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Journal Articles

Heme Attenuates T Cell Exhaustion and Drives Effector Function: Implications for Immune and Adoptive T Cell Therapy

Pulkit Gupta, Heather Lin, Remya Nair, Ruby Freeman, Dejah Blake, Kiran Lakhani, Doris R. Powell, Sagar Lonial, Benjamin G. Barwick, Ajay K. Nooka, Sarwish Rafiq, Mala Shanmugam

Blood (2023) 142 (Supplement 1): 6807.

https://doi.org/10.1182/blood-2023-186634

Published: 2023

Journal Articles

Antagonizing Vasoactive Intestinal Peptide (VIP) Receptors on CAR T Cells Improves Efficacy and Persistence

Heather Lin, Dejah Blake, Abhijay Mudigonda, Alysa N Evans, Ruby Freeman, Tanisha Sinha, Fan Fei, Elyse Christensen, Tenzin Passang Fnu, Sruthi Ravindranathan, Tongrui Liu, Lily Yang, Edmund K. Waller, Sarwish Rafiq

Blood (2023) 142 (Supplement 1): 4806.

https://doi.org/10.1182/blood-2023-182952

Published: 2023

Journal Articles

Engineering Novel Multi-Cytokine Backpacks for Manufacturing Functionally Improved CAR T Cell Products

Heather Lin, A K M Nawshad Hossian, Biaggio Uricoli, Ruby Mei Freeman, Dejah A Blake, Jonathan Legier, Remya Nair, Jean L. Koff, Mala Shanmugam, Erik Dreaden, Sarwish Rafiq

Blood (2022) 140 (Supplement 1): 10245–10246.

https://doi.org/10.1182/blood-2022-162498

Published: 2022

Journal Articles

Enhancing CAR T Cell Anti-Tumor Efficacy through Secreted Single Chain Variable Fragment (scFv) Immune Checkpoint Blockade

Sarwish Rafiq, PhD, Hollie J. Jackson, PhD, Oladapo Yeku, MD PhD, Terence J Purdon, MS, Dayenne G. van Leeuwen, Kevin J. Curran, MD, Ryan N Ahmed, Grace D Cullen, Su Yan, Pei Wang, PhD, Jingyi Xiang, Cheng Liu, PhD, Renier J. Brentjens, MD PhD

Blood (2017) 130 (Supplement 1): 842.

https://doi.org/10.1182/blood.V130.Suppl_1.842.842

Published: 2017

Journal Articles

CD33-Directed Chimeric Antigen Receptor (CAR) T Cells for the Treatment of Acute Myeloid Leukemia (AML)

Sarwish Rafiq, PhD, Terence J. Purdon, Liora M. Schultz, MD, Renier J. Brentjens, MD PhD

Blood (2016) 128 (22): 2825.

https://doi.org/10.1182/blood.V128.22.2825.2825

Published: 2016

Journal Articles

Engineered T Cell Receptor-Mimic Antibody, (TCRm) Chimeric Antigen Receptor (CAR) T Cells Against the Intracellular Protein Wilms Tumor-1 (WT1) for Treatment of Hematologic and Solid Cancers

Sarwish Rafiq, PhD, Tao Dao, MDPhD, Cheng Liu, PhD, David A. Scheinberg, MD PhD, Renier J Brentjens, MD PhD

Blood (2014) 124 (21): 2155.

https://doi.org/10.1182/blood.V124.21.2155.2155

Published: 2014

Journal Articles

Ibrutinib antagonizes rituximab-dependent NK cell–mediated cytotoxicity

Holbrook E. Kohrt, Idit Sagiv-Barfi, Sarwish Rafiq, Sarah E. M. Herman, Jonathon P. Butchar, Carolyn Cheney, Xiaoli Zhang, Joseph J. Buggy, Natarajan Muthusamy, Ronald Levy, Amy J. Johnson, John C. Byrd

Blood (2014) 123 (12): 1957–1960.

https://doi.org/10.1182/blood-2014-01-547869

Published: 2014

Journal Articles

Ibrutinib (PCI-32765) Antagonizes Rituximab-Dependent NK-Cell Mediated Cytotoxicity

Holbrook E Kohrt, MD, PhD, Idit Sagiv-Barfi, PhD, Sarwish Rafiq, MS, Sarah E.M. Herman, Jonathan P Butchar, Ph.D., Carolyn Cheney, B.S, Xiaoli Zhang, PhD, MS, Joseph J. Buggy, PhD, Natarajan Muthusamy, DVM, Ph.D, Ronald Levy, MD, Amy J Johnson, PhD, John C. Byrd, MD

Blood (2013) 122 (21): 373.

https://doi.org/10.1182/blood.V122.21.373.373

Published: 2013

Journal Articles

TLR7/8 Agonists Overcome the Suppression of FcγR Activity in Monocytes From Chronic Lymphocytic Leukemia Patients

Jonathan P. Butchar, Ph.D., Prexy Shah, B. Sci, Hemal Patel, B. Sci, Kavin Fatehchand, Sarwish Rafiq, MS, Carolyn Cheney, B.S, John P Vasilakos, Ph.D., Natarajan Muthusamy, DVM, Ph.D, John C. Byrd, MD, Susheela Tridandapani, PhD

Blood (2012) 120 (21): 4595.

https://doi.org/10.1182/blood.V120.21.4595.4595

Published: 2012

Journal Articles

Comparative Assessment of Different Clinically Utilized CD20 Directed Antibodies in Chronic Lymphocytic Leukemia (CLL) Cells Reveals Divergent NK-Cell, Monocyte and Macrophage Properties,

Sarwish Rafiq, MS, Jonathan P. Butchar, PhD, Carolyn Cheney, Xiaokui Mo, PhD, David Jarjoura, PhD, Susheela Tridandapani, PhD, Natarajan Muthusamy, DVM, Ph.D, John C. Byrd, MD

Blood (2011) 118 (21): 3717.

https://doi.org/10.1182/blood.V118.21.3717.3717

Published: 2011

Journal Articles

GlycoVariant Anti-CD37 Small Modular Immuno-Pharmaceutical Exhibits Superior Natural Killer Cell Mediated Cytotoxicity Against Chronic Lymphocytic Leukemia Cells at Low Concentrations and Low Antigen Density

Sarwish Rafiq, MA, Carolyn M Cheney, BS, Gerard Lozanski, MD, Rosa Lapalombella, PhD, Xiaokui Mo, PhD, Anthony Siadak, MD, David Jarjoura, PhD, John C. Byrd, MD, Natarajan Muthusamy, DVM, PhD

Blood (2010) 116 (21): 1847.

https://doi.org/10.1182/blood.V116.21.1847.1847

Published: 2010

Journal Articles

Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma

Blood (2010) 116 (7): 1025–1034.

https://doi.org/10.1182/blood-2009-12-257485

Published: 2010

Includes: Supplemental data

Journal Articles

Glycovariant CD37 Small Modular Immuno-Pharmaceutical (TruADhanCe™ SMIP) Promotes Enhanced Natural Killer Cell Mediated Cytotoxicity against Primary Chronic Lymphocytic Leukemia Cells.

Sarwish Rafiq, Carolyn Cheney, Peter A Thompson, MD, FRACP, Tony Siadak, Paul Algate, Chuck Cerveny, John C. Byrd, Natarajan Muthusamy, PhD

Blood (2009) 114 (22): 1744.

https://doi.org/10.1182/blood.V114.22.1744.1744

Published: 2009

Journal Articles

A Phase 1 Trial of TRU-016, An Anti-CD37 Small Modular Immunopharmaceutical (SMIP TM ) Protein in Relapsed and Refractory CLL: Early Promising Clinical Activity.

Leslie Andritsos, MD, Richard R Furman, Ian W Flinn, Andres Foreno-Torres, M.D., Joseph M. Flynn, DO, MPH, FACP, Natarajan Muthusamy, PhD, Sarwish Rafiq, MS, Scott Stromatt, MD, John C. Byrd

Blood (2009) 114 (22): 3424.

https://doi.org/10.1182/blood.V114.22.3424.3424

Published: 2009

NARROW

Heme Attenuates T Cell Exhaustion and Drives Effector Function: Implications for Immune and Adoptive T Cell Therapy

Antagonizing Vasoactive Intestinal Peptide (VIP) Receptors on CAR T Cells Improves Efficacy and Persistence

Engineering Novel Multi-Cytokine Backpacks for Manufacturing Functionally Improved CAR T Cell Products

Enhancing CAR T Cell Anti-Tumor Efficacy through Secreted Single Chain Variable Fragment (scFv) Immune Checkpoint Blockade

CD33-Directed Chimeric Antigen Receptor (CAR) T Cells for the Treatment of Acute Myeloid Leukemia (AML)

Engineered T Cell Receptor-Mimic Antibody, (TCRm) Chimeric Antigen Receptor (CAR) T Cells Against the Intracellular Protein Wilms Tumor-1 (WT1) for Treatment of Hematologic and Solid Cancers

Ibrutinib antagonizes rituximab-dependent NK cell–mediated cytotoxicity

Ibrutinib (PCI-32765) Antagonizes Rituximab-Dependent NK-Cell Mediated Cytotoxicity

TLR7/8 Agonists Overcome the Suppression of FcγR Activity in Monocytes From Chronic Lymphocytic Leukemia Patients

Comparative Assessment of Different Clinically Utilized CD20 Directed Antibodies in Chronic Lymphocytic Leukemia (CLL) Cells Reveals Divergent NK-Cell, Monocyte and Macrophage Properties,

GlycoVariant Anti-CD37 Small Modular Immuno-Pharmaceutical Exhibits Superior Natural Killer Cell Mediated Cytotoxicity Against Chronic Lymphocytic Leukemia Cells at Low Concentrations and Low Antigen Density

Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma

Glycovariant CD37 Small Modular Immuno-Pharmaceutical (TruADhanCe™ SMIP) Promotes Enhanced Natural Killer Cell Mediated Cytotoxicity against Primary Chronic Lymphocytic Leukemia Cells.

A Phase 1 Trial of TRU-016, An Anti-CD37 Small Modular Immunopharmaceutical (SMIP TM ) Protein in Relapsed and Refractory CLL: Early Promising Clinical Activity.

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American Society of Hematology

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American Society of Hematology

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