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Mala Shanmugam
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Journal Articles

Heme Attenuates T Cell Exhaustion and Drives Effector Function: Implications for Immune and Adoptive T Cell Therapy

Pulkit Gupta, Heather Lin, Remya Nair, Ruby Freeman, Dejah Blake, Kiran Lakhani, Doris R. Powell, Sagar Lonial, Benjamin G. Barwick, Ajay K. Nooka, Sarwish Rafiq, Mala Shanmugam
Journal: Blood
Blood (2023) 142 (Supplement 1): 6807.
https://doi.org/10.1182/blood-2023-186634
Published: 2023
Journal Articles

Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma

Corynn Kasap, Adila Izgutdina, Bonell Patino Escobar, Yu-Hsiu Tony Lin, Huimin Geng, Gianina Wicaksono, Daphne Dupere-Richer, Emilio Ramos, Abhilash Barpanda, Anjanaa Vijayanarayanan, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, Veronica Steri, William Karlon, Mala Shanmugam, Lawrence H. Boise, Benjamin G. Barwick, Jonathan D. Licht, Arun P Wiita
Journal: Blood
Blood (2023) 142 (Supplement 1): 465.
https://doi.org/10.1182/blood-2023-182578
Published: 2023
Journal Articles

Engineering Novel Multi-Cytokine Backpacks for Manufacturing Functionally Improved CAR T Cell Products

Heather Lin, A K M Nawshad Hossian, Biaggio Uricoli, Ruby Mei Freeman, Dejah A Blake, Jonathan Legier, Remya Nair, Jean L. Koff, Mala Shanmugam, Erik Dreaden, Sarwish Rafiq
Journal: Blood
Blood (2022) 140 (Supplement 1): 10245–10246.
https://doi.org/10.1182/blood-2022-162498
Published: 2022
Journal Articles

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

Christopher Ronald Funk, Shuhua Wang, Kevin Z. Chen, Alexandra Waller, Aditi Sharma, Claudia L. Edgar, Vikas A. Gupta, Shanmuganathan Chandrakasan, Jaquelyn T. Zoine, Andrew Fedanov, Sunil S. Raikar, Jean L. Koff, Christopher R. Flowers, Silvia Coma, Jonathan A. Pachter, Sruthi Ravindranathan, H. Trent Spencer, Mala Shanmugam, Edmund K. Waller
Journal: Blood
Blood (2022) 139 (4): 523–537.
https://doi.org/10.1182/blood.2021011597
Published: 2022
Includes: Supplemental data
Journal Articles

Duvelisib Promotes Mitochondrial Fusion and Epigenetic Reprogramming to Drive Therapeutic T Cell Persistence and Function

Kevin Z. Chen, Christopher R. Funk, Shuhua Wang, Aditi Sharma, Edmund K. Waller, Mala Shanmugam
Journal: Blood
Blood (2021) 138 (Supplement 1): 1714.
https://doi.org/10.1182/blood-2021-153446
Published: 2021
Journal Articles

Mitochondrial Electron Transport Chain Inhibition Promotes Resistance to Proteasome Inhibitors in Multiple Myeloma

Aditi Sharma, Abhinav Achreja, Remya Nair, Pulkit Gupta, Claudia L Edgar, Olamide Animasahun, Anjali Mittal, Bhakti Dwivedi, Manoj Bhasin, Vikas A Gupta, Benjamin G Barwick, Shannon M Matulis, Sagar Lonial, Lawrence H. Boise, David L Jaye, Arun P Wiita, Ajay K. Nooka, Deepak Nagrath, Mala Shanmugam
Journal: Blood
Blood (2021) 138 (Supplement 1): 1611.
https://doi.org/10.1182/blood-2021-153744
Published: 2021
Journal Articles

BRAF Mutations and Inflammatory Gene Expression in Myeloma Cells from Patients with Renal Dysfunction

Theodora Alese, Benjamin G Barwick, Vikas A. Gupta, Nisha Joseph, Craig C. Hofmeister, Mala Shanmugam, Jonathan L. Kaufman, Madhav V Dhodapkar, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise
Journal: Blood
Blood (2021) 138 (Supplement 1): 1624.
https://doi.org/10.1182/blood-2021-154092
Published: 2021
Journal Articles

The Role of Proteasome Activator PA28α in Multiple Myeloma

Yanyan Gu, MD PhD, Benjamin G Barwick, PhD, Mala Shanmugam, PhD, Craig C Hofmeister, MDMPH, Jonathan L. Kaufman, MD, Ajay K Nooka, MDMPH, Vikas A. Gupta, MD PhD, Madhav V Dhodapkar, MBBS, Lawrence H. Boise, PhD, Sagar Lonial
Journal: Blood
Blood (2019) 134 (Supplement_1): 5499.
https://doi.org/10.1182/blood-2019-128216
Published: 2019
Journal Articles

Succinate Ubiquinone Reductase Activity Predicts Multiple Myeloma Sensitivity to Venetoclax

Richa Bajpai, PhD, Changyong Wei, PhD BS, Shannon Matulis, PhD, Ajay K. Nooka, MDMPH, Samuel McBrayer, PhD, Sagar Lonial, MD, Vikas A. Gupta, MD PhD, Lawrence H. Boise, PhD, Mala Shanmugam, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4409.
https://doi.org/10.1182/blood.V130.Suppl_1.4409.4409
Published: 2017
Journal Articles

Glutamine Catabolism Maintains MCL-1 Expression in Glucose-Deprived Multiple Myeloma

Changyong Wei, PhD BS, Richa Bajpai, PhD, Alisha D Hunter, MS, Darius Mahboubi, MS, Mala Shanmugam, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3076.
https://doi.org/10.1182/blood.V130.Suppl_1.3076.3076
Published: 2017
Journal Articles

Targeting Glycolysis and Compensatory Mitochondrial Metabolism In An In Vivo Xenograft Model Of Multiple Myeloma With FDA Approved Ritonavir and Metformin

Sevim Dalva-Aydemir, MS, Kehinde U.A. Adekola, MBBS, Jennifer Koblinski, PhD, Noopur Raje, MD, Steven T. Rosen, MD, FRCPA, Mala Shanmugam, PhD
Journal: Blood
Blood (2013) 122 (21): 1922.
https://doi.org/10.1182/blood.V122.21.1922.1922
Published: 2013
Journal Articles

Targeting Glycolysis and Compensatory Mitochondrial Metabolism in Multiple Myeloma with FDA Approved Ritonavir and Metformin Via Synthetic Lethality

Kehinde U. A. Adekola, M.B.B.S, Maylyn Martinez, Steven T. Rosen, MD, FRCPA, Mala Shanmugam, PhD
Journal: Blood
Blood (2012) 120 (21): 4016.
https://doi.org/10.1182/blood.V120.21.4016.4016
Published: 2012
Journal Articles

Targeting Glucose Metabolism and Compensatory Metabolic Resistance in Chronic Lymphocytic Leukemia

Kehinde U.A. Adekola, MBBS, Vivian Liu, Shuo Ma, MD, PhD, Steven T. Rosen, MD, FRCPA, Mala Shanmugam, PhD
Journal: Blood
Blood (2012) 120 (21): 1801.
https://doi.org/10.1182/blood.V120.21.1801.1801
Published: 2012
Journal Articles

Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy

Samuel K. McBrayer, Javelin C. Cheng, Seema Singhal, Nancy L. Krett, Steven T. Rosen, Mala Shanmugam
Journal: Blood
Blood (2012) 119 (20): 4686–4697.
https://doi.org/10.1182/blood-2011-09-377846
Published: 2012
Includes: Supplemental data
Journal Articles

Myeloma Exhibits Dependence on Atypical Glucose Transporters: Targeting MCL-1 Through GLUT4 Inhibition

Mala Shanmugam, PhD, Javelin C Cheng, MS, Samuel K McBrayer, Steven T. Rosen, MD, FRCPA
Journal: Blood
Blood (2011) 118 (21): 1850.
https://doi.org/10.1182/blood.V118.21.1850.1850
Published: 2011
Journal Articles

8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma

Jennifer B. Dennison, Mala Shanmugam, Mary L. Ayres, Jun Qian, Nancy L. Krett, L. Jeffrey Medeiros, Sattva S. Neelapu, Steven T. Rosen, Varsha Gandhi
Journal: Blood
Blood (2010) 116 (25): 5622–5630.
https://doi.org/10.1182/blood-2010-05-285866
Published: 2010
Includes: Supplemental data
Journal Articles

Pre-Clincial Evaluation of a Novel Purine Analogue 8-NH 2 -Adenosine in Mantle Cell Lymphoma Indicates Efficacy Via Alterations in RNA/DNA Synthesis and Cellular Bioenergetics

Mala Shanmugam, Ph.D., Jennifer Dennison, Ph.D., Jun Qian, M.D., Varsha Gandhi, PhD, Mary Ayres, Amareshwar Singh, PhD, Samuel McBrayer, Carter Neugarten, Priya Shanmugam, Karthik Singh, Leo I. Gordon, MD, Nancy Krett, PhD, Steven T. Rosen, MD
Journal: Blood
Blood (2008) 112 (11): 4987.
https://doi.org/10.1182/blood.V112.11.4987.4987
Published: 2008