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Journal Articles

KDM6A regulates immune response genes in multiple myeloma

Daphné Dupéré-Richer, Alberto Riva, Benjamin G. Barwick, Sayantan Maji, Heidi Casellas Román, Jianping Li, Umasankar De, Amin Sobh, Gabrielle Quickstad, Crissandra Piper, Marta Kulis, Teresa Ezponda, José Ignacio Martín-Subero, Giovanni Tonon, Weizhou Zhang, Constantine S. Mitsiades, Lawrence H. Boise, Richard L. Bennett, Jonathan D. Licht

Blood (2024) 144 (14): 1508–1520.

https://doi.org/10.1182/blood.2024024518

Published: 2024

Includes: Supplemental data

Journal Articles

NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome

Blood (2024) 144 (3): 283–295.

https://doi.org/10.1182/blood.2023022859

Published: 2024

Includes: Supplemental data

Journal Articles

Compound Loss of Dnmt3a and Kmt2c in Myeloid Malignancies

Prabhjot Kaur, Cassandra Berntsen, James Leonard, Daniil Shabashvili, Qingchen Yuan, Bowen Yan, Richard Lynn Bennett, Alberto Riva, Jonathan D. Licht, Olga A. Guryanova

Blood (2023) 142 (Supplement 1): 4584.

https://doi.org/10.1182/blood-2023-189411

Published: 2023

Journal Articles

Activating NSD2 Mutations Drive Oncogenic Reprogramming By Disturbing Epigenetic Landscape in Mantle Cell Lymphoma

Jianping Li, Marta Kulis, Alberto Riva, Heidi Casellas Román, Daphne Dupere-Richer, Monica Clerio, Melanie L. Trejo, Michael Menes, Anthony Joseph Lamberto, Amin Sobh, Charlotte Leonie Kaestner, Richard Lynn Bennett, Iñaki I. Martin Subero, Jonathan D. Licht

Blood (2023) 142 (Supplement 1): 2771.

https://doi.org/10.1182/blood-2023-189748

Published: 2023

Journal Articles

DNA Methylation Landscape of Peripheral T-Cell Lymphomas Not Otherwise Specified

Pawel Nowialis, Katarina Lopusna, Julian Tobon, Alberto Riva, Jana Opavska, Rene Opavsky

Blood (2023) 142 (Supplement 1): 5721.

https://doi.org/10.1182/blood-2023-186545

Published: 2023

Journal Articles

CRISPR-Based Gene-Editing Screens Revealed Modulators of Dexamethasone Sensitivity in Multiple Myeloma

Amin Sobh, Emilie Bonilla, Alisha Patel, Jianping Li, Mansi Dalal, Alberto Riva, Richard Lynn Bennett, Jonathan D. Licht

Blood (2023) 142 (Supplement 1): 6570.

https://doi.org/10.1182/blood-2023-179967

Published: 2023

Journal Articles

Gene Editing and Multi-Omics Reveal Novel Metabolic Vulnerabilities in t(4;14)-Associated Multiple Myeloma

Amin Sobh, Charlotte L Kaestner, Alberto Riva, Karthik Vasan, Alisha Patel, Greeshma Surapaneni, Janai Poullard, Elena Encinas, Richard Lynn Bennett, Constantine S. Mitsiades, Lawrence H. Boise, Navdeep S. Chandel, Jonathan D. Licht

Blood (2022) 140 (Supplement 1): 5911–5912.

https://doi.org/10.1182/blood-2022-169256

Published: 2022

Journal Articles

Dnmt3a Mutations in the Hematopoietic System Promote Colitis-Associated Colon Cancer: A Model of Clonal Hematopoiesis in Solid Tumors

Yang Feng, Rachel Newsome, Troy Robinson, Robert L. Bowman, Ashley Zuniga, Kendra Hall, Cassandra Bernsten, Daniil Shabashvili, Kathryn Krajcik, Chamara Gunaratne, Zachary Zaroogian, Kartika Venugopal, Heidi Casellas Roman, Ross L. Levine, Alberto Riva, Daniel Kopinke, Christian Jobin, Dorina Avram, Olga A Guryanova

Blood (2021) 138 (Supplement 1): 2161.

https://doi.org/10.1182/blood-2021-149740

Published: 2021

Journal Articles

Functional CRISPR Screening Identifies Ptprg As a Driver of Migration and Adhesion in NSD2-E1099K ALL

Charlotte L Kaestner, Amin Sobh, Jianping Li, Alberto Riva, Richard Lynn Bennett, Jonathan D. Licht

Blood (2021) 138 (Supplement 1): 1149.

https://doi.org/10.1182/blood-2021-154009

Published: 2021

Journal Articles

Dysregulation of Epigenetic Landscape Uncovered the Mechanisms Underlying the Relapse of Pediatric Acute Lymphoblastic Leukemia with NSD2 Mutation

Jianping Li, Priscillia Lhoumaud, Alberto Riva, Crissandra Piper, Daphne Dupere-Richer, Heidi Casellas Roman, Amin Sobh, Charlotte L Kaestner, Alok Swaroop, Marta Kulis, Richard Lynn Bennett, Jane Skok, Jonathan D. Licht

Blood (2021) 138 (Supplement 1): 3297.

https://doi.org/10.1182/blood-2021-149985

Published: 2021

Journal Articles

Adenylate Kinase 2 Is a Selective Multiple Myeloma Cell Dependency That Is Preferentially Essential in NSD2-Overexpressing Cells

Amin Sobh, Charlotte L Kaestner, Jianping Li, Alberto Riva, Richard Lynn Bennett, Jonathan D. Licht

Blood (2021) 138 (Supplement 1): 1586.

https://doi.org/10.1182/blood-2021-153284

Published: 2021

Journal Articles

NSD2-E1099K Mutation Leads to Glucocorticoid-Resistant B Cell Lymphocytic Leukemia in Mice

Jianping Li, MD, Crissandra Piper, LATG, Daphne Dupere-Richer, PhD, Heidi Casellas Roman, MS, Alok Swaroop, PhD, Catalina Troche, PhD, Jon Oyer, PhD, Christine Will, MS, Alberto Riva, PhD, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD

Blood (2020) 136 (Supplement 1): 3–4.

https://doi.org/10.1182/blood-2020-141295

Published: 2020

Journal Articles

Adenylate Kinase 2 Is a Selective Dependency in NSD2-High Multiple Myeloma

Amin Sobh, PhD, Charlotte Kaestner, Jianping Li, MD, Alberto Riva, PhD, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD

Blood (2020) 136 (Supplement 1): 31.

https://doi.org/10.1182/blood-2020-141266

Published: 2020

Journal Articles

KDM6A Controls Genes Modulating Immune Surveillance in Multiple Myeloma

Daphne Dupere-Richer, PhD, Sayantan Maji, PhD, Alberto Riva, PhD, Gabrielle Quickstad, Marta Kulis, Darby Monagle, José I. Martín-Subero, PhD, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD

Blood (2020) 136 (Supplement 1): 14.

https://doi.org/10.1182/blood-2020-141285

Published: 2020

Journal Articles

DNMT3A with Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Kartika Venugopal, MS, Daniil E Shabashvili, PhD, Jianping Li, MD, Luisa M Posada, Richard Lynn Bennett, PhD, Yang Feng, MS, Daphne Dupere Richer, PhD, Alberto Riva, PhD, Santhi Pondugula, PhD, Jonathan E. Bird, PhD, Jonathan D. Licht, MD, Olga A Guryanova, MD PhD

Blood (2019) 134 (Supplement_1): 535.

https://doi.org/10.1182/blood-2019-128213

Published: 2019

Journal Articles

Identification of Genetic Vulnerabilities and Synthetic-Lethal Targets in NSD2-High Multiple Myeloma

Amin Sobh, PhD, Charlotte Kaestner, Alberto Riva, PhD, Jonathan D. Licht, MD

Blood (2019) 134 (Supplement_1): 3757.

https://doi.org/10.1182/blood-2019-125951

Published: 2019

Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

Blood (2019) 134 (Supplement_1): 3758.

https://doi.org/10.1182/blood-2019-126910

Published: 2019

Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance of Acute Lymphoblastic Leukemia

Jianping Li, MD, Catalina Troche, PhD, Alok Swaroop, PhD, Marta Kulis, PhD, Jon Oyer, PhD, Christine Will, MS, Daphne Dupere-Richer, PhD, Alberto Riva, PhD, Crissandra Pipe, LATG, Sharon Norton, MS, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD

Blood (2018) 132 (Supplement 1): 653.

https://doi.org/10.1182/blood-2018-99-116309

Published: 2018

NARROW

KDM6A regulates immune response genes in multiple myeloma

NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome

Compound Loss of Dnmt3a and Kmt2c in Myeloid Malignancies

Activating NSD2 Mutations Drive Oncogenic Reprogramming By Disturbing Epigenetic Landscape in Mantle Cell Lymphoma

DNA Methylation Landscape of Peripheral T-Cell Lymphomas Not Otherwise Specified

CRISPR-Based Gene-Editing Screens Revealed Modulators of Dexamethasone Sensitivity in Multiple Myeloma

Gene Editing and Multi-Omics Reveal Novel Metabolic Vulnerabilities in t(4;14)-Associated Multiple Myeloma

Dnmt3a Mutations in the Hematopoietic System Promote Colitis-Associated Colon Cancer: A Model of Clonal Hematopoiesis in Solid Tumors

Functional CRISPR Screening Identifies Ptprg As a Driver of Migration and Adhesion in NSD2-E1099K ALL

Dysregulation of Epigenetic Landscape Uncovered the Mechanisms Underlying the Relapse of Pediatric Acute Lymphoblastic Leukemia with NSD2 Mutation

Adenylate Kinase 2 Is a Selective Multiple Myeloma Cell Dependency That Is Preferentially Essential in NSD2-Overexpressing Cells

NSD2-E1099K Mutation Leads to Glucocorticoid-Resistant B Cell Lymphocytic Leukemia in Mice

Adenylate Kinase 2 Is a Selective Dependency in NSD2-High Multiple Myeloma

KDM6A Controls Genes Modulating Immune Surveillance in Multiple Myeloma

DNMT3A with Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Identification of Genetic Vulnerabilities and Synthetic-Lethal Targets in NSD2-High Multiple Myeloma

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance of Acute Lymphoblastic Leukemia

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American Society of Hematology

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American Society of Hematology

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