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Signe Modvig
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Journal Articles

Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4 -r cases

Hanna Thorsson, Rasmus Henningsson, Noelia Puente-Moncada, Pablo Peña-Martínez, Ludvig Sjöström, Helena Ågerstam, Carl Sandén, Marianne Rissler, Anders Castor, Hanne Marquart, Signe Modvig, Kajsa Paulsson, Cornelis Jan Pronk, Kjeld Schmiegelow, Axel Hyrenius-Wittsten, Christina Orsmark-Pietras, Henrik Lilljebjörn, Thoas Fioretos
Journal: Blood
Blood (2024) 144 (13): 1399–1411.
https://doi.org/10.1182/blood.2023021705
Published: 2024
Includes: Supplemental data
Journal Articles

Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4 -Rearranged Cases

Hanna Thorsson, Rasmus Henningsson, Noelia Puente-Moncada, Ludvig Sjöström, Helena Ågerstam, Pablo Enrique Peña-Martínez, Carl Sandén, Marianne Rissler, Anders Castor, Hanne Vibeke Marquart, Signe Modvig, Kajsa Paulsson, Cornelis Pronk, Kjeld Schmiegelow, Axel Hyrenius Wittsten, Christina Orsmark-Pietras, Henrik PhD Lilljebjörn, Thoas Fioretos
Journal: Blood
Blood (2023) 142 (Supplement 1): 842.
https://doi.org/10.1182/blood-2023-173350
Published: 2023
Journal Articles

Single-Cell Transcriptomics Points to a Role of Stemness and Bone Marrow Niche Interactions in the Poor Response to Induction Therapy in T-Cell Acute Lymphoblastic Leukemia

Signe Modvig, Hanna Thorsson, Bodil Als-Nielsen, Claus Christensen, Nina Friesgaard Øbro, Hans O. Madsen, Henrik Lilljebjörn, Kjeld Schmiegelow, Thoas Fioretos, Hanne Vibeke Marquart
Journal: Blood
Blood (2023) 142 (Supplement 1): 4345.
https://doi.org/10.1182/blood-2023-188631
Published: 2023
Journal Articles

Single Cell Multi-Omic Profiling of Acute Lymphoblastic Leukemia Identifies Altered Cellular Pathways and Highlights Heterogeneity in the Maturation Block of DUX4 -Rearranged ALL

Hanna Thorsson, Rasmus Henningsson, Noelia Puente-Moncada, Carl Sandén, Signe Modvig, Marianne Rissler, Kajsa Paulsson, Anders Castor, Cornelis Jan Pronk, Hanne Vibeke Marquart, Kjeld Schmiegelow, Christina Orsmark-Pietras, Henrik Lilljebjörn, Thoas Fioretos
Journal: Blood
Blood (2022) 140 (Supplement 1): 3467–3468.
https://doi.org/10.1182/blood-2022-163031
Published: 2022
Journal Articles

Bone Marrow Plasma Proteome Analysis By Differential Ultracentrifugation and Tandem Mass Spectrometry Allow for Characterization of Leukemia-Derived Extracellular Vesicles in Patients with Acute Lymphoblastic Leukemia

Ole Østergaard, Hanne Vibeke Marquart, Maria Thastrup, Christian Mirian, Bodil Als-Nielsen, Kjeld Schmiegelow, Jesper V Olsen, Signe Modvig
Journal: Blood
Blood (2022) 140 (Supplement 1): 3473–3474.
https://doi.org/10.1182/blood-2022-166141
Published: 2022
Journal Articles

Value of Flow Cytometry for MRD-Based Relapse Prediction in B-Cell Precursor Acute Lymphoblastic Leukemia in a Multi-Center Setting

Signe Modvig, MD PhD, Hans Madsen, Helene Hallböök, MD PhD, Sanna M. Siitonen, MD PhD, Liv T. N. Osnes, MD PhD, Susanne Rosthøj, PhD, Anne Tierens, MD PhD, Vesa Juvonen, PhD, Helen Vålerhaugen, Magnus Hultdin, MD PhD, Mats Ehinger, MD PhD, Anna Porwit, MD PhD, Reda Matuzeviciene, MD PhD, Mindaugas Stoskus, M Marincevic, PhD, Aili Lilleorg, PhD, Mervi Taskinen, MD PhD, Nina Toft, MD PhD, Ólafur Gísli Jónsson, MD PhD, Kaie Pruunsild, MD, Goda Elizabeta Vaitkeviciene, MD PhD, Kim Vettenranta, MD PhD, Bendik Lund, MD PhD, Jonas Abrahamsson, Kjeld Schmiegelow, Professor MD DMSc., Hanne Vibeke Marquart, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2755.
https://doi.org/10.1182/blood-2019-122311
Published: 2019
Journal Articles

A Comprehensive Study of Human Integrins in Pediatric Lymphoblastic Leukemia Supports a Role of CD49f (Integrin α6) in the Localization to Bone Marrow but Not Spinal Fluid

Bibi F. S. S. Scharff, Signe Modvig, MD PhD, Maria Thastrup, PhD, Mette Levinsen, PhD, Matilda Degn, PhD, Lars Peter Ryder, MSc, Kjeld Schmiegelow, Professor MD DMSc., Claus René Lykke Christensen, MSc, MSc.Eng, PhD, Hanne Vibeke Marquart, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5205.
https://doi.org/10.1182/blood-2019-126701
Published: 2019
Journal Articles

Flow Cytometry Based MRD Monitoring Is an Accurate Risk Stratification Tool in Acute T-Lymphoblastic Leukemia

Signe Modvig, MD PhD, Hans O Madsen, Sanna M. Siitonen, MD PhD, Susanne Rosthøj, PhD, Vesa Juvonen, PhD, Liv T. N. Osnes, MD PhD, Helen Vålerhaugen, Magnus Hultdin, MD PhD, M Marincevic, PhD, Reda Matuzeviciene, MD PhD, Mindaugas Stoskus, Aili Lilleorg, PhD, Nina Toft, MD PhD, Ólafur G. Jónsson, MD, Kjeld Schmiegelow, MD, Hanne Vibeke Marquart, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 372.
https://doi.org/10.1182/blood.V130.Suppl_1.372.372
Published: 2017
Journal Articles

An Immature Immunophenotype (CD34pos, CD38dim, nTdTdim) on Malignant B-Cell Precursor Blasts at Diagnosis Predicts High Minimal Residual Disease in BCP-ALL

Signe Modvig, MD PhD, Nina Friesgaard Øbro, PhD, Susanne Rosthøj, PhD, Gitte W Jürgensen, MD, Kjeld Schmiegelow, MD DMSc, Hanne Vibeke Marquart, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1728.
https://doi.org/10.1182/blood.V128.22.1728.1728
Published: 2016