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Journal Articles

DNA Hydroxymethylation Profiling Reveals That WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

Raajit K. Rampal, MD PhD, Altuna Alkalin, Jozef Madzo, PhD, Aparna Vasanthakumar, BSc, MSc, PhD, Elodie Pronier, PhD, Jay P. Patel, Yushan Li, Jihae Ahn, BS, Omar Abdel-Wahab, MD, Alan H. Shih, MDPhD, Chao Lu, Patrick Ward, Jennifer J Tsai, MD, Todd Hricik, Jacob Tallman, Valeria Tosello, PhD, Xinyang Zhao, PhD, Danette Daniels, Qing Dai, Luisa Ciminio, Iannis Aifantis, PhD, Chuan He, PhD, François Fuks, Martin S. Tallman, MD, Adolfo A. Ferrando, MD PhD, Stephen Nimer, MD, Elisabeth Paietta, PhD, Craig B. Thompson, MD, Jonathan D. Licht, MD, Christopher E Mason, PhD, Lucy A Godley, MD PhD, Ari M Melnick, MD, Maria E Figueroa, MD, Ross L Levine, MD
Journal: Blood
Blood (2014) 124 (21): 365.
https://doi.org/10.1182/blood.V124.21.365.365
Published: 2014
Journal Articles

Development of Acute Megakaryoblastic Leukemia in Down Syndrome Is Associated with Sequential Epigenetic Changes That Target the Down Syndrome Critical Region on Chromosome 21,

Maria E Figueroa, MD, Sebastien Malinge, PhD, Timothy M Chlon, Yushan Li, Elisabeth Paietta, PhD, Hugo F. Fernandez, MD, Martin S. Tallman, MD, Mitchell J Weiss, MD, Stella T Chou, MD, Ari Melnick, MD, John Crispino, PhD
Journal: Blood
Blood (2011) 118 (21): 3451.
https://doi.org/10.1182/blood.V118.21.3451.3451
Published: 2011
Journal Articles

Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1

Sanne Lugthart, Maria E. Figueroa, Eric Bindels, Lucy Skrabanek, Peter J. M. Valk, Yushan Li, Stefan Meyer, Claudia Erpelinck-Verschueren, John Greally, Bob Löwenberg, Ari Melnick, Ruud Delwel
Journal: Blood
Blood (2011) 117 (1): 234–241.
https://doi.org/10.1182/blood-2010-04-281337
Published: 2011
Includes: Supplemental data
Journal Articles

Integrative Genome-Wide DNA Methylation and Gene Expression Analysis Reveals Biological and Clinical Insights In Adult Acute Lymphoblastic Leukemia

Huimin Geng, PhD, Donna Neuberg, ScD, Elisabeth Paietta, PhD, Xutao Deng, PhD, Yushan Li, Yuan Xin, Janis Racevskis, PhD, Rhett Ketterling, MD, Susan M Richards, PhD, Martin S. Tallman, MD, Jacob M. Rowe, MD, Mark R. Litzow, MD, Olivier Elemento, PhD, Ari M. Melnick
Journal: Blood
Blood (2010) 116 (21): 852.
https://doi.org/10.1182/blood.V116.21.852.852
Published: 2010
Journal Articles

Integrated Genetic and Epigenetic Analysis of Childhood Acute Lymphoblastic Leukemia Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Phenotype

Maria E. Figueroa, MD, Shann-Ching Chen, Ph.D., Anna K. Andersson, PhD, Wei Liu, Ph.D., Cheng Cheng, Ph.D., Letha A Phillips, Yushan Li, James R. Downing, MD, Ari M. Melnick, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc
Journal: Blood
Blood (2010) 116 (21): 537.
https://doi.org/10.1182/blood.V116.21.537.537
Published: 2010
Journal Articles

DNA Methylation Profiling Predicts Clinical Outcomes and Reveals Unique Insights Into the Molecular Complexity of Acute Myeloid Leukemia.

Maria E Figueroa, MD, Sanne Lugthart, MD, Yushan Li, Claudia Erpelinck-Verschueren, Xutao Deng, Paul J. Christos, PhD, Elizabeth Schifano, Jim Booth, Lucy Skrabanek, Fabien Campagne, Madhu Mazumdar, PhD, John Greally, MB, PhD, Peter Valk, Bob Lowenberg, MD, PhD, Ruud Delwel, PhD, Ari Melnick
Journal: Blood
Blood (2009) 114 (22): 707.
https://doi.org/10.1182/blood.V114.22.707.707
Published: 2009
Journal Articles

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

Maria E. Figueroa, Lucy Skrabanek, Yushan Li, Anchalee Jiemjit, Tamer E. Fandy, Elisabeth Paietta, Hugo Fernandez, Martin S. Tallman, John M. Greally, Hetty Carraway, Jonathan D. Licht, Steven D. Gore, Ari Melnick
Journal: Blood
Blood (2009) 114 (16): 3448–3458.
https://doi.org/10.1182/blood-2009-01-200519
Published: 2009
Includes: Supplemental data
Journal Articles

Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features

Maria E. Figueroa, Bas J. Wouters, Lucy Skrabanek, Jacob Glass, Yushan Li, Claudia A. J. Erpelinck-Verschueren, Anton W. Langerak, Bob Löwenberg, Melissa Fazzari, John M. Greally, Peter J. M. Valk, Ari Melnick, Ruud Delwel
Journal: Blood
Blood (2009) 113 (12): 2795–2804.
https://doi.org/10.1182/blood-2008-08-172387
Published: 2009
Includes: Supplemental data
Journal Articles

Epigenetic Signatures Identify New Clinically Relevant Subtypes and Define Gene Regulatory Patterns in Patients with Acute Myeloid Leukemia (AML)

Maria E Figueroa, MD, Sanne Lugthart, MD, Yushan Li, Claudia Erpelinck-Verschueren, Paul J Christos, MS, MPH, Madhu Mazumdar, PhD, Bob Löwenberg, MD, PhD, John Greally, MB, PhD, Peter JM Valk, PhD, Ruud Delwel, PhD, Ari Melnick, MD
Journal: Blood
Blood (2008) 112 (11): 756.
https://doi.org/10.1182/blood.V112.11.756.756
Published: 2008
Journal Articles

Two Different EVI1 Expressing Poor-Risk AML Subgroups with Distinct Epigenetic Signatures Uncovered by Genome Wide DNA Methylation Profiling

Sanne Lugthart, MD, Maria E Figueroa, MD, Peter JM Valk, PhD, Yushan Li, Claudia Erpelinck-Verschueren, John Greally, MB, PhD, Bob Löwenberg, MD, PhD, Ari Melnick, MD, Ruud Delwel, PhD
Journal: Blood
Blood (2008) 112 (11): 757.
https://doi.org/10.1182/blood.V112.11.757.757
Published: 2008
Journal Articles

Genetic vs. Epigenetic Disruption of the CEBPA Locus Yields Epigenomically and Biologically Distinct Leukemia Phenotypes.

Maria E. Figueroa, MD, Bas J. Wouters, MD, Yushan Li, Peter Valk, PhD, Bob Lowenberg, MD, PhD, Ari M. Melnick, MD, Ruud Delwel, PhD
Journal: Blood
Blood (2007) 110 (11): 2117.
https://doi.org/10.1182/blood.V110.11.2117.2117
Published: 2007