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Gregory Stephanopoulos
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Journal Articles

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth

Cheuk Him Man, Francois E. Mercier, Nian Liu, Wentao Dong, Gregory Stephanopoulos, Li Jiang, Yookyung Jung, Charles P. Lin, Anskar Y. H. Leung, David T. Scadden
Journal: Blood
Blood (2022) 139 (4): 502–522.
https://doi.org/10.1182/blood.2021011563
Published: 2022
Includes: Supplemental data
Journal Articles

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

Rushdia Zareen Yusuf, Borja Saez, Azeem Sharda, Nick van Gastel, Vionnie W. C. Yu, Ninib Baryawno, Elizabeth W. Scadden, Sanket Acharya, Shrikanta Chattophadhyay, Cherrie Huang, Vasanthi Viswanathan, Dana S'aulis, Julien Cobert, David B. Sykes, Mark A. Keibler, Sudeshna Das, John N. Hutchinson, Michael Churchill, Siddhartha Mukherjee, Dongjun Lee, Francois Mercier, John Doench, Lars Bullinger, David J. Logan, Stuart Schreiber, Gregory Stephanopoulos, William B. Rizzo, David T. Scadden
Journal: Blood
Blood (2020) 136 (11): 1303–1316.
https://doi.org/10.1182/blood.2019001808
Published: 2020
Includes: Supplemental data
Journal Articles

Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting

Cheuk-Him Man, David T. Scadden, MD, Francois Mercier, MD FRCPC, Nian Liu, Wentao Dong, Gregory Stephanopoulos, PhD, Li Jiang, PhD, Yookyung Jung, PhD, Charles Lin, PhD, Anskar Y.-H. Leung, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3765.
https://doi.org/10.1182/blood-2019-123604
Published: 2019