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Maria G Demos
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Journal Articles

The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTK Cys481 ibrutinib resistance

Guang Yang, Jinhua Wang, Li Tan, Manit Munshi, Xia Liu, Amanda Kofides, Jiaji G. Chen, Nicholas Tsakmaklis, Maria G. Demos, Maria Luisa Guerrera, Lian Xu, Zachary R. Hunter, Jinwei Che, Christopher J. Patterson, Kirsten Meid, Jorge J. Castillo, Nikhil C. Munshi, Kenneth C. Anderson, Michael Cameron, Sara J. Buhrlage, Nathanael S. Gray, Steven P. Treon
Journal: Blood
Blood (2021) 138 (20): 1966–1979.
https://doi.org/10.1182/blood.2021011405
Published: 2021
Includes: Supplemental data
Journal Articles

A New Role for the SRC Family Member HCK As a Driver of BCR/SYK Signaling in MYD88 Mutated Lymphomas

Manit Munshi, Xia Liu, Amanda Kofides, Nickolas Tsakmaklis, Maria G Demos, Maria Luisa Guerrera, Zachary R Hunter, M. Lia Palomba, Kimon V. Argyropoulos, Christopher J Patterson, Kirsten Meid, Joshua Gustine, Jorge J. Castillo, Shayna Sarosiek, Catherine A Flynn, Jinhua Wang, Sara J Buhrlage, Nathanael S Gray, Nikhil C. Munshi, Kenneth C. Anderson, Guang Yang, Steven P Treon
Journal: Blood
Blood (2021) 138 (Supplement 1): 3512.
https://doi.org/10.1182/blood-2021-153610
Published: 2021
Journal Articles

The ERK1/2 Regulator WNK2 Shows Differential Expression and Isoform Usage, Primarily Driven By Aberrant Methylation, in MYD88 Mutated Waldenström's Macroglobulinemia

Maria Luisa Guerrera, Guang Yang, Xia Liu, Nickolas Tsakmaklis, Maria G Demos, Amanda Kofides, Manit Munshi, Lian Xu, Christopher J Patterson, Jorge J. Castillo, Shayna Sarosiek, Catherine A Flynn, Kirsten Meid, Joshua Gustine, Tomasz Sewastianik, Ruben D. Carrasco, Steven P Treon, Zachary R Hunter
Journal: Blood
Blood (2021) 138 (Supplement 1): 2692.
https://doi.org/10.1182/blood-2021-154160
Published: 2021
Journal Articles

Phase 1 study of ibrutinib and the CXCR4 antagonist ulocuplumab in CXCR4-mutated Waldenström macroglobulinemia

Clinical Trials & Observations Brief Report
Steven P. Treon, Kirsten Meid, Zachary R. Hunter, Catherine A. Flynn, Shayna R. Sarosiek, Carly R. Leventoff, Timothy P. White, Yang Cao, Aldo M. Roccaro, Antonio Sacco, Maria G. Demos, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Lian Xu, Christopher J. Patterson, Manit Munshi, Nicholas Tsakmaklis, Guang Yang, Irene M. Ghobrial, Andrew R. Branagan, Jorge J. Castillo
Journal: Blood
Blood (2021) 138 (17): 1535–1539.
https://doi.org/10.1182/blood.2021012953
Published: 2021
Includes: Supplemental data
Journal Articles

BTK Cys481Ser drives ibrutinib resistance via ERK1/2 and protects BTK wild-type MYD88-mutated cells by a paracrine mechanism

Jiaji G. Chen, Xia Liu, Manit Munshi, Lian Xu, Nicholas Tsakmaklis, Maria G. Demos, Amanda Kofides, Maria Luisa Guerrera, Gloria G. Chan, Christopher J. Patterson, Kirsten Meid, Joshua Gustine, Toni Dubeau, Patricia Severns, Jorge J. Castillo, Zachary R. Hunter, Jinhua Wang, Sara J. Buhrlage, Nathanael S. Gray, Steven P. Treon, Guang Yang
Journal: Blood
Blood (2018) 131 (18): 2047–2059.
https://doi.org/10.1182/blood-2017-10-811752
Published: 2018
Includes: Supplemental data