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Journal Articles

Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4 -r cases

Hanna Thorsson, Rasmus Henningsson, Noelia Puente-Moncada, Pablo Peña-Martínez, Ludvig Sjöström, Helena Ågerstam, Carl Sandén, Marianne Rissler, Anders Castor, Hanne Marquart, Signe Modvig, Kajsa Paulsson, Cornelis Jan Pronk, Kjeld Schmiegelow, Axel Hyrenius-Wittsten, Christina Orsmark-Pietras, Henrik Lilljebjörn, Thoas Fioretos

Blood (2024) 144 (13): 1399–1411.

https://doi.org/10.1182/blood.2023021705

Published: 2024

Includes: Supplemental data

Journal Articles

Single-Cell Transcriptomics Points to a Role of Stemness and Bone Marrow Niche Interactions in the Poor Response to Induction Therapy in T-Cell Acute Lymphoblastic Leukemia

Signe Modvig, Hanna Thorsson, Bodil Als-Nielsen, Claus Christensen, Nina Friesgaard Øbro, Hans O. Madsen, Henrik Lilljebjörn, Kjeld Schmiegelow, Thoas Fioretos, Hanne Vibeke Marquart

Blood (2023) 142 (Supplement 1): 4345.

https://doi.org/10.1182/blood-2023-188631

Published: 2023

Journal Articles

The 3D Chromatin Landscape of B-Cell Precursor Childhood Acute Lymphoblastic Leukemia

Larissa Helena Moura-Castro, Minjun Yang, Eleanor Woodward, Anders Castor, Thoas Fioretos, Bertil Johansson, Marcus Järås, Anna Hagström, Kajsa Paulsson

Blood (2023) 142 (Supplement 1): 4151.

https://doi.org/10.1182/blood-2023-178491

Published: 2023

Journal Articles

Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4 -Rearranged Cases

Hanna Thorsson, Rasmus Henningsson, Noelia Puente-Moncada, Ludvig Sjöström, Helena Ågerstam, Pablo Enrique Peña-Martínez, Carl Sandén, Marianne Rissler, Anders Castor, Hanne Vibeke Marquart, Signe Modvig, Kajsa Paulsson, Cornelis Pronk, Kjeld Schmiegelow, Axel Hyrenius Wittsten, Christina Orsmark-Pietras, Henrik PhD Lilljebjörn, Thoas Fioretos

Blood (2023) 142 (Supplement 1): 842.

https://doi.org/10.1182/blood-2023-173350

Published: 2023

Journal Articles

Single Cell Multi-Omic Profiling of Acute Lymphoblastic Leukemia Identifies Altered Cellular Pathways and Highlights Heterogeneity in the Maturation Block of DUX4 -Rearranged ALL

Hanna Thorsson, Rasmus Henningsson, Noelia Puente-Moncada, Carl Sandén, Signe Modvig, Marianne Rissler, Kajsa Paulsson, Anders Castor, Cornelis Jan Pronk, Hanne Vibeke Marquart, Kjeld Schmiegelow, Christina Orsmark-Pietras, Henrik Lilljebjörn, Thoas Fioretos

Blood (2022) 140 (Supplement 1): 3467–3468.

https://doi.org/10.1182/blood-2022-163031

Published: 2022

Journal Articles

Why B(-)other? About the gap of unknowns in ALL

Thoas Fioretos

Blood (2022) 139 (24): 3455–3457.

https://doi.org/10.1182/blood.2022015993

Published: 2022

Journal Articles

In Vivo crispr Screening Identifies GLUT1 As a Key Metabolic Regulator of MLL-AF9 -Driven Acute Myeloid Leukemia

Maria Rodriguez Zabala, Ramprasad Ramakrishnan, Katrin Reinbach, Leal Oburoglu, Somadri Ghosh, Ton Falqués, Pablo Peña-Martínez, Noelia Puente-Moncada, Thoas Fioretos, Anna Hagstroem-Andersson, Niels-Bjarne Woods, Marcus Järås

Blood (2021) 138 (Supplement 1): 3439.

https://doi.org/10.1182/blood-2021-152371

Published: 2021

Journal Articles

Genome-Wide Analysis of Allele-Specific Expression Genes in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Minjun Yang, Rebeqa Gunnarsson, Linda Olsson, Andrea Biloglav, Henrik Lilljebjörn, Eleanor L Woodward, Thoas Fioretos, Bertil Johansson, Kajsa Paulsson

Blood (2021) 138 (Supplement 1): 4315.

https://doi.org/10.1182/blood-2021-144808

Published: 2021

Journal Articles

13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking

Minjun Yang, Setareh Safavi, Eleanor L. Woodward, Nicolas Duployez, Linda Olsson-Arvidsson, Jonas Ungerbäck, Mikael Sigvardsson, Marketa Zaliova, Jan Zuna, Thoas Fioretos, Bertil Johansson, Karolin H. Nord, Kajsa Paulsson

Blood (2020) 136 (8): 946–956.

https://doi.org/10.1182/blood.2019004684

Published: 2020

Includes: Supplemental data

Journal Articles

Transcriptome Alterations of Isolated Primary Bone Marrow Endothelial Cells Provide Insigt to MGUS and Multiple Myeloma Pathobiology

Sandro Bräunig, MSc, Dimitra Zacharaki, PhD, Hongzhe Li, PhD, Hooi Ching Lim, PhD, Stefan Lang, PhD, Thoas Fioretos, MD PhD Prof., Stefan Scheding, MD

Blood (2019) 134 (Supplement_1): 4373.

https://doi.org/10.1182/blood-2019-128024

Published: 2019

Journal Articles

CDK8 Inhibitor SEL120-34A Has Therapeutic Efficacy in Murine and Human Acute Myeloid Leukemia Models

Blood (2018) 132 (Supplement 1): 1520.

https://doi.org/10.1182/blood-2018-99-111859

Published: 2018

Journal Articles

AML Xenografts Undergo Extensive Clonal Competition and Unmask Rare Clones in Patient Samples

Carl Sandén, PhD, Henrik Lilljebjörn, PhD, Christina Orsmark-Pietras, PhD, Karim Saba, MSc, Carl Högberg, PhD, Marianne Rissler, MSc, Vladimir Lazarevic, MD PhD, Gunnar Juliusson, MD PhD, Helena Ågerstam, PhD, Thoas Fioretos, MD PhD

Blood (2018) 132 (Supplement 1): 2621.

https://doi.org/10.1182/blood-2018-99-110497

Published: 2018

Journal Articles

Isolated myelosarcoma is characterized by recurrent NFE2 mutations and concurrent preleukemic clones in the bone marrow

Vladimir Lazarevic, Christina Orsmark-Pietras, Henrik Lilljebjörn, Louise Pettersson, Marianne Rissler, Anna Lübking, Mats Ehinger, Gunnar Juliusson, Thoas Fioretos

Blood (2018) 131 (5): 577–581.

https://doi.org/10.1182/blood-2017-07-793620

Published: 2018

Includes: Supplemental data

Journal Articles

Monitoring Leukemic Mutations Using Ultrasensitive IBSAFE Digital Droplet Analysis Predicts Relapse of Acute Myeloid Leukemia

Louise Pettersson, MD, Yilun Chen, MSc, Anthony M George, MSc, Christina Orsmark-Pietras, PhD, Henrik Lilljebjörn, MSc, Robert Rigo, MSc, Vladimir Lazarevic, MD PhD, Thoas Fioretos, MD PhD, Gunnar Juliusson, MD PhD, Mats Ehinger, MD PhD, Lao H Saal, MD PhD

Blood (2017) 130 (Supplement 1): 3951.

https://doi.org/10.1182/blood.V130.Suppl_1.3951.3951

Published: 2017

Journal Articles

Transcriptome Alterations of Prospectively Isolated Bone Marrow Stromal Cells Provide Potential Cues to MGUS and Multiple Myeloma Pathobiology

Dimitra Zacharaki, Roshanak Ghazanfari, PhD, Hongzhe Li, PhD, Hooi Ching Lim, PhD, Sofia Von Palffy, Shamit Soneji, PhD, Thoas Fioretos, MD PhD, Stefan Scheding, MD

Blood (2017) 130 (Supplement 1): 4375.

https://doi.org/10.1182/blood.V130.Suppl_1.4375.4375

Published: 2017

Journal Articles

The Proteogenomic Landscape of High Hyperdiploid and ETV6/RUNX1-Positive Childhood Acute Lymphoblastic Leukemia

Minjun Yang, Mattias Vesterlund, Ioannis Siavelis, Eleanor Woodward, Naveen Ravi, Henrik Lilljebjörn, MSc, Thoas Fioretos, MD PhD, Janne Lehtiö, Kajsa Paulsson

Blood (2017) 130 (Supplement 1): 1433.

https://doi.org/10.1182/blood.V130.Suppl_1.1433.1433

Published: 2017

Journal Articles

New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

Henrik Lilljebjörn, Thoas Fioretos

Blood (2017) 130 (12): 1395–1401.

https://doi.org/10.1182/blood-2017-05-742643

Published: 2017

Journal Articles

Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms

Blood (2017) 129 (16): 2266–2279.

https://doi.org/10.1182/blood-2016-10-743302

Published: 2017

Includes: Supplemental data

Journal Articles

IL1RAP antibodies block IL-1–induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

Helena Ågerstam, Nils Hansen, Sofia von Palffy, Carl Sandén, Kristian Reckzeh, Christine Karlsson, Henrik Lilljebjörn, Niklas Landberg, Maria Askmyr, Carl Högberg, Marianne Rissler, Kimmo Porkka, Hans Wadenvik, Satu Mustjoki, Johan Richter, Marcus Järås, Thoas Fioretos

Blood (2016) 128 (23): 2683–2693.

https://doi.org/10.1182/blood-2015-11-679985

Published: 2016

Includes: Supplemental data

Journal Articles

Telomere Length Shortening in the CML Leukemic Stem Cell Compartment Correlates with the Respective Clone Size: Evidence for Early Vs. Late Chronic Phase

Anne-Sophie Bouillon, Monica S. Ferreira, PhD, Shady Adnan Awad, Johan Richter, MD, Henrik Hjorth-Hansen, MD PhD, Thoas Fioretos, Sebastian Hummel, Mirle Schemionek, PhD, Satu Mustjoki, MD PhD, Fabian Beier, MD, Tim H. Brümmendorf, MD

Blood (2016) 128 (22): 4243.

https://doi.org/10.1182/blood.V128.22.4243.4243

Published: 2016

NARROW

Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4 -r cases

Single-Cell Transcriptomics Points to a Role of Stemness and Bone Marrow Niche Interactions in the Poor Response to Induction Therapy in T-Cell Acute Lymphoblastic Leukemia

The 3D Chromatin Landscape of B-Cell Precursor Childhood Acute Lymphoblastic Leukemia

Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4 -Rearranged Cases

Single Cell Multi-Omic Profiling of Acute Lymphoblastic Leukemia Identifies Altered Cellular Pathways and Highlights Heterogeneity in the Maturation Block of DUX4 -Rearranged ALL

Why B(-)other? About the gap of unknowns in ALL

In Vivo crispr Screening Identifies GLUT1 As a Key Metabolic Regulator of MLL-AF9 -Driven Acute Myeloid Leukemia

Genome-Wide Analysis of Allele-Specific Expression Genes in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking

Transcriptome Alterations of Isolated Primary Bone Marrow Endothelial Cells Provide Insigt to MGUS and Multiple Myeloma Pathobiology

CDK8 Inhibitor SEL120-34A Has Therapeutic Efficacy in Murine and Human Acute Myeloid Leukemia Models

AML Xenografts Undergo Extensive Clonal Competition and Unmask Rare Clones in Patient Samples

Isolated myelosarcoma is characterized by recurrent NFE2 mutations and concurrent preleukemic clones in the bone marrow

Monitoring Leukemic Mutations Using Ultrasensitive IBSAFE Digital Droplet Analysis Predicts Relapse of Acute Myeloid Leukemia

Transcriptome Alterations of Prospectively Isolated Bone Marrow Stromal Cells Provide Potential Cues to MGUS and Multiple Myeloma Pathobiology

The Proteogenomic Landscape of High Hyperdiploid and ETV6/RUNX1-Positive Childhood Acute Lymphoblastic Leukemia

New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms

IL1RAP antibodies block IL-1–induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

Telomere Length Shortening in the CML Leukemic Stem Cell Compartment Correlates with the Respective Clone Size: Evidence for Early Vs. Late Chronic Phase

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American Society of Hematology

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American Society of Hematology

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