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Journal Articles

Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2 -V617F–positive myeloproliferative neoplasms

Marc Usart, Jan Stetka, Damien Luque Paz, Nils Hansen, Quentin Kimmerlin, Tiago Almeida Fonseca, Melissa Lock, Lucia Kubovcakova, Riikka Karjalainen, Hui Hao-Shen, Anastasiya Börsch, Athimed El Taher, Jessica Schulz, Jean-Christophe Leroux, Stefan Dirnhofer, Radek C. Skoda

Blood (2024) 143 (24): 2490–2503.

https://doi.org/10.1182/blood.2023020270

Published: 2024

Includes: Supplemental data

Journal Articles

Iron is a modifier of the phenotypes of JAK2 -mutant myeloproliferative neoplasms

Blood (2023) 141 (17): 2127–2140.

https://doi.org/10.1182/blood.2022017976

Published: 2023

Includes: Supplemental data

Journal Articles

JAK2 -V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality

Tata Nageswara Rao, Nils Hansen, Jan Stetka, Damien Luque Paz, Milena Kalmer, Julian Hilfiker, Max Endele, Nouraiz Ahmed, Lucia Kubovcakova, Margareta Rybarikova, Hui Hao-Shen, Florian Geier, Christian Beisel, Stefan Dirnhofer, Timm Schroeder, Tim H. Brümmendorf, Dominik Wolf, Steffen Koschmieder, Radek C. Skoda

Blood (2021) 137 (16): 2139–2151.

https://doi.org/10.1182/blood.2020005563

Published: 2021

Includes: Supplemental data

Journal Articles

Loss of Dnmt3a Confers Resistance to Pegifnα in JAK2 -V617F Mouse Model

Jan Stetka, Nils Hansen, Lucia Kubovcakova, Hui Hao-Shen, Stefan Dirnhofer, Radek C. Skoda

Blood (2020) 136 (Supplement 1): 8–9.

https://doi.org/10.1182/blood-2020-140548

Published: 2020

Journal Articles

Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms

Blood (2018) 132 (Supplement 1): 3842.

https://doi.org/10.1182/blood-2018-99-116015

Published: 2018

Journal Articles

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms

Blood (2017) 130 (26): 2848–2859.

https://doi.org/10.1182/blood-2017-05-784942

Published: 2017

Includes: Supplemental data

Journal Articles

Ruxolitinib-Induced Defects in DNA Repair Cause Sensitivity to PARP Inhibitors in Myeloproliferative Neoplasms

Margaret Nieborowska-Skorska, Silvia Maifrede, Yashodhara Dasgupta, Katherine Sullivan, Bac Viet Le, Martyna Solecka, Lucia Kubovcakova, Morgan Nawrocki, Martin Kirschner, MD, Huaqing Zhao, Josef T. Prchal, MD, Katarzyna Piwocka, Alison R. Moliterno, MD, Steffen Koschmieder, Anthony R Green, PhD FRCP, FRCPath, FMedSci, Radek C. Skoda, MD, Tomasz Skorski

Blood (2017) 130 (Supplement 1): 2938.

https://doi.org/10.1182/blood.V130.Suppl_1.2938.2938

Published: 2017

Journal Articles

JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis

Jean Grisouard, Sai Li, Lucia Kubovcakova, Tata Nageswara Rao, Sara C. Meyer, Pontus Lundberg, Hui Hao-Shen, Vincent Romanet, Masato Murakami, Thomas Radimerski, Stephan Dirnhofer, Radek C. Skoda

Blood (2016) 128 (6): 839–851.

https://doi.org/10.1182/blood-2015-12-689216

Published: 2016

Includes: Supplemental data

Journal Articles

Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2 -V617F mouse model of MPN

Jean Grisouard, Takafumi Shimizu, Adrian Duek, Lucia Kubovcakova, Hui Hao-Shen, Stephan Dirnhofer, Radek C. Skoda

Blood (2015) 125 (13): 2131–2140.

https://doi.org/10.1182/blood-2014-08-594572

Published: 2015

Includes: Supplemental data

Journal Articles

JAK2V617F and Loss of Ezh2 in Hematopoietic Cells Contribute Synergistically to Myeloproliferative Neoplasm Initiation Potential, and Accelerate Progression of Disease

Takafumi Shimizu, PhD, Hui Hao-Shen, Lucia Kubovcakova, PhD, Pontus Lundberg, PhD, Stephan Dirnhofer, Stuart H. Orkin, MD, Jean Grisouard, PhD, Yukiko Shimizu, Annalisa Pianta, PhD, Barbara Szczerba, Ronny Nienhold, Radek C. Skoda, MD

Blood (2014) 124 (21): 158.

https://doi.org/10.1182/blood.V124.21.158.158

Published: 2014

Journal Articles

Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2 -V617F–driven mouse model of MPNs

Adrian Duek, Pontus Lundberg, Takafumi Shimizu, Jean Grisouard, Axel Karow, Lucia Kubovcakova, Hui Hao-Shen, Stephan Dirnhofer, Radek C. Skoda

Blood (2014) 123 (25): 3943–3950.

https://doi.org/10.1182/blood-2013-07-514208

Published: 2014

Journal Articles

Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2 -V617F polycythemia vera mouse model

Lucia Kubovcakova, Pontus Lundberg, Jean Grisouard, Hui Hao-Shen, Vincent Romanet, Rita Andraos, Masato Murakami, Stephan Dirnhofer, Kay-Uwe Wagner, Thomas Radimerski, Radek C. Skoda

Blood (2013) 121 (7): 1188–1199.

https://doi.org/10.1182/blood-2012-03-415646

Published: 2013

Includes: Supplemental data

Journal Articles

JAK2-V617F Expressing Stem Cells Display a Competitive Advantage At Low Limiting Dilution and Are Capable of Initiating MPN Phenotype

Pontus Lundberg, PhD, Lucia Kubovcakova, PhD, Hitoshi Takizawa, PhD, Hui Hao-Shen, Markus G Manz, MD, Radek C. Skoda, MD

Blood (2011) 118 (21): 615.

https://doi.org/10.1182/blood.V118.21.615.615

Published: 2011

NARROW

Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2 -V617F–positive myeloproliferative neoplasms

Iron is a modifier of the phenotypes of JAK2 -mutant myeloproliferative neoplasms

JAK2 -V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality

Loss of Dnmt3a Confers Resistance to Pegifnα in JAK2 -V617F Mouse Model

Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms

Ruxolitinib-Induced Defects in DNA Repair Cause Sensitivity to PARP Inhibitors in Myeloproliferative Neoplasms

JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis

Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2 -V617F mouse model of MPN

JAK2V617F and Loss of Ezh2 in Hematopoietic Cells Contribute Synergistically to Myeloproliferative Neoplasm Initiation Potential, and Accelerate Progression of Disease

Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2 -V617F–driven mouse model of MPNs

Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2 -V617F polycythemia vera mouse model

JAK2-V617F Expressing Stem Cells Display a Competitive Advantage At Low Limiting Dilution and Are Capable of Initiating MPN Phenotype

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American Society of Hematology

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ASH Publications

American Society of Hematology

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