.
https://doi.org/10.1182/blood-2019-124177
Published: 2019
Journal Articles

EVI1 is critical for the pathogenesis of a subset of MLL-AF9 –rearranged AMLs

Clinical Trials & Observations
Eric M. J. Bindels, Marije Havermans, Sanne Lugthart, Claudia Erpelinck, Elizabeth Wocjtowicz, Andrei V. Krivtsov, Elwin Rombouts, Scott A. Armstrong, Erdogan Taskesen, Jurgen R. Haanstra, H. Berna Beverloo, Hartmut Döhner, Wendy A. Hudson, John H. Kersey, Ruud Delwel, Ashish R. Kumar
Journal: Blood
Blood (2012) 119 (24): 5838–5849.
https://doi.org/10.1182/blood-2011-11-393827
Published: 2012
Includes: Supplemental data
Journal Articles

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

Rachel J. Bergerson, Lara S. Collier, Aaron L. Sarver, Raha A. Been, Sanne Lugthart, Miechaleen D. Diers, Johannes Zuber, Amy R. Rappaport, Molly J. Nixon, Kevin A. T. Silverstein, Danhua Fan, Anne-Francoise J. Lamblin, Linda Wolff, John H. Kersey, Ruud Delwel, Scott W. Lowe, M. Gerard O'Sullivan, Scott C. Kogan, David J. Adams, David A. Largaespada
Journal: Blood
Blood (2012) 119 (19): 4512–4523.
https://doi.org/10.1182/blood-2010-04-281428
Published: 2012
Includes: Supplemental data
Journal Articles

Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1

Sanne Lugthart, Maria E. Figueroa, Eric Bindels, Lucy Skrabanek, Peter J. M. Valk, Yushan Li, Stefan Meyer, Claudia Erpelinck-Verschueren, John Greally, Bob Löwenberg, Ari Melnick, Ruud Delwel
Journal: Blood
Blood (2011) 117 (1): 234–241.
https://doi.org/10.1182/blood-2010-04-281337
Published: 2011
Includes: Supplemental data
Journal Articles

Hoxa9 Suppresses Cellular Senescence and Sustains the Development of Leukemic Stem Cells Induced by Fusion Proteins In the Absence of Bmi1.

Lan-Lan Smith, Jenny Yeung, PhD, Bernd B Zeisig, PhD, Ivo Huijbers, PhD, Nik Popov, PhD, Josephine Barnes, PhD, Amanda J Wilson, Sanne Lugthart, PhD, Ruud Delwel, PhD, Jesus Gil, PhD, Maarten van Lohuizen, PhD, Chi Wai Eric So, PhD
Journal: Blood
Blood (2010) 116 (21): 1578.
https://doi.org/10.1182/blood.V116.21.1578.1578
Published: 2010
Journal Articles

Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value

Brief Report
Saman Abbas, Sanne Lugthart, François G. Kavelaars, Anita Schelen, Jasper E. Koenders, Annelieke Zeilemaker, Wim J. L. van Putten, Anita W. Rijneveld, Bob Löwenberg, Peter J. M. Valk
Journal: Blood
Blood (2010) 116 (12): 2122–2126.
https://doi.org/10.1182/blood-2009-11-250878
Published: 2010
Includes: Supplemental data
Journal Articles

An Insertional Mutagenesis Screen for Genes That Cooperate with Mll-AF9 in Leukemogenesis.

Rachel Joy Bergerson, Lara S Collier, PhD, Sanne Lugthart, MD, Raha Allaei, Molly J Nixon, Kevin A.T. Silverstein, PhD, Aaron Sarver, PhD, Danhua Flora Fan, PhD, Anne-Francoise J Lamblin, PhD, Linda Wolff, PhD, John H. Kersey, MD, M. Gerard O'Sullivan, MVB, PhD, Ruud Delwel, PhD, Scott C. Kogan, MD, David J Adams, PhD, David Largaespada, PhD
Journal: Blood
Blood (2009) 114 (22): 3962.
https://doi.org/10.1182/blood.V114.22.3962.3962
Published: 2009
Journal Articles

DNA Methylation Profiling Predicts Clinical Outcomes and Reveals Unique Insights Into the Molecular Complexity of Acute Myeloid Leukemia.

Maria E Figueroa, MD, Sanne Lugthart, MD, Yushan Li, Claudia Erpelinck-Verschueren, Xutao Deng, Paul J. Christos, PhD, Elizabeth Schifano, Jim Booth, Lucy Skrabanek, Fabien Campagne, Madhu Mazumdar, PhD, John Greally, MB, PhD, Peter Valk, Bob Lowenberg, MD, PhD, Ruud Delwel, PhD, Ari Melnick
Journal: Blood
Blood (2009) 114 (22): 707.
https://doi.org/10.1182/blood.V114.22.707.707
Published: 2009
Journal Articles

High EVI1 Expression Predicts Outcome in Younger Adult (15 to 60 years) Patients with Acute Myeloid Leukemia and Is Associated with Distinctive Cytogenetic Subgroups.

Gröschel Stefan, Sanne Lugthart, Richard Schlenk, Peter Valk, Karina Eiwen, Chantal Goudswaard, Willem JL Van Putten, Sabine Kayser, Leo Verdonck, Michael Lübbert, Gert Ossenkoppele, Ulrich Germing, Ingo Schmidt-Wolf, Jürgen Krauter, Arnold Ganser, Hartmut Döhner, Bob Löwenberg, Konstanze Döhner, Ruud Delwel
Journal: Blood
Blood (2009) 114 (22): 582.
https://doi.org/10.1182/blood.V114.22.582.582
Published: 2009
Journal Articles

Epigenetic Signatures Identify New Clinically Relevant Subtypes and Define Gene Regulatory Patterns in Patients with Acute Myeloid Leukemia (AML)

Maria E Figueroa, MD, Sanne Lugthart, MD, Yushan Li, Claudia Erpelinck-Verschueren, Paul J Christos, MS, MPH, Madhu Mazumdar, PhD, Bob Löwenberg, MD, PhD, John Greally, MB, PhD, Peter JM Valk, PhD, Ruud Delwel, PhD, Ari Melnick, MD
Journal: Blood
Blood (2008) 112 (11): 756.
https://doi.org/10.1182/blood.V112.11.756.756
Published: 2008
Journal Articles

Two Different EVI1 Expressing Poor-Risk AML Subgroups with Distinct Epigenetic Signatures Uncovered by Genome Wide DNA Methylation Profiling

Sanne Lugthart, MD, Maria E Figueroa, MD, Peter JM Valk, PhD, Yushan Li, Claudia Erpelinck-Verschueren, John Greally, MB, PhD, Bob Löwenberg, MD, PhD, Ari Melnick, MD, Ruud Delwel, PhD
Journal: Blood
Blood (2008) 112 (11): 757.
https://doi.org/10.1182/blood.V112.11.757.757
Published: 2008
Journal Articles

EVI1 Overexpression in Pediatric Acute Myeloid Leukemia Associated with Unfavorable Subtypes.

Brian V Balgobind, MD, Sanne Lugthart, MD, Iris H.I.M. Hollink, MD, Susan T.J.C.M. Arentsen-Peters, Elisabeth R van Wering, Sibold S.N. de Graaf, MD, PhD, Dirk Reinhardt, MD, PhD, Gertjan Kaspers, MD, PhD, Jan Stary, MD, PhD, Jan Trka, MD, PhD, Martin Zimmermann, PhD, Ruud Delwel, PhD, Rob Pieters, Christian M Zwaan, MD, PhD, Marry M van den Heuvel-Eibrink, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1802.
https://doi.org/10.1182/blood.V112.11.1802.1802
Published: 2008
Journal Articles

High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated

Sanne Lugthart, Ellen van Drunen, Yvette van Norden, Antoinette van Hoven, Claudia A. J. Erpelinck, Peter J. M. Valk, H. Berna Beverloo, Bob Löwenberg, Ruud Delwel
Journal: Blood
Blood (2008) 111 (8): 4329–4337.
https://doi.org/10.1182/blood-2007-10-119230
Published: 2008
Includes: Supplemental data