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Michael D. Milsom
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Journal Articles

Identification and Functional Interrogation of Dormant Cancer Stem Cells in JAK2V617F-Driven MPNs

Ian Ghezzi, Sercan Öz, Istiffa Nurfauziah, Sena Alptekin, Esther Rodriguez-Correa, Lena Bognar, Foteini Fotopoulou, Michael D. Milsom
Journal: Blood
Blood (2024) 144 (Supplement 1): 753.
https://doi.org/10.1182/blood-2024-207318
Published: 2024
Journal Articles

No Evidence for Hematopoietic Stem Cell Self-Renewal in-Vivo Following Inflammatory Challenge

Ruzhica Bogeska, PhD, Paul Kaschutnig, PhD, Stella V Paffenholz, MSc, Julia Knoch, Jan-Philipp Mallm, PhD, Malak Fawaz, MSc, Florian Buettner, PhD, Dagmar Walter, PhD, Felix Frauhammer, MSc, Tim Holland-Letz, PhD, Noboru Asada, MD PhD, Ana-Matea Mikecin Drazic, PhD, Marleen Buechler-Schaff, MSc, Martha Correno-Gonzalez, Melanie Ball, Sina Staeble, MSc, Julius Gräsel, PhD, Simon Haas, PhD, Daniel B. Lipka, MD, Karsten Rippe, PhD, Benedikt Brors, PhD, Paul S. Frenette, MD, Michael A. Rieger, Marieke A. G. Essers, PhD, Michael D. Milsom, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 456.
https://doi.org/10.1182/blood-2019-125744
Published: 2019
Journal Articles

Deconvolution of Hematopoietic Commitment Decisions By Genome-Wide Analysis of Progressive DNA Methylation Changes

Sina Staeble, MSc, Stephen Kraemer, MSc, Jens Langstein, MSc, Ruzhica Bogeska, PhD, Mark Hartmann, PhD, Maximilian Schoenung, MSc, Melinda Czeh, PhD, Julia Knoch, Natasha Anstee, PhD, Simon Haas, PhD, Abdelrahman Mahmoud, MSc, Julius Graesel, MSc, Daniel Huebschmann, MD PhD, Lars Feuerbach, PhD, Weichenhan Dieter, PhD, Benedikt Brors, PhD, Karsten Rippe, PhD, Jan-Philipp Mallm, PhD, Frank Rosenbauer, PhD, Christoph Plass, PhD, Matthias Schlesner, PhD, Michael D. Milsom, PhD, Daniel B. Lipka, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1179.
https://doi.org/10.1182/blood-2019-124429
Published: 2019
Journal Articles

A Stem Cell-Based Epigenetic Memory Mediates Interferon Response-Heterogeneity within the Hematopoietic System

Simon Haas, PhD, Christoph Hirche, PhD, Alexandra Schnell, Can Sönmezer, Jens Langstein, Stephan Wurzer, PhD, Marc Thier, PhD, Sandra Blaszkiewicz, Franziska Pilz, Michael D. Milsom, PhD, Andreas Trumpp, Prof, PhD, Daniel Lipka, MD, Ulrich Kalinke, Prof, PhD, Marieke A. G. Essers, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 634.
https://doi.org/10.1182/blood.V130.Suppl_1.634.634
Published: 2017
Journal Articles

Hematopoietic Stem Cells Fail to Regenerate In Vivo Following Inflammatory Stress

Ruzhica Bogeska, PhD, Paul Kaschutnig, Stella Paffenholz, Julia Maassen, Jan-Philipp Mallm, Felix Wertek, Dagmar Walter, PhD, Blaszkiewicz Sandra, Tim Holland-Letz, Noboru Asada, MD PhD, Julius Gräsel, Sina Stäble, Milena Block, Özge Gizlenci, Áine M. Prendergast, PhD, Simon Haas, Daniel B Lipka, Karsten Rippe, Benedikt Brors, Paul S. Frenette, MD, Marieke A. G. Essers, Michael D. Milsom, PhD
Journal: Blood
Blood (2016) 128 (22): 1472.
https://doi.org/10.1182/blood.V128.22.1472.1472
Published: 2016
Journal Articles

The RET Receptor Tyrosine Kinase Promotes Acute Myeloid Leukemia through Protection of FLT3-ITD Mutants from Autophagic Degradation

Saskia Rudat, MSc, Anja Pfaus, MSc, Claudia Bühler, MD, Sophie Rabe, MSc, Lars Bullinger, MD, Stefan Gröschel, MD, Stephen M. Sykes, PhD, Michael D. Milsom, PhD, Jana M. Ellegast, MD, Stefan Fröhling, MD, Claudia Scholl, MD
Journal: Blood
Blood (2016) 128 (22): 2849.
https://doi.org/10.1182/blood.V128.22.2849.2849
Published: 2016
Journal Articles

Stem Cell Replicative Stress and Clonal Exhaustion

Michael D. Milsom, PhD
Journal: Blood
Blood (2015) 126 (23): SCI-41.
https://doi.org/10.1182/blood.V126.23.SCI-41.SCI-41
Published: 2015
Journal Articles

Stem Cell-like Megakaryocyte Progenitors As Driving Forces of IFN-Induced Emergency Megakaryopooesis

Simon Haas, Jenny Hansson, Daniel Klimmeck, Dirk Loeffler, Lars Velten, Hannah Uckelmann, Stephan Wurzer, Áine M. Prendergast, PhD, Alexandra Schnell, Klaus Hexel, Rachel Santarella-Mellwig, Sandra Blaszkiewicz, Andrea Kuck, Hartmut Geiger, PhD, Michael D. Milsom, PhD, Lars M Steinmetz, Timm Schroeder, PhD, Andreas Trumpp, PhD, Jeroen Krijgsveld, Marieke A. G. Essers, PhD
Journal: Blood
Blood (2015) 126 (23): 2391.
https://doi.org/10.1182/blood.V126.23.2391.2391
Published: 2015
Journal Articles

Pkc Epsilon Regulates Mitochondrial Redox Biology to Support the Differentiation Blockade in Acute Myeloid Leukemia

Daniela Di Marcantonio, PhD, Jessica Vadaketh, Esteban Martinez, Prisco Mirandola, PhD, Giuliana Gobbi, PhD, Michael D. Milsom, PhD, Claudia Scholl, Stefan Fröhling, Marco Vitale, MD, Stephen Matthew Sykes, PhD
Journal: Blood
Blood (2015) 126 (23): 444.
https://doi.org/10.1182/blood.V126.23.444.444
Published: 2015
Journal Articles

Optimization of Bcl11a Knockdown By miRNA Scaffold Embedded Shrnas Leading to Enhanced Induction of Fetal Hemoglobin in Erythroid Cells for the Treatment of Beta-Hemoglobinopathies

Christian Brendel, PhD, Swaroopa Guda, PhD, Raffaele Renella, MD PhD, Peng Du, PhD, Daniel E. Bauer, MD, PhD, Matthew C. Canver, BS, Sophia C. Kamran, MD, James Thornton, PhD, Helen de Boer, BAS, Michael D. Milsom, PhD, Stuart H. Orkin, MD, Richard Gregory, PhD, David A. Williams, MD
Journal: Blood
Blood (2014) 124 (21): 2150.
https://doi.org/10.1182/blood.V124.21.2150.2150
Published: 2014
Journal Articles

Altered HSC Metabolism in Response to Stress Leads to De Novo dna Damage and Cellular Attrition

Anja Geiselhart, Dagmar Walter, PhD, Amelie Lier, Frederic B. Thalheimer, Sina Huntscha, David Brocks, Irem Bayindir, Paul Kaschutnig, Katja Müdder, Mirko Sobotta, PhD, Tobias Dick, PhD, Tim Holland-Letz, PhD, Peter Schmezer, PhD, Timm Schröder, PhD, Steven W Lane, MD PhD, Marieke Essers, PhD, Michael A. Rieger, PhD, David A. Williams, MD, Andreas Trumpp, PhD, Michael D. Milsom, PhD
Journal: Blood
Blood (2014) 124 (21): 255.
https://doi.org/10.1182/blood.V124.21.255.255
Published: 2014
Journal Articles

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

Theresa Placke, Katrin Faber, Atsushi Nonami, Sarah L. Putwain, Helmut R. Salih, Florian H. Heidel, Alwin Krämer, David E. Root, David A. Barbie, Andrei V. Krivtsov, Scott A. Armstrong, William C. Hahn, Brian J. Huntly, Stephen M. Sykes, Michael D. Milsom, Claudia Scholl, Stefan Fröhling
Journal: Blood
Blood (2014) 124 (1): 13–23.
https://doi.org/10.1182/blood-2014-02-558114
Published: 2014
Includes: Supplemental data
Journal Articles

Requirement For CDK6 In MLL-Rearranged Acute Myeloid Leukemia

Theresa Placke, PhD, Katrin Faber, PhD, Atsushi Nonami, MD, Helmut R. Salih, MD, Stephen M. Sykes, PhD, David E. Root, PhD, David A. Barbie, MD, William C. Hahn, MD, PhD, Michael D. Milsom, PhD, Claudia Scholl, MD, Stefan Fröhling, MD
Journal: Blood
Blood (2013) 122 (21): 3782.
https://doi.org/10.1182/blood.V122.21.3782.3782
Published: 2013
Journal Articles

HSC Exit From Dormancy Provokes De Novo DNA Damage, Leading To Bone Marrow Failure If Unresolved By The Fanconi Anemia Pathway

Dagmar Walter, PhD, Amelie Lier, Anja Geiselhart, Sina Huntscha, David Brocks, Irem Bayindir, Paul Kaschutnig, Peter Schmezer, PhD, Steven W Lane, MD, PhD, Marieke Essers, PhD, David A. Williams, MD, Andreas Trumpp, PhD, Michael D. Milsom, PhD
Journal: Blood
Blood (2013) 122 (21): 799.
https://doi.org/10.1182/blood.V122.21.799.799
Published: 2013
Journal Articles

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment

Adrienne M. Dorrance, Serena De Vita, Maria Radu, Pavankumar N. G. Reddy, Meaghan K. McGuinness, Chad E. Harris, Ronald Mathieu, Steven W. Lane, Rachelle Kosoff, Michael D. Milsom, Jonathan Chernoff, David A. Williams
Journal: Blood
Blood (2013) 121 (13): 2474–2482.
https://doi.org/10.1182/blood-2012-10-460709
Published: 2013
Includes: Multimedia, Supplemental data
Journal Articles

Hematopoietic SIN Lentiviral Micro RNA-Mediated Silencing of BCL11A: Pre-Clinical Evidence for a Sickle Cell Disease Gene-Therapy Trial

Raffaele Renella, MD, PhD, Aleksej Perlov, Chad E Harris, Daniel E. Bauer, MD, PhD, Jian Xu, PhD, Swaroopa Guda, PhD, Michael D. Milsom, PhD, Stuart H. Orkin, MD, David A. Williams, MD
Journal: Blood
Blood (2012) 120 (21): 753.
https://doi.org/10.1182/blood.V120.21.753.753
Published: 2012
Journal Articles

Overcoming reprogramming resistance of Fanconi anemia cells

Lars U. W. Müller, Michael D. Milsom, Chad E. Harris, Rutesh Vyas, Kristina M. Brumme, Kalindi Parmar, Lisa A. Moreau, Axel Schambach, In-Hyun Park, Wendy B. London, Kelly Strait, Thorsten Schlaeger, Alexander L. DeVine, Elke Grassman, Alan D'Andrea, George Q. Daley, David A. Williams
Journal: Blood
Blood (2012) 119 (23): 5449–5457.
https://doi.org/10.1182/blood-2012-02-408674
Published: 2012
Includes: Supplemental data
Journal Articles

Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development

Steven W. Lane, Serena De Vita, Kylie A. Alexander, Ruchan Karaman, Michael D. Milsom, Adrienne M. Dorrance, Amy Purdon, Leeann Louis, Mary L. Bouxsein, David A. Williams
Journal: Blood
Blood (2012) 119 (3): 736–744.
https://doi.org/10.1182/blood-2011-07-368753
Published: 2012
Includes: Supplemental data
Journal Articles

Pak A Proteins Are Essential for Hematopoietic Stem/Progenitor Cell (HSC/P) Engraftment Through Regulation of Signaling Pathways Controlling HSC/P Proliferation, Survival, Migration, and the Actin Cytoskeleton

Adrienne M. Dorrance, PhD, Rachelle Kosoff, Meaghan McGuinness, Chad Harris, Serena De Vita, MD, PhD, Ronald Mathieu, Steven W. Lane, MD, Michael D. Milsom, PhD, Jonathan Chernoff, MD, PhD, David A. Williams, MD
Journal: Blood
Blood (2011) 118 (21): 917.
https://doi.org/10.1182/blood.V118.21.917.917
Published: 2011
Journal Articles

Gene-Correction Rescues Reprogramming of Fanconi Anemia Fibroblasts and Enables Hematopoietic Differentiation of FA Induced Pluripotent Stem Cells in Vitro and In Vivo

Lars Mueller, MD, Michael D. Milsom, PhD, Chad Harris, Rutesh Vyas, Kristina Brumme, Kalindi Parmar, PhD, Axel Schambach, MD PhD, Elke Grassman, Ph.D., In-Hyun Park, PhD, London Wendy, PhD, Kelly Strait, Thorsten Schlaeger, Ph.D, Alexander L. Devine, Alan D. D'Andrea, MD, George Q. Daley, MD, PhD, David A. Williams, MD
Journal: Blood
Blood (2011) 118 (21): 672.
https://doi.org/10.1182/blood.V118.21.672.672
Published: 2011