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Journal Articles

Inactivation of DNA Polymerase Theta (PolΘ) Is Synthetic Lethal in DNMT3A Mutated Myeloid Malignancies - Potential Clinical Applications

Bac Viet Le, Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Marie-Christine Caron, George Vassiliou, Malgorzata Gozdecka, Zayd Haydar, Gurushankar Chandramouly, Emir Hadzijusufovic, Wolfgang R. Sperr, Richard Pomerantz, Peter Valent, Jean-Yves Masson, Gaorav Gupta, Grant A Challen, Tomasz Skorski

Blood (2023) 142 (Supplement 1): 580.

https://doi.org/10.1182/blood-2023-174333

Published: 2023

Journal Articles

Poly(ADP-Ribose) Glycohydrolase (PARG) Removes Repressive Poly-ADP Ribose Marks from DNA Polymerase Theta (PolΘ) to Stimulate DNA Double-Strand Breaks Repair in Myeloid Malignancies

Umeshkumar Vekariya, Leonid Minakhin, Mrityunjay Tyagi, Tatiana Kent, Gurushankar Chandramouly, Katherine Sullivan-Reed, Jessica Atkins, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Richard Pomerantz, Tomasz Skorski

Blood (2023) 142 (Supplement 1): 5693.

https://doi.org/10.1182/blood-2023-174330

Published: 2023

Journal Articles

Clonal Medicine Targeting DNA Damage Response Eradicates AML

Monika Toma, Adam Karami, Margaret Nieborowska-Skorska, Kumaraswamy Chitrala, Peter Valent, Tomasz Skorski

Blood (2023) 142 (Supplement 1): 4301.

https://doi.org/10.1182/blood-2023-174140

Published: 2023

Journal Articles

Clonal Targeting of DNA Damage Response Pathways Eradicates Myeloproliferative Neoplasms

Monika Toma, Margaret Nieborowska-Skorska, Adam Karami, Monika Pepek, Tomasz Stoklosa, Tomasz Skorski

Blood (2023) 142 (Supplement 1): 120.

https://doi.org/10.1182/blood-2023-174280

Published: 2023

Journal Articles

DNA polymerase θ protects leukemia cells from metabolically induced DNA damage

Blood (2023) 141 (19): 2372–2389.

https://doi.org/10.1182/blood.2022018428

Published: 2023

Includes: Supplemental data

Journal Articles

DNA Polymerase Theta Protects Leukemia Cells from Metabolic-Induced DNA Damage

Blood (2022) 140 (Supplement 1): 2972–2974.

https://doi.org/10.1182/blood-2022-156458

Published: 2022

Journal Articles

TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

Blood (2020) 136 (Supplement 1): 4.

https://doi.org/10.1182/blood-2020-137658

Published: 2020

Journal Articles

PARP1 Inhibitors Eliminated Imatinib-Refractory Chronic Myeloid Leukemia Cells in Bone Marrow Microenvironment Conditions

Margaret Nieborowska-Skorska, Paulina Podszywalow-Bartnicka, Silvia Maifrede, Bac Viet Le, Monika Toma, Peter Valent, Tomasz Sliwinski, Wayne Childers, Katarzyna Piwocka, Alexei Tulin, Tomasz Skorski, MD PhD

Blood (2018) 132 (Supplement 1): 3000.

https://doi.org/10.1182/blood-2018-99-115041

Published: 2018

Journal Articles

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Blood (2018) 132 (1): 67–77.

https://doi.org/10.1182/blood-2018-02-834895

Published: 2018

Includes: Supplemental data

Journal Articles

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms

Blood (2017) 130 (26): 2848–2859.

https://doi.org/10.1182/blood-2017-05-784942

Published: 2017

Includes: Supplemental data

Journal Articles

Drugging DNA Repair to Target T-ALL Cells

Yashodhara Dasgupta, Konstantin Golovine, Margaret Nieborowska-Skorska, Li Luo, Ksenia Matlawska-Wasowska, Charles G. Mullighan, MBBS, MD, Tomasz Skorski

Blood (2017) 130 (Supplement 1): 2610.

https://doi.org/10.1182/blood.V130.Suppl_1.2610.2610

Published: 2017

Journal Articles

Ruxolitinib-Induced Defects in DNA Repair Cause Sensitivity to PARP Inhibitors in Myeloproliferative Neoplasms

Margaret Nieborowska-Skorska, Silvia Maifrede, Yashodhara Dasgupta, Katherine Sullivan, Bac Viet Le, Martyna Solecka, Lucia Kubovcakova, Morgan Nawrocki, Martin Kirschner, MD, Huaqing Zhao, Josef T. Prchal, MD, Katarzyna Piwocka, Alison R. Moliterno, MD, Steffen Koschmieder, Anthony R Green, PhD FRCP, FRCPath, FMedSci, Radek C. Skoda, MD, Tomasz Skorski

Blood (2017) 130 (Supplement 1): 2938.

https://doi.org/10.1182/blood.V130.Suppl_1.2938.2938

Published: 2017

Journal Articles

Tyrosine Kinase Inhibitor-Induced Defects in DNA Repair Sensitize FLT3(ITD)-Positive Acute Myeloid Leukemia Quiescent and Proliferative Cells to PARP Inhibitors

Blood (2017) 130 (Supplement 1): 2635.

https://doi.org/10.1182/blood.V130.Suppl_1.2635.2635

Published: 2017

Journal Articles

Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Leukemia Cells

Katherine Sullivan, Elisabeth Bolton-Gillespie, Yashodhara Dasgupta, Samantha Langer, Micheal Siciliano, Margaret Nieborowska-Skorska, Huaqing Zhao, Peter Valent, Tomasz Skorski

Blood (2017) 130 (Supplement 1): 4623.

https://doi.org/10.1182/blood.V130.Suppl_1.4623.4623

Published: 2017

Journal Articles

IGH/MYC Translocation in Burkitt Lymphoma Is Associated with BRCA2 Deficiency and Synthetic Lethality By PARP1 Inhibitors

Silvia Maifrede, Kayla Martin, Paulina Podszywalow-Bartnicka, PhD, Sullivan Katherine, Samantha Langer, Reza Nejati, Yashodhara Dasgupta, Daniel Gritsyuk, Margaret Nieborowska-Skorska, Lena Lupey, Katarzyna Piwocka, Mariusz A Wasik, MD, Italo Tempera, Tomasz Skorski

Blood (2016) 128 (22): 4111.

https://doi.org/10.1182/blood.V128.22.4111.4111

Published: 2016

Journal Articles

Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases

Yashodhara Dasgupta, Mateusz Koptyra, Grazyna Hoser, Kanchan Kantekure, Darshan Roy, Barbara Gornicka, Margaret Nieborowska-Skorska, Elisabeth Bolton-Gillespie, Sabine Cerny-Reiterer, Markus Müschen, Peter Valent, Mariusz A. Wasik, Christine Richardson, Oliver Hantschel, Heiko van der Kuip, Tomasz Stoklosa, Tomasz Skorski

Blood (2016) 127 (17): 2131–2143.

https://doi.org/10.1182/blood-2015-11-681171

Published: 2016

Includes: Supplemental data

Journal Articles

Targeting of Quiescent and Proliferating CML Stem Cells By DNA Repair Inhibitors

Katherine Sullivan, Elisabeth Bolton-Gillespie, Margaret Nieborowska-Skorska, Sabine Cerny-Reiterer, DVM, Peter Valent, MD, Markus Muschen, MDPhD, Richard Pomerantz, Alexander Mazin, Tomasz Skorski

Blood (2015) 126 (23): 50.

https://doi.org/10.1182/blood.V126.23.50.50

Published: 2015

Journal Articles

Identification of a Small Molecule Inhibitor of RAD52 to Induce Synthetic Lethality in BRCA-Deficient Leukemias

Katherine Sullivan, Kimberly Cramer-Morales, Daniel L McElroy, David Ostrov, Kimberly Haas, Margaret Nieborowska-Skorska, Wayne Childers, Alexander Mazin, Robert A Hromas, Richard Pomerantz, Tomasz Skorski

Blood (2015) 126 (23): 4434.

https://doi.org/10.1182/blood.V126.23.4434.4434

Published: 2015

Journal Articles

Downregulation of BRCA1 Protein in BCR-ABL1–positive Cells Depends on Tiar-Mediated Repression of BRCA1 mRNA Translation

Paulina Podszywalow-Bartnicka, PhD, Magdalena Wolczyk, MSc, Monika Kusio-Kobialka, PhD, Kamila Wolanin, PhD, Krzysztof Skowronek, PhD, Margaret Nieborowska-Skorska, MD PhD, Yashodhara Dasgupta, PhD, Tomasz Skorski, MD PhD, Katarzyna Piwocka, PhD

Blood (2014) 124 (21): 3129.

https://doi.org/10.1182/blood.V124.21.3129.3129

Published: 2014

Journal Articles

Chronic Myeloid Leukemia Stem Cells (LSCs) and Leukemia Progenitor Cells (LPCs) Display Overlapping and Unique Mechanisms of Genomic Instability: The Role of PI3k-AKT and PI3k-Rac2-PAK Pathways

Margaret Nieborowska-Skorska, MD PhD, Sylwia Flis, PhD, Tomasz Skorski, MD PhD

Blood (2014) 124 (21): 1791.

https://doi.org/10.1182/blood.V124.21.1791.1791

Published: 2014

NARROW

Inactivation of DNA Polymerase Theta (PolΘ) Is Synthetic Lethal in DNMT3A Mutated Myeloid Malignancies - Potential Clinical Applications

Poly(ADP-Ribose) Glycohydrolase (PARG) Removes Repressive Poly-ADP Ribose Marks from DNA Polymerase Theta (PolΘ) to Stimulate DNA Double-Strand Breaks Repair in Myeloid Malignancies

Clonal Medicine Targeting DNA Damage Response Eradicates AML

Clonal Targeting of DNA Damage Response Pathways Eradicates Myeloproliferative Neoplasms

DNA polymerase θ protects leukemia cells from metabolically induced DNA damage

DNA Polymerase Theta Protects Leukemia Cells from Metabolic-Induced DNA Damage

TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

PARP1 Inhibitors Eliminated Imatinib-Refractory Chronic Myeloid Leukemia Cells in Bone Marrow Microenvironment Conditions

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms

Drugging DNA Repair to Target T-ALL Cells

Ruxolitinib-Induced Defects in DNA Repair Cause Sensitivity to PARP Inhibitors in Myeloproliferative Neoplasms

Tyrosine Kinase Inhibitor-Induced Defects in DNA Repair Sensitize FLT3(ITD)-Positive Acute Myeloid Leukemia Quiescent and Proliferative Cells to PARP Inhibitors

Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Leukemia Cells

IGH/MYC Translocation in Burkitt Lymphoma Is Associated with BRCA2 Deficiency and Synthetic Lethality By PARP1 Inhibitors

Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases

Targeting of Quiescent and Proliferating CML Stem Cells By DNA Repair Inhibitors

Identification of a Small Molecule Inhibitor of RAD52 to Induce Synthetic Lethality in BRCA-Deficient Leukemias

Downregulation of BRCA1 Protein in BCR-ABL1–positive Cells Depends on Tiar-Mediated Repression of BRCA1 mRNA Translation

Chronic Myeloid Leukemia Stem Cells (LSCs) and Leukemia Progenitor Cells (LPCs) Display Overlapping and Unique Mechanisms of Genomic Instability: The Role of PI3k-AKT and PI3k-Rac2-PAK Pathways

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American Society of Hematology

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ASH Publications

American Society of Hematology

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