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Giuseppe Gaipa
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Journal Articles

CD371-positive pediatric B-cell acute lymphoblastic leukemia: propensity to lineage switch and slow early response to treatment

Clinical Trials & Observations
Barbara Buldini, Elena Varotto, Margarita Maurer-Granofszky, Giuseppe Gaipa, Angela Schumich, Monika Brüggemann, Ester Mejstrikova, Giovanni Cazzaniga, Ondrej Hrusak, Monika Szczepanowski, Pamela Scarparo, Martin Zimmermann, Sabine Strehl, Dagmar Schinnerl, Marketa Zaliova, Leonid Karawajew, Jean-Pierre Bourquin, Tamar Feuerstein, Gunnar Cario, Julia Alten, Anja Möricke, Alessandra Biffi, Rosanna Parasole, Franca Fagioli, Maria Grazia Valsecchi, Andrea Biondi, Franco Locatelli, Andishe Attarbaschi, Martin Schrappe, Valentino Conter, Giuseppe Basso, Michael N. Dworzak
Journal: Blood
Blood (2024) 143 (17): 1738–1751.
https://doi.org/10.1182/blood.2023021952
Published: 2024
Includes: Supplemental data
Journal Articles

Role of Microenvironment in Influencing the Activity of CD19 CAR T Cells in B-Cell Precursor Acute Lymphoblastic Leukemia (B-ALL)

Marianna Ponzo, Lorenzo Drufuca, Chiara Buracchi, Silvia Nucera, Cristina Bugarin, Grazisa Rossetti, Raoul Bonnal, Benedetta Rambaldi, Andrea Biondi, Giuseppe Gaipa, Massimiliano Pagani, Chiara Francesca Magnani
Journal: Blood
Blood (2023) 142 (Supplement 1): 3475.
https://doi.org/10.1182/blood-2023-180608
Published: 2023
Journal Articles

Carcik-CD19 Cells Expand In Vivo Toward a CD8 + Memory Phenotype and Their Persistence Is Associated with a Longer Duration of Response

Benedetta Rambaldi, Stefania Galimberti, Giuliana Rizzuto, Chiara Francesca Magnani, Chiara Buracchi, Giulia Risca, Martina Paredi, Daniela Belotti, Alex Moretti, Marianna Ponzo, Sarah Tettamanti, Gian Maria Borleri, Cristian Meli, Muriel Paganessi, Silvia Zaninelli, Elisa Gotti, Chiara Capelli, Martino Introna, Federico Lussana, Giuseppe Gritti, Silvia Ferrari, Anna Grassi, Sara Napolitano, Adriana Balduzzi, Maria Grazia Valsecchi, Giuseppe Dastoli, Alessandro Rambaldi, Andrea Biondi, Giuseppe Gaipa
Journal: Blood
Blood (2022) 140 (Supplement 1): 10339–10340.
https://doi.org/10.1182/blood-2022-166788
Published: 2022
Journal Articles

Final Results of Phase I/II Study of Donor-Derived CAR T Cells Engineered with Sleeping Beauty in Pediatric and Adult Patients with B-Cell Acute Lymphoblastic Leukemia Relapsed Post-HSCT

Federico Lussana, Chiara Francesca Magnani, Giuseppe Gaipa, Stefania Galimberti, Giuseppe Gritti, Daniela Belotti, Sara Napolitano, Chiara Buracchi, Gian Maria Borleri, Benedetta Rambaldi, Giuliana Rizzuto, Anna Grassi, Muriel Paganessi, Silvia Ferrari, Sarah Tettamanti, Giovanni Gazzaniga, Chiara Capelli, Elisa Gotti, Martino Introna, Adriana Balduzzi, Maria Grazia Valsecchi, Giuseppe Dastoli, Alessandro Rambaldi, Andrea Biondi
Journal: Blood
Blood (2022) 140 (Supplement 1): 4568–4569.
https://doi.org/10.1182/blood-2022-165448
Published: 2022
Journal Articles

Donor-Derived CAR T Cells Engineered with Sleeping Beauty in Pediatric and Adult Patients with Acute Lymphoblastic Leukemia Relapsed Post-HSCT

Chiara F Magnani, Giuseppe Gaipa, Federico Lussana, Giuseppe Gritti, Daniela Belotti, Sara Napolitano, Chiara Buracchi, Gian Maria Borleri, Benedetta Rambaldi, Silvia Zaninelli, Giuliana Rizzuto, Gianluca Cavallaro, Sarah Tettamanti, Giovanni Cazzaniga, Stefania Galimberti, Silvia Ferrari, Martino Introna, Adriana Balduzzi, Maria Grazia Valsecchi, Giuseppe Dastoli, Alessandro Rambaldi, Andrea Biondi
Journal: Blood
Blood (2021) 138 (Supplement 1): 472.
https://doi.org/10.1182/blood-2021-148703
Published: 2021
Journal Articles

Glucocorticoid-Resistant B-Cell Acute Lymphoblastic Leukemic Cells Can be Targeted By BCR-Signaling Inhibition

Jolanda Sarno, Pablo Domizi, Yuxuan Liu, Milton Merchant, Dorra Jedoui, Astraea Jager, Andrea Biondi, Giuseppe Gaipa, Alessio Felice Bava, Kara L. Davis
Journal: Blood
Blood (2021) 138 (Supplement 1): 617.
https://doi.org/10.1182/blood-2021-150356
Published: 2021
Journal Articles

Absent B cells, agammaglobulinemia, and hypertrophic cardiomyopathy in folliculin-interacting protein 1 deficiency

Brief Report
Francesco Saettini, Cecilia Poli, Jaime Vengoechea, Sonia Bonanomi, Julio C. Orellana, Grazia Fazio, Fred H. Rodriguez, III, Loreani P. Noguera, Claire Booth, Valentina Jarur-Chamy, Marissa Shams, Maria Iascone, Maja Vukic, Serena Gasperini, Manuel Quadri, Amairelys Barroeta Seijas, Elizabeth Rivers, Mario Mauri, Raffaele Badolato, Gianni Cazzaniga, Cristina Bugarin, Giuseppe Gaipa, Wilma G. M. Kroes, Daniele Moratto, Monique M. van Oostaijen-ten Dam, Frank Baas, Silvère van der Maarel, Rocco Piazza, Zeynep H. Coban-Akdemir, James R. Lupski, Bo Yuan, Ivan K. Chinn, Lucia Daxinger, Andrea Biondi
Journal: Blood
Blood (2021) 137 (4): 493–499.
https://doi.org/10.1182/blood.2020006441
Published: 2021
Includes: Supplemental data
Journal Articles

Donor-Derived CAR T Cells Engineered with Sleeping Beauty Achieve Anti-Leukemic Activity without Severe Toxicity

Chiara F Magnani, Giuseppe Gaipa, PhD, Federico Lussana, MD, Daniela Belotti, Giuseppe Gritti, MD PhD, Sara Napolitano, MD, Chiara Buracchi, PhD, Gian Maria Borleri, Silvia Zaninelli, Giuliana Rizzuto, Sarah Tettamanti, PhD, Valentina Colombo, Giovanni Cazzaniga, PhD, Benedetta Cabiati, Attilio Rovelli, MD, Ettore Biagi, MD PhD, Stefania Galimberti, PhD, Fabrizio Benedicenti, Eugenio Montini, PhD, Silvia Ferrari, MD, Martino Introna, MD, Adriana Balduzzi, MD, Maria Grazia Valsecchi, PhD, Giuseppe Dastoli, MD, Alessandro Rambaldi, MD, Andrea Biondi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-141236
Published: 2020
Journal Articles

Single-Cell Profiling of Signal Transduction Pathways in Pediatric T-Cell Acute Lymphoblastic Leukemia By Mass Cytometry:Dissecting JAK/STAT and PI3K/Akt/mTOR Active Signalling

Daniela Kužílková, PhD, Tomas Kalina, MD PhD, Cristina Bugarin, Dr., Katerina Rejlová, Dr., Daniel Thurner, Dr., Pavel Semerák, Dr., Jan Stuchly, MSc, Andrea Biondi, MD PhD, Giuseppe Gaipa, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 38–39.
https://doi.org/10.1182/blood-2020-141973
Published: 2020
Journal Articles

Transient Switch to Myeloid Lineage in Acute Lymphoblastic Leukemia during Induction Therapy: The Role of CD371 Expression and Implication for Minimal Residual Disease Detection

Elena Varotto, MD PhD, Margarita Maurer-Granofszky, PhD, Daniela Silvestri, Pamela Scarparo, PhD, Ester Mejstrikova, MD PhD, Monika Brüggemann, Giovanni Cazzaniga, PhD, Valentino Conter, MD, Ondrej Hrusak, MD PhD, Giuseppe Gaipa, PhD, Angela Schumich, Maria Grazia Valsecchi, PhD, Giuseppe Basso, MD PhD, Michael Dworzak, MD, Barbara Buldini, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 377.
https://doi.org/10.1182/blood-2019-127287
Published: 2019
Journal Articles

Donor-Derived CD19 CAR Cytokine Induced Killer (CIK) Cells Engineered with Sleeping Beauty Transposon for Relapsed B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Chiara F Magnani, PhD, Giuseppe Gaipa, PhD, Daniela Belotti, Giada Matera, Sarah Tettamanti, PhD, Benedetta Cabiati, Chiara Buracchi, PhD, Grazia Fazio, Silvia Zaninelli, Silvia Rigamonti, Stefania Cesana, Valentina Colombo, Giovanni Cazzaniga, PhD, Attilio Rovelli, MD, Adriana Balduzzi, MD, Sara Napolitano, MD, Fabrizio Benedicenti, Eugenio Montini, PhD, Gian Maria Borleri, Silvia Ferrari, MD, Giuseppe Gritti, MD PhD, Federico Lussana, MD, Martino Introna, MD, Alessandro Rambaldi, MD, Giuseppe Dastoli, MD, Andrea Biondi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 200.
https://doi.org/10.1182/blood-2019-125894
Published: 2019
Journal Articles

Targeting a Specific Glycosylated Epitope of CD43 with a New Humanized Monoclonal Antibody for the Treatment of Pediatric and Adult T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Cirino Botta, MD, Giuseppe Gaipa, PhD, Maria Eugenia Gallo Cantafio, PhD, Chiara Buracchi, PhD, Maria Anna Siciliano, MD, Caterina Riillo, MD, Katia Grillone, PhD, Alessandro Gulino, Maria Cucè, Nicoletta Staropoli, Andrea Ghelli Luserna Di Rora, Franca Maria Tuccillo, Maria Teresa Di Martino, Claudio Tripodo, MD, Marco Rossi, MD, Giovanni Martinelli, Andrea Biondi, MD, Pierosandro Tagliaferri, Pierfrancesco Tassone, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1418.
https://doi.org/10.1182/blood-2018-99-118572
Published: 2018
Journal Articles

Glucocorticoids-Resistant Leukemic B-Cells Undergo a Phenotypic Change That Increases Sensitivity to SRC/ABL Inhibition

Jolanda Sarno, PhD, Christina Bligaard Pedersen, MSc, Astraea Jager, BS, Tyler Burns, PhD, Giuseppe Gaipa, PhD, Garry P. Nolan, PhD, Alessio Felice Bava, PhD, Kara L. Davis, DO
Journal: Blood
Blood (2018) 132 (Supplement 1): 1546.
https://doi.org/10.1182/blood-2018-99-117443
Published: 2018
Journal Articles

Flow Cytometric Measurement of the Initial In Vivo Response to Prednisone Provides New Prognostic Information in Childhood Acute Lymphoblastic Leukemia (ALL)

Giuseppe Gaipa, PhD, Oscar Maglia, Simona Sala, Bsc, Noemi Marino, Daniela Silvestri, Maria Grazia Valsecchi, PhD, Andrea Biondi, MD, Valentino Conter, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2827.
https://doi.org/10.1182/blood-2018-99-116782
Published: 2018
Journal Articles

Clinical-Grade Transduction of Allogeneic Cytokine Induced Killer (CIK) Cells with CD19 Chimeric Antigen Receptor (CAR) Using Sleeping Beauty (SB) Transposon: Successful GMP-Compliant Manufacturing for Clinical Applications

Giuseppe Gaipa, PhD, Chiara Francesca Magnani, PhD, Daniela Belotti, Giada Matera, Sarah Tettamanti, PhD, Benedetta Cabiati, Stefania Cesana, Valentina Colombo, Giovanni Cazzaniga, PhD, Grazia Fazio, PhD, Chiara Buracchi, PhD, Silvia Rigamonti, Attilio Rovelli, MD, Adriana Balduzzi, MD, Sara Napolitano, MD, Eugenio Montini, Gian Maria Borleri, Giuseppe Gritti, MD PhD, Federico Lussana, MD PhD, Martino Introna, MD, Alessandro Rambaldi, MD, Giuseppe Dastoli, MD, Andrea Biondi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 196.
https://doi.org/10.1182/blood-2018-196
Published: 2018
Journal Articles

Standardized flow cytometry for highly sensitive MRD measurements in B-cell acute lymphoblastic leukemia

Prisca Theunissen, Ester Mejstrikova, Lukasz Sedek, Alita J. van der Sluijs-Gelling, Giuseppe Gaipa, Marius Bartels, Elaine Sobral da Costa, Michaela Kotrová, Michaela Novakova, Edwin Sonneveld, Chiara Buracchi, Paola Bonaccorso, Elen Oliveira, Jeroen G. te Marvelde, Tomasz Szczepanski, Ludovic Lhermitte, Ondrej Hrusak, Quentin Lecrevisse, Georgiana Emilia Grigore, Eva Froňková, Jan Trka, Monika Brüggemann, Alberto Orfao, Jacques J. M. van Dongen, Vincent H. J. van der Velden
Journal: Blood
Blood (2017) 129 (3): 347–357.
https://doi.org/10.1182/blood-2016-07-726307
Published: 2017
Includes: Supplemental data
Journal Articles

Final Analysis of a Multicenter Pilot Phase 2 Study of Cytokine Induced Killer (CIK) Cells for Patients with Relapse after Allogeneic Transplantation

Federico Lussana, MD, Martino Introna, MD, Josee Golay, PhDBA, Federica Delaini, Chiara Pavoni, MSc, Ruth Valgarsddottir, Elisa Gotti, BA, Alessandra Algarotti, MD, Caterina Micò, MD, Anna Grassi, MD, Maria Chiara Finazzi, MD, Irene Cavattoni, MD, Adriana Balduzzi, MD, Sara Napolitano, MD, Attilio Rovelli, MD, Giusi Sgroi, Paolo Perseghin, MD, Giuseppe Gaipa, PhD, Ettore Biagi, MD PhD, Andrea Biondi, MD, Alessandro Rambaldi, MD
Journal: Blood
Blood (2016) 128 (22): 1160.
https://doi.org/10.1182/blood.V128.22.1160.1160
Published: 2016
Journal Articles

Manufacturing of Mesenchymal Stromal Cells for the Treatment of Graft-Versus-Host Disease: A Survey within the European Society of Blood and Marrow Transplantation

Trento Cristina, PhD, Maria Ester Bernardo, MD PhD, Arnon Nagler, MD, Selim Kuci, Martin Bornhäuser, MD, Ulrike Köhl, MD, Dirk Strunk, Giuseppe Gaipa, PhD, Martino Introna, MD, Lorenza Lazzari, PhD, Jane F. Apperley, MD, Adomas Bukauskas, Katarina Le Blanc, MD PhD, Ann Van Campenhout, Yves Beguin, MD PhD, Jurgen Kuball, MD PhD, Steffi Maria van der Werf, PhD, Carmen Ruiz de Elvira, Christian Chabannon, MD PhD, Helene Roelofs, PhD, Chiara Bonini, MD, Francesco Dazzi, PhD
Journal: Blood
Blood (2016) 128 (22): 3374.
https://doi.org/10.1182/blood.V128.22.3374.3374
Published: 2016
Journal Articles

Euroflow-Based Immunophenotypic Characterization of CD34+ Cell Compartment in Juvenile Myelomonocytic Leukemia (JMML): A New Tool for Differential Diagnosis

Giuseppe Gaipa, PhD, Cristina Bugarin, Sergio Matarraz, Chiara Buracchi, PhD, Lukasz Sedek, MDPhD, Vincent H.J. van der Velden, PhD, Tomasz Szczepanski, Prof MD PhD, Alita van der Sluijs, Elaine Sobral da Costa, Michaela Novakova, Ester Mejstrikova, MD PhD, Carmen Aanei, Jacques JM van Dongen, Andrea Biondi, MD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3127.
https://doi.org/10.1182/blood.V128.22.3127.3127
Published: 2016
Journal Articles

Mass Cytometry Analysis Dissects CRLF2-Driven Signaling Pathways in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)

Jolanda Sarno, Kara L. Davis, DO, Angela Maria Savino, PhD, Cristina Bugarin, Stefania Pinto, Chiara Buracchi, PhD, Astraea Jager, BS, Chiara Palmi, PhD, Ruth C Barber, PhD, Daniela Silvestri, Gianni Cazzaniga, PhD, Martin J.S. Dyer, Prof., Andrea Biondi, Prof, MD, Garry P. Nolan, Prof, PhD, Giuseppe Gaipa, PhD
Journal: Blood
Blood (2015) 126 (23): 906.
https://doi.org/10.1182/blood.V126.23.906.906
Published: 2015