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Marc Usart
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Journal Articles

Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2 -V617F–positive myeloproliferative neoplasms

Marc Usart, Jan Stetka, Damien Luque Paz, Nils Hansen, Quentin Kimmerlin, Tiago Almeida Fonseca, Melissa Lock, Lucia Kubovcakova, Riikka Karjalainen, Hui Hao-Shen, Anastasiya Börsch, Athimed El Taher, Jessica Schulz, Jean-Christophe Leroux, Stefan Dirnhofer, Radek C. Skoda
Journal: Blood
Blood (2024) 143 (24): 2490–2503.
https://doi.org/10.1182/blood.2023020270
Published: 2024
Includes: Supplemental data
Journal Articles

Cellular Barcoding of JAK2 -V617F Hematopoietic Stem Cells Reveals No Substantial Preferences in the Contribution of Individual Stem Cell Clones to Erythroid Versus Megakaryocytic Lineages

Marc Usart, Tiago Almeida, Julien Roux, Athimed El Taher, Riikka Karjalainen, Quentin Kimmerlin, Shivam Rai, Hui Hao-Shen, Radek C. Skoda
Journal: Blood
Blood (2023) 142 (Supplement 1): 859.
https://doi.org/10.1182/blood-2023-181695
Published: 2023
Journal Articles

Iron is a modifier of the phenotypes of JAK2 -mutant myeloproliferative neoplasms

Jan Stetka, Marc Usart, Lucia Kubovcakova, Shivam Rai, Tata Nageswara Rao, Joshua Sutter, Hui Hao-Shen, Stefan Dirnhofer, Florian Geier, Michael S. Bader, Jakob R. Passweg, Vania Manolova, Franz Dürrenberger, Nouraiz Ahmed, Timm Schroeder, Tomas Ganz, Elizabeta Nemeth, Laura Silvestri, Antonella Nai, Clara Camaschella, Radek C. Skoda
Journal: Blood
Blood (2023) 141 (17): 2127–2140.
https://doi.org/10.1182/blood.2022017976
Published: 2023
Includes: Supplemental data
Journal Articles

The Second Generation Type II JAK2 Inhibitor, AJ1-10502, Demonstrates Enhanced Selectivity, Improved Therapeutic Efficacy and Reduced Mutant Cell Fraction Compared to Type I JAK2 Inhibitors in Models of Myeloproliferative Neoplasms (MPNs)

Shivam Rai, Jan Stetka, MARC Usart, Hui Hao-Shen, Young Park, Remie Houston, Anthony R. Martinez Benitez, Matthew Wereski, Emily Guzzardi, Sonali Persaud, Hailey Ramzan, Alan Futran, Charley Xu, Jeremy Greenwood, Sayan Mondal, Craig Masse, Ross L. Levine, Radek C. Skoda, Andrew Dunbar
Journal: Blood
Blood (2022) 140 (Supplement 1): 6722–6723.
https://doi.org/10.1182/blood-2022-162621
Published: 2022
Journal Articles

Combination of 5-Azacytidine and Pegifna Is Able to Overcome Resistance in JAK2 -V617F Positive MPN with Loss of Dnmt3a

Melissa Lock, Damien Luque Paz, Nils Hansen, Tiago Almeida Fonseca, MARC Usart, Shivam Rai, Hui Hao-Shen, Gabriele Mild, Stephan Dirnhofer, Radek C. Skoda, Jan Stetka
Journal: Blood
Blood (2022) 140 (Supplement 1): 3876–3877.
https://doi.org/10.1182/blood-2022-167002
Published: 2022
Journal Articles

Disrupting the Socs2 -Mediated Negative Feedback to JAK-STAT Signaling Boosts Molecular Responses Induced By Interferon-α in a Mouse Model of Myeloproliferative Neoplasms

Marc Usart, Cédric B. Stoll, Riikka Karjalainen, Hui Hao-Shen, Radek C. Skoda
Journal: Blood
Blood (2022) 140 (Supplement 1): 9580–9581.
https://doi.org/10.1182/blood-2022-169232
Published: 2022
Journal Articles

Exploring the Functional Role of an Alternative mRNA Transcript of the EPO Gene

Cédric B. Stoll, Marc Usart, Michal Remen, Jakub Zmajkovic, Radek C. Skoda
Journal: Blood
Blood (2022) 140 (Supplement 1): 2434–2435.
https://doi.org/10.1182/blood-2022-170133
Published: 2022
Journal Articles

Inhibiting Glutamine Metabolism with CB-839 Reduces Erythrocytosis in MPN Mice

MARC Usart, Shivam Rai, Nils Hansen, Alexandre Guy, Jan Stetka, Hui Hao-Shen, Tata Nageswara Rao, Radek C. Skoda
Journal: Blood
Blood (2021) 138 (Supplement 1): 3585.
https://doi.org/10.1182/blood-2021-150321
Published: 2021