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Journal Articles

NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol

Michael Svaton, Aneta Skotnicova, Leona Reznickova, Andrea Rennerova, Tatana Valova, Michaela Kotrova, Vincent H. J. van der Velden, Monika Brüggemann, Nikos Darzentas, Anton W. Langerak, Jan Zuna, Jan Stary, Jan Trka, Eva Fronkova

Blood (2023) 141 (5): 529–533.

https://doi.org/10.1182/blood.2022017003

Published: 2023

Includes: Supplemental data

Journal Articles

Genotyping and Minimal Residual Disease (MRD) Assessment in cfDNA By the Euroclonality-NGS DNA Capture (EC-NDC) Panel in Mantle Cell Lymphoma (MCL)

Blood (2022) 140 (Supplement 1): 3518–3520.

https://doi.org/10.1182/blood-2022-166043

Published: 2022

Journal Articles

BCR::ABL1-Positive Acute Lymphoblastic Leukemia: Different Clinical Behavior and Relevance of Prognostic Features in Typical ALL and in CML-like Disease

Blood (2022) 140 (Supplement 1): 9179–9180.

https://doi.org/10.1182/blood-2022-158926

Published: 2022

Journal Articles

Single Cycle of Blinatumomab Followed By High-Dose Chemotherapy in the Induction Therapy for Ph-Negative Acute Lymphoblastic Leukemia in Adults. Primary Endpoint Analysis of the Blina-Cell Trial

Cyril Salek, Frantisek Folber, Stepan Hrabovsky, Zdenek Koristek, Jan M Horacek, Eva Fronkova, Petr Soukup, Katerina Benkova, Petr Cetkovsky, Jan Trka, Michael Doubek

Blood (2022) 140 (Supplement 1): 3258–3259.

https://doi.org/10.1182/blood-2022-157361

Published: 2022

Journal Articles

Sequencing-Based Analysis of Clonal Evolution of 25 Mantle Cell Lymphoma Patients at Diagnosis and after Failure of Standard Immunochemotherapy

Jana Karolova, Dmitry Kazantsev, Michael Svaton, Liliana Tušková, Kristina Forsterova, Diana Malarikova, Katerina Benesova, Tomáš Heizer, Alexandra Dolníková, Magdalena Klanova, Eva Fronkova, Marek Trněný, Pavel Klener, Jr.

Blood (2022) 140 (Supplement 1): 6409–6410.

https://doi.org/10.1182/blood-2022-166069

Published: 2022

Journal Articles

NGS-Based MRD Quantitation: An Alternative to qPCR Validated on a Large Consecutive Cohort of Children with ALL

Michael Svaton, Aneta Skotnicova, Leona Reznickova, Andrea Rennerova, Tatana Valova, Michaela Kotrova, Vincent H.J. van der Velden, Monika Brüggemann, Nikos Darzentas, Anton W. Langerak, Jan Zuna, Jan Stary, Jan Trka, Eva Fronkova

Blood (2021) 138 (Supplement 1): 1314.

https://doi.org/10.1182/blood-2021-152971

Published: 2021

Journal Articles

A homozygous deletion in the SLC19 A1 gene as a cause of folate-dependent recurrent megaloblastic anemia

Michael Svaton, Karolina Skvarova Kramarzova, Veronika Kanderova, Andrea Mancikova, Petr Smisek, Pavel Jesina, Jakub Krijt, Blanka Stiburkova, Robert Dobrovolny, Jitka Sokolova, Violeta Bakardjieva-Mihaylova, Elena Vodickova, Marketa Rackova, Jan Stuchly, Tomas Kalina, Jan Stary, Jan Trka, Eva Fronkova, Viktor Kozich

Blood (2020) 135 (26): 2427–2431.

https://doi.org/10.1182/blood.2019003178

Published: 2020

Includes: Supplemental data

Journal Articles

Deep Immunoprofiling By Flow Cytometry and NGS Reveals Distinct T Cell Profile in Pediatric Hepatitis-Associated Aplastic Anemia

Michaela Novakova, Michael Svaton, MD, Martina Sukova, MD, Veronika Kanderova, MSc, PhD, Nikos Darzentas, PhD, Lenka Kramna, MSc, PhD, Ondrej Cinek, Prof., MD PhD, Dagmar Pospisilova, Prof MD PhD, Jan Trka, Prof., MD PhD, Ondrej Hrusak, MD PhD, Jan Stary, Prof., MD PhD, Ester Mejstrikova, MD PhD, Eva Fronkova, MD PhD

Blood (2019) 134 (Supplement_1): 2508.

https://doi.org/10.1182/blood-2019-127986

Published: 2019

Journal Articles

B Cell Precursor Lymphoblastic Leukemia Patients with Good Treatment Response Have Low Levels of Erythroid Precursors

Barbora Vakrmanova, MD, Michaela Novakova, Martina Vaskova, Iveta Janotová, Elena Vodickova, MD, Monika Brüggemann, Eva Fronkova, MD PhD, Jan Trka, MD PhD, Jan Stary, MD PhD, Ondrej Hrusak, Ester Mejstrikova, MD PhD

Blood (2018) 132 (Supplement 1): 2832.

https://doi.org/10.1182/blood-2018-99-117976

Published: 2018

Journal Articles

Switching Towards Monocytic Lineage and Discordancy between Flow Cytometric and PCR Minimal Residual Disease Results Is a Hallmark Feature of DUX4 Rearranged B-Cell Precursor Acute Lymphoblastic Leukemia

Michaela Novakova, Barbora Vakrmanova, MD, Lucie Slamova, Alena Musilova, Monika Brüggemann, Matthias Ritgen, MD, Eva Fronkova, MD PhD, Tomas Kalina, MD PhD, Jan Trka, MD PhD, Jan Stary, MD PhD, Martina Vaskova, Lucie Winkowska, Marketa Zaliova, Karel Fišer, PhD, Ondrej Hrusak, Ester Mejstrikova, MD PhD

Blood (2018) 132 (Supplement 1): 2825.

https://doi.org/10.1182/blood-2018-99-116575

Published: 2018

Journal Articles

Co-Targeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Refractory Mantle Cell Lymphoma with Complex Karyotype Changes

Pavel Klener, Jr., Marek Trněný, Ladislav Andera, MSc, PhD, Zuzana Nahacka, MSc, Magdalena Klanova, MD PhD, Jana Karolova, MD, Michael Svaton, MD, Ondrej Havranek, MDPhD, Jan Soukup, MD, Zuzana Zemanova, PhD, Diana Tuskova, MD, Eva Pokorna, Kristina Forsterova, MSc, PhD, Petra Vockova, MD, Eva Fronkova, MD PhD, Dana Prukova, Ing, PhD

Blood (2018) 132 (Supplement 1): 42.

https://doi.org/10.1182/blood-2018-99-112437

Published: 2018

Journal Articles

Folate-Dependent Normocytic Anemia Caused By a Hypomorphic Mutation in SLC19A1 gene

Michael Svaton, MD, Karolina Skvarova Kramarzova, MSc, PhD, Veronika Kanderova, MSc, PhD, Petr Smisek, MD, Pavel Jesina, MSc, MD, PhD, Jakub Krijt, MSc, Blanka Stiburkova, MSc, PhD, Andrea Mancikova, MSc, Robert Dobrovolny, MSc, PhD, Violeta Bakardjieva-Mihaylova, MSc, Elena Vodickova, MD, Jan Stuchly, MSc, Tomas Kalina, MD PhD, Jan Stary, MD PhD, Jan Trka, MD PhD, Eva Fronkova, MD PhD, Viktor Kozich, MD PhD

Blood (2018) 132 (Supplement 1): 502.

https://doi.org/10.1182/blood-2018-99-113501

Published: 2018

Journal Articles

When Standard Markers Are Not Sufficient for Monitoring Minimal Residual Disease or Targeted Treatment: New Transcriptome Derived Flow Cytometry Markers for Switching B Cell Precursor Leukemias

Michaela Novakova, Alena Musilova, Lucie Slamova, Barbora Vakrmanova, Monika Brüggemann, Matthias Ritgen, Eva Fronkova, Tomas Kalina, Ondrej Hrusak, Jan Trka, Jan Stary, Martina Vaskova, Lucie Winkowska, Marketa Zaliova, Karel Fiser, Ester Mejstrikova

Blood (2017) 130 (Supplement 1): 3982.

https://doi.org/10.1182/blood.V130.Suppl_1.3982.3982

Published: 2017

Journal Articles

Monitoring of childhood ALL using BCR-ABL1 genomic breakpoints identifies a subgroup with CML-like biology

Lenka Hovorkova, Marketa Zaliova, Nicola C. Venn, Kirsten Bleckmann, Marie Trkova, Eliska Potuckova, Martina Vaskova, Jana Linhartova, Katerina Machova Polakova, Eva Fronkova, Walter Muskovic, Jodie E. Giles, Peter J. Shaw, Gunnar Cario, Rosemary Sutton, Jan Stary, Jan Trka, Jan Zuna

Blood (2017) 129 (20): 2771–2781.

https://doi.org/10.1182/blood-2016-11-749978

Published: 2017

Includes: Supplemental data

Journal Articles

Standardized flow cytometry for highly sensitive MRD measurements in B-cell acute lymphoblastic leukemia

Blood (2017) 129 (3): 347–357.

https://doi.org/10.1182/blood-2016-07-726307

Published: 2017

Includes: Supplemental data

Journal Articles

NGS-Based Minimal Residual Disease (MRD) after Stem Cell Transplantation (SCT) Is More Specific for Relapse Prediction Than qPCR and Suggests the Possibility of False-Positive qPCR Results

Michaela Kotrova, MD, Vincent H.J. van der Velden, PhD, Jacques J.M. van Dongen, MD PhD, Renata Formankova, MD PhD, Petr Sedlacek, MD PhD, Monika Brüggemann, MD PhD, Jan Zuna, MD PhD, Jan Stary, MD, Jan Trka, MD PhD, Eva Fronkova, M. D., Ph. D.

Blood (2016) 128 (22): 3494.

https://doi.org/10.1182/blood.V128.22.3494.3494

Published: 2016

Journal Articles

Library Preparation Is the Major Factor Affecting Differences in Results of Immunoglobulin Gene Rearrangements Detection on Two Major Next-Generation Sequencing Platforms

Blood (2015) 126 (23): 1411.

https://doi.org/10.1182/blood.V126.23.1411.1411

Published: 2015

Journal Articles

The predictive strength of next-generation sequencing MRD detection for relapse compared with current methods in childhood ALL

Michaela Kotrova, Katerina Muzikova, Ester Mejstrikova, Michaela Novakova, Violeta Bakardjieva-Mihaylova, Karel Fiser, Jan Stuchly, Mathieu Giraud, Mikaël Salson, Christiane Pott, Monika Brüggemann, Marc Füllgrabe, Jan Stary, Jan Trka, Eva Fronkova

Blood (2015) 126 (8): 1045–1047.

https://doi.org/10.1182/blood-2015-07-655159

Published: 2015

Includes: Supplemental data

Journal Articles

Potential Involvement of Physiological TCR Gamma Delta Clones in Immune Surveillance of Preleukemic Cells

Olga Zimmermannova, Marketa Zaliova, Anthony V. Moorman, Eva Fronkova, MD, PhD, Jan Stary, Jan Trka, Tomas Kalina, Jan Zuna

Blood (2014) 124 (21): 3775.

https://doi.org/10.1182/blood.V124.21.3775.3775

Published: 2014

Journal Articles

Refinement of IKZF1 Genomic Status in Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia

Tobia Lana, Paola de Lorenzo, Silvia Bresolin, PhD, Ilaria Bronzini, Monique L. Den Boer, MSc, PhD, Helene Cave, PhD, Eva Fronkova, MD, PhD, Martin Stanulla, MD, Marketa Zaliova, Christine J. Harrison, Hester de Groot-Kruseman, Claire Schwab, Maria Grazia Valsecchi, Andrea Biondi, Giuseppe Basso, MD, Giovanni Cazzaniga, PhD, Geertruy te Kronnie

Blood (2014) 124 (21): 3785.

https://doi.org/10.1182/blood.V124.21.3785.3785

Published: 2014

NARROW

NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol

Genotyping and Minimal Residual Disease (MRD) Assessment in cfDNA By the Euroclonality-NGS DNA Capture (EC-NDC) Panel in Mantle Cell Lymphoma (MCL)

BCR::ABL1-Positive Acute Lymphoblastic Leukemia: Different Clinical Behavior and Relevance of Prognostic Features in Typical ALL and in CML-like Disease

Single Cycle of Blinatumomab Followed By High-Dose Chemotherapy in the Induction Therapy for Ph-Negative Acute Lymphoblastic Leukemia in Adults. Primary Endpoint Analysis of the Blina-Cell Trial

Sequencing-Based Analysis of Clonal Evolution of 25 Mantle Cell Lymphoma Patients at Diagnosis and after Failure of Standard Immunochemotherapy

NGS-Based MRD Quantitation: An Alternative to qPCR Validated on a Large Consecutive Cohort of Children with ALL

A homozygous deletion in the SLC19 A1 gene as a cause of folate-dependent recurrent megaloblastic anemia

Deep Immunoprofiling By Flow Cytometry and NGS Reveals Distinct T Cell Profile in Pediatric Hepatitis-Associated Aplastic Anemia

B Cell Precursor Lymphoblastic Leukemia Patients with Good Treatment Response Have Low Levels of Erythroid Precursors

Switching Towards Monocytic Lineage and Discordancy between Flow Cytometric and PCR Minimal Residual Disease Results Is a Hallmark Feature of DUX4 Rearranged B-Cell Precursor Acute Lymphoblastic Leukemia

Co-Targeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Refractory Mantle Cell Lymphoma with Complex Karyotype Changes

Folate-Dependent Normocytic Anemia Caused By a Hypomorphic Mutation in SLC19A1 gene

When Standard Markers Are Not Sufficient for Monitoring Minimal Residual Disease or Targeted Treatment: New Transcriptome Derived Flow Cytometry Markers for Switching B Cell Precursor Leukemias

Monitoring of childhood ALL using BCR-ABL1 genomic breakpoints identifies a subgroup with CML-like biology

Standardized flow cytometry for highly sensitive MRD measurements in B-cell acute lymphoblastic leukemia

NGS-Based Minimal Residual Disease (MRD) after Stem Cell Transplantation (SCT) Is More Specific for Relapse Prediction Than qPCR and Suggests the Possibility of False-Positive qPCR Results

Library Preparation Is the Major Factor Affecting Differences in Results of Immunoglobulin Gene Rearrangements Detection on Two Major Next-Generation Sequencing Platforms

The predictive strength of next-generation sequencing MRD detection for relapse compared with current methods in childhood ALL

Potential Involvement of Physiological TCR Gamma Delta Clones in Immune Surveillance of Preleukemic Cells

Refinement of IKZF1 Genomic Status in Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia

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American Society of Hematology

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