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Journal Articles

Transcription Factor Redistributors Pharmacologically Actuate Non-Canonical Gene Networks to Drive AML Differentiation

Samuel Taylor, Jacob Stauber, Oliver Bohorquez, Emily Schwenger, Sriram Sundaravel, Abdelbasset Farahat, Boris Bartholdy, David Boykin, Gregory Poon, Ulrich Steidl

Blood (2023) 142 (Supplement 1): 119.

https://doi.org/10.1182/blood-2023-186698

Published: 2023

Journal Articles

Mechanisms of Cistromic Repositioning of the Transcription Factor PU.1

Samuel Taylor, Jacob Stauber, Oliver Bohorquez, Boris Bartholdy, Emily Schwenger, Abdelbasset A Farahat, Justin Wheat, David W Boykin, Gregory MK Poon, Ulrich G. Steidl

Blood (2022) 140 (Supplement 1): 3011.

https://doi.org/10.1182/blood-2022-160080

Published: 2022

Journal Articles

TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

Blood (2020) 136 (Supplement 1): 4.

https://doi.org/10.1182/blood-2020-137658

Published: 2020

Journal Articles

PU.1-Dependent Enhancer Decommissioning Drives Transformation of Tet2 deficient Hematopoietic Stem and Progenitor Cells

Maria M. Aivalioti, MS., Tushar D Bhagat, PhD, Aditi Paranjpe, MS., Boris Bartholdy, PhD, Kith Pradhan, PhD, Mario Pujato, PhD, Amit Verma, MBBS, Britta Will, PhD

Blood (2020) 136 (Supplement 1): 40.

https://doi.org/10.1182/blood-2020-142070

Published: 2020

Journal Articles

Therapeutic Targeting of the Ubiquitin Conjugating Enzyme UBE2N in Myeloid Malignancies

Blood (2018) 132 (Supplement 1): 4050.

https://doi.org/10.1182/blood-2018-99-115359

Published: 2018

Journal Articles

PI3Kinase Alpha and Delta Promote Hematopoietic Stem Activation Under Stress

Shayda Hemmati, PhD, Taneisha Sinclair, Meng Tong, Boris Bartholdy, PhD, Rachel Okabe, MD, Kristina Ames, PhD, Leanne Ostrodka, MD, Tamanna Haque, MD, Imit Kaur, PhD, Anupriya Agarwal, PhD, Jean Zhao, PhD, Thomas Roberts, PhD, Kira Gritsman, MD PhD

Blood (2018) 132 (Supplement 1): 329.

https://doi.org/10.1182/blood-2018-99-114891

Published: 2018

Journal Articles

Direct Pharmacological Inhibition of the Transcription Factor PU.1 in Acute Myeloid Leukemia

Blood (2017) 130 (Supplement 1): 858.

https://doi.org/10.1182/blood.V130.Suppl_1.858.858

Published: 2017

Journal Articles

Dual Inhibition of Mdmx and Mdm2 Using an Alpha-Helical P53 Stapled Peptide (ALRN-6924) As a Novel Therapeutic Strategy in Acute Myeloid Leukemia

Luis A. Carvajal, PhD, Daniela Ben-Neriah, B.S, Adrien Senecal, PhD, Lumie Bernard, M.S, Swathi-Rao Narayanagari, M.S, Charles Kenworthy, B.S, Victor Thiruthuvanathan, M.S, Vincent Guerlavais, PhD, D. Allen Annis, PhD, Boris Bartholdy, PhD, Britta Will, PhD, Jesus Anampa, MD, Ioannis Mantzaris, MD, Manuel A. Aivado, MD PhD, Robert H Singer, PhD, Robert Coleman, PhD, Amit Verma, MD, Ulrich G. Steidl, MDPhD

Blood (2017) 130 (Supplement 1): 795.

https://doi.org/10.1182/blood.V130.Suppl_1.795.795

Published: 2017

Journal Articles

An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL

Yun Mai, J. Jessica Yu, Boris Bartholdy, Zijun Y. Xu-Monette, Esther E. Knapp, Fei Yuan, Hongshan Chen, B. Belinda Ding, Zhihua Yao, Bhaskar Das, Yiyu Zou, Ken He Young, Samir Parekh, B. Hilda Ye

Blood (2016) 128 (24): 2797–2807.

https://doi.org/10.1182/blood-2016-03-705814

Published: 2016

Includes: Supplemental data

Journal Articles

Minimal Reduction of PU.1 Is Sufficient to Induce a Preleukemic State and Promote Development of Acute Myeloid Leukemia

Britta Will, PhD, Thomas O. Vogler, Swathi-rao Narayanagari, Boris Bartholdy, Tihomira I. Todorova, MSc, Jiahao Chen, Yiting Yu, Jillian Mayer, Mariana da Silva Ferreira, Laura Barreyro, PhD, Luis Carvajal, Michael Roth, MD, Johanna van Oers, Sonja Schaetzlein, Christine McMahon, MD, Winifried Edelmann, Amit Verma, MD, Ulrich Steidl, MDPhD

Blood (2015) 126 (23): 305.

https://doi.org/10.1182/blood.V126.23.305.305

Published: 2015

Journal Articles

New Allosteric Inhibitors of Mutant IDH1 in Acute Myeloid Leukemia

Blood (2015) 126 (23): 787.

https://doi.org/10.1182/blood.V126.23.787.787

Published: 2015

Journal Articles

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome

Ashley Pandolfi, Robert F. Stanley, Yiting Yu, Boris Bartholdy, Gopichand Pendurti, Kira Gritsman, Jacqueline Boultwood, Jonathan Chernoff, Amit Verma, Ulrich Steidl

Blood (2015) 126 (9): 1118–1127.

https://doi.org/10.1182/blood-2014-12-618801

Published: 2015

Includes: Supplemental data

Journal Articles

Molecular and Functional Characterization Of The Novel Protein-Coding Gene Tihl (Translocated in Hodgkin’s Lymphoma) in Hematopoiesis

Ujunwa Cynthia Okoye-Okafor, M.Sc., Laura Barreyro, M.Sc., Heng Rui Wang, M.Sc., Boris Bartholdy, Ph.D., Britta Will, PhD, Tihomira I Todorova, B.A., Swathi-Rao Narayanagari, M.Sc., Mario Pujato, M.Sc., Masahiro Kawahara, MD, PhD, Bruce W. Woolcock, MSc, Randy D. Gascoyne, MD, Christian Steidl, MD, Ulrich Steidl, MD PhD

Blood (2013) 122 (21): 3680.

https://doi.org/10.1182/blood.V122.21.3680.3680

Published: 2013

Journal Articles

H2.0-Like Homeobox (HLX) Causes Pre-Leukemic Myeloid Expansion and Initiates AML In Cooperation With FLT3-ITD

Ashley Pandolfi, M.Sc., Boris Bartholdy, Ph.D., Britta Will, PhD, Robert Stanley, Tihomira I Todorova, B.A., Christine McMahon, MD, Ulrich Steidl, MD PhD

Blood (2013) 122 (21): 4201.

https://doi.org/10.1182/blood.V122.21.4201.4201

Published: 2013

Journal Articles

Identification of a Novel Protein-Coding Gene ( TIHL) and Its Functional Relevance in Myeloid Cells.

Ujunwa Cynthia Okoye-Okafor, M.Sc., Boris Bartholdy, Ph.D., Bruce Woolcock, M.Sc., Masahiro Kawahara, MD, PhD, Tihomira I Todorova, B.A., Randy D. Gascoyne, MD, Christian Steidl, MD, Ulrich Steidl, MD, PhD

Blood (2012) 120 (21): 2333.

https://doi.org/10.1182/blood.V120.21.2333.2333

Published: 2012

Journal Articles

Parallel Transcriptional Analysis of Multiple Stem and Progenitor Populations Identifies Novel Commonly Dysregulated and Functionally Relevant Targets in AML

Blood (2012) 120 (21): 1875.

https://doi.org/10.1182/blood.V120.21.1875.1875

Published: 2012

Journal Articles

H2.0-Like Homeobox (HLX) Induces Unlimited Clonogenicity, Blocks Differentiation, and Cooperates with FLT3-ITD in the Induction of Acute Myeloid Leukemia

Ashley Pandolfi, M.Sc., Boris Bartholdy, Ph.D., Masahiro Kawahara, MD, Laura Barreyro, Britta Will, PhD, Robert Stanley, Roth Michael, MD, Ujunwa Cynthia Okoye-Okafor, M.Sc., Tihomira I Todorova, B.A., Maria E. Figueroa, MD, Ari Melnick, MD, Constantine S. Mitsiades, MD, PhD, Ulrich Steidl, MD, PhD

Blood (2012) 120 (21): 651.

https://doi.org/10.1182/blood.V120.21.651.651

Published: 2012

Journal Articles

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

Blood (2012) 120 (6): 1290–1298.

https://doi.org/10.1182/blood-2012-01-404699

Published: 2012

Includes: Supplemental data

Journal Articles

Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation

Michael Roth, Britta Will, Guillermo Simkin, Swathi Narayanagari, Laura Barreyro, Boris Bartholdy, Roni Tamari, Constantine S. Mitsiades, Amit Verma, Ulrich Steidl

Blood (2012) 120 (2): 386–394.

https://doi.org/10.1182/blood-2011-12-399667

Published: 2012

Includes: Supplemental data

Journal Articles

PU.1 - c-Jun Interactions Are Crucial for PU.1 Function in Myeloid Development.

Boris Bartholdy, PhD, Yukiya Yamamoto, Erica Evans, PhD, John Crispino, PhD, Daniel G. Tenen, MD

Blood (2009) 114 (22): 3651.

https://doi.org/10.1182/blood.V114.22.3651.3651

Published: 2009

NARROW

Transcription Factor Redistributors Pharmacologically Actuate Non-Canonical Gene Networks to Drive AML Differentiation

Mechanisms of Cistromic Repositioning of the Transcription Factor PU.1

TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

PU.1-Dependent Enhancer Decommissioning Drives Transformation of Tet2 deficient Hematopoietic Stem and Progenitor Cells

Therapeutic Targeting of the Ubiquitin Conjugating Enzyme UBE2N in Myeloid Malignancies

PI3Kinase Alpha and Delta Promote Hematopoietic Stem Activation Under Stress

Direct Pharmacological Inhibition of the Transcription Factor PU.1 in Acute Myeloid Leukemia

Dual Inhibition of Mdmx and Mdm2 Using an Alpha-Helical P53 Stapled Peptide (ALRN-6924) As a Novel Therapeutic Strategy in Acute Myeloid Leukemia

An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL

Minimal Reduction of PU.1 Is Sufficient to Induce a Preleukemic State and Promote Development of Acute Myeloid Leukemia

New Allosteric Inhibitors of Mutant IDH1 in Acute Myeloid Leukemia

PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome

Molecular and Functional Characterization Of The Novel Protein-Coding Gene Tihl (Translocated in Hodgkin’s Lymphoma) in Hematopoiesis

H2.0-Like Homeobox (HLX) Causes Pre-Leukemic Myeloid Expansion and Initiates AML In Cooperation With FLT3-ITD

Identification of a Novel Protein-Coding Gene ( TIHL) and Its Functional Relevance in Myeloid Cells.

Parallel Transcriptional Analysis of Multiple Stem and Progenitor Populations Identifies Novel Commonly Dysregulated and Functionally Relevant Targets in AML

H2.0-Like Homeobox (HLX) Induces Unlimited Clonogenicity, Blocks Differentiation, and Cooperates with FLT3-ITD in the Induction of Acute Myeloid Leukemia

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation

PU.1 - c-Jun Interactions Are Crucial for PU.1 Function in Myeloid Development.

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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