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Journal Articles

Forward Genetic Screen Implicates Drivers of Leukemic Progression in a Novel Model of Trp53 R270H myelodysplastic Syndrome

Daniel Chang, Klara E Noble-Orcutt, Wendy Hudson, Aishwarya Iyer, Emily Pomeroy, Craig E. Eckfeldt, Aaron Sarver, Nuri Alpay Temiz, Michael Linden, Chad L Myers, David A. Largaespada, Zohar Sachs

Blood (2023) 142 (Supplement 1): 315.

https://doi.org/10.1182/blood-2023-189336

Published: 2023

Journal Articles

NRAS G12V -Mediated Self-Renewal Signaling in Self-Renewing AML Stem Cells.

Marie Lue Antony, PhD, Klara Noble-Orcutt, Karen Sachs, PhD, Anna Khoroshilov, Daniel Chang, Alexandria Hillesheim, Hesham Mohei, Merve Pamukcuoglu, MD, Christine Bergene, David A. Largaespada, PhD, Zohar Sachs, MD PhD

Blood (2018) 132 (Supplement 1): 2626.

https://doi.org/10.1182/blood-2018-99-119448

Published: 2018

Journal Articles

Single-Cell Transcriptional Profiling of Acute Myeloid Leukemia Identifies Prognostic Transcriptional Profiles at Diagnosis

Karen Sachs, PhD, Aaron Sarver, PhD, Klara Noble-Orcutt, Connor Navis, Alexandria Hillesheim, Ian Nykaza, Rebecca S. Larue, PhD, Conner Hansen, Nuri Temiz, Ngoc Ha, Michael A. Linden, MDPhD, David A. Largaespada, PhD, Zohar Sachs, MD PhD

Blood (2017) 130 (Supplement 1): 2704.

https://doi.org/10.1182/blood.V130.Suppl_1.2704.2704

Published: 2017

Journal Articles

Immunoproteasome Inhibition to Target AML with Activated RAS Pathways

Connor Navis, Klara Noble-Orcutt, Rebecca S LaRue, PhD, Conner Hansen, B.S., Ngoc Ha, B.S., Alexandria Hillesheim, Ryan Schulz, Do-Hyung Kim, David A Largaespada, PhD, Zohar Sachs, MD PhD

Blood (2016) 128 (22): 577.

https://doi.org/10.1182/blood.V128.22.577.577

Published: 2016

Journal Articles

Single-Cell Analysis Reveals Molecular Mechanisms of NRAS-Mediated Leukemia Stem Cell Self-Renewal in a Murine Model of AML

Rebecca S. Larue, PhD, Klara E Noble, B.S., Conner Hansen, B.S., Ngoc Ha, B.S., David A Largaespada, PhD, Zohar Sachs, MD PhD

Blood (2015) 126 (23): 3060.

https://doi.org/10.1182/blood.V126.23.3060.3060

Published: 2015

Journal Articles

Ras Effector Pathways Differentially Support Proliferation and Survival of Acute Myeloid Leukemia

Craig E Eckfeldt, MDPhD, Emily J Pomeroy, MS, Robin DW Lee, Katherine S Hazen, Branden S Moriarity, PhD, David A Largaespada, PhD

Blood (2014) 124 (21): 3755.

https://doi.org/10.1182/blood.V124.21.3755.3755

Published: 2014

Journal Articles

NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Zohar Sachs, Rebecca S. LaRue, Hanh T. Nguyen, Karen Sachs, Klara E. Noble, Nurul Azyan Mohd Hassan, Ernesto Diaz-Flores, Susan K. Rathe, Aaron L. Sarver, Sean C. Bendall, Ngoc A. Ha, Miechaleen D. Diers, Garry P. Nolan, Kevin M. Shannon, David A. Largaespada

Blood (2014) 124 (22): 3274–3283.

https://doi.org/10.1182/blood-2013-08-521708

Published: 2014

Includes: Supplemental data

Journal Articles

Cellular Intrinsic Mechanism Affecting The Outcome Of AML Treatment With Ara-C In a Syngeneic Mouse Model

Zheng Chen, B.S., Dongming Tan, B.S., Wenjun Zhao, B.S., Guangsong Su, B.S., Yanwen Zheng, MS, Chao He, M.S., Miechaleen D Diers, B.S., Zhengwei Mao, BS, Timothy Singleton, MD, David A. Largaespada, PhD, Bin Yin, PhD

Blood (2013) 122 (21): 5025.

https://doi.org/10.1182/blood.V122.21.5025.5025

Published: 2013

Journal Articles

Retroviral Insertional Mutagenesis In Egr1 +/- mice, Haploinsufficient For a Human Del(5q) Myeloid Leukemia Gene, Develop Myeloid Neoplasms With Proviral Insertions In Genes Syntenic To Human 5q

Angela Stoddart, PhD, Anthony Fernald, Rachel Joy Bergerson, PhD, Jianghong Wang, M.D., Megan E. McNerney, MD, PhD, Theodore Karrison, Ph.D., John Anastasi, MD, Elizabeth Bartom, Ph.D., Aaron G. Sarver, Ph.D., Zhijian Qian, PhD, Linda Wolff, PhD, David A. Largaespada, PhD, Michelle M. le Beau, PhD

Blood (2013) 122 (21): 1275.

https://doi.org/10.1182/blood.V122.21.1275.1275

Published: 2013

Journal Articles

Ras-Pathway Inhibition With Targeted Therapies Abrogates Self-Renewal In Acute Myelogenous Leukemia

Rebecca S. LaRue, PhD, Hanh Nguyen, Karen Sachs, Nurul Azyan Mohd Hassan, Ernesto Diaz-Flores, PhD, Susan K. Rathe, Aaron G. Sarver, Ph.D., Sean C. Bendall, Ngoc A. Ha, Miechaleen D. Diers, B.S., Garry P. Nolan, PhD, Kevin Shannon, MD, Zohar Sachs, MD, PhD, David A. Largaespada, PhD

Blood (2013) 122 (21): 819.

https://doi.org/10.1182/blood.V122.21.819.819

Published: 2013

Journal Articles

Activated NRAS Mediates Self-Renewal Capacity in AML by Facilitating the Mll/AF9 -Specified Gene Expression Signature

Zohar Sachs, MD, PhD, Hanh Nguyen, Nurul Azyan Mohd Hassan, Susan K Rathe, Karen Sachs, Ph. D., Ernesto Diaz-Flores, PhD, Sean C Bendall, PhD, Miechaleen D Diers, Garry P. Nolan, Ph. D., Kevin M. Shannon, MD, David A. Largaespada, PhD

Blood (2012) 120 (21): 5116.

https://doi.org/10.1182/blood.V120.21.5116.5116

Published: 2012

Journal Articles

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

Blood (2012) 119 (19): 4512–4523.

https://doi.org/10.1182/blood-2010-04-281428

Published: 2012

Includes: Supplemental data

Journal Articles

RNA-Sequencing of the Transcriptome of Ara-C Resistant Murine AML Cell Lines Identifies Potential Drug Targets

Susan K. Rathe, Christopher B. Stoltenberg, David A. Largaespada, PhD

Blood (2011) 118 (21): 2489.

https://doi.org/10.1182/blood.V118.21.2489.2489

Published: 2011

Journal Articles

Mechanisms of Relapse Following Targeted Therapy in An NRAS G12V and Mll-AF9 Driven Mouse Model of AML

Craig E. Eckfeldt, MD, PhD, Ernesto Diaz-Flores, PhD, Michaeleen D. Diers, Susan K. Rathe, Kevin M. Shannon, MD, David A. Largaespada, PhD

Blood (2011) 118 (21): 2620.

https://doi.org/10.1182/blood.V118.21.2620.2620

Published: 2011

Journal Articles

Delineating Critical Effectors of Remission Induction in a Mouse Model of AML

Zohar Sachs, MD, PhD, Susan K. Rathe, Ernesto Diaz-Flores, PhD, Miechaleen D Diers, Kevin M. Shannon, MD, David A. Largaespada, PhD

Blood (2011) 118 (21): 5232.

https://doi.org/10.1182/blood.V118.21.5232.5232

Published: 2011

Journal Articles

Assessing Potential Genotoxicity of Sleeping Beauty Transposition Events in T-Cell Immunotherapy by Supercomputer-Based High Throughput Profiling,

Sonny O. Ang, PhD, Sourindra Maiti, PHD, Branden Moriarity, Martin Ossowski, PHD, Kim Andrews, PHD, Kathy Tzeng, PHD, Richard Talbot, PHD, Denise Kellar, Helen Huls, BS, Partow Kebriaei, MD, David A. Largaespada, PhD, Richard Champlin, MD, Perry Hackett, PHD, Laurence J N Cooper, MD, PhD

Blood (2011) 118 (21): 4174.

https://doi.org/10.1182/blood.V118.21.4174.4174

Published: 2011

Journal Articles

A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene

Bin Yin, Ruud Delwel, Peter J. Valk, Margaret R. Wallace, Mignon L. Loh, Kevin M. Shannon, David A. Largaespada

Blood (2009) 113 (5): 1075–1085.

https://doi.org/10.1182/blood-2008-03-144436

Published: 2009

Includes: Supplemental data

Journal Articles

RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia

Won-Il Kim, Ilze Matise, Miechaleen D. Diers, David A. Largaespada

Blood (2009) 113 (5): 1086–1096.

https://doi.org/10.1182/blood-2008-01-132316

Published: 2009

Includes: Supplemental data

Journal Articles

A Murine AML Model for the Development of Resistance to NRAS(G12V) Oncogene Repression and/or Ara-C Treatment in Vivo

Won-IL Kim, Ph.D., Susan K Rathe, Miechaleen D Diers, David A Largaespada, Ph.D

Blood (2008) 112 (11): 4030.

https://doi.org/10.1182/blood.V112.11.4030.4030

Published: 2008

Journal Articles

What gene have I ID'ed?

Rachel J. Bergerson, David A. Largaespada

Blood (2008) 111 (2): 471–472.

https://doi.org/10.1182/blood-2007-10-118067

Published: 2008

NARROW

Forward Genetic Screen Implicates Drivers of Leukemic Progression in a Novel Model of Trp53 R270H myelodysplastic Syndrome

NRAS G12V -Mediated Self-Renewal Signaling in Self-Renewing AML Stem Cells.

Single-Cell Transcriptional Profiling of Acute Myeloid Leukemia Identifies Prognostic Transcriptional Profiles at Diagnosis

Immunoproteasome Inhibition to Target AML with Activated RAS Pathways

Single-Cell Analysis Reveals Molecular Mechanisms of NRAS-Mediated Leukemia Stem Cell Self-Renewal in a Murine Model of AML

Ras Effector Pathways Differentially Support Proliferation and Survival of Acute Myeloid Leukemia

NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Cellular Intrinsic Mechanism Affecting The Outcome Of AML Treatment With Ara-C In a Syngeneic Mouse Model

Retroviral Insertional Mutagenesis In Egr1 +/- mice, Haploinsufficient For a Human Del(5q) Myeloid Leukemia Gene, Develop Myeloid Neoplasms With Proviral Insertions In Genes Syntenic To Human 5q

Ras-Pathway Inhibition With Targeted Therapies Abrogates Self-Renewal In Acute Myelogenous Leukemia

Activated NRAS Mediates Self-Renewal Capacity in AML by Facilitating the Mll/AF9 -Specified Gene Expression Signature

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

RNA-Sequencing of the Transcriptome of Ara-C Resistant Murine AML Cell Lines Identifies Potential Drug Targets

Mechanisms of Relapse Following Targeted Therapy in An NRAS G12V and Mll-AF9 Driven Mouse Model of AML

Delineating Critical Effectors of Remission Induction in a Mouse Model of AML

Assessing Potential Genotoxicity of Sleeping Beauty Transposition Events in T-Cell Immunotherapy by Supercomputer-Based High Throughput Profiling,

A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene

RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia

A Murine AML Model for the Development of Resistance to NRAS(G12V) Oncogene Repression and/or Ara-C Treatment in Vivo

What gene have I ID'ed?

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American Society of Hematology

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American Society of Hematology

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