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Journal Articles

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

Blood (2024) 143 (21): 2201–2216.

https://doi.org/10.1182/blood.2023023549

Published: 2024

Includes: Supplemental data

Journal Articles

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

Blood (2023) 142 (24): 2079–2091.

https://doi.org/10.1182/blood.2023020331

Published: 2023

Includes: Supplemental data

Journal Articles

Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors

Catherine Rhee, Elizabeth W. Scadden, Lai Ping Wong, Giulia Schiroli, Michael C. Mazzola, Phillip L. Chea, Hiroki Kato, Friedrich F. Hoyer, Meeta Mistry, Bum-Kyu Lee, Jonghwan Kim, Matthias Nahrendorf, Michael K. Mansour, David B. Sykes, Ruslan I. Sadreyev, David T. Scadden

Blood (2023) 142 (7): 658–674.

https://doi.org/10.1182/blood.2023020257

Published: 2023

Includes: Supplemental data

Journal Articles

Cap-Independent Protein Translation in Hematopoiesis

Michael Mazzola, Ting Zhao, Karin Gustafsson, Trine Kristiansen, Giulia Schiroli, Jelena Milosevic, Youmna Kfoury, Tsuyoshi Fukushima, Anna Kiem, Azeem Sharda, Hiroki Kato, David Sykes, Pavel Ivanov, Vijay G. Sankaran, David T. Scadden

Blood (2022) 140 (Supplement 1): 1983–1984.

https://doi.org/10.1182/blood-2022-170506

Published: 2022

Journal Articles

Human NGFR+/VCAM-1+/Mcam+ Bone Marrow-Derived Stromal Cells (NVML) Provide Enhanced Support for Normal Hematopoiesis and Are Disrupted in Myelodysplastic Syndrome

Yuko Kawano, Hiroki Kawano, Daniel K. Byun, Dalia Ghoneim, Thomas J Fountaine, Mark W. LaMere, John M. Ashton, Mitra Azadniv, Jane L. Liesveld, Youmna Kfoury, David T. Scadden, Michael W. Becker, Laura M. Calvi

Blood (2022) 140 (Supplement 1): 5772–5773.

https://doi.org/10.1182/blood-2022-170070

Published: 2022

Journal Articles

The Thymus Is Critical for Adult Immune Function

Kameron Kooshesh, Karin Gustafsson, Brody Foy, David Sykes, David T. Scadden

Blood (2022) 140 (Supplement 1): 1648–1649.

https://doi.org/10.1182/blood-2022-170925

Published: 2022

Journal Articles

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth

Cheuk Him Man, Francois E. Mercier, Nian Liu, Wentao Dong, Gregory Stephanopoulos, Li Jiang, Yookyung Jung, Charles P. Lin, Anskar Y. H. Leung, David T. Scadden

Blood (2022) 139 (4): 502–522.

https://doi.org/10.1182/blood.2021011563

Published: 2022

Includes: Supplemental data

Journal Articles

Inhibition of S-Adenosylmethionine Synthesis Promotes Erythropoiesis Via Epigenetic Modifications

Hiroki Kato, Nguyen Chi Long, Yusho Ishii, Mitsuyo Matsumoto, Catherine Rhee, Daisuke Saigusa, Ryo Funayama, Hiroaki Okae, Tohru Fujiwara, Akihiko Muto, Hideo Harigae, David T. Scadden, Kazuhiko Igarashi

Blood (2021) 138 (Supplement 1): 1991.

https://doi.org/10.1182/blood-2021-147065

Published: 2021

Journal Articles

Myeloid-Biased HSC Require Semaphorin4a from the Bone Marrow Niche for Self-Renewal Under Stress and Life-Long Persistence

Blood (2021) 138 (Supplement 1): 3283.

https://doi.org/10.1182/blood-2021-153831

Published: 2021

Journal Articles

Spatial Transcriptomics Reveals DPP4 As Novel Marker of a More Proliferative Phenotype in Early AML Progression

Christa Haase, Karin Gustafsson, Shenglin Mei, Jelena Milosevic, Shu-Chi Yeh, David Sykes, Peter Kharchenko, David T. Scadden, Charles Lin

Blood (2021) 138 (Supplement 1): 3310.

https://doi.org/10.1182/blood-2021-151917

Published: 2021

Journal Articles

Rigidity of Cell Fate and Function Among Monocytes

Catherine Rhee, Elizabeth W Scadden, Lai Ping Wong, Giulia Schiroli, Michael Mazzola, Phillip Chea, Hiroki Kato, Friedrich F Hoyer, Meeta Mistry, Bum-Kyu Lee, Jonghwan Kim, Matthias Nahrendorf, Michael K Mansour, David Sykes, Ruslan I Sadreyev, David T. Scadden

Blood (2021) 138 (Supplement 1): 2057.

https://doi.org/10.1182/blood-2021-151110

Published: 2021

Journal Articles

Progression signature underlies clonal evolution and dissemination of multiple myeloma

Yu Jia Shen, Yuji Mishima, Jiantao Shi, Romanos Sklavenitis-Pistofidis, Robert A. Redd, Michele Moschetta, Salomon Manier, Aldo M. Roccaro, Antonio Sacco, Yu-Tzu Tai, Francois Mercier, Yawara Kawano, Nang Kham Su, Brianna Berrios, John G. Doench, David E. Root, Franziska Michor, David T. Scadden, Irene M. Ghobrial

Blood (2021) 137 (17): 2360–2372.

https://doi.org/10.1182/blood.2020005885

Published: 2021

Includes: Supplemental data

Journal Articles

Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations

Konstantinos D. Kokkaliaris, Leo Kunz, Nina Cabezas-Wallscheid, Constantina Christodoulou, Simon Renders, Fernando Camargo, Andreas Trumpp, David T. Scadden, Timm Schroeder

Blood (2020) 136 (20): 2296–2307.

https://doi.org/10.1182/blood.2020006574

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Reversing Clonal Hematopoiesis and Associated Atherosclerotic Disease By Targeted Antibody-Drug-Conjugate (ADC) Conditioning and Transplant

Karin Gustafsson, PhD, Catherine S Rhee, PhD, Elizabeth W Scadden, Vanessa Frodermann, Rahul Palchaudhuri, PhD, Sharon L. Hyzy, MS, Jennifer L Proctor, BS, Geoff O Gillard, PhD, Anthony E Boitano, PhD, Michael P. Cooke, PhD, Matthias Nahrendorf, PhD, David T. Scadden, MD

Blood (2020) 136 (Supplement 1): 34–35.

https://doi.org/10.1182/blood-2020-143176

Published: 2020

Journal Articles

Mgta-145, in Combination with Plerixafor in a Phase 1 Clinical Trial, Mobilizes Large Numbers of Human Hematopoietic Stem Cells and a Graft with Immunosuppressive Effects for Allogeneic Transplant

Kevin A. Goncalves, PhD, Sharon L. Hyzy, MS, Katelyn J. Hammond, BS, Patrick C. Falahee, PhD, Haley Howell, BS, BA, Jan Pinkas, PhD, Veit Schmelmer, PhD, Jonathan G. Hoggatt, PhD, David T. Scadden, MD, Steven M Devine, MD, John F. DiPersio, MD PhD, Will J. Savage, MDPhD, John C. Davis, Jr., MD MPH, MS

Blood (2020) 136 (Supplement 1): 31–32.

https://doi.org/10.1182/blood-2020-142804

Published: 2020

Journal Articles

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

Blood (2020) 136 (11): 1303–1316.

https://doi.org/10.1182/blood.2019001808

Published: 2020

Includes: Supplemental data

Journal Articles

Functionally Distinct Subsets of Monocytes in Mouse and Human Blood

Catherine S Rhee, PhD, Elizabeth W Scadden, Chea L Phillip, Bum-Kyu Lee, PhD, Meeta Mistry, Friedrich F Hoyer, MD, Hiroki Kato, MD PhD, Giovanna Mantica, Jonghwan Kim, PhD, Matthias Nahrendorf, PhD, Michael K Mansour, MD PhD, David B Sykes, MD PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 438.

https://doi.org/10.1182/blood-2019-124054

Published: 2019

Journal Articles

Thymus Regeneration Is Dependent on Distinct Mesenchymal Stromal Cell Populations

Karin Gustafsson, PhD, Nikolas Barkas, PhD, Ninib Baryawno, PhD, Elizabeth W Scadden, Nicolas Severe, PhD, Joel A Spencer, PhD, Hayalneh Gessessew, Kameron Kooshesh, Jimin Guo, PhD, Charles Lin, PhD, Peter Kharchenko, PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 586.

https://doi.org/10.1182/blood-2019-126708

Published: 2019

Journal Articles

A Specific Mesenchymal Stem and Progenitor Cell (MSPC) Subpopulation with a Multi-Potent Gene Signature Is Transcriptionally Altered in the Setting of Myelodysplastic Syndrome (MDS) in Primary Human Bone Marrow Aspirates

Thomas J Fountaine, MD, Mark W LaMere, BA, Daniel K Byun, BS, Jason R Myers, MS, John M Ashton, PhD, Jane L. Liesveld, MD, Youmna Kfoury, PhD, David T. Scadden, MD, Michael W. Becker, MD, Laura M. Calvi, MD

Blood (2019) 134 (Supplement_1): 1708.

https://doi.org/10.1182/blood-2019-130227

Published: 2019

Journal Articles

Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to Stress

Youmna Kfoury, PhD, Fei Ji, Michael Mazzola, BS, David B Sykes, MD PhD, Anselmo Anthony, Yasutoshi Akiyama, Allison Scherer, PhD, Francois Mercier, MD FRCPC, Nicolas Severe, PhD, Borja Saez, Jefferson Seidl, BA, Ani Papazian, BS, Thomas Brouse, Michael K Mansour, MD PhD, Pavel Ivanov, Ruslan I Sadreyev, PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 1207.

https://doi.org/10.1182/blood-2019-124794

Published: 2019

NARROW

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors

Cap-Independent Protein Translation in Hematopoiesis

Human NGFR+/VCAM-1+/Mcam+ Bone Marrow-Derived Stromal Cells (NVML) Provide Enhanced Support for Normal Hematopoiesis and Are Disrupted in Myelodysplastic Syndrome

The Thymus Is Critical for Adult Immune Function

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth

Inhibition of S-Adenosylmethionine Synthesis Promotes Erythropoiesis Via Epigenetic Modifications

Myeloid-Biased HSC Require Semaphorin4a from the Bone Marrow Niche for Self-Renewal Under Stress and Life-Long Persistence

Spatial Transcriptomics Reveals DPP4 As Novel Marker of a More Proliferative Phenotype in Early AML Progression

Rigidity of Cell Fate and Function Among Monocytes

Progression signature underlies clonal evolution and dissemination of multiple myeloma

Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations

Reversing Clonal Hematopoiesis and Associated Atherosclerotic Disease By Targeted Antibody-Drug-Conjugate (ADC) Conditioning and Transplant

Mgta-145, in Combination with Plerixafor in a Phase 1 Clinical Trial, Mobilizes Large Numbers of Human Hematopoietic Stem Cells and a Graft with Immunosuppressive Effects for Allogeneic Transplant

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

Functionally Distinct Subsets of Monocytes in Mouse and Human Blood

Thymus Regeneration Is Dependent on Distinct Mesenchymal Stromal Cell Populations

A Specific Mesenchymal Stem and Progenitor Cell (MSPC) Subpopulation with a Multi-Potent Gene Signature Is Transcriptionally Altered in the Setting of Myelodysplastic Syndrome (MDS) in Primary Human Bone Marrow Aspirates

Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to Stress

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American Society of Hematology

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American Society of Hematology

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