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Journal Articles

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells

Blood blood.2024025536.

https://doi.org/10.1182/blood.2024025536

Published: 2025

Includes: Supplemental data

Journal Articles

Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis

Blood (2025) 145 (7): 732–747.

https://doi.org/10.1182/blood.2024025690

Published: 2025

Includes: Supplemental data

Journal Articles

Mitochondrial Priming Is Heterogenous in t(4;14) Multiple Myeloma and Can be Induced By Inhibition of NSD2

Shannon M Matulis, Robert M Chavez, Rebecca Owens, Arun P Wiita, Mala Shanmugam, Ricardo De Matos Simoes, Constantine S Mitsiades, Nisha S. Joseph, Craig C. Hofmeister, Jonathan L. Kaufman, Madhav V. Dhodapkar, Sagar Lonial, Ajay K. Nooka, Vikas A. Gupta, Jonathan D. Licht, Benjamin G. Barwick, Lawrence H. Boise

Blood (2024) 144 (Supplement 1): 4663.

https://doi.org/10.1182/blood-2024-210441

Published: 2024

Journal Articles

Heme Attenuates T Cell Exhaustion and Drives Effector Function: Implications for Immune and Adoptive T Cell Therapy

Pulkit Gupta, Heather Lin, Remya Nair, Ruby Freeman, Dejah Blake, Kiran Lakhani, Doris R. Powell, Sagar Lonial, Benjamin G. Barwick, Ajay K. Nooka, Sarwish Rafiq, Mala Shanmugam

Blood (2023) 142 (Supplement 1): 6807.

https://doi.org/10.1182/blood-2023-186634

Published: 2023

Journal Articles

Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma

Blood (2023) 142 (Supplement 1): 465.

https://doi.org/10.1182/blood-2023-182578

Published: 2023

Journal Articles

Engineering Novel Multi-Cytokine Backpacks for Manufacturing Functionally Improved CAR T Cell Products

Heather Lin, A K M Nawshad Hossian, Biaggio Uricoli, Ruby Mei Freeman, Dejah A Blake, Jonathan Legier, Remya Nair, Jean L. Koff, Mala Shanmugam, Erik Dreaden, Sarwish Rafiq

Blood (2022) 140 (Supplement 1): 10245–10246.

https://doi.org/10.1182/blood-2022-162498

Published: 2022

Journal Articles

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

Christopher Ronald Funk, Shuhua Wang, Kevin Z. Chen, Alexandra Waller, Aditi Sharma, Claudia L. Edgar, Vikas A. Gupta, Shanmuganathan Chandrakasan, Jaquelyn T. Zoine, Andrew Fedanov, Sunil S. Raikar, Jean L. Koff, Christopher R. Flowers, Silvia Coma, Jonathan A. Pachter, Sruthi Ravindranathan, H. Trent Spencer, Mala Shanmugam, Edmund K. Waller

Blood (2022) 139 (4): 523–537.

https://doi.org/10.1182/blood.2021011597

Published: 2022

Includes: Supplemental data

Journal Articles

Mitochondrial Electron Transport Chain Inhibition Promotes Resistance to Proteasome Inhibitors in Multiple Myeloma

Aditi Sharma, Abhinav Achreja, Remya Nair, Pulkit Gupta, Claudia L Edgar, Olamide Animasahun, Anjali Mittal, Bhakti Dwivedi, Manoj Bhasin, Vikas A Gupta, Benjamin G Barwick, Shannon M Matulis, Sagar Lonial, Lawrence H. Boise, David L Jaye, Arun P Wiita, Ajay K. Nooka, Deepak Nagrath, Mala Shanmugam

Blood (2021) 138 (Supplement 1): 1611.

https://doi.org/10.1182/blood-2021-153744

Published: 2021

Journal Articles

BRAF Mutations and Inflammatory Gene Expression in Myeloma Cells from Patients with Renal Dysfunction

Theodora Alese, Benjamin G Barwick, Vikas A. Gupta, Nisha Joseph, Craig C. Hofmeister, Mala Shanmugam, Jonathan L. Kaufman, Madhav V Dhodapkar, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise

Blood (2021) 138 (Supplement 1): 1624.

https://doi.org/10.1182/blood-2021-154092

Published: 2021

Journal Articles

Duvelisib Promotes Mitochondrial Fusion and Epigenetic Reprogramming to Drive Therapeutic T Cell Persistence and Function

Kevin Z. Chen, Christopher R. Funk, Shuhua Wang, Aditi Sharma, Edmund K. Waller, Mala Shanmugam

Blood (2021) 138 (Supplement 1): 1714.

https://doi.org/10.1182/blood-2021-153446

Published: 2021

Journal Articles

The Role of Proteasome Activator PA28α in Multiple Myeloma

Yanyan Gu, MD PhD, Benjamin G Barwick, PhD, Mala Shanmugam, PhD, Craig C Hofmeister, MDMPH, Jonathan L. Kaufman, MD, Ajay K Nooka, MDMPH, Vikas A. Gupta, MD PhD, Madhav V Dhodapkar, MBBS, Lawrence H. Boise, PhD, Sagar Lonial

Blood (2019) 134 (Supplement_1): 5499.

https://doi.org/10.1182/blood-2019-128216

Published: 2019

Journal Articles

Succinate Ubiquinone Reductase Activity Predicts Multiple Myeloma Sensitivity to Venetoclax

Richa Bajpai, PhD, Changyong Wei, PhD BS, Shannon Matulis, PhD, Ajay K. Nooka, MDMPH, Samuel McBrayer, PhD, Sagar Lonial, MD, Vikas A. Gupta, MD PhD, Lawrence H. Boise, PhD, Mala Shanmugam, PhD

Blood (2017) 130 (Supplement 1): 4409.

https://doi.org/10.1182/blood.V130.Suppl_1.4409.4409

Published: 2017

Journal Articles

Glutamine Catabolism Maintains MCL-1 Expression in Glucose-Deprived Multiple Myeloma

Changyong Wei, PhD BS, Richa Bajpai, PhD, Alisha D Hunter, MS, Darius Mahboubi, MS, Mala Shanmugam, PhD

Blood (2017) 130 (Supplement 1): 3076.

https://doi.org/10.1182/blood.V130.Suppl_1.3076.3076

Published: 2017

Journal Articles

Targeting Glycolysis and Compensatory Mitochondrial Metabolism In An In Vivo Xenograft Model Of Multiple Myeloma With FDA Approved Ritonavir and Metformin

Sevim Dalva-Aydemir, MS, Kehinde U.A. Adekola, MBBS, Jennifer Koblinski, PhD, Noopur Raje, MD, Steven T. Rosen, MD, FRCPA, Mala Shanmugam, PhD

Blood (2013) 122 (21): 1922.

https://doi.org/10.1182/blood.V122.21.1922.1922

Published: 2013

Journal Articles

Targeting Glucose Metabolism and Compensatory Metabolic Resistance in Chronic Lymphocytic Leukemia

Kehinde U.A. Adekola, MBBS, Vivian Liu, Shuo Ma, MD, PhD, Steven T. Rosen, MD, FRCPA, Mala Shanmugam, PhD

Blood (2012) 120 (21): 1801.

https://doi.org/10.1182/blood.V120.21.1801.1801

Published: 2012

Journal Articles

Targeting Glycolysis and Compensatory Mitochondrial Metabolism in Multiple Myeloma with FDA Approved Ritonavir and Metformin Via Synthetic Lethality

Kehinde U. A. Adekola, M.B.B.S, Maylyn Martinez, Steven T. Rosen, MD, FRCPA, Mala Shanmugam, PhD

Blood (2012) 120 (21): 4016.

https://doi.org/10.1182/blood.V120.21.4016.4016

Published: 2012

Journal Articles

Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy

Samuel K. McBrayer, Javelin C. Cheng, Seema Singhal, Nancy L. Krett, Steven T. Rosen, Mala Shanmugam

Blood (2012) 119 (20): 4686–4697.

https://doi.org/10.1182/blood-2011-09-377846

Published: 2012

Includes: Supplemental data

Journal Articles

Myeloma Exhibits Dependence on Atypical Glucose Transporters: Targeting MCL-1 Through GLUT4 Inhibition

Mala Shanmugam, PhD, Javelin C Cheng, MS, Samuel K McBrayer, Steven T. Rosen, MD, FRCPA

Blood (2011) 118 (21): 1850.

https://doi.org/10.1182/blood.V118.21.1850.1850

Published: 2011

Journal Articles

8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma

Jennifer B. Dennison, Mala Shanmugam, Mary L. Ayres, Jun Qian, Nancy L. Krett, L. Jeffrey Medeiros, Sattva S. Neelapu, Steven T. Rosen, Varsha Gandhi

Blood (2010) 116 (25): 5622–5630.

https://doi.org/10.1182/blood-2010-05-285866

Published: 2010

Includes: Supplemental data

Journal Articles

Pre-Clincial Evaluation of a Novel Purine Analogue 8-NH 2 -Adenosine in Mantle Cell Lymphoma Indicates Efficacy Via Alterations in RNA/DNA Synthesis and Cellular Bioenergetics

Mala Shanmugam, Ph.D., Jennifer Dennison, Ph.D., Jun Qian, M.D., Varsha Gandhi, PhD, Mary Ayres, Amareshwar Singh, PhD, Samuel McBrayer, Carter Neugarten, Priya Shanmugam, Karthik Singh, Leo I. Gordon, MD, Nancy Krett, PhD, Steven T. Rosen, MD

Blood (2008) 112 (11): 4987.

https://doi.org/10.1182/blood.V112.11.4987.4987

Published: 2008

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Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells

Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis

Mitochondrial Priming Is Heterogenous in t(4;14) Multiple Myeloma and Can be Induced By Inhibition of NSD2

Heme Attenuates T Cell Exhaustion and Drives Effector Function: Implications for Immune and Adoptive T Cell Therapy

Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma

Engineering Novel Multi-Cytokine Backpacks for Manufacturing Functionally Improved CAR T Cell Products

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

Mitochondrial Electron Transport Chain Inhibition Promotes Resistance to Proteasome Inhibitors in Multiple Myeloma

BRAF Mutations and Inflammatory Gene Expression in Myeloma Cells from Patients with Renal Dysfunction

Duvelisib Promotes Mitochondrial Fusion and Epigenetic Reprogramming to Drive Therapeutic T Cell Persistence and Function

The Role of Proteasome Activator PA28α in Multiple Myeloma

Succinate Ubiquinone Reductase Activity Predicts Multiple Myeloma Sensitivity to Venetoclax

Glutamine Catabolism Maintains MCL-1 Expression in Glucose-Deprived Multiple Myeloma

Targeting Glycolysis and Compensatory Mitochondrial Metabolism In An In Vivo Xenograft Model Of Multiple Myeloma With FDA Approved Ritonavir and Metformin

Targeting Glucose Metabolism and Compensatory Metabolic Resistance in Chronic Lymphocytic Leukemia

Targeting Glycolysis and Compensatory Mitochondrial Metabolism in Multiple Myeloma with FDA Approved Ritonavir and Metformin Via Synthetic Lethality

Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy

Myeloma Exhibits Dependence on Atypical Glucose Transporters: Targeting MCL-1 Through GLUT4 Inhibition

8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma

Pre-Clincial Evaluation of a Novel Purine Analogue 8-NH 2 -Adenosine in Mantle Cell Lymphoma Indicates Efficacy Via Alterations in RNA/DNA Synthesis and Cellular Bioenergetics

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American Society of Hematology

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