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Shayna R Sarosiek
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Journal Articles

Changes in Methylation and Chromatin Accessibility Underlie Subtype Classification and Disease Evolution in Waldenström's Macroglobulinemia

Zachary R Hunter, Nickolas Tsakmaklis, Kris Richardson, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Catherine A. Flynn, Kirsten Meid, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Kenneth C. Anderson, Nikhil C Munshi, Shayna R Sarosiek, Jorge J. Castillo, Ari M Melnick, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 755.
https://doi.org/10.1182/blood-2023-190825
Published: 2023
Journal Articles

Establishment of the Bcwm.2 Cell Line As a BTK-Inhibitor Resistant, BCL2 Inhibitor Sensitive in Vitro and In Vivo Study Model for Waldenström's Macroglobulinemia

Shirong Liu, Xia Liu, Kara M Soroko, Alexa G Canning, Amanda Kofides, Choudhury Fabliha Binte Yusuf, Johany Penailillo, Nickolas Tsakmaklis, Christopher J Patterson, Ruben D. Carrasco, Zachary R Hunter, Prafulla C. Gokhale, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 6613.
https://doi.org/10.1182/blood-2023-190147
Published: 2023
Journal Articles

Real-World Treatment Patterns and Healthcare Resource Utilization in Patients with Waldenström Macroglobulinemia Initiating First-Line Treatment with Ibrutinib or Zanubrutinib

Jonas Paludo, Shayna R Sarosiek, Gottfried R. von Keudell, Monika Salkar, Summera Zhou, Sonia Kim, Ning Cheng, Michelle Pacia, Sudeep Karve, Jorge J. Castillo
Journal: Blood
Blood (2023) 142 (Supplement 1): 7385.
https://doi.org/10.1182/blood-2023-181053
Published: 2023
Journal Articles

Pacritinib Blocks Key Pro-Survival Signaling Related to Mutated MYD88, Produces High Levels of Apoptosis and Overcomes Mutated BTK Cys481 Related BTK-Inhibitor Resistance

Shirong Liu, Amanda Kofides, Xia Liu, Alexa G Canning, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Kris Richardson, Catherine A. Flynn, Kirsten Meid, Megan Little, Katherine Stockman, Timothy P. White, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 3300.
https://doi.org/10.1182/blood-2023-190463
Published: 2023
Journal Articles

Aberrant Expression of Spliced WNK2 Is an Early Event in MYD88 Mutated WM That Activates ERK1/2 and Supports Tumor Growth

Maria Luisa Guerrera, Zachary R Hunter, Kris Richardson, Nickolas Tsakmaklis, Amanda Kofides, Shirong Liu, Christopher J Patterson, Eugenio Morelli, Jorge J. Castillo, Shayna R Sarosiek, Catherine A. Flynn, Kirsten Meid, Andrew R. Branagan, Ruben D. Carrasco, Kenneth C. Anderson, Nikhil C Munshi, Steven P Treon, Xia Liu
Journal: Blood
Blood (2023) 142 (Supplement 1): 3303.
https://doi.org/10.1182/blood-2023-190880
Published: 2023
Journal Articles

Prospective Study of Acalabrutinib with Rituximab in Patients with Symptomatic Anti-MAG Mediated IgM Peripheral Neuropathy

Shayna R Sarosiek, Andrew R. Branagan, Christopher Doughty, Catherine A. Flynn, Megan Little, Katherine Stockman, Timothy P. White, Kirsten Meid, Steven P Treon, Jorge J. Castillo
Journal: Blood
Blood (2023) 142 (Supplement 1): 213.
https://doi.org/10.1182/blood-2023-185113
Published: 2023
Journal Articles

Novel Isoforms Identified By Isoseq Analysis Drive Expression Differences in Key Genes That Delineate the Subtypes of Waldenstrom's Macroglobulinemia

Kris Richardson, Nickolas Tsakmaklis, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Shirong Liu, Catherine A. Flynn, Kirsten Meid, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Kenneth C. Anderson, Nikhil C Munshi, Shayna R Sarosiek, Jorge J. Castillo, Zachary R Hunter, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 1946.
https://doi.org/10.1182/blood-2023-190631
Published: 2023
Journal Articles

Real-World Outcomes Following Dose Modifications of First-Line Ibrutinib in Patients with Waldenström Macroglobulinemia

Shayna R Sarosiek, Gottfried R. von Keudell, Jonas Paludo, Monika Salkar, Barnabie Agatep, Anjali Franco, Samuel Crawford, Michelle Pacia, Jorge J. Castillo
Journal: Blood
Blood (2023) 142 (Supplement 1): 3780.
https://doi.org/10.1182/blood-2023-181925
Published: 2023
Journal Articles

Novel Protacs Demonstrate Dual Kinase Inhibition and Degradation of HCK and BTK, and Are Highly Active in MYD88 Mutated WM and ABC DLBCL Cells

Shirong Liu, John M Hatcher, Amanda Kofides, Alexa G Canning, Jinhua Wang, Xia Liu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Zachary R Hunter, Shayna R Sarosiek, Jorge J. Castillo, Sara J. Buhrlage, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 3298.
https://doi.org/10.1182/blood-2023-190369
Published: 2023
Journal Articles

Quantitative MYD88 L265P Analysis Represents a Powerful Tool for Assessing Disease Response and Evaluating Clinical Trial Performance in Waldenstrom's Macroglobulinemia

Nickolas Tsakmaklis, Zachary R Hunter, Xia Liu, Amanda Kofides, Shirong Liu, Alexa G Canning, Kris Richardson, Maria Luisa Guerrera, Christopher J Patterson, Kirsten Meid, Timothy P. White, Megan Little, Katherine Stockman, Joshua Gustine, Catherine A. Flynn, Andrew R. Branagan, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 211.
https://doi.org/10.1182/blood-2023-190520
Published: 2023
Journal Articles

Outcomes of Patients with Relapsed/Refractory Lymphoplasmacytic Lymphoma Treated with Venetoclax: A Multicenter Retrospective Analysis

Yazeed Sawalha, Shayna R Sarosiek, Rina Li Welkie, Sherif Seif, Shrinjaya Thapa, Saurabh Zanwar, Kirk Cahill, Rachel Treitman, Haikoo Shah, Shagun Arora, Georgios Pongas, Allison Winter, Ajay Major, Peter A. Riedell, Maria Lia Palomba, Prashant Kapoor, Ariel F. Grajales-Cruz, Kenneth H. Shain, Sheeba K. Thomas, Jorge J. Castillo
Journal: Blood
Blood (2023) 142 (Supplement 1): 3045.
https://doi.org/10.1182/blood-2023-187237
Published: 2023
Journal Articles

Modified Staging System for Waldenström Macroglobulinemia (MSS-WM): A Multi-Institutional Externally Validated Prognostic Model for Active/Symptomatic Waldenström Macroglobulinemia

Saurabh Zanwar, Jennifer Le-Rademacher, Eric Durot, Shirley D'Sa, Jithma Prasad Abeykoon, Patrizia Mondello, Shaji Kunnathu Kumar, Shayna R Sarosiek, Jonas Paludo, Saurabh Chhabra, Joselle Cook, Ricardo Parrondo, Angela Dispenzieri, Wilson I. Gonsalves, Eli Muchtar, Sikander Ailawadhi, Robert Kyle, Vincent Rajkumar, Alain Jacques Delmer, Rafael Fonseca, Morie A. Gertz, Steven P Treon, Stephen M Ansell, Jorge J. Castillo, Prshant Kapoor
Journal: Blood
Blood (2023) 142 (Supplement 1): 3030.
https://doi.org/10.1182/blood-2023-179940
Published: 2023
Journal Articles

Ibrutinib and Venetoclax in Symptomatic, Treatment-Naive Patients with Waldenström Macroglobulinemia

Jorge J. Castillo, Shayna R Sarosiek, Andrew R. Branagan, Catherine A. Flynn, Megan Little, Katherine Stockman, Timothy P. White, Alexandra N. Eurell, Maria Luisa Guerrera, Amanda Kofides, Shirong Liu, Xia Liu, Kris Richardson, Nickolas Tsakmaklis, Kirsten Meid, Christopher J Patterson, Zachary R Hunter, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 1661.
https://doi.org/10.1182/blood-2023-174375
Published: 2023
Journal Articles

Final Results of a Multicenter Pilot Study Evaluating Brentuximab Vedotin with Cyclophosphamide, Doxorubicin, Etoposide, and Prednisone (BV-CHEP) for the Treatment of Aggressive Adult T-Cell Leukemia/Lymphoma

Christopher Dittus, Matthew Weinstock, Jeffrey A. Barnes, Jose Sandoval-Sus, Natalie S. Grover, Anne Beaven, Xianming Tan, Areej El-Jawahri, Shayna R Sarosiek, John Mark Sloan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1692.
https://doi.org/10.1182/blood-2023-173822
Published: 2023
Journal Articles

Early Subclones Showing Aberrant Co-Expression of Stem Cell, T Cell and Myeloid Genes Can be Detected By Flow Cytometry in MYD88 Mutated Waldenström's Macroglobulinemia Patients

Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Nickolas Tsakmaklis, Kris Richardson, Shirong Liu, Christopher J Patterson, Catherine A. Flynn, Kirsten Meid, Nikhil C Munshi, Kenneth C. Anderson, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon, Zachary R Hunter
Journal: Blood
Blood (2023) 142 (Supplement 1): 1952.
https://doi.org/10.1182/blood-2023-190942
Published: 2023
Journal Articles

Atypical Stem Cell, Pre-B-Cell, T-Cell and Myeloid Gene Expression Characterizes Early Waldenstrom's Macroglobulinemia Clones Which Diminishes with Advancing Disease and Has Therapeutic Implications

Zachary R Hunter, Maria Luisa Guerrera, Ruben D. Carrasco, Nickolas Tsakmaklis, Kris Richardson, Amanda Kofides, Xia Liu, Shirong Liu, Catherine A. Flynn, Kirsten Meid, Joshua Gustine, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Tomasz Sewastianik, Kenneth C. Anderson, Nikhil C Munshi, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 756.
https://doi.org/10.1182/blood-2023-190685
Published: 2023
Journal Articles

Phase 1 study of ibrutinib and the CXCR4 antagonist ulocuplumab in CXCR4-mutated Waldenström macroglobulinemia

Clinical Trials & Observations Brief Report
Steven P. Treon, Kirsten Meid, Zachary R. Hunter, Catherine A. Flynn, Shayna R. Sarosiek, Carly R. Leventoff, Timothy P. White, Yang Cao, Aldo M. Roccaro, Antonio Sacco, Maria G. Demos, Maria Luisa Guerrera, Amanda Kofides, Xia Liu, Lian Xu, Christopher J. Patterson, Manit Munshi, Nicholas Tsakmaklis, Guang Yang, Irene M. Ghobrial, Andrew R. Branagan, Jorge J. Castillo
Journal: Blood
Blood (2021) 138 (17): 1535–1539.
https://doi.org/10.1182/blood.2021012953
Published: 2021
Includes: Supplemental data