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Journal Articles

Mutational and transcriptional landscape of pediatric B-cell precursor lymphoblastic lymphoma

Emma Kroeze, Ingram Iaccarino, Michelle M. Kleisman, Mayukh Mondal, Thomas Beder, Mouhamad Khouja, Marc P. Höppner, Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Monika Brüggemann, Claudia D. Baldus, Gunnar Cario, Reno S. Bladergroen, Nathalie Garnier, Andishe Attarbaschi, Jaime Verdu-Amorós, Rosemary Sutton, Elizabeth Macintyre, Kenneth Scholten, Laura Arias Padilla, Birgit Burkhardt, Auke Beishuizen, Monique L. den Boer, Roland P. Kuiper, Jan L. C. Loeffen, Judith M. Boer, Wolfram Klapper
Journal: Blood
Blood (2024) 144 (1): 74–83.
https://doi.org/10.1182/blood.2024023938
Published: 2024
Includes: Supplemental data
Journal Articles

The IL-7R antagonist lusvertikimab reduces leukemic burden in xenograft ALL via antibody-dependent cellular phagocytosis

Lennart Lenk, Irène Baccelli, Anna Laqua, Julia Heymann, Claas Reimer, Anna Dietterle, Dorothee Winterberg, Caroline Mary, Frédérique Corallo, Julien Taurelle, Emma Narbeburu, Stéphanie Neyton, Mylène Déramé, Sabrina Pengam, Fotini Vogiatzi, Beat Bornhauser, Jean-Pierre Bourquin, Simon Raffel, Vladyslava Dovhan, Thomas Schüler, Gabriele Escherich, Monique L. den Boer, Judith M. Boer, Wiebke Wessels, Matthias Peipp, Julia Alten, Željko Antić, Anke K. Bergmann, Martin Schrappe, Gunnar Cario, Monika Brüggemann, Nicolas Poirier, Denis M. Schewe
Journal: Blood
Blood (2024) 143 (26): 2735–2748.
https://doi.org/10.1182/blood.2023021088
Published: 2024
Includes: Supplemental data
Journal Articles

CD371-positive pediatric B-cell acute lymphoblastic leukemia: propensity to lineage switch and slow early response to treatment

Clinical Trials & Observations
Barbara Buldini, Elena Varotto, Margarita Maurer-Granofszky, Giuseppe Gaipa, Angela Schumich, Monika Brüggemann, Ester Mejstrikova, Giovanni Cazzaniga, Ondrej Hrusak, Monika Szczepanowski, Pamela Scarparo, Martin Zimmermann, Sabine Strehl, Dagmar Schinnerl, Marketa Zaliova, Leonid Karawajew, Jean-Pierre Bourquin, Tamar Feuerstein, Gunnar Cario, Julia Alten, Anja Möricke, Alessandra Biffi, Rosanna Parasole, Franca Fagioli, Maria Grazia Valsecchi, Andrea Biondi, Franco Locatelli, Andishe Attarbaschi, Martin Schrappe, Valentino Conter, Giuseppe Basso, Michael N. Dworzak
Journal: Blood
Blood (2024) 143 (17): 1738–1751.
https://doi.org/10.1182/blood.2023021952
Published: 2024
Includes: Supplemental data
Journal Articles

Developmental trajectories and cooperating genomic events define molecular subtypes of BCR :: ABL1 -positive ALL

Clinical Trials & Observations Brief Report
Lorenz Bastian, Thomas Beder, Malwine J. Barz, Sonja Bendig, Lorenz Bartsch, Wencke Walter, Nadine Wolgast, Björn Brändl, Christian Rohrandt, Björn-Thore Hansen, Alina M. Hartmann, Katharina Iben, Dennis Das Gupta, Miriam Denker, Johannes Zimmermann, Michael Wittig, Guranda Chitadze, Martin Neumann, Folker Schneller, Walter Fiedler, Björn Steffen, Matthias Stelljes, Christoph Faul, Stefan Schwartz, Franz-Josef Müller, Gunnar Cario, Lana Harder, Claudia Haferlach, Heike Pfeifer, Nicola Gökbuget, Monika Brüggemann, Claudia D. Baldus
Journal: Blood
Blood (2024) 143 (14): 1391–1398.
https://doi.org/10.1182/blood.2023021752
Published: 2024
Includes: Supplemental data
Journal Articles

Molecular Subtypes in BCR::ABL1 -Positive ALL Are Defined By Cellular Origins and Cooperating Genomic Events

Lorenz Bastian, Thomas Beder, Malwine Barz, Sonja Bendig, Lorenz Bartsch, Wencke Walter, Nadine Wolgast, Björn Brändl, Christian Rohrandt, Björn-Thore Hansen, Alina M. Hartmann, Katharina Iben, Miriam Bultmann, Johannes Zimmermann, Michael Wittig, Guranda Chitadze, Martin Neumann, Folker Schneller, Walter Fiedler, Björn Steffen, Matthias Stelljes, Christoph Faul, Stefan Schwartz, Franz-Josef Müller, Gunnar Cario, Lana Harder, Claudia Haferlach, Heike Pfeifer, Nicola Goekbuget, Monika Brüggemann, Claudia D Baldus
Journal: Blood
Blood (2023) 142 (Supplement 1): 843.
https://doi.org/10.1182/blood-2023-187315
Published: 2023
Journal Articles

Distinct Pattern of ABL1 Genomic Breakpoints in Chronic Myeloid Leukemia and BCR::ABL1-Positive Acute Lymphoblastic Leukemia: Analysis of 884 Patients with Minor and Major BCR::ABL1 Fusion

Lenka Hovorkova, Lucie Winkowska, Justina Krotka, Manuela Krumbholz, Claus Meyer, Rosemary Sutton, Michelle Henderson, Emmanuelle Clappier, Sabina Chiaretti, Lucie Sramkova, Jan Stary, Adela Benesova, Katerina Machova Polakova, Rolf Marschalek, Markus Metzler, Giovanni Cazzaniga, Gunnar Cario, Jan Trka, Marketa Zaliova, Jan Zuna
Journal: Blood
Blood (2023) 142 (Supplement 1): 1605.
https://doi.org/10.1182/blood-2023-180355
Published: 2023
Journal Articles

CNS Invasion of TCF3::PBX1 + Leukemia Cells Requires Upregulation of AP-1 Signaling As Revealed By Brain Organoid Model

Philip Gebing, Stefanos Loizou, Sebastian Hänsch, Julian Schliehe-Diecks, Lea Spory, Pawel Stachura, Aleksandra Pandyra, Martin Schrappe, Gunnar Cario, Ameera Alsadeq, Denis Martin Schewe, Arndt Borkhardt, Lennart Lenk, Ute Fischer, Sanil Bhatia
Journal: Blood
Blood (2023) 142 (Supplement 1): 1407.
https://doi.org/10.1182/blood-2023-178613
Published: 2023
Journal Articles

Multinational Retrospective Analysis of Bridging Therapy Prior to Chimeric Antigen Receptor T Cells for Relapsed/Refractory Acute Lymphoblastic Leukemia in Children and Young Adults

Maike Breidenbach, Peter Bader, Andishe Attarbaschi, Claudia Rossig, Roland Meisel, Markus Metzler, Marion Subklewe, Fabian Mueller, Paul-Gerhardt Schlegel, Irene Teichert von Lüttichau, Jean-Pierre Bourquin, Gabriele Escherich, Gunnar Cario, Peter Lang, Ramona Krauss, Arend von Stackelberg, Semjon Willier, Christina Peters, Tobias Feuchtinger
Journal: Blood
Blood (2023) 142 (Supplement 1): 2135.
https://doi.org/10.1182/blood-2023-190117
Published: 2023
Journal Articles

Drug Response Profiling Informs Personalized Bridging to Cell Therapy for Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

Fabio D. Steffen, Andrej Lissat, Julia Alten, Cornelia Eckert, Nicole Bodmer, Bodil E. Thorhauge Als-Nielsen, Adriana Balduzzi, Barbara Buldini, Sarah Elitzur, Andras Kriston, Gergely Nyiri, Imre Västrik, Ferenc Kovacs, Francesco Ceppi, Lucie Sramkova, Larissa Schori, Arianna Arpagaus, Silvia Gutnik, Andishe Attarbaschi, Birgitte Klug Albertsen, Jeanette Greiner, Marc Ansari, Judith M. Boer, Elad Jacoby, Martin Stanulla, Uri Ilan, Peter M. Hoogerbrugge, Tim Lammens, Barbara De Moerloose, Petter Svenberg, Nicolas von der Weid, David O'Connor, Hélène Cavé, Franco Locatelli, Martin Schrappe, André Baruchel, Andreas Kulozik, Kjeld Schmiegelow, Gunnar Cario, Arend von Stackelberg, Peter Horvath, Beat Bornhauser, Jean-Pierre Bourquin
Journal: Blood
Blood (2023) 142 (Supplement 1): 4350.
https://doi.org/10.1182/blood-2023-179306
Published: 2023
Journal Articles

Pediatric Patients with High-Risk B-Cell ALL in First Complete Remission May Benefit from Less Toxic Immunotherapy with Blinatumomab - Results from Randomized Controlled Phase 3 Trial AIEOP-BFM ALL 2017

Martin Schrappe, Franco Locatelli, Maria Grazia Valsecchi, Gunnar Cario, Michaela Vossen-Gajcy, Jan Stary, Andishe Attarbaschi, Nicole Bodmer, Draga Barbaric, Sarah Elitzur, Daniela Silvestri, Alexandra Kolenova, Anja Möricke, Jean-Pierre Bourquin, Luciano Dalla-Pozza, Martin Stanulla, Shai Izraeli, Carmelo Rizzari, Fiona Poyer, Arend von Stackelberg, Valentino Conter, Martin Zimmermann, Andrea Biondi
Journal: Blood
Blood (2023) 142 (Supplement 1): 825.
https://doi.org/10.1182/blood-2023-181524
Published: 2023
Journal Articles

In-Depth Immune Profiling in Children with BCP-ALL within the AIEOP-BFM ALL 2017 Study

Anna Laqua, Hartmann Raifer, Miriam Kelm, Johanna Horns, Arunabh Sharma, Anja Möricke, Michaela Vossen-Gajcy, Julia Alten, Lena Fischer-Riepe, Bianca Altvater, Mahdi Rasa, Britta Kehden, Constantin Proske, Jan Kässens, Thomas Beder, Sonja Bendig, Nadine Wolgast, Lorenz Bastian, Matthias Ritgen, Magdalena Huber, Astrid Dempfle, Claudia D Baldus, Gunnar Cario, Martin Schrappe, Claudia Rossig, Monika Brüggemann, Guranda Chitadze
Journal: Blood
Blood (2023) 142 (Supplement 1): 595.
https://doi.org/10.1182/blood-2023-186998
Published: 2023
Journal Articles

A Novel Fc-Optimized Antibody Drug Conjugate Targeting CD7 As a Therapeutic Strategy in T-Cell Acute Lymphoblastic Leukemia

Carina Lynn Gehlert, Denis Martin Schewe, Katja Klausz, Steffen Krohn, Dorothee Winterberg, Fotini Vogiatzi, Ammelie Svea Boje, Anja Lux, Falk Nimmerjahn, Regina Scherließ, Andreas Humpe, Martin Schrappe, Gunnar Cario, Thomas Valerius, Lars Fransecky, Monika Brüggemann, Claudia D Baldus, Martin Gramatzki, Lennart Lenk, Christian Kellner, Matthias Peipp
Journal: Blood
Blood (2023) 142 (Supplement 1): 4190.
https://doi.org/10.1182/blood-2023-185875
Published: 2023
Journal Articles

CD19-CAR-T Cells Are Effective and Safe Treatment of Post-Transplant Relapse in Pediatric and Young Adult Patients with B-Lineage ALL: Real-World Data from Germany

Peter Bader, Claudia Rossig, Martin Hutter, Francis A. Ayuk, Claudia D. Baldus, Veit L Buecklein, Halvard Bonig, Gunnar Cario, Hermann Einsele, Udo Holtick, Christian Koenecke, Annette Künkele, Roland Meisel, Fabian Mueller, Ingo Müller, Olaf Penack, Eva Rettinger, Martin G. Sauer, Paul-Gerhardt Schlegel, Jan Soerensen, Arend von Stackelberg, Tobias Feuchtinger, Andrea Jarisch
Journal: Blood
Blood (2022) 140 (Supplement 1): 10407–10409.
https://doi.org/10.1182/blood-2022-156775
Published: 2022
Journal Articles

Recurrent DNMT3B Alterations Are Associated with Unfavorable Outcome in Dicentric (9;20)-Positive Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Željko Antić, Alena van Bömmel, Konstantin Riege, Jana Lentes, Charlotte Schröder, Julia Alten, Lara Fuhrmann, Martin Zimmermann, Cornelia Eckert, Gunnar Cario, Martin Schrappe, Brigitte Schlegelberger, Steve Hoffmann, Anke K. Bergmann
Journal: Blood
Blood (2022) 140 (Supplement 1): 9185–9186.
https://doi.org/10.1182/blood-2022-163404
Published: 2022
Journal Articles

Ph-like and IKZF1plus Features in Children with Down Syndrome and B Cell Precursor Acute Lymphoblastic Leukemia

Chiara Palmi, Silvia Bresolin, Stefanie V. Junk, Grazia Fazio, Daniela Silvestri, Marketa Zaliova, Athanasios Oikonomou, Katerina Scharov, Martin Stanulla, Anja Moericke, Martin Zimmermann, Martin Schrappe, Barbara Buldini, Claudia Saitta, Marta Galbiati, Michela Bardini, Sanil Bhatia, Arndt Borkhardt, Luca Lo Nigro, Valentino Conter, Maria Grazia Valsecchi, Andrea Biondi, Geertruij Te Kronnie, Gunnar Cario, Giovanni Cazzaniga
Journal: Blood
Blood (2022) 140 (Supplement 1): 6367–6368.
https://doi.org/10.1182/blood-2022-169131
Published: 2022
Journal Articles

BCR::ABL1-Positive Acute Lymphoblastic Leukemia: Different Clinical Behavior and Relevance of Prognostic Features in Typical ALL and in CML-like Disease

Jan Zuna, Lenka Hovorkova, Justina Krotka, Amelie Koehrmann, Michela Bardini, Lucie Winkowska, Eva Fronkova, Julia Alten, Rolf Koehler, Cornelia Eckert, Lisa Brizzolara, Jan Stuchly, Martin Zimmermann, Paola De Lorenzo, Maria Grazia Valsecchi, Valentino Conter, Jan Stary, Martin Schrappe, Andrea Biondi, Jan Trka, Marketa Zaliova, Giovanni Cazzaniga, Gunnar Cario
Journal: Blood
Blood (2022) 140 (Supplement 1): 9179–9180.
https://doi.org/10.1182/blood-2022-158926
Published: 2022
Journal Articles

Impact of Additional Intensive L-Asparaginase Therapy during Consolidation Phase for High-Risk Acute Lymphoblastic Leukemia: Results of a Randomized Controlled Trial in the AIEOP-BFM ALL 2009 Protocol

Valentino Conter, Maria Grazia Valsecchi, Gunnar Cario, Martin Zimmermann, Andishe Attarbaschi, Jan Stary, Felix Niggli, Luciano Dalla Pozza, Sarah Elitzur, Daniela Silvestri, Franco Locatelli, Anja Moericke, Gernot Engstler, Petr Smisek, Nicole Bodmer, Draga Barbaric, Shai Izraeli, Carmelo Rizzari, Joachim Boos, Barbara Buldini, Claudia Lanvers-Kaminsky, Giovanni Cazzaniga, Bernd Gruhn, Andrea Biondi, Martin Schrappe
Journal: Blood
Blood (2022) 140 (Supplement 1): 109–111.
https://doi.org/10.1182/blood-2022-166583
Published: 2022
Journal Articles

A Multi-Cohort Gene Expression Classifier (ALLCatchR) Identifies B-Precursor ALL Subtypes and Their Developmental Trajectories across Age Groups

Thomas Beder, Björn Thore Hansen, Alina M. Hartmann, Johannes Zimmermann, Eric Amelunxen, Nadine Kraft, Wencke Walter, Marketa Zaliova, Željko Antić, Philippe Chouvarine, Lorenz Bartsch, Miriam Bultmann, Sonja Bendig, Jan Kässens, Sören Franzenburg, Christoph Kaleta, Andre Franke, Gunnar Cario, Martin Schrappe, Martin Neumann, Nicola Goekbuget, Anke K. Bergmann, Jan Trka, Claudia Haferlach, Monika Brüggemann, Claudia D. Baldus, Lorenz Bastian
Journal: Blood
Blood (2022) 140 (Supplement 1): 1053–1055.
https://doi.org/10.1182/blood-2022-163311
Published: 2022
Journal Articles

Hypersensitivity Reactions to Native E. coli L-Asparaginase in Children with Acute Lymphoblastic Leukemia May Vary By Treatment Schedule and Type of Glucocorticoid in Induction: Results of Trial ALL-BFM 2000

Anja Möricke, Martin Schrappe, Carmelo Rizzari, Julia Alten, Andishe Attarbaschi, Rita Beier, Andrea Biondi, Birgit Burkhardt, Nicole Bodmer, Joachim Boos, Gunnar Cario, Valentino Conter, Christian Flotho, Andreas E. Kulozik, Claudia Lanvers-Kaminsky, Georg Mann, Felix Niggli, Daniela Silvestri, Arend von Stackelberg, Martin Stanulla, Maria Grazia Valsecchi, Martin Zimmermann
Journal: Blood
Blood (2022) 140 (Supplement 1): 11676–11678.
https://doi.org/10.1182/blood-2022-163142
Published: 2022
Journal Articles

The IL7R-Antagonist OSE-127 Blocks Acute Lymphoblastic Leukemia Development Via a Dual Mode of Action

Lennart Lenk, Irène Baccelli, Dorothee Winterberg, Anna Dietterle, Frédérique Corallo, Julien Taurelle, Emma Narbeburu, Anna Laqua, Beat Bornhauser, Jean-Pierre Bourquin, Fotini Vogiatzi, Martin Schrappe, Gunnar Cario, Monika Brüggemann, Nicolas Poirier, Denis Martin Schewe
Journal: Blood
Blood (2022) 140 (Supplement 1): 1045–1047.
https://doi.org/10.1182/blood-2022-162261
Published: 2022