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Journal Articles

Cord Blood-Derived Carcik Cells As Off-the-Shelf Non-Viral Cell Therapy for Hematological Malignancies

Ilaria Pisani, Giusi Melita, Simone Naso, Michele Francesco Quaroni, Giada Matera, Daniela Belotti, Benedetta Cabiati, Elisa Gotti, Carolina Cuofano, Chiara Capelli, Jolanda Sarno, Angela Maria Savino, Ilaria Ratti, Daniele Prati, Benedetta Rambaldi, Giorgio Ottaviano, Giovanna Lucchini, Giuseppe Dastoli, Andrea Biondi, Alessandro Rambaldi, Josee Golay, Martino Introna, Giuseppe Gaipa, Sarah Tettamanti
Journal: Blood
Blood (2024) 144 (Supplement 1): 4849.
https://doi.org/10.1182/blood-2024-211472
Published: 2024
Journal Articles

Carcik-CD19 Cells Expand In Vivo Toward a CD8 + Memory Phenotype and Their Persistence Is Associated with a Longer Duration of Response

Benedetta Rambaldi, Stefania Galimberti, Giuliana Rizzuto, Chiara Francesca Magnani, Chiara Buracchi, Giulia Risca, Martina Paredi, Daniela Belotti, Alex Moretti, Marianna Ponzo, Sarah Tettamanti, Gian Maria Borleri, Cristian Meli, Muriel Paganessi, Silvia Zaninelli, Elisa Gotti, Chiara Capelli, Martino Introna, Federico Lussana, Giuseppe Gritti, Silvia Ferrari, Anna Grassi, Sara Napolitano, Adriana Balduzzi, Maria Grazia Valsecchi, Giuseppe Dastoli, Alessandro Rambaldi, Andrea Biondi, Giuseppe Gaipa
Journal: Blood
Blood (2022) 140 (Supplement 1): 10339–10340.
https://doi.org/10.1182/blood-2022-166788
Published: 2022
Journal Articles

Immune Reconstitution Following Infusion of Autologous Blinatumomab Expanded T-Cells (BET) in CD20+ Indolent Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia Receiving Front-Line Treatment with Fludarabine-Cyclophosphamide-Rituximab or Bendamustine-Rituximab

Giuseppe Gritti, Federico Lussana, Silvia Ferrari, Anna Maria Barbui, Francesco Landi, Giulia Quaresmini, Gianmaria Borleri, Muriel Paganessi, Chiara Pavoni, Elisa Gotti, Chiara Capelli, Josee Golay, Martino Introna, Alessandro Rambaldi
Journal: Blood
Blood (2022) 140 (Supplement 1): 10325–10326.
https://doi.org/10.1182/blood-2022-170120
Published: 2022
Journal Articles

Final Results of Phase I/II Study of Donor-Derived CAR T Cells Engineered with Sleeping Beauty in Pediatric and Adult Patients with B-Cell Acute Lymphoblastic Leukemia Relapsed Post-HSCT

Federico Lussana, Chiara Francesca Magnani, Giuseppe Gaipa, Stefania Galimberti, Giuseppe Gritti, Daniela Belotti, Sara Napolitano, Chiara Buracchi, Gian Maria Borleri, Benedetta Rambaldi, Giuliana Rizzuto, Anna Grassi, Muriel Paganessi, Silvia Ferrari, Sarah Tettamanti, Giovanni Gazzaniga, Chiara Capelli, Elisa Gotti, Martino Introna, Adriana Balduzzi, Maria Grazia Valsecchi, Giuseppe Dastoli, Alessandro Rambaldi, Andrea Biondi
Journal: Blood
Blood (2022) 140 (Supplement 1): 4568–4569.
https://doi.org/10.1182/blood-2022-165448
Published: 2022
Journal Articles

Donor-Derived CAR T Cells Engineered with Sleeping Beauty in Pediatric and Adult Patients with Acute Lymphoblastic Leukemia Relapsed Post-HSCT

Chiara F Magnani, Giuseppe Gaipa, Federico Lussana, Giuseppe Gritti, Daniela Belotti, Sara Napolitano, Chiara Buracchi, Gian Maria Borleri, Benedetta Rambaldi, Silvia Zaninelli, Giuliana Rizzuto, Gianluca Cavallaro, Sarah Tettamanti, Giovanni Cazzaniga, Stefania Galimberti, Silvia Ferrari, Martino Introna, Adriana Balduzzi, Maria Grazia Valsecchi, Giuseppe Dastoli, Alessandro Rambaldi, Andrea Biondi
Journal: Blood
Blood (2021) 138 (Supplement 1): 472.
https://doi.org/10.1182/blood-2021-148703
Published: 2021
Journal Articles

Donor-Derived CAR T Cells Engineered with Sleeping Beauty Achieve Anti-Leukemic Activity without Severe Toxicity

Chiara F Magnani, Giuseppe Gaipa, PhD, Federico Lussana, MD, Daniela Belotti, Giuseppe Gritti, MD PhD, Sara Napolitano, MD, Chiara Buracchi, PhD, Gian Maria Borleri, Silvia Zaninelli, Giuliana Rizzuto, Sarah Tettamanti, PhD, Valentina Colombo, Giovanni Cazzaniga, PhD, Benedetta Cabiati, Attilio Rovelli, MD, Ettore Biagi, MD PhD, Stefania Galimberti, PhD, Fabrizio Benedicenti, Eugenio Montini, PhD, Silvia Ferrari, MD, Martino Introna, MD, Adriana Balduzzi, MD, Maria Grazia Valsecchi, PhD, Giuseppe Dastoli, MD, Alessandro Rambaldi, MD, Andrea Biondi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-141236
Published: 2020
Journal Articles

Donor-Derived CD19 CAR Cytokine Induced Killer (CIK) Cells Engineered with Sleeping Beauty Transposon for Relapsed B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Chiara F Magnani, PhD, Giuseppe Gaipa, PhD, Daniela Belotti, Giada Matera, Sarah Tettamanti, PhD, Benedetta Cabiati, Chiara Buracchi, PhD, Grazia Fazio, Silvia Zaninelli, Silvia Rigamonti, Stefania Cesana, Valentina Colombo, Giovanni Cazzaniga, PhD, Attilio Rovelli, MD, Adriana Balduzzi, MD, Sara Napolitano, MD, Fabrizio Benedicenti, Eugenio Montini, PhD, Gian Maria Borleri, Silvia Ferrari, MD, Giuseppe Gritti, MD PhD, Federico Lussana, MD, Martino Introna, MD, Alessandro Rambaldi, MD, Giuseppe Dastoli, MD, Andrea Biondi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 200.
https://doi.org/10.1182/blood-2019-125894
Published: 2019
Journal Articles

Human neutrophils express low levels of FcγRIIIA, which plays a role in PMN activation

Josée Golay, Rut Valgardsdottir, Gerta Musaraj, Damiano Giupponi, Orietta Spinelli, Martino Introna
Journal: Blood
Blood (2019) 133 (13): 1395–1405.
https://doi.org/10.1182/blood-2018-07-864538
Published: 2019
Includes: Supplemental data
Journal Articles

Human Umbilical Cord Derived Mesenchymal Stromal Cells to Treat Steroid-Refractory Acute GvHD III/IV or Overlap Syndrome: Interim Analysis of a Multicenter Phase I/II Study

Maria Mico', Alessandra Algarotti, MD, Anna Grassi, MD, Chiara Pavoni, Statistician, Francesco Onida, MD, Nicola Mordini, Maria Luisa Ferrari, Federico Lussana, MD PhD, Maria Chiara Finazzi, MD, Daniela Taurino, MD, Chiara Capelli, Martino Introna, MD, Alessandro Rambaldi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3404.
https://doi.org/10.1182/blood-2018-99-118444
Published: 2018
Journal Articles

Clinical-Grade Transduction of Allogeneic Cytokine Induced Killer (CIK) Cells with CD19 Chimeric Antigen Receptor (CAR) Using Sleeping Beauty (SB) Transposon: Successful GMP-Compliant Manufacturing for Clinical Applications

Giuseppe Gaipa, PhD, Chiara Francesca Magnani, PhD, Daniela Belotti, Giada Matera, Sarah Tettamanti, PhD, Benedetta Cabiati, Stefania Cesana, Valentina Colombo, Giovanni Cazzaniga, PhD, Grazia Fazio, PhD, Chiara Buracchi, PhD, Silvia Rigamonti, Attilio Rovelli, MD, Adriana Balduzzi, MD, Sara Napolitano, MD, Eugenio Montini, Gian Maria Borleri, Giuseppe Gritti, MD PhD, Federico Lussana, MD PhD, Martino Introna, MD, Alessandro Rambaldi, MD, Giuseppe Dastoli, MD, Andrea Biondi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 196.
https://doi.org/10.1182/blood-2018-196
Published: 2018
Journal Articles

Human neutrophils mediate trogocytosis rather than phagocytosis of CLL B cells opsonized with anti-CD20 antibodies

Rut Valgardsdottir, Irene Cattaneo, Christian Klein, Martino Introna, Marina Figliuzzi, Josée Golay
Journal: Blood
Blood (2017) 129 (19): 2636–2644.
https://doi.org/10.1182/blood-2016-08-735605
Published: 2017
Includes: Multimedia, Supplemental data
Journal Articles

Final Analysis of a Multicenter Pilot Phase 2 Study of Cytokine Induced Killer (CIK) Cells for Patients with Relapse after Allogeneic Transplantation

Federico Lussana, MD, Martino Introna, MD, Josee Golay, PhDBA, Federica Delaini, Chiara Pavoni, MSc, Ruth Valgarsddottir, Elisa Gotti, BA, Alessandra Algarotti, MD, Caterina Micò, MD, Anna Grassi, MD, Maria Chiara Finazzi, MD, Irene Cavattoni, MD, Adriana Balduzzi, MD, Sara Napolitano, MD, Attilio Rovelli, MD, Giusi Sgroi, Paolo Perseghin, MD, Giuseppe Gaipa, PhD, Ettore Biagi, MD PhD, Andrea Biondi, MD, Alessandro Rambaldi, MD
Journal: Blood
Blood (2016) 128 (22): 1160.
https://doi.org/10.1182/blood.V128.22.1160.1160
Published: 2016
Journal Articles

Manufacturing of Mesenchymal Stromal Cells for the Treatment of Graft-Versus-Host Disease: A Survey within the European Society of Blood and Marrow Transplantation

Trento Cristina, PhD, Maria Ester Bernardo, MD PhD, Arnon Nagler, MD, Selim Kuci, Martin Bornhäuser, MD, Ulrike Köhl, MD, Dirk Strunk, Giuseppe Gaipa, PhD, Martino Introna, MD, Lorenza Lazzari, PhD, Jane F. Apperley, MD, Adomas Bukauskas, Katarina Le Blanc, MD PhD, Ann Van Campenhout, Yves Beguin, MD PhD, Jurgen Kuball, MD PhD, Steffi Maria van der Werf, PhD, Carmen Ruiz de Elvira, Christian Chabannon, MD PhD, Helene Roelofs, PhD, Chiara Bonini, MD, Francesco Dazzi, PhD
Journal: Blood
Blood (2016) 128 (22): 3374.
https://doi.org/10.1182/blood.V128.22.3374.3374
Published: 2016
Journal Articles

A Multicenter Phase II Study of Sequential Administration of Unmanipulated DLI and Donor Derived Cytokine Induced Killer (CIK) Cells in HSCT Patients, Relapsed of Disease

Martino Introna, MD, Elisa Gotti, BA, Michela Bonzi, BA, Josee Golay, PhDBA, Alessandra Algarotti, MD, Caterina Micò, MD, Anna Grassi, MD, Cristina Boschini, Maria Luisa Ferrari, BSc, Irene Cavattoni, MD, Ettore Biagi, MD, Adriana Balduzzi, Sr., MD, Attilio Rovelli, MD, Paolo Perseghin, MD, Giuseppe Gaipa, PhD, Andrea Biondi, Alessandro Rambaldi, MD
Journal: Blood
Blood (2015) 126 (23): 3160.
https://doi.org/10.1182/blood.V126.23.3160.3160
Published: 2015
Journal Articles

Glycoengineered CD20 Antibody Obinutuzumab Activates Neutrophils and Mediates Phagocytosis Through CD16B More Efficiently Than Rituximab

Josée Golay, PhD, Fabio Da Roit, BSc, Luca Bologna, BSc, Claudia Ferrara Koller, PhD, Jeanette H. W. Leusen, PhD, Alessandro Rambaldi, MD, Christian Klein, PhD, Martino Introna, MD
Journal: Blood
Blood (2013) 122 (21): 4419.
https://doi.org/10.1182/blood.V122.21.4419.4419
Published: 2013
Journal Articles

Massive, Clinical Grade Expansion Of Polyclonal T Cells Using Blinatumomab For Adoptive Autologous Cellular Therapy Of CLL Patients

Josée Golay, PhD, Anna D’amico, PhD, Gianmaria Borleri, Maria Chiara Finazzi, MD, Giulia Quaresmini, MD, Martino Introna, MD, Alessandro Rambaldi, MD
Journal: Blood
Blood (2013) 122 (21): 3272.
https://doi.org/10.1182/blood.V122.21.3272.3272
Published: 2013
Journal Articles

Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab

Josée Golay, Fabio Da Roit, Luca Bologna, Claudia Ferrara, Jeanette H. Leusen, Alessandro Rambaldi, Christian Klein, Martino Introna
Journal: Blood
Blood (2013) 122 (20): 3482–3491.
https://doi.org/10.1182/blood-2013-05-504043
Published: 2013
Includes: Supplemental data
Journal Articles

Safe and Effective Treatment of Graft Versus Host Disease with Platelet Lysate-Expanded Human Mesenchymal Stromal Cells: A Phase 1 Study On 47 Adult and Pediatric Patients

Martino Introna, MD, Giovanna Lucchini, Erica Dander, PhD, Attilio Rovelli, MD, Adriana Balduzzi, MD, Daniela Longoni, Fabio Pavan, Francesca Masciochi, Alessandra Algarotti, MD, Caterina Micò, MD, Anna Grassi, MD, Irene Cavattoni, MD, Sara Deola, MD, Giuseppe Gaipa, Daniela Belotti, Paolo Perseghin, MD, Matteo Parma, MD, Enrico Maria Pogliani, MD, Josée Golay, PhD, Elisa Gotti, Chiara Capelli, Sergio Cortelazzo, MD, Giovanna D'Amico, Andrea Biondi, MD, Alessandro Rambaldi, MD, Ettore Biagi, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 743.
https://doi.org/10.1182/blood.V120.21.743.743
Published: 2012
Journal Articles

A Phase II Study of Sequential Administration of DLI and Cytokine Induced Killer (CIK) Cells in Patients with Hematologic Malignancies Relapsing After Allogeneic Hematopoietic Stem Cell Transplantation: Preliminary Results

Martino Introna, MD, Alessandra Algarotti, MD, Caterina Micò, MD, Anna Grassi, MD, Alice Pievani, PhD, Gianmaria Borleri, Josée Golay, PhD, Irene Cavattoni, MD, Sergio Cortelazzo, MD, Alessandro Rambaldi
Journal: Blood
Blood (2011) 118 (21): 657.
https://doi.org/10.1182/blood.V118.21.657.657
Published: 2011
Journal Articles

Dual-functional capability of CD3 + CD56 + CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity

Alice Pievani, Gianmaria Borleri, Daniela Pende, Lorenzo Moretta, Alessandro Rambaldi, Josée Golay, Martino Introna
Journal: Blood
Blood (2011) 118 (12): 3301–3310.
https://doi.org/10.1182/blood-2011-02-336321
Published: 2011
Includes: Supplemental data