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Journal Articles

ABL001 (asciminib) Efficiently Targets Transplantable BCR::ABL1 Lymphoid Blast Crisis in the Scl-Tta-p210-BCR::ABL1 Mouse Model

Nicolas Chatain, Julian Baumeister, Marcelo Szymanski de Toledo, Dickson W.L. Wong, Siddharth Gupta, Kristina Pannen, Bärbel Junge, Tim H. Brümmendorf, Peter Boor, Steffen Koschmieder

Blood (2023) 142 (Supplement 1): 4193.

https://doi.org/10.1182/blood-2023-179809

Published: 2023

Journal Articles

Non-Canonical Gli1 Activation Mediates Profibrotic Hematopoiesis-Stroma Crosstalk in MPN

Jessica E. Pritchard, Juliette Pearce, Inge Snoeren, Stijn Fuchs, Katrin Götz, Silke Wagner, Kathrin Olschok, Nicolas Chatain, Steffen Koschmieder, Marie-Luise Berres, Ivan Costa, Helene Gleitz, Rafael Kramann, Rebekka K. Schneider

Blood (2022) 140 (Supplement 1): 6728–6729.

https://doi.org/10.1182/blood-2022-160142

Published: 2022

Journal Articles

The Unfolded Protein Response Mediates Resistance in AML and Its Therapeutic Targeting Enhances TKI Induced Cell Death in FLT3-ITD + AML

Timo Jaquet, Christian Preisinger, Marlena Bütow, Stefan Tillmann, Nicolas Chatain, Michael Huber, Steffen Koschmieder, Martin Kirschner, Edgar Jost, Tim H Brümmendorf, Bezhad Kharabi, Iris Appelmann, Mirle Schemionek

Blood (2021) 138 (Supplement 1): 2246.

https://doi.org/10.1182/blood-2021-150066

Published: 2021

Journal Articles

Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis

Blood (2021) 137 (15): 2070–2084.

https://doi.org/10.1182/blood.2019004509

Published: 2021

Includes: Supplemental data

Journal Articles

STAT1 Transcriptional Response Predicts Molecular Responses of PB-Derived Clonogenic Cells from MPN Patients to Interferon Alpha

Milena Kalmer, MSc, Kristina Feldberg, Deniz Gezer, Susanne Isfort, Tim H Brümmendorf, MD, Nicolas Chatain, Steffen Koschmieder

Blood (2019) 134 (Supplement_1): 1679.

https://doi.org/10.1182/blood-2019-122676

Published: 2019

Journal Articles

Hematopoietic Stem and Progenitor Cell Proliferation and Differentiation Requires the Trithorax Protein Ash2l In Vivo

Nicolas Chatain, PhD, Juliane Lüscher-Firzlaff, Chao-Chung Kuo, Agnieszka Bochyńska, Andrea Ullius, Bernd Denecke, Ivan Costa, Steffen Koschmieder, MD, Bernhard Lüscher

Blood (2018) 132 (Supplement 1): 2566.

https://doi.org/10.1182/blood-2018-99-115950

Published: 2018

Journal Articles

Implication of Hypoxia-Inducible Factor-1 (HIF-1) As a New Therapeutic Target in JAK2 V617F Positive Myeloproliferative Neoplasms (MPN)

Julian Baumeister, MSc, Nicolas Chatain, PhD, Annika Hubrich, Caroline Küstermann, M.Sc., Stephanie Sontag, PhD, Kristin Seré, PhD, Martin Zenke, PhD, Tim H Brümmendorf, MD, Kamil Kranc, MD, Steffen Koschmieder, MD, Deniz Gezer, MD

Blood (2018) 132 (Supplement 1): 4318.

https://doi.org/10.1182/blood-2018-99-113332

Published: 2018

Journal Articles

Eosinophil Differentiation and Viability in Hypereosinophilia Is Impaired By Genetic and Pharmacologic Targeting of LCP1 and PKC Beta

Guangxin Ma, Deniz Gezer, MD, Oliver Herrmann, Msc, Andreas Reiter, MD, Mohamad Jawhar, Mirle Schemionek, Tim H. Brümmendorf, MD, Steffen Koschmieder, MD, Nicolas Chatain, PhD

Blood (2018) 132 (Supplement 1): 4320.

https://doi.org/10.1182/blood-2018-99-114646

Published: 2018

Journal Articles

The Impact of the Mutational Landscape upon the Molecular Responses to Interferon-Alfa2 in Calr-Mutated MPN Patients

Vibe Skov, PhD, Lasse Kjær, PhD, Mads Thomassen, PhD, Steffen Koschmieder, MD, Julia Czech, Nicolas Chatain, PhD, Niels Pallisgaard, Sabrina Cordua, MD, Torben A Kruse, Hans Carl Hasselbalch, Professor, dr.MD

Blood (2018) 132 (Supplement 1): 4327.

https://doi.org/10.1182/blood-2018-99-119158

Published: 2018

Journal Articles

Characterization of Hematopoietic Differentiation Profiles of MPN Patient-Derived Inducible Pluripotent Stem Cells Harboring Homozygous Vs Heterozygous Calreticulin Mutations

Lijuan Han, MD, Marcelo A. Szymanski Toledo, PhD, Alexandre Theocharides, MD, Angela Maurer, M.Sc, Tim H. Brümmendorf, MD, Martin Zenke, PhD, Nicolas Chatain, PhD, Steffen Koschmieder, MD

Blood (2018) 132 (Supplement 1): 3065.

https://doi.org/10.1182/blood-2018-99-113372

Published: 2018

Journal Articles

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Blood (2018) 132 (1): 67–77.

https://doi.org/10.1182/blood-2018-02-834895

Published: 2018

Includes: Supplemental data

Journal Articles

Critical Interferon-Response Genes Are Induced By JAK2 V617F but Repressed By BCR-ABL, and They Are Responsible for the Differential Effects of Interferon in PV Vs. CML

Claudia Schubert, Ivan G. Costa, Mirle Schemionek, PhD, Kristina Feldberg, Julian Baumeister, Tim H. Brümmendorf, MD, Steffen Koschmieder, Nicolas Chatain

Blood (2017) 130 (Supplement 1): 4226.

https://doi.org/10.1182/blood.V130.Suppl_1.4226.4226

Published: 2017

Journal Articles

Higher Rates of Molecular Response to Peg-IFNa in JAK2V617F Vs. Calr Mutant MPN Patients Are Due to JAK1-Mediated STAT1 Activation and Autoregulation

Julia Czech, Sabrina Cordua, Barbora Weinbergerova, Lijuan Han, Claudia Schubert, Tim H. Brümmendorf, MD, Jiri Mayer, Prof, MD SCs, Zdenek Racil, MD, Blanka Kubesova, MSc, Trine Alma Knudsen, MD, Anders Sørensen, Morten Holmstrøm, Lasse Kjær, MSc, PhD, Vibe Skov, MSc, PhD, Thomas Stauffer Larsen, MD PhD, Hans Carl Hasselbalch, MD Professor, DMSc, Nicolas Chatain, Steffen Koschmieder

Blood (2017) 130 (Supplement 1): 4194.

https://doi.org/10.1182/blood.V130.Suppl_1.4194.4194

Published: 2017

Journal Articles

Dasatinib Exerts Differential Effects on Normal and BCR-ABL Positive Hematopoietic Cells in a Transgenic Mouse Model of Chronic Phase-CML

Claudia Schubert, Msc, Nicolas Chatain, PhD, Till Braunschweig, MD, Mirle Schemionek, PhD, Kristina Feldberg, Melanie Hoffmann, Tim H. Brümmendorf, MD, Satu Mustjoki, MD PhD, Olli Dufva, Steffen Koschmieder, MD

Blood (2016) 128 (22): 1885.

https://doi.org/10.1182/blood.V128.22.1885.1885

Published: 2016

Journal Articles

Novel Deletion Mutants in the Juxtamembrane Domain of Fms-like Tyrosine Kinase 3 (FLT3) Induce Transformation By Release from Autoinhibition in AML

Nicolas Chatain, PhD, Janine Rossa, Giulia Rossetti, PhD, Rodrigo Casasnovas Perera, PhD, Paolo Carloni, PhD, Torsten Haferlach, MD, Tim H. Brümmendorf, MD, Susanne Schnittger, PhD, Steffen Koschmieder, MD

Blood (2014) 124 (21): 885.

https://doi.org/10.1182/blood.V124.21.885.885

Published: 2014

Journal Articles

Dissecting Genomic Aberrations In CML and Bcr-Abl Negative Myeloproliferative Neoplasms By The Use Of Multiplex-PCR and Parallel Resequencing

Martin M. Kirschner, Mirle Schemionek, Claudia Schubert, Nicolas Chatain, Stephanie Sontag, Susanne Isfort, Nadina Ortiz-Brüchle, Karla Bennemann, Klaus Zerres, Martin Zenke, Tim H. Bruemmendorf, MD, Steffen Koschmieder

Blood (2013) 122 (21): 1612.

https://doi.org/10.1182/blood.V122.21.1612.1612

Published: 2013

NARROW

ABL001 (asciminib) Efficiently Targets Transplantable BCR::ABL1 Lymphoid Blast Crisis in the Scl-Tta-p210-BCR::ABL1 Mouse Model

Non-Canonical Gli1 Activation Mediates Profibrotic Hematopoiesis-Stroma Crosstalk in MPN

The Unfolded Protein Response Mediates Resistance in AML and Its Therapeutic Targeting Enhances TKI Induced Cell Death in FLT3-ITD + AML

Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis

STAT1 Transcriptional Response Predicts Molecular Responses of PB-Derived Clonogenic Cells from MPN Patients to Interferon Alpha

Hematopoietic Stem and Progenitor Cell Proliferation and Differentiation Requires the Trithorax Protein Ash2l In Vivo

Implication of Hypoxia-Inducible Factor-1 (HIF-1) As a New Therapeutic Target in JAK2 V617F Positive Myeloproliferative Neoplasms (MPN)

Eosinophil Differentiation and Viability in Hypereosinophilia Is Impaired By Genetic and Pharmacologic Targeting of LCP1 and PKC Beta

The Impact of the Mutational Landscape upon the Molecular Responses to Interferon-Alfa2 in Calr-Mutated MPN Patients

Characterization of Hematopoietic Differentiation Profiles of MPN Patient-Derived Inducible Pluripotent Stem Cells Harboring Homozygous Vs Heterozygous Calreticulin Mutations

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Critical Interferon-Response Genes Are Induced By JAK2 V617F but Repressed By BCR-ABL, and They Are Responsible for the Differential Effects of Interferon in PV Vs. CML

Higher Rates of Molecular Response to Peg-IFNa in JAK2V617F Vs. Calr Mutant MPN Patients Are Due to JAK1-Mediated STAT1 Activation and Autoregulation

Dasatinib Exerts Differential Effects on Normal and BCR-ABL Positive Hematopoietic Cells in a Transgenic Mouse Model of Chronic Phase-CML

Novel Deletion Mutants in the Juxtamembrane Domain of Fms-like Tyrosine Kinase 3 (FLT3) Induce Transformation By Release from Autoinhibition in AML

Dissecting Genomic Aberrations In CML and Bcr-Abl Negative Myeloproliferative Neoplasms By The Use Of Multiplex-PCR and Parallel Resequencing

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American Society of Hematology

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ASH Publications

American Society of Hematology

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