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Journal Articles

Development of a novel multiomic sequencing approach to characterize infused donor memory-like NK cells in an immune compatible environment

Free
Roman Shapiro, Grace Birch, Chen Weng, Jonas Gudera, Michael Poeschla, Matthew Booker, Michael Tolstorukov, Michal Sheffer, Remy Dulery, Sarah Nikiforow, John Koreth, Catherine Wu, Robert Soiffer, Jerome Ritz, Vijay Sankaran, Rizwan Romee
Journal: Blood
Blood (2025) 146 (Supplement 1): 2352.
https://doi.org/10.1182/blood-2025-2352
Published: 2025
Journal Articles

Negative regulators of survival and proliferation (NRSPs) identified by CRISPR activation studies in multiple myeloma (MM) vs. other neoplasias: Therapeutic implications

Free
Olga Dashevsky, Ricardo De Matos Simoes, Huihui Tang, Torsten Steinbrunn, Shizuka Yamano, Eleni Anastasakou, Benjamin Barwick, Sara Gandolfi, Ryosuke Shirasaki, Vikas Gupta, Michal Sheffer, Jonathan Licht, Lawrence Boise, Matthew Oser, Constantine Mitsiades
Journal: Blood
Blood (2025) 146 (Supplement 1): 688.
https://doi.org/10.1182/blood-2025-688
Published: 2025
Journal Articles

Dual-function engineered bacteria remodel AML tumor microenvironment via IL-12 delivery and adenosine depletion to sustain NK cell immunity

Free
Stephanie Sendker, Shaobo Yang, Anna Clara Bader, Alice Chen, Eden Bobilev, Ashley Hu, Xingyu Deng, Fuguo Liu, Veronica Hui, Maily Nguyen, Andreia Maia, Sara Piccinelli, Kerim Berkay Aslan, Fabian Göllner, Alaa Ali, Remy Dulery, Hetal Nath, Daniel Chen, Mounica Vallurupalli, Andrew Lu, Stephanie Chamberlain, Tereza Kochs, Nathalie Javidi-Sharifi, Michal Sheffer, Roman Shapiro, Andrew Lane, Robert Soiffer, Mubin Tarannum, Jerome Ritz, Rizwan Romee
Journal: Blood
Blood (2025) 146 (Supplement 1): 5912.
https://doi.org/10.1182/blood-2025-5912
Published: 2025
Journal Articles

LIME: A first-in-class of live bacterial immune engagers for cancer immunotherapy

Free
Anna Clara Bader, Shaobo Yang, Ashley Hu, Stephanie Sendker, Daniel Chen, Michal Sheffer, Eden Bobilev, Fuguo Liu, Xingyu Deng, Hetal Nath, Isabel Kaplan, Maily Nyugen, Mila Stanojevic, Mubin Tarannum, Alaa Ali, Roman Shapiro, Young Rock Chung, Erin Parry, Nathalie Javidi-Sharifi, Julissa Tello, Stephanie Dougan, Hermann Einsele, Evelyn Ullrich, John Koreth, Robert Soiffer, Catherine Wu, Jerome Ritz, Rizwan Romee
Journal: Blood
Blood (2025) 146 (Supplement 1): 264.
https://doi.org/10.1182/blood-2025-264
Published: 2025
Journal Articles

Mesothelin Targeting IL12-Engineered CAR Memory-like NK Cells Demonstrate Promising Efficacy in Acute Myeloid Leukemia

Free
Jieun Jang, Mila Stanojevic, Sara Piccinelli, Michal Sheffer, Grace Caroline Birch, Roman M. Shapiro, Maximilian Stahl, John Koreth, Catherine J. Wu, Robert J. Soiffer, Jerome Ritz, Mubin Tarannum, Rizwan Romee
Journal: Blood
Blood (2024) 144 (Supplement 1): 917.
https://doi.org/10.1182/blood-2024-204369
Published: 2024
Journal Articles

Natural Killer Cells Are Active Against Myeloma, Leukemia or Lymphoma Cells with Loss of Tumor Suppressor Genes

Free
Olga Dashevsky, Sara Gandolfi, Olli Dufva, Ricardo De Matos Simoes, Jani Huuhtanen, Benjamin G. Barwick, Ryosuke Shirasaki, Michal Sheffer, Aidan Culhane, Jonathan D. Licht, Christine-Ivy Liacos, Evangelos Terpos, Efstathios Kastritis, Meletios Athanasios Dimopoulos, Lawrence H. Boise, Francisca Vazquez, Matti Kankainen, Satu Mustjoki, Constantine S Mitsiades
Journal: Blood
Blood (2023) 142 (Supplement 1): 6842.
https://doi.org/10.1182/blood-2023-189570
Published: 2023
Journal Articles

CTLA-4 Blockade Results in the Enrichment of Proliferative CD56 dim CD16 + NK Cells Following Infusion of Haploidentical Donor Memory-like Natural Killer Cells Plus IL-15 Superagonist in a Phase 1 Trial

Free
Roman M. Shapiro, Michal Sheffer, Matthew Aaron Booker, Michael Yevgeniy Tolstorukov, Michela Ansuinelli, Moshe Sade-Feldman, Jacy Fang, Grace Caroline Birch, Juliana Vergara-Cadavid, Yasmin Z Abdulhamid, Isabel E Kaplan, Dinh Khanhlinh, Robert A. Redd, Alejandro Alonso, Denbaa Bat-Erdene, Ravindra Uppaluri, Heather Daley, Diego Hernandez Rodriguez, John Koreth, Jerome Ritz, Sarah Nikiforow, Robert J. Soiffer, Glenn J Hanna, Rizwan Romee
Journal: Blood
Blood (2023) 142 (Supplement 1): 6850.
https://doi.org/10.1182/blood-2023-178362
Published: 2023
Journal Articles

Single-Cell Functional Genomics of Natural Killer Cell Interaction with Blood Cancers

Free
Olli Dufva, Sara Gandolfi, Jani Huuhtanen, Olga Dashevsky, Khalid Saeed, Jay Klievink, Petra Johanna Nygren, Jonas Bouhlal, Jenni Lahtela, Anna Näätänen, Bishwa Ghimire, Tiina Hannunen, Pekka Ellonen, Hanna Duàn, Jason Theodoropoulos, Essi Laajala, Aino Häkkinen, Jouni Härkönen, Petri Pölönen, Merja Heinäniemi, Shizuka Yamano, Ryosuke Shirasaki, David Barbie, Jennifer A. Roth, Rizwan Romee, Michal Sheffer, Harri Lähdesmäki, Dean Anthony Lee, Ricardo De Matos Simoes, Matti Kankainen, Constantine S. Mitsiades, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 8343–8344.
https://doi.org/10.1182/blood-2022-167535
Published: 2022
Journal Articles

Functional Genomic Landscape of Natural Killer Cell Evasion in Multiple Myeloma

Free
Sara Gandolfi, Olli Dufva, Jani Huuhtanen, Olga Dashevsky, Jay Klievink, Jonas Bouhlal, Michal Sheffer, Matti Kankainen, Ricardo De Matos Simoes, Satu Mustjoki, Constantine S. Mitsiades
Journal: Blood
Blood (2021) 138 (Supplement 1): 732.
https://doi.org/10.1182/blood-2021-153925
Published: 2021
Journal Articles

Functional Genomic and Immune Response Characterization of PTEN Loss: Therapeutic Implications for Myeloma

Free
Olga Dashevsky, Ricardo De Matos Simoes, Benjamin G Barwick, Sara Gandolfi, Ryosuke Shirasaki, Michal Sheffer, Aedin Culhane, Richard WJ Groen, Aviad Tsherniak, Francisca Vazquez, Jonathan D. Licht, Lawrence H. Boise, Constantine S. Mitsiades
Journal: Blood
Blood (2021) 138 (Supplement 1): 1612.
https://doi.org/10.1182/blood-2021-153870
Published: 2021
Journal Articles

Use of Olfactory Receptor Genes As Controls for Genome-Scale CRISPR Functional Genomic Studies to Define Treatment Resistance Mechanisms

Free
Olga Dashevsky, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Sara Gandolfi, MD, Huihui Tang, PhD, Sondra L. Downey-Kopyscinski, PhD, Megan Bariteau, B.Sc., Jeffrey Sorrell, BA, Brian Glassner, PhD, John Doench, PhD, Larry H. Boise, PhD, Jonathan D. Licht, MD, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 36.
https://doi.org/10.1182/blood-2020-142651
Published: 2020
Journal Articles

POU2AF1 As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma

Free
Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Huihui Tang, PhD, Shizuka Yamano, Benjamin G Barwick, PhD, Sara Gandolfi, MD, Eugen Dhimolea, PhD, Sondra L. Downey-Kopyscinski, PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Michal Sheffer, PhD, Dhvanir Kansara, Megan Bariteau, BSc, Jeffrey Sorrell, BA, Vikas Gupta, MD PhD, Aedin Culhane, PhD, Aviad Tsherniak, PhD, Francisca Vazquez, PhD, Larry H. Boise, PhD, Jonathan D. Licht, MD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-142580
Published: 2020
Journal Articles

Heterogeneity of Molecular Mechanisms Determining Blood Cancer Cell Lines Resistance to Natural Killer Cells in the Context of Tumor-Stromal Interactions: Insights from Studies of Pooled "DNA-Barcoded" Cell Line Panels

Free
Sara Gandolfi, MD, Michal Sheffer, PhD, Olli Dufva, Khalid Saeed, Emily Lowry, Olga Dashevsky, PhD, Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Jennifer Roth, Rizwan Romee, MD PhD, Satu Mustjoki, MD PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 620.
https://doi.org/10.1182/blood-2019-130793
Published: 2019
Journal Articles

Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma

Free
Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Sondra L. Downey-Kopyscinski, PhD, Geoffrey Matthews, PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Joshua Dempster, PhD, Robin M. Meyers, PhD, Jordan Bryan, James M. McFarland, Johanna Brueggenthies, Huihui Tang, PhD, Megan Bariteau, BSc, Minasri Borah, Quinlan L Sievers, PhD, Benjamin Ebert, MD, Brian Glassner, PhD, Christopher J. Ott, PhD, Nicholas P Kwiatkowski, PhD, John G Doench, PhD, Daniel Auclair, Joan Levy, PhD, Lawrence H. Boise, PhD, Jonathan J Keats, PhD, Jonathan D. Licht, MD, Richard Groen, Nathanael Gray, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4407.
https://doi.org/10.1182/blood-2019-130901
Published: 2019
Journal Articles

CRISPR Screens Identify Mechanisms of Natural Killer Cell Evasion across Blood Cancers

Free
Olli Dufva, Khalid Saeed, Sara Gandolfi, MD, Michal Sheffer, PhD, Jay Klievink, Petri Pölönen, MSc, Tiina Hannunen, Mette Ilander, PhD, Pekka Ellonen, BSc, Matti Kankainen, PhD, Dean Anthony Lee, MD PhD, Constantine S. Mitsiades, MD PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3597.
https://doi.org/10.1182/blood-2019-129837
Published: 2019
Journal Articles

Functional Characterization of Genes Driving Enhanced Biological Aggressiveness of Myeloma Cells: Identification of Novel and Understudied "Drivers" of Myeloma

Free
Huihui Tang, PhD, Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Sara Gandolfi, MD, Olga Dashevsky, PhD, Sondra L. Downey-Kopyscinski, PhD, Brian Glassner, PhD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 313.
https://doi.org/10.1182/blood-2019-128919
Published: 2019
Journal Articles

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Free
Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey M Matthews, PhD, Dennis Buckley, Joseline Raja, Quinlan L Sievers, PhD, Olga Dashevsky, PhD, Haley Poarch, Huihui Tang, PhD, Megan Bariteau, BSc, Michal Sheffer, PhD, Sondra L. Downey-Kopyscinski, PhD, Paul Hengeveld, Brian Glassner, PhD, Eugen Dhimolea, PhD, Christopher J. Ott, PhD, Tinghu Zhang, PhD, Nicholas P Kwiatkowski, PhD, Jacob P. Laubach, MD, Robert L. Schlossman, MD, Paul G. Richardson, MD, Aedin Culhane, PhD, Richard W.J. Groen, PhD, Eric Fischer, Benjamin L. Ebert, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, PhD, Daniel Auclair, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, James Bradner, MD, Nathanael Gray, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 318.
https://doi.org/10.1182/blood-2019-130549
Published: 2019
Journal Articles

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

Free
Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Dennis Buckley, Olga Dashevsky, PhD, Sondra L. Downey-Kopyscinski, PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Brian Glassner, PhD, Megan Bariteau, BSc, Jeffrey Sorrell, BA, Johanna B Bruggenthies, Quinlan Sievers, BA, Haley Poarch, Nicholas P Kwiatkowski, PhD, Tinghu Zhang, PhD, Jacob Laubach, MD, Robert L. Schlossman, MD, Paul Richardson, Aedin Culhane, PhD, Richard WJ Groen, PhD, Eric S. Fischer, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, Daniel Auclair, PhD, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, Benjamin L. Ebert, MDPhD, James Bradner, MD, Nathanae Gray, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1367.
https://doi.org/10.1182/blood-2018-99-116232
Published: 2018
Journal Articles

CRISPR Activation Screen for HDAC Inhibitor Resistance

Free
Huihui Tang, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Sondra L. Downey-Kopyscinski, PhD, Sara Gandolfi, MD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3958.
https://doi.org/10.1182/blood-2018-99-119044
Published: 2018
Journal Articles

CRISPR Activation Screen for Drivers of MM Cell Proliferation

Free
Huihui Tang, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Sondra L. Downey-Kopyscinski, PhD, Sara Gandolfi, MD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3197.
https://doi.org/10.1182/blood-2018-99-118712
Published: 2018