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Journal Articles

Distinct Pattern of ABL1 Genomic Breakpoints in Chronic Myeloid Leukemia and BCR::ABL1-Positive Acute Lymphoblastic Leukemia: Analysis of 884 Patients with Minor and Major BCR::ABL1 Fusion

Lenka Hovorkova, Lucie Winkowska, Justina Krotka, Manuela Krumbholz, Claus Meyer, Rosemary Sutton, Michelle Henderson, Emmanuelle Clappier, Sabina Chiaretti, Lucie Sramkova, Jan Stary, Adela Benesova, Katerina Machova Polakova, Rolf Marschalek, Markus Metzler, Giovanni Cazzaniga, Gunnar Cario, Jan Trka, Marketa Zaliova, Jan Zuna
Journal: Blood
Blood (2023) 142 (Supplement 1): 1605.
https://doi.org/10.1182/blood-2023-180355
Published: 2023
Journal Articles

Somatic Mutations in Cancer-Related Genes Were Observed More Frequently in AYA CML Patients Compared to Elderly at Diagnosis, Whereas the Frequency Was Markedly Higher in Elderly Patients during TKI Treatment

Jitka Krizkova, Vaclava Polivkova, Nikola Curik, Adam Laznicka, Adela Benesova, Hana Klamova, Marketa Stastna Markova, Dana Srbova, Jan Zuna, Marketa Zaliova, Jan Trka, Pavel Semerak, Tomas Kalina, Cyril Salek, Katerina Machova Polakova
Journal: Blood
Blood (2023) 142 (Supplement 1): 4544.
https://doi.org/10.1182/blood-2023-189017
Published: 2023
Journal Articles

Independent Prognostic Value of DNA-Based Minimal Residual Disease Assessment in Unselected Population-Based Cohort of Pediatric Acute Myeloid Leukemia

Marketa Zaliova, Jan Zuna, Lucie Winkowska, Iveta Janotova, Justina Skorepova, Julius Lukes, Claus Meyer, Rolf Marschalek, Jiri Domansky, Zbynek Novak, Jan Stary, Lucie Sramkova, Jan Trka
Journal: Blood
Blood (2023) 142 (Supplement 1): 4327.
https://doi.org/10.1182/blood-2023-179723
Published: 2023
Journal Articles

Constitutional and Somatic Variants in ARID5B in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Charlotte Ragnarsson, Minjun Yang, Larissa Helena Moura-Castro, Rebeqa Gunnarsson, Linda Olsson-Arvidsson, Nicolas Duployez, Marketa Zaliova, Jan Zuna, Anders Castor, Bertil Johansson, Kajsa Paulsson
Journal: Blood
Blood (2023) 142 (Supplement 1): 5736.
https://doi.org/10.1182/blood-2023-179488
Published: 2023
Journal Articles

NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol

Clinical Trials & Observations Brief Report
Michael Svaton, Aneta Skotnicova, Leona Reznickova, Andrea Rennerova, Tatana Valova, Michaela Kotrova, Vincent H. J. van der Velden, Monika Brüggemann, Nikos Darzentas, Anton W. Langerak, Jan Zuna, Jan Stary, Jan Trka, Eva Fronkova
Journal: Blood
Blood (2023) 141 (5): 529–533.
https://doi.org/10.1182/blood.2022017003
Published: 2023
Includes: Supplemental data
Journal Articles

BCR::ABL1-Positive Acute Lymphoblastic Leukemia: Different Clinical Behavior and Relevance of Prognostic Features in Typical ALL and in CML-like Disease

Jan Zuna, Lenka Hovorkova, Justina Krotka, Amelie Koehrmann, Michela Bardini, Lucie Winkowska, Eva Fronkova, Julia Alten, Rolf Koehler, Cornelia Eckert, Lisa Brizzolara, Jan Stuchly, Martin Zimmermann, Paola De Lorenzo, Maria Grazia Valsecchi, Valentino Conter, Jan Stary, Martin Schrappe, Andrea Biondi, Jan Trka, Marketa Zaliova, Giovanni Cazzaniga, Gunnar Cario
Journal: Blood
Blood (2022) 140 (Supplement 1): 9179–9180.
https://doi.org/10.1182/blood-2022-158926
Published: 2022
Journal Articles

Minimal Residual Disease and Outcome Characteristics in Infant KMT2A-Germline Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

Janine Stutterheim, Paola De Lorenzo, Inge M. Van Der Sluis, Julia Alten, Philip Ancliffe, Andishe Attarbaschi, Luis Alberto Aversa, Judith M. Boer, Andrea Biondi, Benoit Brethon, Paulina Diaz, Giovanni Gazzaniga, Gabriele Escherich, Alina Ferster, Rishi S Kotecha, Birgitte Lausen, Alex WK Leung, Franco Locatelli, Lewis B. Silverman, Jan Stary, Tomasz Szczepanski, Vincent H.J. Van Der Velden, Ajay Vora, Jan Zuna, Martin Schrappe, Maria Grazia Valsecchi, Rob Pieters
Journal: Blood
Blood (2021) 138 (Supplement 1): 2383.
https://doi.org/10.1182/blood-2021-145058
Published: 2021
Journal Articles

NGS-Based MRD Quantitation: An Alternative to qPCR Validated on a Large Consecutive Cohort of Children with ALL

Michael Svaton, Aneta Skotnicova, Leona Reznickova, Andrea Rennerova, Tatana Valova, Michaela Kotrova, Vincent H.J. van der Velden, Monika Brüggemann, Nikos Darzentas, Anton W. Langerak, Jan Zuna, Jan Stary, Jan Trka, Eva Fronkova
Journal: Blood
Blood (2021) 138 (Supplement 1): 1314.
https://doi.org/10.1182/blood-2021-152971
Published: 2021
Journal Articles

Clinical Implications of Minimal Residual Disease Detection in Infants with KMT2A -Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

Janine Stutterheim, MDPhD, Inge M. van der Sluis, MD PhD, Paola De Lorenzo, Julia Alten, MD, Philip Ancliff, MD, Andishe Attarbaschi, MD, Benoit Brethon, MD, Andrea Biondi, MD, Myriam Campbell, MD, Giovanni Cazzaniga, PhD, Gabriele Escherich, MD, Alina Ferster, MD, Rishi Sury Kotecha, MBBChir, PhD, Birgitte Lausen, MD, Chi Kong Li, MD, Luca Lo Nigro, PhDMD, Franco Locatelli, MD PhD, Rolf Marschalek, PhD, Martin Schrappe, MDPhD, Jan Stary, MD PhD, Ajay Vora, MD, Jan Zuna, PhD, Vincent H.J. Van Der Velden, PhD, Tomasz Szczepanski, MD PhD, Maria Grazia Valsecchi, PhD, Rob Pieters, MDPhDMSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-134303
Published: 2020
Journal Articles

13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking

Minjun Yang, Setareh Safavi, Eleanor L. Woodward, Nicolas Duployez, Linda Olsson-Arvidsson, Jonas Ungerbäck, Mikael Sigvardsson, Marketa Zaliova, Jan Zuna, Thoas Fioretos, Bertil Johansson, Karolin H. Nord, Kajsa Paulsson
Journal: Blood
Blood (2020) 136 (8): 946–956.
https://doi.org/10.1182/blood.2019004684
Published: 2020
Includes: Supplemental data
Journal Articles

Poor Prognosis in Children with ABL -Class Fusion Positive B-Cell Acute Lymphoblastic Leukemia Treated According to AIEOP-BFM Protocols

Gunnar Cario, MD PhD, Veronica Leoni, Valentino Conter, MD, Andishe Attarbaschi, MD, Marketa Zaliova, MD PhD, Lucie Sramkova, Giovanni Cazzaniga, PhD, Grazia Fazio, Rosemary Sutton, BSc MSc PhD, Sarah Elitzur, MD, Shai Izraeli, MD, Melchior Lauten, Franco Locatelli, MD PhD, Giuseppe Basso, MD PhD, Barbara Buldini, MD PhD, Anke K Bergmann, Jana Lentes, Doris Steinemann, Gudrun Gohring, Brigitte Schlegelberger, MD, Oskar A Haas, Denis Martin Schewe, Swantje Buchmann, Anja Moericke, Deborah L. White, PhD FFSc (RCPA), Tamas Revesz, Martin Stanulla, Georg Mann, MD, Nicole Bodmer, Nira Arad-Cohen, Jan Zuna, Maria Grazia Valsecchi, PhD, Martin Zimmermann, PhD, Martin Schrappe, MD PhD, Andrea Biondi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1351.
https://doi.org/10.1182/blood-2019-126523
Published: 2019
Journal Articles

Reconstruction of Human AML Reveals Stem Cell Origin and Therapeutic Targets for Treatment Resistant CD34 -/Lo MLL-Rearranged Leukemia

Tsz Kan Fung, Bernd Zeisig, Magdalena Zarowiecki, Huacheng Luo, Chiou Tsun Tsai, Boban Stanojevic, Claire Lynn, Anskar Y.-H. Leung, MD PhD, Jan Zuna, Marketa Zaliova, MD PhD, Martin Bornhaeuser, MD, Malte Von Bonin, Boris Lenhard, Suming Huang, PhD, Ghulam J. Mufti, Chi Wai Eric So
Journal: Blood
Blood (2019) 134 (Supplement_1): 3203.
https://doi.org/10.1182/blood-2019-125078
Published: 2019
Journal Articles

Characterization of a Novel JAK1 Pseudokinase Mutation in the First Case of Trisomy 21-Independent GATA1-Mutated Transient Abnormal Myelopoiesis

Julius Lukes, Jr., MD, Petr Danek, MSc, Oriol Alejo, Eliska Potuckova, Ondrej Gahura, Dirk Heckl, PhD, Julia Starkova, PhD, Jan Zuna, Jan Stary, Prof., MD PhD, Jan Trka, Prof., MD PhD, Jan-Henning Klusmann, Marketa Zaliova, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4208.
https://doi.org/10.1182/blood-2019-122168
Published: 2019
Journal Articles

MLL-USP2 : An Underestimated New Entity of MLL -Rearranged Leukemia Identified By NGS Analysis

Claus Meyer, PhD, Bruno Lopes, PhD, Aurélie Caye-Eude, PharmD, Hélène Cavé, PharmD, PhD, Chloé Arfeuille, PhD, Rosemary Sutton, PhD, Nicola Venn, BSc, Patrizia Larghero, PhD, Seung Hwan Oh, MD, Grigory Tsaur, MD PhD, Marketa Zaliova, Jan Zuna, Vesa Juvonen, PhD, Renate Panzer-Grümayer, MD, Grazia Fazio, PhD, Giovanni Cazzaniga, PhD, Mariana Emerenciano, PhD, Rolf Marschalek, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3920.
https://doi.org/10.1182/blood-2018-99-112594
Published: 2018
Journal Articles

Chromosome 21 Gain Is Dispensable for Transient Myeloproliferative Disorder (TMD) Development

Julius Lukes, Jr., MD, Eliska Potuckova, Julia Starkova, Jan Stary, MD PhD, Jan Zuna, Jan Trka, MD PhD, Marketa Zaliova
Journal: Blood
Blood (2018) 132 (Supplement 1): 2764.
https://doi.org/10.1182/blood-2018-99-112078
Published: 2018
Journal Articles

DNA Analysis of Mutations in the Kinase Domain of BCR-ABL1 By Allele-Specific Digital PCR Is Highly Sensitive and Refines Prediction of Kinetics of Resistant CML Clones

Vaclava Polivkova, Nikola Curik, Hana Zizkova, Adela Benesova, Pavel Burda, Pavla Pecherkova, Eliska Motlova, Jana Brezinova, Sarka Ransdorfova, Hana Klamova, Lenka Hovorkova, Jan Zuna, Thomas Ernst, Simona Soverini, PhD, Katerina Machova
Journal: Blood
Blood (2018) 132 (Supplement 1): 1743.
https://doi.org/10.1182/blood-2018-99-119710
Published: 2018
Journal Articles

Limited Therapeutical Impact of Extensive Genomic Profiling in Relapsed Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia: Population-Based Four-Year Consecutive Cohort

Marketa Zaliova, Jan Stuchly, Karel Fiser, Alena Musilova, Martina Slamova, Lucie Winkowska, Julia Starkova, Ester Mejstrikova, Jan Zuna, Lucie Sramkova, Jan Stary, Jan Trka
Journal: Blood
Blood (2017) 130 (Supplement 1): 2717.
https://doi.org/10.1182/blood.V130.Suppl_1.2717.2717
Published: 2017
Journal Articles

Dissecting Childhood B-Other Acute Lymphoblastic Leukemia: Lower Frequency of Druggable Gene Fusions in European Population?

Marketa Zaliova, Jan Stuchly, Karel Fiser, Alena Musilova, Martina Slamova, Lucie Winkowska, Julia Starkova, Martina Vaskova, Jan Zuna, Jan Stary, Jan Trka
Journal: Blood
Blood (2017) 130 (Supplement 1): 3973.
https://doi.org/10.1182/blood.V130.Suppl_1.3973.3973
Published: 2017
Journal Articles

Monitoring of childhood ALL using BCR-ABL1 genomic breakpoints identifies a subgroup with CML-like biology

Clinical Trials & Observations
Lenka Hovorkova, Marketa Zaliova, Nicola C. Venn, Kirsten Bleckmann, Marie Trkova, Eliska Potuckova, Martina Vaskova, Jana Linhartova, Katerina Machova Polakova, Eva Fronkova, Walter Muskovic, Jodie E. Giles, Peter J. Shaw, Gunnar Cario, Rosemary Sutton, Jan Stary, Jan Trka, Jan Zuna
Journal: Blood
Blood (2017) 129 (20): 2771–2781.
https://doi.org/10.1182/blood-2016-11-749978
Published: 2017
Includes: Supplemental data
Journal Articles

GNB1 K89M Drives TKI Resistance in ETV6-ABL1-Positive Leukemia

Olga Zimmermannova, Eliska Doktorova, Jan Stuchly, Meritxell Alberich Jorda, Jiri Petrak, JH Frederik Falkenburg, Julia Starkova, Jan Trka, Jan Zuna, MD PhD, Marketa Zaliova
Journal: Blood
Blood (2016) 128 (22): 751.
https://doi.org/10.1182/blood.V128.22.751.751
Published: 2016