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Journal Articles

Novel Protacs Demonstrate Dual Kinase Inhibition and Degradation of HCK and BTK, and Are Highly Active in MYD88 Mutated WM and ABC DLBCL Cells

Shirong Liu, John M Hatcher, Amanda Kofides, Alexa G Canning, Jinhua Wang, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Shayna R Sarosiek, Jorge J. Castillo, Sara J. Buhrlage, Steven P Treon

Blood (2023) 142 (Supplement 1): 3298.

https://doi.org/10.1182/blood-2023-190369

Published: 2023

Journal Articles

The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTK Cys481 ibrutinib resistance

Blood (2021) 138 (20): 1966–1979.

https://doi.org/10.1182/blood.2021011405

Published: 2021

Includes: Supplemental data

Journal Articles

A New Role for the SRC Family Member HCK As a Driver of BCR/SYK Signaling in MYD88 Mutated Lymphomas

Blood (2021) 138 (Supplement 1): 3512.

https://doi.org/10.1182/blood-2021-153610

Published: 2021

Journal Articles

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo

Yusuke Tarumoto, Shan Lin, Jinhua Wang, Joseph P. Milazzo, Yali Xu, Bin Lu, Zhaolin Yang, Yiliang Wei, Sofya Polyanskaya, Mark Wunderlich, Nathanael S. Gray, Kimberly Stegmaier, Christopher R. Vakoc

Blood (2020) 135 (1): 56–70.

https://doi.org/10.1182/blood.2019001576

Published: 2020

Includes: Supplemental data

Journal Articles

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Ken Morita, MD PhD, Shuning He, PhD, Radosław P. Nowak, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Eric S. Fischer, PhD, A. Thomas Look, MD

Blood (2019) 134 (Supplement_1): 406.

https://doi.org/10.1182/blood-2019-123573

Published: 2019

Journal Articles

A Novel HCK and BTK Dual Inhibitor Kin-8194 Shows Superior Activity over Ibrutinib and Overcomes BTK C481S Mediated Ibrutinib Resistance in Vitro and In Vivo in MYD88 Mutated B-Cell Lymphomas

Guang Yang, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Amanda Kofides, Lian Xu, MS, Nicholas Tsakmaklis, Maria Demos, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Cristina Jimenez, PhD, Zachary R Hunter, PhD, Christopher Patterson, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael Gray, Steven P Treon, MD PhD FRCP

Blood (2019) 134 (Supplement_1): 394.

https://doi.org/10.1182/blood-2019-130636

Published: 2019

Journal Articles

Targeting Salt-Inducible Kinase 3 As a Therapeutic Approach for Acute Myeloid Leukemia

Shan Lin, Yusuke Tarumoto, Jinhua Wang, PhD, Joseph Milazzo, Yali Xu, Nathanael Gray, Christopher Vakoc, Kimberly Stegmaier, MD

Blood (2019) 134 (Supplement_1): 3941.

https://doi.org/10.1182/blood-2019-125278

Published: 2019

Journal Articles

MYD88 Triggered SYK Activation Promotes BCR Cross-Talk, and Identifies SYK As a Novel Therapeutic Target of Mutated MYD88 Signaling

Manit Munshi, MS, Jiaji Chen, BS, Xia Liu, MD, Lian Xu, MS, Nickolas Tsakmaklis, BA, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Christopher Patterson, MAcc, Kirsten Meid, MPH, Joshua Gustine, MPH, Jorge J. Castillo, MD, Zachary R Hunter, PhD, Jinhua Wang, PhD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP, Guang Yang, PhD

Blood (2018) 132 (Supplement 1): 4116.

https://doi.org/10.1182/blood-2018-99-117372

Published: 2018

Journal Articles

A Novel HCK Inhibitor Kin-8193 Blocks BTK Activity in BTK Cys481 Mutated Ibrutinib Resistant B-Cell Lymphomas Driven By Mutated MYD88

Guang Yang, PhD, Jinhua Wang, PhD, Li Tan, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Lian Xu, MS, Nickolas Tsakmaklis, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Zachary R Hunter, PhD, Christopher Patterson, MAcc, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP

Blood (2018) 132 (Supplement 1): 40.

https://doi.org/10.1182/blood-2018-99-119171

Published: 2018

Journal Articles

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

Christopher J. Ott, PhD, Raphael Szalat, MD, Matthew Lawlor, Mehmet Kemal Samur, PhD, Yan Xu, MD, Charles B Epstein, Charles Y Lin, PhD, Rao Prabhala, PhD, Nina Farrell, Lauren D Walter, Logan Schwartz, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Kenneth Anderson, MD, Richard A. Young, PhD, Nikhil Munshi, MD

Blood (2018) 132 (Supplement 1): 1313.

https://doi.org/10.1182/blood-2018-99-119941

Published: 2018

Journal Articles

BTK Cys481Ser drives ibrutinib resistance via ERK1/2 and protects BTK wild-type MYD88-mutated cells by a paracrine mechanism

Blood (2018) 131 (18): 2047–2059.

https://doi.org/10.1182/blood-2017-10-811752

Published: 2018

Includes: Supplemental data

Journal Articles

A Novel, Highly Selective IRAK1 Inhibitor Jh-X-119-01 Shows Synergistic Tumor Cell Killing with Ibrutinib in MYD88 Mutated B-Cell Lymphoma Cells

Guang Yang, PhD, John Hatcher, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji Chen, BS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Gloria Chan, MS, Zachary Hunter, PhD, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Nathanael Gray, PhD, Steven P Treon, MDPhDFRCP, Sara Buhrlage, PhD

Blood (2017) 130 (Supplement 1): 719.

https://doi.org/10.1182/blood.V130.Suppl_1.719.719

Published: 2017

Journal Articles

Using Whole Exome Sequencing in Pediatric Acute Lymphoblastic Leukemia Germline, Diagnosis, and Relapse Trios to Discover Novel Relapse Enriched Mutations for Clonal Backtracking By Ddpcr

Jason Saliba, PhD, Nikki Ann Evensen, PhD BS, Julia Meyer, PhD, Igor Dolgalev, MS, Daniel Newman, BA, BSc, Ashfiyah Chowdhury, BSc, Jacob Nersting, PhD, Jinhua Wang, PhD, Kjeld Schmiegelow, MD DMSc, William L. Carroll, MD

Blood (2016) 128 (22): 4085.

https://doi.org/10.1182/blood.V128.22.4085.4085

Published: 2016

Journal Articles

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia

Blood (2015) 126 (19): 2202–2212.

https://doi.org/10.1182/blood-2015-04-639138

Published: 2015

Includes: Supplemental data

Journal Articles

Citron Rho-Interacting Serine/Threonine kinase (CIT) Is a Novel Therapeutic Target in Multiple Myeloma Cells

Yawara Kawano, MDPhD, Ilyas Sahin, MD, Michele Moschetta, MD, Jinhua Wang, Salomon Manier, MD, Siobhan Glavey, MD, Yuji Mishima, PhD, Katsutoshi Kokubun, PhD, Shokichi Tsukamoto, MD PhD, Antonio Sacco, BS, Kenneth C. Anderson, MD, Aldo M Roccaro, MD PhD, Nathanael S. Gray, PhD, Irene M. Ghobrial, MD

Blood (2014) 124 (21): 3430.

https://doi.org/10.1182/blood.V124.21.3430.3430

Published: 2014

Journal Articles

Deciphering the Epigenetic Landscape of Relapsed Pediatric Acute Lymphoblastic Leukemia

Teena Bhatla, MD, Roy Blum, PhD, Jinhua Wang, PhD, Courtney L Jones, PhD, Debra J. Morrison, PhD, Elizabeth A Raetz, MD, Michael J. Burke, MD, Patrick Brown, MD, Richard C. Harvey, PhD, Cheryl L. Willman, MD, Mignon Loh, MD, Stephen P. Hunger, MD, William L. Carroll, MD

Blood (2014) 124 (21): 612.

https://doi.org/10.1182/blood.V124.21.612.612

Published: 2014

Journal Articles

Development and Repurposing of Small-Molecule Kinase Inhibitors to Target Novel Leukemogenic TNK2 Mutations

Julia Elizabeth Maxson, PhD, Abel L Melissa, BS, Jinhua Wang, PhD, Xianming Deng, PhD, Samuel B Luty, BS, Huahang Sun, MA, Julie Gorenstein, MS, Richard Middleton, PhD, Nathanael S. Gray, PhD, Brian J. Druker, Jeffrey W. Tyner, PhD

Blood (2014) 124 (21): 435.

https://doi.org/10.1182/blood.V124.21.435.435

Published: 2014

Journal Articles

Identification of MLL-Fusion/Myc⊣miR-26a/Mir-29a⊣Tet1 Signaling Circuit in MLL -Rearranged Leukemia

Hao Huang, PhD, Xi Jiang, PhD, Jinhua Wang, Yuanyuan Li, Ping Chen, Stephen Arnovitz, Shenglai Li, Yungui Wang, Hengyou Weng, PhD, Mary Elizabeth Neilly, Zejuan Li, MD PhD, Jianjun Chen, PhD

Blood (2014) 124 (21): 1011.

https://doi.org/10.1182/blood.V124.21.1011.1011

Published: 2014

Journal Articles

MAPK Signaling Cascades Mediate Distinct Glucocorticoid Resistance Mechanisms in Pediatric B-Precursor ALL

Courtney L Jones, PhD, Christy M Gearheart, PhD, Susan Fosmire, Cristina Delgado-Martin, PhD, Faye Pais, MD, Jinhua Wang, PhD, Teena Bhatla, MD, Danielle S Bitterman, Simone R de Rijk, Wallace Bourgeois, Smita C. Dandekar, MD, Elizabeth A. Raetz, MD, Michelle L. Hermiston, MD PhD, Michael J Garabedian, PhD, Christopher C. Porter, MD, William L. Carroll, MD

Blood (2014) 124 (21): 789.

https://doi.org/10.1182/blood.V124.21.789.789

Published: 2014

Journal Articles

Deletions In TBL1XR1 Results In Glucocorticoid Resistance By Decreasing Glucocorticoid Signaling In Childhood B-Lymphoblastic Leukemia

Courtney L Jones, Teena Bhatla, MD, Jinhua Wang, PhD, Wallace Bourgeois, Bitterman S Danielle, Elizabeth A. Raetz, MD, Debra J. Morrison, PhD, David T. Teachey, MD, Garabedian Michael, William L. Carroll, MD

Blood (2013) 122 (21): 602.

https://doi.org/10.1182/blood.V122.21.602.602

Published: 2013

NARROW

Novel Protacs Demonstrate Dual Kinase Inhibition and Degradation of HCK and BTK, and Are Highly Active in MYD88 Mutated WM and ABC DLBCL Cells

The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTK Cys481 ibrutinib resistance

A New Role for the SRC Family Member HCK As a Driver of BCR/SYK Signaling in MYD88 Mutated Lymphomas

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

A Novel HCK and BTK Dual Inhibitor Kin-8194 Shows Superior Activity over Ibrutinib and Overcomes BTK C481S Mediated Ibrutinib Resistance in Vitro and In Vivo in MYD88 Mutated B-Cell Lymphomas

Targeting Salt-Inducible Kinase 3 As a Therapeutic Approach for Acute Myeloid Leukemia

MYD88 Triggered SYK Activation Promotes BCR Cross-Talk, and Identifies SYK As a Novel Therapeutic Target of Mutated MYD88 Signaling

A Novel HCK Inhibitor Kin-8193 Blocks BTK Activity in BTK Cys481 Mutated Ibrutinib Resistant B-Cell Lymphomas Driven By Mutated MYD88

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

BTK Cys481Ser drives ibrutinib resistance via ERK1/2 and protects BTK wild-type MYD88-mutated cells by a paracrine mechanism

A Novel, Highly Selective IRAK1 Inhibitor Jh-X-119-01 Shows Synergistic Tumor Cell Killing with Ibrutinib in MYD88 Mutated B-Cell Lymphoma Cells

Using Whole Exome Sequencing in Pediatric Acute Lymphoblastic Leukemia Germline, Diagnosis, and Relapse Trios to Discover Novel Relapse Enriched Mutations for Clonal Backtracking By Ddpcr

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia

Citron Rho-Interacting Serine/Threonine kinase (CIT) Is a Novel Therapeutic Target in Multiple Myeloma Cells

Deciphering the Epigenetic Landscape of Relapsed Pediatric Acute Lymphoblastic Leukemia

Development and Repurposing of Small-Molecule Kinase Inhibitors to Target Novel Leukemogenic TNK2 Mutations

Identification of MLL-Fusion/Myc⊣miR-26a/Mir-29a⊣Tet1 Signaling Circuit in MLL -Rearranged Leukemia

MAPK Signaling Cascades Mediate Distinct Glucocorticoid Resistance Mechanisms in Pediatric B-Precursor ALL

Deletions In TBL1XR1 Results In Glucocorticoid Resistance By Decreasing Glucocorticoid Signaling In Childhood B-Lymphoblastic Leukemia

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American Society of Hematology

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American Society of Hematology

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