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Anskar Y. H. Leung
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Journal Articles

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth

Cheuk Him Man, Francois E. Mercier, Nian Liu, Wentao Dong, Gregory Stephanopoulos, Li Jiang, Yookyung Jung, Charles P. Lin, Anskar Y. H. Leung, David T. Scadden
Journal: Blood
Blood (2022) 139 (4): 502–522.
https://doi.org/10.1182/blood.2021011563
Published: 2022
Includes: Supplemental data
Journal Articles

Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting

Cheuk-Him Man, David T. Scadden, MD, Francois Mercier, MD FRCPC, Nian Liu, Wentao Dong, Gregory Stephanopoulos, PhD, Li Jiang, PhD, Yookyung Jung, PhD, Charles Lin, PhD, Anskar Y.-H. Leung, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3765.
https://doi.org/10.1182/blood-2019-123604
Published: 2019
Journal Articles

Reconstruction of Human AML Reveals Stem Cell Origin and Therapeutic Targets for Treatment Resistant CD34 -/Lo MLL-Rearranged Leukemia

Tsz Kan Fung, Bernd Zeisig, Magdalena Zarowiecki, Huacheng Luo, Chiou Tsun Tsai, Boban Stanojevic, Claire Lynn, Anskar Y.-H. Leung, MD PhD, Jan Zuna, Marketa Zaliova, MD PhD, Martin Bornhaeuser, MD, Malte Von Bonin, Boris Lenhard, Suming Huang, PhD, Ghulam J. Mufti, Chi Wai Eric So
Journal: Blood
Blood (2019) 134 (Supplement_1): 3203.
https://doi.org/10.1182/blood-2019-125078
Published: 2019
Journal Articles

Characterization of Genomic Landscape and Risk Stratification of De Novo Cytogenetically Normal Acute Myeloid Leukaemia

Sze Pui Tsui, MSc, Tommy W.F. Tang, Ho-Wan Ip, MBBS, FRCPA, Jason Chi Chiu So, FRCPath, MBBS, Chun Hang Au, PhD, Edmond S. K. Ma, MD, Chris TL Chan, Margaret Ng, Kelvin C K Cheng, Kit Fai Wong, MBBS, MD FRCP, FRCPath, Lisa L.P. Siu, Sze Fai Yip, Sy Lin, Szeman June Lau, T.H. Luk, Harold K K Lee, Chi Kuen Lau, FRCP, Bonnie Kho, Chunxiao Zhang, Yok Lam Kwong, MD FRCP, Anskar Y.-H. Leung, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5267.
https://doi.org/10.1182/blood-2018-99-118909
Published: 2018
Journal Articles

Efficacy and Safety of Single-Agent Quizartinib (Q), a Potent and Selective FLT3 Inhibitor (FLT3i), in Patients (pts) with FLT3 -Internal Tandem Duplication ( FLT3 -ITD)-Mutated Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) Enrolled in the Global, Phase 3, Randomized Controlled Quantum-R Trial

Jorge E. Cortes, MD, Samer K. Khaled, MD, Giovanni Martinelli, MD, Alexander E. Perl, MD, Siddhartha Ganguly, MD, Nigel H. Russell, Alwin Kramer, MD, Herve Dombret, MD, Donna Hogge, Brian A. Jonas, MD PhD, Anskar Y.-H. Leung, MD PhD, Priyanka Mehta, Pau Montesinos, MD PhD, Markus P. Radsak, MD, Simona Sica, MD, Meena Arunachalam, Melissa Holmes, Ken Kobayashi, MD, Ruth Namuyinga, MD MPH, Nanxiang Ge, Antoine Yver, MD, Yufen Zhang, Mark J. Levis, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 563.
https://doi.org/10.1182/blood-2018-99-110439
Published: 2018
Journal Articles

Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia

Cheuk Him Man, Tsz Kan Fung, Haixia Wan, Chae Yin Cher, August Fan, Nelson Ng, Christa Ho, Thomas S. K. Wan, Toshiyuki Tanaka, Chi Wai Eric So, Yok Lam Kwong, Anskar Y. H. Leung
Journal: Blood
Blood (2015) 125 (25): 3928–3936.
https://doi.org/10.1182/blood-2014-06-580993
Published: 2015
Includes: Supplemental data
Journal Articles

Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish

Xiangguo Shi, Bai-Liang He, Alvin C. H. Ma, Yuhan Guo, Yali Chi, Cheuk Him Man, Wenqing Zhang, Yiyue Zhang, Zilong Wen, Tao Cheng, Anskar Y. H. Leung
Journal: Blood
Blood (2015) 125 (19): 2974–2984.
https://doi.org/10.1182/blood-2014-09-601187
Published: 2015
Includes: Supplemental data
Journal Articles

A novel tescalcin-sodium/hydrogen exchange axis underlying sorafenib resistance in FLT3-ITD + AML

Cheuk Him Man, Stephen S. Y. Lam, Murphy K. H. Sun, Howard C. H. Chow, Harinder Gill, Yok Lam Kwong, Anskar Y. H. Leung
Journal: Blood
Blood (2014) 123 (16): 2530–2539.
https://doi.org/10.1182/blood-2013-07-512194
Published: 2014
Includes: Supplemental data
Journal Articles

Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

Bai-Liang He, Xiangguo Shi, Cheuk Him Man, Alvin C. H. Ma, Stephen C. Ekker, Howard C. H. Chow, Chi Wai Eric So, William W. L. Choi, Wenqing Zhang, Yiyue Zhang, Anskar Y. H. Leung
Journal: Blood
Blood (2014) 123 (16): 2518–2529.
https://doi.org/10.1182/blood-2013-02-486688
Published: 2014
Includes: Multimedia, Supplemental data
Journal Articles

Acquired Fms-Like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3 ITD) During Leukaemic Transformation From Underlying Myelodysplasia: Successful Rescue with Sorafenib

Harinder Gill, MBBS, MRCP (UK), Cheuk Him Man, Karen Lam, Raymond Liang, MD, FRACP, MBBS, FRCP, Edmond Ma, MD, FRCP, FRCPath, Yok Lam Kwong, MD, Anskar Y. H. Leung, MD
Journal: Blood
Blood (2012) 120 (21): 4927.
https://doi.org/10.1182/blood.V120.21.4927.4927
Published: 2012
Journal Articles

SMILE for natural killer/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group

Clinical Trials & Observations
Yok-Lam Kwong, Won Seog Kim, Soon Thye Lim, Seok Jin Kim, Tiffany Tang, Eric Tse, Anskar Y. H. Leung, Chor-Sang Chim
Journal: Blood
Blood (2012) 120 (15): 2973–2980.
https://doi.org/10.1182/blood-2012-05-431460
Published: 2012
Includes: Supplemental data
Journal Articles

Sorafenib treatment of FLT3-ITD + acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation

Clinical Trials & Observations
Cheuk Him Man, Tsz Kan Fung, Christa Ho, Heron H. C. Han, Howard C. H. Chow, Alvin C. H. Ma, William W. L. Choi, Si Lok, Alice M. S. Cheung, Connie Eaves, Yok Lam Kwong, Anskar Y. H. Leung
Journal: Blood
Blood (2012) 119 (22): 5133–5143.
https://doi.org/10.1182/blood-2011-06-363960
Published: 2012
Includes: Supplemental data
Journal Articles

Methionine aminopeptidase 2 is required for HSC initiation and proliferation

Alvin C. H. Ma, Tsz K. Fung, Rachel H. C. Lin, Martin I. S. Chung, Dan Yang, Stephen C. Ekker, Anskar Y. H. Leung
Journal: Blood
Blood (2011) 118 (20): 5448–5457.
https://doi.org/10.1182/blood-2011-04-350173
Published: 2011
Includes: Multimedia, Supplemental data
Journal Articles

The role of jak2a in zebrafish hematopoiesis

Alvin C. H. Ma, Alister C. Ward, Raymond Liang, Anskar Y. H. Leung
Journal: Blood
Blood (2007) 110 (6): 1824–1830.
https://doi.org/10.1182/blood-2007-03-078287
Published: 2007
Includes: Supplemental data
Journal Articles

Genetic polymorphism in exon 4 of cytochrome P450 CYP2C9 may be associated with warfarin sensitivity in Chinese patients

Brief Report
Anskar Y. H. Leung, Howard C. H. Chow, Y. L. Kwong, Albert K. W. Lie, Alvin T. K. Fung, W. H. Chow, Alex S. B. Yip, Raymond Liang
Journal: Blood
Blood (2001) 98 (8): 2584–2587.
https://doi.org/10.1182/blood.V98.8.2584
Published: 2001
Journal Articles

Quantification of polyoma BK viruria in hemorrhagic cystitis complicating bone marrow transplantation

Clinical Trials & Observations
Anskar Y. H. Leung, Christine K. M. Suen, Albert K. W. Lie, Raymond H. S. Liang, Kwok Y. Yuen, Yok L. Kwong
Journal: Blood
Blood (2001) 98 (6): 1971–1978.
https://doi.org/10.1182/blood.V98.6.1971
Published: 2001