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Richard Pomerantz
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Journal Articles

Inactivation of DNA Polymerase Theta (PolΘ) Is Synthetic Lethal in DNMT3A Mutated Myeloid Malignancies - Potential Clinical Applications

Bac Viet Le, Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Marie-Christine Caron, George Vassiliou, Malgorzata Gozdecka, Zayd Haydar, Gurushankar Chandramouly, Emir Hadzijusufovic, Wolfgang R. Sperr, Richard Pomerantz, Peter Valent, Jean-Yves Masson, Gaorav Gupta, Grant A Challen, Tomasz Skorski
Journal: Blood
Blood (2023) 142 (Supplement 1): 580.
https://doi.org/10.1182/blood-2023-174333
Published: 2023
Journal Articles

Poly(ADP-Ribose) Glycohydrolase (PARG) Removes Repressive Poly-ADP Ribose Marks from DNA Polymerase Theta (PolΘ) to Stimulate DNA Double-Strand Breaks Repair in Myeloid Malignancies

Umeshkumar Vekariya, Leonid Minakhin, Mrityunjay Tyagi, Tatiana Kent, Gurushankar Chandramouly, Katherine Sullivan-Reed, Jessica Atkins, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Richard Pomerantz, Tomasz Skorski
Journal: Blood
Blood (2023) 142 (Supplement 1): 5693.
https://doi.org/10.1182/blood-2023-174330
Published: 2023
Journal Articles

DNA Polymerase Theta Protects Leukemia Cells from Metabolic-Induced DNA Damage

Umeshkumar M Vekariya, Katherine Sullivan-Reed, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Paulina Podszywalow-Bartnicka, Kumaraswamy Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Maslawska-Wasowska, Reza Nejati, Mariusz A Wasik, Stephen M. Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth Paietta, Ross L. Levine, Martin S. Tallman, Hugo F Fernandez, Mark R. Litzow, Gaorav P Gupta, Jean-Yves Masson, Tomasz Skorski
Journal: Blood
Blood (2022) 140 (Supplement 1): 2972–2974.
https://doi.org/10.1182/blood-2022-156458
Published: 2022
Journal Articles

Identification of a Novel Nucleoside Prodrug with Preferential Activity in Lymphoma and Leukemia Subtypes

Marissa L Calbert, Gurushankar Chandramouly, Tatiana Kent, Clare M Adams, Mrityunjay Tyagi, Yifan Wang, John Krais, Hoora Shaghaghi, Jessica Atkins, Tomasz Skorski, Neil Johnson, Christine M Eischen, Richard Pomerantz
Journal: Blood
Blood (2022) 140 (Supplement 1): 10701.
https://doi.org/10.1182/blood-2022-165514
Published: 2022
Journal Articles

Targeting of Quiescent and Proliferating CML Stem Cells By DNA Repair Inhibitors

Katherine Sullivan, Elisabeth Bolton-Gillespie, Margaret Nieborowska-Skorska, Sabine Cerny-Reiterer, DVM, Peter Valent, MD, Markus Muschen, MDPhD, Richard Pomerantz, Alexander Mazin, Tomasz Skorski
Journal: Blood
Blood (2015) 126 (23): 50.
https://doi.org/10.1182/blood.V126.23.50.50
Published: 2015
Journal Articles

Identification of a Small Molecule Inhibitor of RAD52 to Induce Synthetic Lethality in BRCA-Deficient Leukemias

Katherine Sullivan, Kimberly Cramer-Morales, Daniel L McElroy, David Ostrov, Kimberly Haas, Margaret Nieborowska-Skorska, Wayne Childers, Alexander Mazin, Robert A Hromas, Richard Pomerantz, Tomasz Skorski
Journal: Blood
Blood (2015) 126 (23): 4434.
https://doi.org/10.1182/blood.V126.23.4434.4434
Published: 2015