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Journal Articles

A Transcriptional Classifier Identifies Pediatric T-Cell Acute Lymphoblastic Leukemias at High Risk for End of Induction Minimal Residual Disease

Lauren K. Meyer, Ritu P. Roy, Petri Pölönen, Abdelrahman Elsayed, Benjamin J. Huang, Shunsuke Kimura, Cristina Delgado-Martin, Tiffaney L. Vincent, Theresa Ryan, Brent L. Wood, Zhiguo Chen, Yu Liu, Jinghui Zhang, Terzah M. Horton, Mignon L. Loh, Meenakshi Devidas, Elizabeth A. Raetz, Robert J. Hayashi, Stuart S. Winter, Kimberly P. Dunsmore, Stephen P. Hunger, Stanley B. Pounds, Michelle L. Hermiston, Jun J. Yang, Charles G. Mullighan, David T. Teachey, Adam B. Olshen
Journal: Blood
Blood (2022) 140 (Supplement 1): 1722–1723.
https://doi.org/10.1182/blood-2022-165233
Published: 2022
Journal Articles

Protein Translocation Inhibitors Overcome Cytokine-Induced Glucocorticoid Resistance in T-Cell Acute Lymphoblastic Leukemia

Lauren K. Meyer, Cristina Delgado-Martin, PhD, Phillip P. Sharp, PhD, Dustin McMinn, PhD, Christopher J. Kirk, PhD, Jack Taunton, PhD, Michelle L. Hermiston, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 805.
https://doi.org/10.1182/blood-2019-127537
Published: 2019
Journal Articles

Glucocorticoids Paradoxically Induce Intrinsic Steroid Resistance through a STAT5-Mediated Survival Mechanism in T-Cell Acute Lymphoblastic Leukemia

Lauren K. Meyer, Benjamin Huang, MD, Ritu Roy, PhD, Aaron Hechmer, PhD, Anica Wandler, PhD, Cristina Delgado-Martin, PhD, Adam B. Olshen, PhD, Terzah M. Horton, MD PhD, David T Teachey, MD, Kevin M. Shannon, MD, Michelle L. Hermiston, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 913.
https://doi.org/10.1182/blood-2018-99-119930
Published: 2018
Journal Articles

CRLF2 Rearrangement Status in Ph-like ALL Predicts Intrinsic Glucocorticoid Resistance In Vitro that is Reversible with Targeted MAPK and PI3K Pathway Inhibition

Lauren K Meyer, Cristina Delgado-Martin, PhD, Shannon L Maude, MD PhD, David T Teachey, MD, Michelle L. Hermiston, MD PhD
Journal: Blood
Blood (2016) 128 (22): 910.
https://doi.org/10.1182/blood.V128.22.910.910
Published: 2016
Journal Articles

Measurement of Phosphorylated ERK As a Prognostic and Predictive Marker for MEK Inhibition in Pediatric B-Lymphoblastic Leukemia: A Pilot Study

Pillai Pallavi Madhusoodhan, MD, Nikki Ann Evensen, PhD BS, Jason Saliba, PhD, Ashfiyah Chowdhury, BS, Daniel Newman, BA, BS, Cristina Delgado-Martin, PhD, Teena Bhatla, MD, Mignon L. Loh, MD, Michelle L. Hermiston, MD PhD, William L. Carroll, MD
Journal: Blood
Blood (2016) 128 (22): 1739.
https://doi.org/10.1182/blood.V128.22.1739.1739
Published: 2016
Journal Articles

JAK/STAT Pathway Inhibition Reverts IL7-Induced Glucocorticoid Resistance in a Subset of Human T-Cell Acute Lymphoblastic Leukemia

Cristina Delgado-Martin, PhD, Kristin Shimano, MD, Matthew S Zinter, MD, Justin T. Wahlstrom, MD, Geoffrey A. Smith, Jack Taunton, PhD, Stuart S. Winter, MD, Justine E. Roderick, PhD, Michelle Kelliher, PhD, Terzah M. Horton, MD PhD, Brent L. Wood, MD PhD, David T Teachey, MD, Michelle L. Hermiston, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3963.
https://doi.org/10.1182/blood.V128.22.3963.3963
Published: 2016
Journal Articles

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia

Courtney L. Jones, Christy M. Gearheart, Susan Fosmire, Cristina Delgado-Martin, Nikki A. Evensen, Karen Bride, Angela J. Waanders, Faye Pais, Jinhua Wang, Teena Bhatla, Danielle S. Bitterman, Simone R. de Rijk, Wallace Bourgeois, Smita Dandekar, Eugene Park, Tamara M. Burleson, Pillai Pallavi Madhusoodhan, David T. Teachey, Elizabeth A. Raetz, Michelle L. Hermiston, Markus Müschen, Mignon L. Loh, Stephen P. Hunger, Jinghui Zhang, Michael J. Garabedian, Christopher C. Porter, William L. Carroll
Journal: Blood
Blood (2015) 126 (19): 2202–2212.
https://doi.org/10.1182/blood-2015-04-639138
Published: 2015
Includes: Supplemental data
Journal Articles

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia

Shannon L. Maude, Sibasish Dolai, Cristina Delgado-Martin, Tiffaney Vincent, Alissa Robbins, Arthavan Selvanathan, Theresa Ryan, Junior Hall, Andrew C. Wood, Sarah K. Tasian, Stephen P. Hunger, Mignon L. Loh, Charles G. Mullighan, Brent L. Wood, Michelle L. Hermiston, Stephan A. Grupp, Richard B. Lock, David T. Teachey
Journal: Blood
Blood (2015) 125 (11): 1759–1767.
https://doi.org/10.1182/blood-2014-06-580480
Published: 2015
Includes: Supplemental data
Journal Articles

The CXCR4/CXCL12 Axis Mediates Chemotaxis, Survival, and Chemoresistance in T-Cell Acute Lymphoblastic Leukemia

Angela Liou, BA, Cristina Delgado-Martin, PhD, David T. Teachey, MD, Michelle L. Hermiston, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3629.
https://doi.org/10.1182/blood.V124.21.3629.3629
Published: 2014
Journal Articles

MAPK Signaling Cascades Mediate Distinct Glucocorticoid Resistance Mechanisms in Pediatric B-Precursor ALL

Courtney L Jones, PhD, Christy M Gearheart, PhD, Susan Fosmire, Cristina Delgado-Martin, PhD, Faye Pais, MD, Jinhua Wang, PhD, Teena Bhatla, MD, Danielle S Bitterman, Simone R de Rijk, Wallace Bourgeois, Smita C. Dandekar, MD, Elizabeth A. Raetz, MD, Michelle L. Hermiston, MD PhD, Michael J Garabedian, PhD, Christopher C. Porter, MD, William L. Carroll, MD
Journal: Blood
Blood (2014) 124 (21): 789.
https://doi.org/10.1182/blood.V124.21.789.789
Published: 2014