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Journal Articles

Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML

Cheuk-Him Man, Wing Lam, Chee-Chean Dang, Xiao-yuan Zeng, Li-Chuan Zheng, Natalie Nok-Man Chan, Ka-Lam Ng, Koon-Chuen Chan, Tsz-Ho Kwok, Timothy Chi-Chun Ng, Wing-Yan Leung, Michael Shing-Yan Huen, Carmen Chak-Lui Wong, Chi Wai Eric So, Zhixun Dou, Susumu Goyama, Mark Robert Bray, Tak Wah Mak, Anskar Yu-Hung Leung

Blood (2023) 142 (23): 2002–2015.

https://doi.org/10.1182/blood.2023019782

Published: 2023

Journal Articles

Homoharringtonine Overcomes Drug Resistance and Synergises with Venetoclax in Acute Myeloid Leukemia Via Inhibiting Protein Synthesis

Tsz Ho Kwok, Kelvin King Wai Wong, Wing Lam, Chee Chean Dang, Xiaoyuan Zeng, Wing Yan Leung, Timothy Chi Chun Ng, Anskar Leung, Cheuk Him Man

Blood (2022) 140 (Supplement 1): 11540.

https://doi.org/10.1182/blood-2022-168364

Published: 2022

Journal Articles

Inhibition of Polo-like Kinase 4 Induced Both Cell Intrinsic and Non-Cell Intrinsic Anti-Leukemia Effects on TP53 -Mutated Acute Myeloid Leukemia

Chee Chean Dang, Ka Lam Nelson Ng, Wing Lam, Xiao Yuan Zeng, Li Chuan Zheng, Koon Chuen Chan, Timothy Chi Chun Ng, Tsz Ho Kwok, Wing Yan Leung, Michael Shing Yan Huen, Carmen Chak Lui Wong, Zhi Xun Dou, Tak Wah Mak, Cheuk Him Man, Anskar Yu Hung Leung

Blood (2022) 140 (Supplement 1): 3099.

https://doi.org/10.1182/blood-2022-165205

Published: 2022

Journal Articles

Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness

Blood (2022) 140 (15): 1686–1701.

https://doi.org/10.1182/blood.2022016112

Published: 2022

Includes: Supplemental data

Journal Articles

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth

Cheuk Him Man, Francois E. Mercier, Nian Liu, Wentao Dong, Gregory Stephanopoulos, Li Jiang, Yookyung Jung, Charles P. Lin, Anskar Y. H. Leung, David T. Scadden

Blood (2022) 139 (4): 502–522.

https://doi.org/10.1182/blood.2021011563

Published: 2022

Includes: Supplemental data

Journal Articles

Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting

Cheuk-Him Man, David T. Scadden, MD, Francois Mercier, MD FRCPC, Nian Liu, Wentao Dong, Gregory Stephanopoulos, PhD, Li Jiang, PhD, Yookyung Jung, PhD, Charles Lin, PhD, Anskar Y.-H. Leung, MD PhD

Blood (2019) 134 (Supplement_1): 3765.

https://doi.org/10.1182/blood-2019-123604

Published: 2019

Journal Articles

A Genome-Wide, In Vivo, Dropout CRISPR Screen in Acute Myeloid Leukemia Identifies an Essential Role for Beta-Galactosylation in Leukemic Cell Homing

Francois Mercier, MD, Jiantao Shi, PhD, David B Sykes, MD PhD, Elizabeth Miller, Toshihiko Oki, MD PhD, Cheuk-Him Man, PhD, Xiao-Jing Yan, MD PhD, Youmna Kfoury, PhD, Dongjun Lee, PhD, John G Doench, PhD, Franziska Michor, PhD, David T. Scadden, MD

Blood (2017) 130 (Supplement 1): 2493.

https://doi.org/10.1182/blood.V130.Suppl_1.2493.2493

Published: 2017

Journal Articles

Whole Exome Sequencing of FLT3-ITD Sorafenib-Resistant Acute Myeloid Leukaemia

Stephen Sze Yuen Lam, Chae Yin Cher, Nelson K. L. Ng, Cheuk Him Man, PhD, Anskar Y.H. Leung, MD

Blood (2015) 126 (23): 1400.

https://doi.org/10.1182/blood.V126.23.1400.1400

Published: 2015

Journal Articles

Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia

Cheuk Him Man, Tsz Kan Fung, Haixia Wan, Chae Yin Cher, August Fan, Nelson Ng, Christa Ho, Thomas S. K. Wan, Toshiyuki Tanaka, Chi Wai Eric So, Yok Lam Kwong, Anskar Y. H. Leung

Blood (2015) 125 (25): 3928–3936.

https://doi.org/10.1182/blood-2014-06-580993

Published: 2015

Includes: Supplemental data

Journal Articles

Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish

Xiangguo Shi, Bai-Liang He, Alvin C. H. Ma, Yuhan Guo, Yali Chi, Cheuk Him Man, Wenqing Zhang, Yiyue Zhang, Zilong Wen, Tao Cheng, Anskar Y. H. Leung

Blood (2015) 125 (19): 2974–2984.

https://doi.org/10.1182/blood-2014-09-601187

Published: 2015

Includes: Supplemental data

Journal Articles

Development of a Clinically Relevant in Vitro Drug Screening Platform for Chemo-Refractory AML Patients

Stephen Sze Yuen Lam, Chae Yin Cher, Nelson Ka Lam Ng, Eric SK Ho, Cheuk Him Man, PhD, Howard CH Chow, Connie J Eaves, Alice MS Cheung, PhD, Anskar Y.H. Leung, MD

Blood (2014) 124 (21): 3624.

https://doi.org/10.1182/blood.V124.21.3624.3624

Published: 2014

Journal Articles

Bringing an Old Drug to a New Treatment Strategy in Treating FLT-ITD AML - Combination of Homoharringtonine and Sorafenib

Eric S.K. Ho, Stephen Sze Yuen Lam, Cheuk Him Man, PhD, Chae Yin Cher, Yok Lam Kwong, MD, Anskar Y.H. Leung, MD

Blood (2014) 124 (21): 3610.

https://doi.org/10.1182/blood.V124.21.3610.3610

Published: 2014

Journal Articles

Targeting Polo-like Kinase in Acute Myeloid Leukemia

Chae Yin Cher, Cheuk Him Man, Stephen S.Y. Lam, Eric S.K. Ho, Nelson K.L. Ng, Marie-Anne Hospital, Jerome Tamburini, Anskar Y.H. Leung, MD

Blood (2014) 124 (21): 2234.

https://doi.org/10.1182/blood.V124.21.2234.2234

Published: 2014

Journal Articles

Novel Therapeutic Strategy Targeting NHE1 and Its Upstream Activators in Acute Myeloid Leukemia

Cheuk-Him Man, PhD, Chae-Yin Cher, Stephen S.Y. Lam, Eric S.K. Ho, Nelson K.L. Ng, Anskar Y.H. Leung, MD

Blood (2014) 124 (21): 913.

https://doi.org/10.1182/blood.V124.21.913.913

Published: 2014

Journal Articles

A novel tescalcin-sodium/hydrogen exchange axis underlying sorafenib resistance in FLT3-ITD + AML

Cheuk Him Man, Stephen S. Y. Lam, Murphy K. H. Sun, Howard C. H. Chow, Harinder Gill, Yok Lam Kwong, Anskar Y. H. Leung

Blood (2014) 123 (16): 2530–2539.

https://doi.org/10.1182/blood-2013-07-512194

Published: 2014

Includes: Supplemental data

Journal Articles

Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

Bai-Liang He, Xiangguo Shi, Cheuk Him Man, Alvin C. H. Ma, Stephen C. Ekker, Howard C. H. Chow, Chi Wai Eric So, William W. L. Choi, Wenqing Zhang, Yiyue Zhang, Anskar Y. H. Leung

Blood (2014) 123 (16): 2518–2529.

https://doi.org/10.1182/blood-2013-02-486688

Published: 2014

Includes: Multimedia, Supplemental data

Journal Articles

A Novel Role Of Tescalcin-Sodium/Hydrogen Exchange Axis Underlying Sorafenib Resistance In FLT3-ITD + AML

Cheuk Him Man, Anskar Y.H. Leung, MD, Stephen Sze Yuen Lam, Murphy Ka Hei Sun, Howard Chun Hung Chow, Harinder Gill, MBBS, MRCP (UK), Yok Lam Kwong, MD

Blood (2013) 122 (21): 3848.

https://doi.org/10.1182/blood.V122.21.3848.3848

Published: 2013

Journal Articles

Acquired Fms-Like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3 ITD) During Leukaemic Transformation From Underlying Myelodysplasia: Successful Rescue with Sorafenib

Harinder Gill, MBBS, MRCP (UK), Cheuk Him Man, Karen Lam, Raymond Liang, MD, FRACP, MBBS, FRCP, Edmond Ma, MD, FRCP, FRCPath, Yok Lam Kwong, MD, Anskar Y. H. Leung, MD

Blood (2012) 120 (21): 4927.

https://doi.org/10.1182/blood.V120.21.4927.4927

Published: 2012

Journal Articles

Sorafenib treatment of FLT3-ITD + acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation

Cheuk Him Man, Tsz Kan Fung, Christa Ho, Heron H. C. Han, Howard C. H. Chow, Alvin C. H. Ma, William W. L. Choi, Si Lok, Alice M. S. Cheung, Connie Eaves, Yok Lam Kwong, Anskar Y. H. Leung

Blood (2012) 119 (22): 5133–5143.

https://doi.org/10.1182/blood-2011-06-363960

Published: 2012

Includes: Supplemental data

NARROW

Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML

Homoharringtonine Overcomes Drug Resistance and Synergises with Venetoclax in Acute Myeloid Leukemia Via Inhibiting Protein Synthesis

Inhibition of Polo-like Kinase 4 Induced Both Cell Intrinsic and Non-Cell Intrinsic Anti-Leukemia Effects on TP53 -Mutated Acute Myeloid Leukemia

Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth

Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting

A Genome-Wide, In Vivo, Dropout CRISPR Screen in Acute Myeloid Leukemia Identifies an Essential Role for Beta-Galactosylation in Leukemic Cell Homing

Whole Exome Sequencing of FLT3-ITD Sorafenib-Resistant Acute Myeloid Leukaemia

Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia

Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish

Development of a Clinically Relevant in Vitro Drug Screening Platform for Chemo-Refractory AML Patients

Bringing an Old Drug to a New Treatment Strategy in Treating FLT-ITD AML - Combination of Homoharringtonine and Sorafenib

Targeting Polo-like Kinase in Acute Myeloid Leukemia

Novel Therapeutic Strategy Targeting NHE1 and Its Upstream Activators in Acute Myeloid Leukemia

A novel tescalcin-sodium/hydrogen exchange axis underlying sorafenib resistance in FLT3-ITD + AML

Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

A Novel Role Of Tescalcin-Sodium/Hydrogen Exchange Axis Underlying Sorafenib Resistance In FLT3-ITD + AML

Acquired Fms-Like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3 ITD) During Leukaemic Transformation From Underlying Myelodysplasia: Successful Rescue with Sorafenib

Sorafenib treatment of FLT3-ITD + acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation

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American Society of Hematology

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ASH Publications

American Society of Hematology

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