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Journal Articles

Synergistic Effect of Trifluridine and PARPi Combination in Targeting TP53 -Mutated AML

Phani Krishna Parcha, Vivek M. Shastri, Jonathan D. Licht, Jatinder K. Lamba

Blood (2024) 144 (Supplement 1): 5787.

https://doi.org/10.1182/blood-2024-201781

Published: 2024

Journal Articles

Mitochondrial Priming Is Heterogenous in t(4;14) Multiple Myeloma and Can be Induced By Inhibition of NSD2

Shannon M Matulis, Robert M Chavez, Rebecca Owens, Arun P Wiita, Mala Shanmugam, Ricardo De Matos Simoes, Constantine S Mitsiades, Nisha S. Joseph, Craig C. Hofmeister, Jonathan L. Kaufman, Madhav V. Dhodapkar, Sagar Lonial, Ajay K. Nooka, Vikas A. Gupta, Jonathan D. Licht, Benjamin G. Barwick, Lawrence H. Boise

Blood (2024) 144 (Supplement 1): 4663.

https://doi.org/10.1182/blood-2024-210441

Published: 2024

Journal Articles

KDM6A regulates immune response genes in multiple myeloma

Daphné Dupéré-Richer, Alberto Riva, Benjamin G. Barwick, Sayantan Maji, Heidi Casellas Román, Jianping Li, Umasankar De, Amin Sobh, Gabrielle Quickstad, Crissandra Piper, Marta Kulis, Teresa Ezponda, José Ignacio Martín-Subero, Giovanni Tonon, Weizhou Zhang, Constantine S. Mitsiades, Lawrence H. Boise, Richard L. Bennett, Jonathan D. Licht

Blood (2024) 144 (14): 1508–1520.

https://doi.org/10.1182/blood.2024024518

Published: 2024

Includes: Supplemental data

Journal Articles

NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome

Blood (2024) 144 (3): 283–295.

https://doi.org/10.1182/blood.2023022859

Published: 2024

Includes: Supplemental data

Journal Articles

Activating NSD2 Mutations Drive Oncogenic Reprogramming By Disturbing Epigenetic Landscape in Mantle Cell Lymphoma

Jianping Li, Marta Kulis, Alberto Riva, Heidi Casellas Román, Daphne Dupere-Richer, Monica Clerio, Melanie L. Trejo, Michael Menes, Anthony Joseph Lamberto, Amin Sobh, Charlotte Leonie Kaestner, Richard Lynn Bennett, Iñaki I. Martin Subero, Jonathan D. Licht

Blood (2023) 142 (Supplement 1): 2771.

https://doi.org/10.1182/blood-2023-189748

Published: 2023

Journal Articles

Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma

Blood (2023) 142 (Supplement 1): 465.

https://doi.org/10.1182/blood-2023-182578

Published: 2023

Journal Articles

Compound Loss of Dnmt3a and Kmt2c in Myeloid Malignancies

Prabhjot Kaur, Cassandra Berntsen, James Leonard, Daniil Shabashvili, Qingchen Yuan, Bowen Yan, Richard Lynn Bennett, Alberto Riva, Jonathan D. Licht, Olga A. Guryanova

Blood (2023) 142 (Supplement 1): 4584.

https://doi.org/10.1182/blood-2023-189411

Published: 2023

Journal Articles

Natural Killer Cells Are Active Against Myeloma, Leukemia or Lymphoma Cells with Loss of Tumor Suppressor Genes

Olga Dashevsky, Sara Gandolfi, Olli Dufva, Ricardo De Matos Simoes, Jani Huuhtanen, Benjamin G. Barwick, Ryosuke Shirasaki, Michal Sheffer, Aidan Culhane, Jonathan D. Licht, Christine-Ivy Liacos, Evangelos Terpos, Efstathios Kastritis, Meletios Athanasios Dimopoulos, Lawrence H. Boise, Francisca Vazquez, Matti Kankainen, Satu Mustjoki, Constantine S Mitsiades

Blood (2023) 142 (Supplement 1): 6842.

https://doi.org/10.1182/blood-2023-189570

Published: 2023

Journal Articles

CRISPR-Based Gene-Editing Screens Revealed Modulators of Dexamethasone Sensitivity in Multiple Myeloma

Amin Sobh, Emilie Bonilla, Alisha Patel, Jianping Li, Mansi Dalal, Alberto Riva, Richard Lynn Bennett, Jonathan D. Licht

Blood (2023) 142 (Supplement 1): 6570.

https://doi.org/10.1182/blood-2023-179967

Published: 2023

Journal Articles

Gene Editing and Multi-Omics Reveal Novel Metabolic Vulnerabilities in t(4;14)-Associated Multiple Myeloma

Amin Sobh, Charlotte L Kaestner, Alberto Riva, Karthik Vasan, Alisha Patel, Greeshma Surapaneni, Janai Poullard, Elena Encinas, Richard Lynn Bennett, Constantine S. Mitsiades, Lawrence H. Boise, Navdeep S. Chandel, Jonathan D. Licht

Blood (2022) 140 (Supplement 1): 5911–5912.

https://doi.org/10.1182/blood-2022-169256

Published: 2022

Journal Articles

Dysregulation of Epigenetic Landscape Uncovered the Mechanisms Underlying the Relapse of Pediatric Acute Lymphoblastic Leukemia with NSD2 Mutation

Jianping Li, Priscillia Lhoumaud, Alberto Riva, Crissandra Piper, Daphne Dupere-Richer, Heidi Casellas Roman, Amin Sobh, Charlotte L Kaestner, Alok Swaroop, Marta Kulis, Richard Lynn Bennett, Jane Skok, Jonathan D. Licht

Blood (2021) 138 (Supplement 1): 3297.

https://doi.org/10.1182/blood-2021-149985

Published: 2021

Journal Articles

Adenylate Kinase 2 Is a Selective Multiple Myeloma Cell Dependency That Is Preferentially Essential in NSD2-Overexpressing Cells

Amin Sobh, Charlotte L Kaestner, Jianping Li, Alberto Riva, Richard Lynn Bennett, Jonathan D. Licht

Blood (2021) 138 (Supplement 1): 1586.

https://doi.org/10.1182/blood-2021-153284

Published: 2021

Journal Articles

Functional Genomic and Immune Response Characterization of PTEN Loss: Therapeutic Implications for Myeloma

Olga Dashevsky, Ricardo De Matos Simoes, Benjamin G Barwick, Sara Gandolfi, Ryosuke Shirasaki, Michal Sheffer, Aedin Culhane, Richard WJ Groen, Aviad Tsherniak, Francisca Vazquez, Jonathan D. Licht, Lawrence H. Boise, Constantine S. Mitsiades

Blood (2021) 138 (Supplement 1): 1612.

https://doi.org/10.1182/blood-2021-153870

Published: 2021

Journal Articles

Functional Oncogenomic and Immune Response Landscape for Genes Recurrently Mutated in Myeloma

Ricardo De Matos Simoes, Benjamin G Barwick, Ryosuke Shirasaki, Olga Dashevsky, Sara Gandolfi, Huihui Tang, Brian Glassner, Richard W.J. Groen, Daniel Auclair, Aedin Culhane, Aviad Tsherniak, Francisca Vazquez, Jonathan D. Licht, Lawrence H. Boise, Constantine S. Mitsiades

Blood (2021) 138 (Supplement 1): 1589.

https://doi.org/10.1182/blood-2021-154359

Published: 2021

Journal Articles

Functional CRISPR Screening Identifies Ptprg As a Driver of Migration and Adhesion in NSD2-E1099K ALL

Charlotte L Kaestner, Amin Sobh, Jianping Li, Alberto Riva, Richard Lynn Bennett, Jonathan D. Licht

Blood (2021) 138 (Supplement 1): 1149.

https://doi.org/10.1182/blood-2021-154009

Published: 2021

Journal Articles

NSD2-E1099K Mutation Leads to Glucocorticoid-Resistant B Cell Lymphocytic Leukemia in Mice

Jianping Li, MD, Crissandra Piper, LATG, Daphne Dupere-Richer, PhD, Heidi Casellas Roman, MS, Alok Swaroop, PhD, Catalina Troche, PhD, Jon Oyer, PhD, Christine Will, MS, Alberto Riva, PhD, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD

Blood (2020) 136 (Supplement 1): 3–4.

https://doi.org/10.1182/blood-2020-141295

Published: 2020

Journal Articles

Adenylate Kinase 2 Is a Selective Dependency in NSD2-High Multiple Myeloma

Amin Sobh, PhD, Charlotte Kaestner, Jianping Li, MD, Alberto Riva, PhD, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD

Blood (2020) 136 (Supplement 1): 31.

https://doi.org/10.1182/blood-2020-141266

Published: 2020

Journal Articles

Functional Genomic Characterization of Endoplasmic Reticulum-Associated Dependencies in Multiple Myeloma - Biologic and Therapeutic Implications

Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Shizuka Yamano, Sondra L. Downey-Kopyscinski, PhD, Brian Glassner, PhD, Huihui Tang, PhD, Vikas Gupta, MD PhD, Aviad Tsherniak, PhD, Francisca Vazquez, PhD, Jonathan D. Licht, MD, Larry H. Boise, PhD, Constantine S. Mitsiades, MD PhD

Blood (2020) 136 (Supplement 1): 3–4.

https://doi.org/10.1182/blood-2020-143117

Published: 2020

Journal Articles

KDM6A Controls Genes Modulating Immune Surveillance in Multiple Myeloma

Daphne Dupere-Richer, PhD, Sayantan Maji, PhD, Alberto Riva, PhD, Gabrielle Quickstad, Marta Kulis, Darby Monagle, José I. Martín-Subero, PhD, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD

Blood (2020) 136 (Supplement 1): 14.

https://doi.org/10.1182/blood-2020-141285

Published: 2020

Journal Articles

POU2AF1 As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma

Blood (2020) 136 (Supplement 1): 18–19.

https://doi.org/10.1182/blood-2020-142580

Published: 2020

NARROW

Synergistic Effect of Trifluridine and PARPi Combination in Targeting TP53 -Mutated AML

Mitochondrial Priming Is Heterogenous in t(4;14) Multiple Myeloma and Can be Induced By Inhibition of NSD2

KDM6A regulates immune response genes in multiple myeloma

NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome

Activating NSD2 Mutations Drive Oncogenic Reprogramming By Disturbing Epigenetic Landscape in Mantle Cell Lymphoma

Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma

Compound Loss of Dnmt3a and Kmt2c in Myeloid Malignancies

Natural Killer Cells Are Active Against Myeloma, Leukemia or Lymphoma Cells with Loss of Tumor Suppressor Genes

CRISPR-Based Gene-Editing Screens Revealed Modulators of Dexamethasone Sensitivity in Multiple Myeloma

Gene Editing and Multi-Omics Reveal Novel Metabolic Vulnerabilities in t(4;14)-Associated Multiple Myeloma

Dysregulation of Epigenetic Landscape Uncovered the Mechanisms Underlying the Relapse of Pediatric Acute Lymphoblastic Leukemia with NSD2 Mutation

Adenylate Kinase 2 Is a Selective Multiple Myeloma Cell Dependency That Is Preferentially Essential in NSD2-Overexpressing Cells

Functional Genomic and Immune Response Characterization of PTEN Loss: Therapeutic Implications for Myeloma

Functional Oncogenomic and Immune Response Landscape for Genes Recurrently Mutated in Myeloma

Functional CRISPR Screening Identifies Ptprg As a Driver of Migration and Adhesion in NSD2-E1099K ALL

NSD2-E1099K Mutation Leads to Glucocorticoid-Resistant B Cell Lymphocytic Leukemia in Mice

Adenylate Kinase 2 Is a Selective Dependency in NSD2-High Multiple Myeloma

Functional Genomic Characterization of Endoplasmic Reticulum-Associated Dependencies in Multiple Myeloma - Biologic and Therapeutic Implications

KDM6A Controls Genes Modulating Immune Surveillance in Multiple Myeloma

POU2AF1 As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma

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American Society of Hematology

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American Society of Hematology

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