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Jaroslav Jelinek
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Journal Articles

DNA polymerase θ protects leukemia cells from metabolically induced DNA damage

Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Katherine Sullivan-Reed, Paulina Podszywalow-Bartnicka, Kumaraswamy N. Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Srinivas Chatla, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Matlawska-Wasowska, Gurushankar Chandramouly, Reza Nejati, Mariusz Wasik, Stephen M. Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard T. Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth M. Paietta, Ross L. Levine, Martin S. Tallman, Hugo F. Fernandez, Mark R. Litzow, Gaorav P. Gupta, Jean-Yves Masson, Tomasz Skorski
Journal: Blood
Blood (2023) 141 (19): 2372–2389.
https://doi.org/10.1182/blood.2022018428
Published: 2023
Includes: Supplemental data
Journal Articles

DNA Polymerase Theta Protects Leukemia Cells from Metabolic-Induced DNA Damage

Umeshkumar M Vekariya, Katherine Sullivan-Reed, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Paulina Podszywalow-Bartnicka, Kumaraswamy Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Maslawska-Wasowska, Reza Nejati, Mariusz A Wasik, Stephen M. Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth Paietta, Ross L. Levine, Martin S. Tallman, Hugo F Fernandez, Mark R. Litzow, Gaorav P Gupta, Jean-Yves Masson, Tomasz Skorski
Journal: Blood
Blood (2022) 140 (Supplement 1): 2972–2974.
https://doi.org/10.1182/blood-2022-156458
Published: 2022
Journal Articles

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan-Reed, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Elizaveta A. Belyaeva, Alina Nersesyan, Marcin M. Machnicki, Monika Toma, Nicolas Chatain, Malgorzata Rydzanicz, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Sliwinski, Tomasz Stoklosa, Rafal Ploski, Thomas Fischer, Stephen M. Sykes, Steffen Koschmieder, Lars Bullinger, Peter Valent, Mariusz A. Wasik, Jian Huang, Tomasz Skorski
Journal: Blood
Blood (2018) 132 (1): 67–77.
https://doi.org/10.1182/blood-2018-02-834895
Published: 2018
Includes: Supplemental data
Journal Articles

Tyrosine Kinase Inhibitor-Induced Defects in DNA Repair Sensitize FLT3(ITD)-Positive Acute Myeloid Leukemia Quiescent and Proliferative Cells to PARP Inhibitors

Silvia Maifrede, Margaret Nieborowska-Skorska, Katherine Sullivan, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Bac Viet Le, Martyna Solecka, Zhaorui Lian, Marcin M Machnicki, Huaqing Zhao, Jaroslav Jelinek, Katarzyna Piwocka, Tomasz Stoklosa, Thomas Fischer, Stephen M. Sykes, Steffen Koschmieder, Lars Bullinger, MD, Peter Valent, MD, Jian Huang, Tomasz Skorski
Journal: Blood
Blood (2017) 130 (Supplement 1): 2635.
https://doi.org/10.1182/blood.V130.Suppl_1.2635.2635
Published: 2017
Journal Articles

Genetic Determinants of Response to Guadecitabine (SGI-110) in AML

Patricia L. Kropf, MD, Woonbok Chung, PhD, Andrew D. Kelly, BA, Hagop M. Kantarjian, MD, Gail J. Roboz, Karen W.L. Yee, MD, Pietro Taverna, PhD, Sue Naim, Mohammad Azab, MD, Jaroslav Jelinek, MD PhD, Jean-Pierre J. Issa, MD
Journal: Blood
Blood (2016) 128 (22): 1680.
https://doi.org/10.1182/blood.V128.22.1680.1680
Published: 2016
Journal Articles

Focal Reactivation of Some X-Chromosome Genes in PV and ET Clones

Soo Jin Kim, MS, Sabina Swierczek, PhD, Jihyun Song, PhD, Jaroslav Jelinek, MD PhD, Josef T. Prchal, MD
Journal: Blood
Blood (2016) 128 (22): 1966.
https://doi.org/10.1182/blood.V128.22.1966.1966
Published: 2016
Journal Articles

Reactivation of the X-Chromosome Genes within PV Clone

Soo Jin Kim, MS, Jaroslav Jelinek, MD PhD, Jean-Pierre J Issa, MD, Josef T. Prchal, MD, Sabina Swierczek, PhD
Journal: Blood
Blood (2015) 126 (23): 4086.
https://doi.org/10.1182/blood.V126.23.4086.4086
Published: 2015
Journal Articles

Focal Reactivation of X-Chromosome in Female Patients with PV and ET

Soo Jin Kim, MS, Sabina Swierczek, PhD, Jihyun Song, MS, Jean-Pierre Issa, MD, Jaroslav Jelinek, MD PhD, Josef T. Prchal, MD
Journal: Blood
Blood (2014) 124 (21): 3225.
https://doi.org/10.1182/blood.V124.21.3225.3225
Published: 2014
Journal Articles

Mice with Myelodysplastic Syndrome Respond to Treatment with Azanucleosides: A Preclinical Model for MDS Therapies

Sheryl M Gough, PhD, Yang Jo Chung, PhD, Maegawa Shinji, PhD, Jaroslav Jelinek, MD, PhD, Jean-Pierre Issa, MD, Peter Aplan, MD
Journal: Blood
Blood (2012) 120 (21): 3829.
https://doi.org/10.1182/blood.V120.21.3829.3829
Published: 2012
Journal Articles

Methylation of AR locus does not always reflect X chromosome inactivation state

e-blood
Sabina I. Swierczek, Lucie Piterkova, Jaroslav Jelinek, Neeraj Agarwal, Sue Hammoud, Andrew Wilson, Kimberly Hickman, Charles J. Parker, Bradley R. Cairns, Josef T. Prchal
Journal: Blood
Blood (2012) 119 (13): e100–e109.
https://doi.org/10.1182/blood-2011-11-390351
Published: 2012
Includes: Supplemental data
Journal Articles

Cancer Drivers Affected by Aberrant DNA Methylation in MDS and AML

Jaroslav Jelinek, MD, PhD, Shoudan Liang, PhD, Frank Neumann, MD, PhD, Rong He, Yue Lu, PhD, Jumpei Yamazaki, DVM, PhD, Rodolphe F Taby, MD, Louis Ramagli, PhD, Marcos R Estecio, PhD, Jean-Pierre Issa, MD
Journal: Blood
Blood (2011) 118 (21): 1716.
https://doi.org/10.1182/blood.V118.21.1716.1716
Published: 2011
Journal Articles

Dnmt3a Is Essential for Hematopoietic Stem Cell Differentiation

Grant A. Challen, PhD, Deqiang Sun, Ph.D., Mira Jeong, Ph.D., Min Luo, Ph.D., Jaroslav Jelinek, MD, PhD, Aparna Vasanthakumar, Ph.D., Alexander Meissner, Ph.D., Jean-Pierre Issa, MD, Lucy Godley, MD, PhD, Wei Li, Ph.D., Margaret A. Goodell, Ph.D.
Journal: Blood
Blood (2011) 118 (21): 386.
https://doi.org/10.1182/blood.V118.21.386.386
Published: 2011
Journal Articles

Limited Effect of TET2 Mutations on Promoter DNA Methylation in Chronic Myelomonocytic Leukemia

Jumpei Yamazaki, DVM, PhD, Rodolphe F Taby, MD, Aparna Vasanthakumar, PhD, Trisha Macrae, Kelly R Ostler, BA, Lanlan Shen, MD, PhD, Hagop M. Kantarjian, Marcos R Estecio, PhD, Jaroslav Jelinek, MD, PhD, Lucy Godley, MD, PhD, Jean-Pierre Issa, MD
Journal: Blood
Blood (2011) 118 (21): 1365.
https://doi.org/10.1182/blood.V118.21.1365.1365
Published: 2011
Journal Articles

Digital Restriction Enzyme Analysis of Methylation (DREAM) by Next Generation Sequencing Uncovers Epigenetic Disturbances In Acute Myelogenous Leukemia.

Frank Neumann, MD, PhD, Jean-Pierre Issa, MD, Yue Lu, PhD, Marcos R Estecio, PhD, Rong He, Louis Ramagli, PhD, Shoudan Liang, PhD, Jaroslav Jelinek, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3635.
https://doi.org/10.1182/blood.V116.21.3635.3635
Published: 2010
Journal Articles

Genome-Wide Epigenetic Analysis of Cancer Stem Cells (CSCs) In Acute Myeloid Leukemia.

Jumpei Yamazaki, DVM, PhD, Marcos R Estecio, PhD, Jaroslav Jelinek, MD, PhD, David Graber, BA, Yue Lu, Louis Ramagli, PhD, Shoudan Liang, PhD, Steven M. Kornblau, MD, Jean-Pierre Issa, MD
Journal: Blood
Blood (2010) 116 (21): 3640.
https://doi.org/10.1182/blood.V116.21.3640.3640
Published: 2010
Journal Articles

Validation of a DNA Methylation Signature of Favorable Prognosis in Newly Diagnosed Acute Myeloid Leukemia.

Rodolphe F Taby, Sarvari Venkata Yellapragada, Heike Kroeger, Rong He, Steven M. Kornblau, Hagop Kantarjian, Farhad Ravandi, Jaroslav Jelinek, Jean-Pierre J Issa
Journal: Blood
Blood (2009) 114 (22): 1615.
https://doi.org/10.1182/blood.V114.22.1615.1615
Published: 2009
Journal Articles

Polycythemia Vera with Multiple Clones Carrying Different Mutations (L611V, V617F, L611V/V617F) in Exon 14 of JAK2 .

Cédric Cleyrat, Jaroslav Jelinek, François Girodon, Marjorie Boissinot, Thierry Ponge, Jean-Luc Harousseau, Jean-Pierre Issa, Sylvie Hermouet, Sylvie Hermouet
Journal: Blood
Blood (2009) 114 (22): 3908.
https://doi.org/10.1182/blood.V114.22.3908.3908
Published: 2009
Journal Articles

Monoallelic Methylation of the Human Androgen Receptor Gene as Detected by the HUMARA Clonality Assay Does Not Consistently Reflect X-Chromosome Inactivation and Is Therefore Unreliable for Assessment of Clonal Hematopoiesis.

Sabina Swierczek, PhD, Jaroslav Jelinek, PhD, Neeraj Agarwal, MD, Andrew Wilson, Kimberly Hickman, Charles J. Parker, MD, Josef T. Prchal, MD
Journal: Blood
Blood (2009) 114 (22): 4566.
https://doi.org/10.1182/blood.V114.22.4566.4566
Published: 2009
Journal Articles

Digital Restriction Enzyme Analysis of Methylation (DREAM) by Next Generation Sequencing Yields High Resolution Maps of DNA Methylation.

Jaroslav Jelinek, MD, PhD, Shoudan Liang, PhD, Marcos R. H. Estecio, PhD, Rong He, Yue Lu, PhD, Louis S. Ramagli, PhD, Jean-Pierre J. Issa, MD
Journal: Blood
Blood (2009) 114 (22): 567.
https://doi.org/10.1182/blood.V114.22.567.567
Published: 2009
Journal Articles

Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines

Taichun Qin, Jaroslav Jelinek, Jiali Si, Jingmin Shu, Jean-Pierre J. Issa
Journal: Blood
Blood (2009) 113 (3): 659–667.
https://doi.org/10.1182/blood-2008-02-140038
Published: 2009